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Items: 1 to 50 of 159

1.

Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells.

Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, Sasaki Y, Shimoda R, Osako Y, Sawada Y, Kubo Y, Miyashita A, Fukushima S, Cheng Z, Nakaki R, Takubo K, Okada S, Kaneko S, Ihn H, Kaisho T, Nishimura Y, Senju S, Endo I, Nakatsura T, Uemura Y.

Cell Rep. 2019 Oct 1;29(1):162-175.e9. doi: 10.1016/j.celrep.2019.08.086.

2.

Systems analysis reveals complex biological processes during virus infection fate decisions.

Argilaguet J, Pedragosa M, Esteve-Codina A, Riera G, Vidal E, Peligero-Cruz C, Casella V, Andreu D, Kaisho T, Bocharov G, Ludewig B, Heath S, Meyerhans A.

Genome Res. 2019 Jun;29(6):907-919. doi: 10.1101/gr.241372.118. Epub 2019 May 28.

3.

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice.

Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, Hase K.

J Exp Med. 2019 Apr 1;216(4):831-846. doi: 10.1084/jem.20181604. Epub 2019 Mar 15.

4.

Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice.

Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S.

J Invest Dermatol. 2019 Jun;139(6):1329-1338.e7. doi: 10.1016/j.jid.2019.01.029. Epub 2019 Feb 15.

PMID:
30776434
5.

Identification of a novel CCDC22 mutation in a patient with severe Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia.

Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI, Yoshiura KI, Kaisho T, Sonoki T, Tamura S.

Int J Hematol. 2019 Jun;109(6):744-750. doi: 10.1007/s12185-019-02595-0. Epub 2019 Jan 31.

PMID:
30706328
6.

Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9-genome editing promotes antitumor immunity and suppresses ovarian cancer progression.

Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda-Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K.

Cancer Sci. 2019 Apr;110(4):1279-1292. doi: 10.1111/cas.13958. Epub 2019 Feb 27.

7.

Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome.

Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T.

Int Immunol. 2019 Sep 18;31(10):657-668. doi: 10.1093/intimm/dxz004.

8.

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.

Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K.

Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23.

PMID:
30675064
9.

[In Vivo Antigen Delivery to Dendritic Cells-A Novel Peptide Vaccine for Cancer Therapy].

Mizumoto Y, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Hemmi H, Tamada K, Kaisho T, Yamaue H.

Gan To Kagaku Ryoho. 2018 Oct;45(10):1469-1471. Japanese.

PMID:
30382048
10.

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8418-8423. doi: 10.1073/pnas.1808426115. Epub 2018 Jul 30.

11.

Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.

Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL, Iwasaki A.

Nat Microbiol. 2018 May;3(5):611-621. doi: 10.1038/s41564-018-0138-2. Epub 2018 Apr 9.

12.

Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration.

Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Hemmi H, Sasaki I, Kaisho T, Mukaida N, Kondo T.

Sci Rep. 2017 Dec 4;7(1):16833. doi: 10.1038/s41598-017-17007-8.

13.

Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin.

Yamazaki S, Odanaka M, Nishioka A, Kasuya S, Shime H, Hemmi H, Imai M, Riethmacher D, Kaisho T, Ohkura N, Sakaguchi S, Morita A.

J Immunol. 2018 Jan 1;200(1):119-129. doi: 10.4049/jimmunol.1701056. Epub 2017 Nov 20.

14.

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR.

J Immunol. 2017 Dec 15;199(12):4165-4179. doi: 10.4049/jimmunol.1700186. Epub 2017 Oct 30.

15.

Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice.

Nagai H, Kaisho T, Yokoyama K, Asakawa T, Fujita H, Matsumiya K, Noguchi J, Tsuchimori K, Nishizawa N, Kanematsu-Yamaki Y, Dote K, Inooka H, Sakamoto JI, Ohtaki T, Asami T, Takekawa S.

Br J Pharmacol. 2018 Jan;175(2):359-373. doi: 10.1111/bph.14077. Epub 2017 Dec 18.

16.

Effects of peripheral administration of a Neuromedin U receptor 2-selective agonist on food intake and body weight in obese mice.

Kaisho T, Nagai H, Asakawa T, Suzuki N, Fujita H, Matsumiya K, Nishizawa N, Kanematsu-Yamaki Y, Dote K, Sakamoto JI, Asami T, Takekawa S.

Int J Obes (Lond). 2017 Dec;41(12):1790-1797. doi: 10.1038/ijo.2017.176. Epub 2017 Jul 31.

PMID:
28757640
17.

Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.

Kanematsu-Yamaki Y, Nishizawa N, Kaisho T, Nagai H, Mochida T, Asakawa T, Inooka H, Dote K, Fujita H, Matsumiya K, Hirabayashi H, Sakamoto J, Ohtaki T, Takekawa S, Asami T.

J Med Chem. 2017 Jul 27;60(14):6089-6097. doi: 10.1021/acs.jmedchem.7b00330. Epub 2017 Jul 18.

PMID:
28657315
18.

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.

Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.

Immunity. 2017 May 16;46(5):863-874.e4. doi: 10.1016/j.immuni.2017.04.017.

19.

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.

20.

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M.

JCI Insight. 2016 Jul 21;1(11):e87680. doi: 10.1172/jci.insight.87680.

21.

Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.

Roberts EW, Broz ML, Binnewies M, Headley MB, Nelson AE, Wolf DM, Kaisho T, Bogunovic D, Bhardwaj N, Krummel MF.

Cancer Cell. 2016 Aug 8;30(2):324-336. doi: 10.1016/j.ccell.2016.06.003. Epub 2016 Jul 14.

22.

In Vivo Ablation of a Dendritic Cell Subset Expressing the Chemokine Receptor XCR1.

Hemmi H, Hoshino K, Kaisho T.

Methods Mol Biol. 2016;1423:247-53. doi: 10.1007/978-1-4939-3606-9_17.

PMID:
27142021
23.

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.

Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T.

Sci Rep. 2016 Mar 23;6:23505. doi: 10.1038/srep23505.

24.

Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node.

Kitano M, Yamazaki C, Takumi A, Ikeno T, Hemmi H, Takahashi N, Shimizu K, Fraser SE, Hoshino K, Kaisho T, Okada T.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1044-9. doi: 10.1073/pnas.1513607113. Epub 2016 Jan 11.

25.
26.

Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.

Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W.

Cell. 2015 Sep 10;162(6):1322-37. doi: 10.1016/j.cell.2015.08.004. Epub 2015 Aug 18.

27.

Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.

Daniels NJ, Hyde E, Ghosh S, Seo K, Price KM, Hoshino K, Kaisho T, Okada T, Ronchese F.

Mucosal Immunol. 2016 Jan;9(1):229-39. doi: 10.1038/mi.2015.55. Epub 2015 Jun 24.

PMID:
26104914
28.

Correction: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.

Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S.

J Immunol. 2015 Apr 1;194(7):3526. doi: 10.4049/jimmunol.1500168. No abstract available.

29.

Corrigendum: Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.

Pathak SK, Basu S, Basu KK, Banerjee A, Pathak S, Bhattacharyya A, Kaisho T, Kundu M, Basu J.

Nat Immunol. 2015 Mar;16(3):326. doi: 10.1038/ni0315-326b. No abstract available.

PMID:
25689444
30.

HSP70 mediates degradation of the p65 subunit of nuclear factor κB to inhibit inflammatory signaling.

Tanaka T, Shibazaki A, Ono R, Kaisho T.

Sci Signal. 2014 Dec 16;7(356):ra119. doi: 10.1126/scisignal.2005533.

PMID:
25515536
31.

Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.

Sasaki H, Kurotaki D, Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC 3rd, Ozato K, Tamura T.

Blood. 2015 Jan 8;125(2):358-69. doi: 10.1182/blood-2014-02-557983. Epub 2014 Nov 14.

32.

Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation.

Akiyama N, Shinzawa M, Miyauchi M, Yanai H, Tateishi R, Shimo Y, Ohshima D, Matsuo K, Sasaki I, Hoshino K, Wu G, Yagi S, Inoue J, Kaisho T, Akiyama T.

J Exp Med. 2014 Nov 17;211(12):2425-38. doi: 10.1084/jem.20141207. Epub 2014 Nov 10.

33.

Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin.

Yamazaki S, Nishioka A, Kasuya S, Ohkura N, Hemmi H, Kaisho T, Taguchi O, Sakaguchi S, Morita A.

J Immunol. 2014 Dec 1;193(11):5488-97. doi: 10.4049/jimmunol.1400985. Epub 2014 Oct 27.

34.

Homeostatic inflammation in innate immunity.

Miyake K, Kaisho T.

Curr Opin Immunol. 2014 Oct;30:85-90. doi: 10.1016/j.coi.2014.08.003. Epub 2014 Sep 3. Review.

PMID:
25190609
35.

Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response.

Liu T, Yamaguchi Y, Shirasaki Y, Shikada K, Yamagishi M, Hoshino K, Kaisho T, Takemoto K, Suzuki T, Kuranaga E, Ohara O, Miura M.

Cell Rep. 2014 Aug 21;8(4):974-82. doi: 10.1016/j.celrep.2014.07.012. Epub 2014 Aug 7.

36.

IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.

Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H.

Biochem Biophys Res Commun. 2014 Aug 22;451(2):215-21. doi: 10.1016/j.bbrc.2014.07.096. Epub 2014 Aug 1.

PMID:
25088998
37.

Transcriptional control of dendritic cell differentiation.

Sasaki I, Kaisho T.

Curr Top Microbiol Immunol. 2014;381:257-78. doi: 10.1007/82_2014_378. Review.

PMID:
24875951
38.

Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

Zhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C.

Cell Host Microbe. 2014 May 14;15(5):551-63. doi: 10.1016/j.chom.2014.04.008.

39.

[Innate immunity and allergy].

Kaisho T.

Arerugi. 2013 Jul;62(7):789-96. Review. Japanese. No abstract available.

PMID:
24129654
40.

Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, Kaneko D, Kumagai Y, You DJ, Carreras J, Uematsu S, Jang MH, Takeuchi O, Kaisho T, Akira S, Miyake K, Tsutsui H, Saito T, Nishimura I, Tsuji NM.

Immunity. 2013 Jun 27;38(6):1187-97. doi: 10.1016/j.immuni.2013.02.024. Epub 2013 Jun 20.

41.

Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.

Yamazaki C, Sugiyama M, Ohta T, Hemmi H, Hamada E, Sasaki I, Fukuda Y, Yano T, Nobuoka M, Hirashima T, Iizuka A, Sato K, Tanaka T, Hoshino K, Kaisho T.

J Immunol. 2013 Jun 15;190(12):6071-82. doi: 10.4049/jimmunol.1202798. Epub 2013 May 13.

42.

Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction.

Shimizu K, Asakura M, Shinga J, Sato Y, Kitahara S, Hoshino K, Kaisho T, Schoenberger SP, Ezaki T, Fujii S.

J Immunol. 2013 Jun 1;190(11):5609-19. doi: 10.4049/jimmunol.1300033. Epub 2013 Apr 29.

43.

Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren's syndrome-like autoimmune disease.

Okuma A, Hoshino K, Ohba T, Fukushi S, Aiba S, Akira S, Ono M, Kaisho T, Muta T.

Immunity. 2013 Mar 21;38(3):450-60. doi: 10.1016/j.immuni.2012.11.016. Epub 2013 Feb 28.

44.

Pathogen sensors and chemokine receptors in dendritic cell subsets.

Kaisho T.

Vaccine. 2012 Dec 14;30(52):7652-7. doi: 10.1016/j.vaccine.2012.10.043. Epub 2012 Nov 8. Review.

PMID:
23142133
45.

Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18.

Kosaka A, Yan H, Ohashi S, Gotoh Y, Sato A, Tsutsui H, Kaisho T, Toda T, Tsuji NM.

Int Immunopharmacol. 2012 Dec;14(4):729-33. doi: 10.1016/j.intimp.2012.10.007. Epub 2012 Oct 23.

PMID:
23102661
46.

Spi-B is critical for plasmacytoid dendritic cell function and development.

Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T.

Blood. 2012 Dec 6;120(24):4733-43. doi: 10.1182/blood-2012-06-436527. Epub 2012 Oct 11.

PMID:
23065153
47.

Dynamism of immune reactions and regulation.

Kurosaki T, Saito T, Kumanogoh A, Takeda K, Kaisho T.

Int Immunol. 2012 Aug;24(8):473-5. doi: 10.1093/intimm/dxs079. No abstract available.

PMID:
22843775
48.

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.

Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H.

Nat Immunol. 2012 Jun 17;13(8):729-36. doi: 10.1038/ni.2352.

49.

Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.

Kasai S, Kamata M, Masada S, Kunitomo J, Kamaura M, Okawa T, Takami K, Ogino H, Nakano Y, Ashina S, Watanabe K, Kaisho T, Imai YN, Ryu S, Nakayama M, Nagisa Y, Takekawa S, Kato K, Murata T, Suzuki N, Ishihara Y.

J Med Chem. 2012 May 10;55(9):4336-51. doi: 10.1021/jm300167z. Epub 2012 Apr 23.

PMID:
22490048
50.

Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein.

Mizukami S, Kajiwara C, Tanaka M, Kaisho T, Udono H.

Cancer Sci. 2012 May;103(5):851-9. doi: 10.1111/j.1349-7006.2012.02233.x. Epub 2012 Mar 14.

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