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Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.

Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.

Sci Rep. 2019 Nov 26;9(1):17548. doi: 10.1038/s41598-019-54082-5.


Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.

Ide Y, Horie T, Saito N, Watanabe S, Otani C, Miyasaka Y, Kuwabara Y, Nishino T, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Koyama S, Kimura M, Tsuji S, Rodriguez RR, Xu S, Yamasaki T, Watanabe T, Yamamoto M, Yanagita M, Kimura T, Kakizuka A, Ono K.

JACC Basic Transl Sci. 2019 Oct 28;4(6):701-714. doi: 10.1016/j.jacbts.2019.06.001. eCollection 2019 Oct.


Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells.

Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A.

Genes Cells. 2019 Nov;24(11):688-704. doi: 10.1111/gtc.12719. Epub 2019 Oct 17.


KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion.

Kinoshita H, Maki T, Yasuda K, Kishida N, Sasaoka N, Takagi Y, Kakizuka A, Takahashi R.

Sci Rep. 2019 Aug 8;9(1):11519. doi: 10.1038/s41598-019-47993-w.


Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.

Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A.

Genes Cells. 2019 Aug;24(8):569-584. doi: 10.1111/gtc.12712. Epub 2019 Jul 28.


PPARα-Mediated Positive-Feedback Loop Contributes to Cold Exposure Memory.

Alfaqaan S, Yoshida T, Imamura H, Tsukano C, Takemoto Y, Kakizuka A.

Sci Rep. 2019 Mar 14;9(1):4538. doi: 10.1038/s41598-019-40633-3.


A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation.

Sasaoka N, Imamura H, Kakizuka A.

iScience. 2018 Dec 21;10:211-221. doi: 10.1016/j.isci.2018.11.035. Epub 2018 Nov 23.


Corrigendum to "Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma" [Heliyon 4(2) (March 2018) e00544].

Hasegawa T, Ikeda HO, Iwai S, Muraoka Y, Tsuruyama T, Okamoto-Furuta K, Kohda H, Kakizuka A, Yoshimura N.

Heliyon. 2018 Aug 21;4(8):e00739. doi: 10.1016/j.heliyon.2018.e00739. eCollection 2018 Aug.


In vivo targeted single-nucleotide editing in zebrafish.

Tanaka S, Yoshioka S, Nishida K, Hosokawa H, Kakizuka A, Maegawa S.

Sci Rep. 2018 Jul 30;8(1):11423. doi: 10.1038/s41598-018-29794-9.


The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.

Nie X, Kitaoka S, Tanaka K, Segi-Nishida E, Imoto Y, Ogawa A, Nakano F, Tomohiro A, Nakayama K, Taniguchi M, Mimori-Kiyosue Y, Kakizuka A, Narumiya S, Furuyashiki T.

Neuron. 2018 Aug 8;99(3):464-479.e7. doi: 10.1016/j.neuron.2018.06.035. Epub 2018 Jul 19.


KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration.

Muraoka Y, Iida Y, Ikeda HO, Iwai S, Hata M, Iwata T, Nakayama M, Shimozawa N, Katakai Y, Kakizuka A, Yoshimura N, Tsujikawa A.

Heliyon. 2018 May 14;4(5):e00624. doi: 10.1016/j.heliyon.2018.e00624. eCollection 2018 May.


VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders.

Kakizuka A.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.


Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma.

Hasegawa T, Ikeda HO, Iwai S, Muraoka Y, Tsuruyama T, Okamoto-Furuta K, Kohda H, Kakizuka A, Yoshimura N.

Heliyon. 2018 Mar 1;4(2):e00544. doi: 10.1016/j.heliyon.2018.e00544. eCollection 2018 Feb. Erratum in: Heliyon. 2018 Aug 21;4(8):e00739.


Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation.

Matsubara M, Kanda H, Imamura H, Inoue M, Noguchi M, Hosoda K, Kakizuka A, Nakao K.

Sci Rep. 2018 Jan 17;8(1):949. doi: 10.1038/s41598-018-19264-7.


A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs.

Konagaya Y, Terai K, Hirao Y, Takakura K, Imajo M, Kamioka Y, Sasaoka N, Kakizuka A, Sumiyama K, Asano T, Matsuda M.

Cell Rep. 2017 Nov 28;21(9):2628-2638. doi: 10.1016/j.celrep.2017.10.113.


ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease.

Nakano M, Imamura H, Sasaoka N, Yamamoto M, Uemura N, Shudo T, Fuchigami T, Takahashi R, Kakizuka A.

EBioMedicine. 2017 Aug;22:225-241. doi: 10.1016/j.ebiom.2017.07.024. Epub 2017 Jul 25.


KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.

Hata M, Ikeda HO, Kikkawa C, Iwai S, Muraoka Y, Hasegawa T, Kakizuka A, Yoshimura N.

Sci Rep. 2017 Mar 20;7:44873. doi: 10.1038/srep44873.


BTeam, a Novel BRET-based Biosensor for the Accurate Quantification of ATP Concentration within Living Cells.

Yoshida T, Kakizuka A, Imamura H.

Sci Rep. 2016 Dec 21;6:39618. doi: 10.1038/srep39618.


Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration.

Hasegawa T, Muraoka Y, Ikeda HO, Tsuruyama T, Kondo M, Terasaki H, Kakizuka A, Yoshimura N.

Sci Rep. 2016 Aug 9;6:31184. doi: 10.1038/srep31184.


Neuroprotective effects of VCP modulators in mouse models of glaucoma.

Nakano N, Ikeda HO, Hasegawa T, Muraoka Y, Iwai S, Tsuruyama T, Nakano M, Fuchigami T, Shudo T, Kakizuka A, Yoshimura N.

Heliyon. 2016 Apr 19;2(4):e00096. doi: 10.1016/j.heliyon.2016.e00096. eCollection 2016 Apr.


Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics.

Ikura M, Furuya K, Fukuto A, Matsuda R, Adachi J, Matsuda T, Kakizuka A, Ikura T.

Mol Cell Biol. 2016 May 2;36(10):1595-607. doi: 10.1128/MCB.01085-15. Print 2016 May 15.


Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy.

Ohtera A, Miyamae Y, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M.

ACS Chem Biol. 2015 Dec 18;10(12):2794-804. doi: 10.1021/acschembio.5b00628. Epub 2015 Oct 12.


Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.

Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, Ikura M, Ikura T, Matsuda T.

Nucleic Acids Res. 2016 Jan 29;44(2):636-47. doi: 10.1093/nar/gkv967. Epub 2015 Sep 23.


VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast.

Ohnuma Y, Takata T, Kawawaki J, Yasuda K, Tanaka K, Kimura Y, Kakizuka A.

FEBS Lett. 2015 Feb 27;589(5):576-80. doi: 10.1016/j.febslet.2015.01.017. Epub 2015 Jan 24.


Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging.

Yaginuma H, Kawai S, Tabata KV, Tomiyama K, Kakizuka A, Komatsuzaki T, Noji H, Imamura H.

Sci Rep. 2014 Oct 6;4:6522. doi: 10.1038/srep06522.


Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa.

Ikeda HO, Sasaoka N, Koike M, Nakano N, Muraoka Y, Toda Y, Fuchigami T, Shudo T, Iwata A, Hori S, Yoshimura N, Kakizuka A.

Sci Rep. 2014 Aug 6;4:5970. doi: 10.1038/srep05970.


Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice.

Sasaoka N, Sakamoto M, Kanemori S, Kan M, Tsukano C, Takemoto Y, Kakizuka A.

PLoS One. 2014 Jan 29;9(1):e87185. doi: 10.1371/journal.pone.0087185. eCollection 2014.


Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation.

Yasuda K, Ohyama K, Onga K, Kakizuka A, Mori N.

PLoS One. 2013 Dec 16;8(12):e82523. doi: 10.1371/journal.pone.0082523. eCollection 2013.


Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations.

Tanaka T, Nagashima K, Inagaki N, Kioka H, Takashima S, Fukuoka H, Noji H, Kakizuka A, Imamura H.

J Biol Chem. 2014 Jan 24;289(4):2205-16. doi: 10.1074/jbc.M113.499111. Epub 2013 Dec 3.


Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system.

Kimura Y, Fukushi J, Hori S, Matsuda N, Okatsu K, Kakiyama Y, Kawawaki J, Kakizuka A, Tanaka K.

Genes Cells. 2013 Dec;18(12):1131-43. doi: 10.1111/gtc.12103. Epub 2013 Nov 12.


In vivo fluorescent adenosine 5'-triphosphate (ATP) imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATP biosensor optimized for low temperatures.

Tsuyama T, Kishikawa J, Han YW, Harada Y, Tsubouchi A, Noji H, Kakizuka A, Yokoyama K, Uemura T, Imamura H.

Anal Chem. 2013 Aug 20;85(16):7889-96. doi: 10.1021/ac4015325. Epub 2013 Aug 8.


Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.

Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S.

Mol Pharmacol. 2013 Sep;84(3):476-86. doi: 10.1124/mol.113.087288. Epub 2013 Jul 10.


VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.

Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A.

PLoS One. 2013;8(2):e56012. doi: 10.1371/journal.pone.0056012. Epub 2013 Feb 14.


In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.

Sakurai H, Sakaguchi Y, Shoji E, Nishino T, Maki I, Sakai H, Hanaoka K, Kakizuka A, Sehara-Fujisawa A.

PLoS One. 2012;7(10):e47078. doi: 10.1371/journal.pone.0047078. Epub 2012 Oct 24.


Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs.

Takata T, Kimura Y, Ohnuma Y, Kawawaki J, Kakiyama Y, Tanaka K, Kakizuka A.

J Struct Biol. 2012 Aug;179(2):93-103. doi: 10.1016/j.jsb.2012.06.005. Epub 2012 Jun 19.


Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography.

Muraoka Y, Ikeda HO, Nakano N, Hangai M, Toda Y, Okamoto-Furuta K, Kohda H, Kondo M, Terasaki H, Kakizuka A, Yoshimura N.

PLoS One. 2012;7(4):e36135. doi: 10.1371/journal.pone.0036135. Epub 2012 Apr 27.


Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5.

Ohyama K, Yasuda K, Onga K, Kakizuka A, Mori N.

Gene Expr Patterns. 2012 Jan-Feb;12(1-2):36-45. doi: 10.1016/j.gep.2011.11.001. Epub 2011 Nov 10.


Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate.

Nakano N, Ikeda HO, Hangai M, Muraoka Y, Toda Y, Kakizuka A, Yoshimura N.

Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8754-62. doi: 10.1167/iovs.10-6654.


Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain.

Takeshita Y, Fujinaga R, Kokubu K, Islam MN, Jahan MR, Yanai A, Kakizuka A, Shinoda K.

Neuroreport. 2011 Mar 30;22(5):232-8. doi: 10.1097/WNR.0b013e32834505f4.


Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells.

Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Hori S, Kakizuka A, Obata K, Yanagawa Y, Hirano T, Sasai Y.

Nat Neurosci. 2010 Oct;13(10):1171-80. doi: 10.1038/nn.2638. Epub 2010 Sep 12.


Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.

Manno A, Noguchi M, Fukushi J, Motohashi Y, Kakizuka A.

Genes Cells. 2010 Aug;15(8):911-22. doi: 10.1111/j.1365-2443.2010.01428.x. Epub 2010 Jul 5.


Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression.

Koike M, Fukushi J, Ichinohe Y, Higashimae N, Fujishiro M, Sasaki C, Yamaguchi M, Uchihara T, Yagishita S, Ohizumi H, Hori S, Kakizuka A.

J Biol Chem. 2010 Jul 9;285(28):21736-49. doi: 10.1074/jbc.M109.099283. Epub 2010 Apr 21.


Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress.

Okamoto A, Koike M, Yasuda K, Kakizuka A.

Biochem Biophys Res Commun. 2010 Mar 26;394(1):42-7. doi: 10.1016/j.bbrc.2010.02.065. Epub 2010 Feb 19.


Glucosamine induces autophagy via an mTOR-independent pathway.

Shintani T, Yamazaki F, Katoh T, Umekawa M, Matahira Y, Hori S, Kakizuka A, Totani K, Yamamoto K, Ashida H.

Biochem Biophys Res Commun. 2010 Jan 22;391(4):1775-9. doi: 10.1016/j.bbrc.2009.12.154. Epub 2010 Jan 5.


Listeria monocytogenes ActA-mediated escape from autophagic recognition.

Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C.

Nat Cell Biol. 2009 Oct;11(10):1233-40. doi: 10.1038/ncb1967. Epub 2009 Sep 13.


An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.

Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Tanaka K.

Cell. 2009 May 1;137(3):549-59. doi: 10.1016/j.cell.2009.02.028.


p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.

Mori-Konya C, Kato N, Maeda R, Yasuda K, Higashimae N, Noguchi M, Koike M, Kimura Y, Ohizumi H, Hori S, Kakizuka A.

Genes Cells. 2009 Apr;14(4):483-97. doi: 10.1111/j.1365-2443.2009.01286.x.


Roles of VCP in human neurodegenerative disorders.

Kakizuka A.

Biochem Soc Trans. 2008 Feb;36(Pt 1):105-8. doi: 10.1042/BST0360105. Review.


Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor.

Nomura R, Suzuki Y, Kakizuka A, Jingami H.

J Biol Chem. 2008 Feb 22;283(8):4665-73. doi: 10.1074/jbc.M705202200. Epub 2007 Dec 28.


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