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Items: 1 to 50 of 110

1.

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA.

Upton JW, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2019 Oct 9;26(4):564. doi: 10.1016/j.chom.2019.09.004. No abstract available.

PMID:
31600504
2.

ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.

Ingram JP, Thapa RJ, Fisher A, Tummers B, Zhang T, Yin C, Rodriguez DA, Guo H, Lane R, Williams R, Slifker MJ, Basagoudanavar SH, Rall GF, Dillon CP, Green DR, Kaiser WJ, Balachandran S.

J Immunol. 2019 Sep 1;203(5):1348-1355. doi: 10.4049/jimmunol.1900216. Epub 2019 Jul 29.

PMID:
31358656
3.

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.

Zhang CJ, Jiang M, Zhou H, Liu W, Wang C, Kang Z, Han B, Zhang Q, Chen X, Xiao J, Fisher A, Kaiser WJ, Murayama MA, Iwakura Y, Gao J, Carman J, Dongre A, Dubyak G, Abbott DW, Shi FD, Ransohoff RM, Li X.

J Clin Invest. 2018 Dec 3;128(12):5399-5412. doi: 10.1172/JCI121901. Epub 2018 Oct 29.

4.

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1.

Guo H, Gilley RP, Fisher A, Lane R, Landsteiner VJ, Ragan KB, Dovey CM, Carette JE, Upton JW, Mocarski ES, Kaiser WJ.

Cell Death Dis. 2018 Jul 26;9(8):816. doi: 10.1038/s41419-018-0868-3.

5.

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE.

Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7.

6.

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis.

Sasikumar P, AlOuda KS, Kaiser WJ, Holbrook LM, Kriek N, Unsworth AJ, Bye AP, Sage T, Ushioda R, Nagata K, Farndale RW, Gibbins JM.

J Thromb Haemost. 2018 May;16(5):946-959. doi: 10.1111/jth.13998. Epub 2018 Apr 15.

7.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

8.

Murine cytomegalovirus IE3-dependent transcription is required for DAI/ZBP1-mediated necroptosis.

Sridharan H, Ragan KB, Guo H, Gilley RP, Landsteiner VJ, Kaiser WJ, Upton JW.

EMBO Rep. 2017 Aug;18(8):1429-1441. doi: 10.15252/embr.201743947. Epub 2017 Jun 12.

9.

A RIPtide Protects Neurons from Infection.

Gilley RP, Kaiser WJ.

Cell Host Microbe. 2017 Apr 12;21(4):415-416. doi: 10.1016/j.chom.2017.03.014.

10.

ESCRTing Necroptosis.

Guo H, Kaiser WJ.

Cell. 2017 Apr 6;169(2):186-187. doi: 10.1016/j.cell.2017.03.030.

11.

Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways.

Daley-Bauer LP, Roback L, Crosby LN, McCormick AL, Feng Y, Kaiser WJ, Mocarski ES.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2786-E2795. doi: 10.1073/pnas.1616829114. Epub 2017 Mar 14.

12.

DAI Another Way: Necroptotic Control of Viral Infection.

Upton JW, Kaiser WJ.

Cell Host Microbe. 2017 Mar 8;21(3):290-293. doi: 10.1016/j.chom.2017.01.016.

13.

RIPK1 prevents aberrant ZBP1-initiated necroptosis.

Vanden Berghe T, Kaiser WJ.

Oncotarget. 2017 Jan 3;8(1):1-2. doi: 10.18632/oncotarget.13926. No abstract available.

14.

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S.

Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.

15.

Molecular crosstalk between apoptosis, necroptosis, and survival signaling.

Vanden Berghe T, Kaiser WJ, Bertrand MJ, Vandenabeele P.

Mol Cell Oncol. 2015 Apr 8;2(4):e975093. doi: 10.4161/23723556.2014.975093. eCollection 2015 Oct-Dec. Review.

16.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.

17.

Use of metabolomics for the chemotaxonomy of legume-associated Ascochyta and allied genera.

Kim W, Peever TL, Park JJ, Park CM, Gang DR, Xian M, Davidson JA, Infantino A, Kaiser WJ, Chen W.

Sci Rep. 2016 Feb 5;6:20192. doi: 10.1038/srep20192.

18.

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.

Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR.

J Biol Chem. 2015 Aug 14;290(33):20167-84. doi: 10.1074/jbc.M115.652321. Epub 2015 Jun 22.

19.

Manipulation of apoptosis and necroptosis signaling by herpesviruses.

Guo H, Kaiser WJ, Mocarski ES.

Med Microbiol Immunol. 2015 Jun;204(3):439-48. doi: 10.1007/s00430-015-0410-5. Epub 2015 Apr 1. Review.

20.

Necroptosis: The Trojan horse in cell autonomous antiviral host defense.

Mocarski ES, Guo H, Kaiser WJ.

Virology. 2015 May;479-480:160-6. doi: 10.1016/j.virol.2015.03.016. Epub 2015 Mar 24. Review.

21.

Suppression of RIP3-dependent necroptosis by human cytomegalovirus.

Omoto S, Guo H, Talekar GR, Roback L, Kaiser WJ, Mocarski ES.

J Biol Chem. 2015 May 1;290(18):11635-48. doi: 10.1074/jbc.M115.646042. Epub 2015 Mar 16.

22.

Herpes simplex virus suppresses necroptosis in human cells.

Guo H, Omoto S, Harris PA, Finger JN, Bertin J, Gough PJ, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2015 Feb 11;17(2):243-51. doi: 10.1016/j.chom.2015.01.003.

23.

Use of inertial sensors to predict pivot-shift grade and diagnose an ACL injury during preoperative testing.

Borgstrom PH, Markolf KL, Wang Y, Xu X, Yang PR, Joshi NB, Yeranosian MG, Petrigliano FA, Hame SL, Kaiser WJ, McAllister DR.

Am J Sports Med. 2015 Apr;43(4):857-64. doi: 10.1177/0363546514565090. Epub 2015 Jan 22.

PMID:
25612764
24.

Personalized Multilayer Daily Life Profiling Through Context Enabled Activity Classification and Motion Reconstruction: An Integrated System Approach.

Xu JY, Wang Y, Barrett M, Dobkin B, Pottie GJ, Kaiser WJ.

IEEE J Biomed Health Inform. 2016 Jan;20(1):177-88. doi: 10.1109/JBHI.2014.2385694. Epub 2014 Dec 23.

PMID:
25546868
25.

RIP3 induces apoptosis independent of pronecrotic kinase activity.

Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, Casillas LN, Haile PA, Sehon CA, Marquis RW, Upton J, Daley-Bauer LP, Roback L, Ramia N, Dovey CM, Carette JE, Chan FK, Bertin J, Gough PJ, Mocarski ES, Kaiser WJ.

Mol Cell. 2014 Nov 20;56(4):481-95. doi: 10.1016/j.molcel.2014.10.021. Epub 2014 Nov 20.

26.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.

27.

Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.

Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA.

J Immunol. 2014 Sep 1;193(5):2519-2530. doi: 10.4049/jimmunol.1400276. Epub 2014 Jul 25.

28.

Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.

Jones CI, Tucker KL, Sasikumar P, Sage T, Kaiser WJ, Moore C, Emerson M, Gibbins JM.

J Thromb Haemost. 2014 Aug;12(8):1342-52. doi: 10.1111/jth.12620. Epub 2014 Jul 31.

29.

Integrated inertial sensors and mobile computing for real-time cycling performance guidance via pedaling profile classification.

Xu JY, Nan X, Ebken V, Wang Y, Pottie GJ, Kaiser WJ.

IEEE J Biomed Health Inform. 2015 Mar;19(2):440-5. doi: 10.1109/JBHI.2014.2322871. Epub 2014 May 9.

PMID:
24833607
30.

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ.

J Immunol. 2014 Jun 15;192(12):5476-80. doi: 10.4049/jimmunol.1400499. Epub 2014 May 12.

31.

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7753-8. doi: 10.1073/pnas.1401857111. Epub 2014 May 12.

32.

Measurements of tibial rotation during a simulated pivot shift manoeuvre using a gyroscopic sensor.

Petrigliano FA, Borgstrom PH, Kaiser WJ, McAllister DR, Markolf KL.

Knee Surg Sports Traumatol Arthrosc. 2015 Aug;23(8):2237-2243. doi: 10.1007/s00167-014-3015-4. Epub 2014 May 11.

PMID:
24817161
33.

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. doi: 10.1073/pnas.1403477111. Epub 2014 May 5.

34.

Is SIRT2 required for necroptosis?

Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, Strasser A, Degterev A, Silke J.

Nature. 2014 Feb 27;506(7489):E4-6. doi: 10.1038/nature13024.

35.

True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity.

Mocarski ES, Kaiser WJ, Livingston-Rosanoff D, Upton JW, Daley-Bauer LP.

J Immunol. 2014 Mar 1;192(5):2019-26. doi: 10.4049/jimmunol.1302426. Review.

36.

The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.

Ambily A, Kaiser WJ, Pierro C, Chamberlain EV, Li Z, Jones CI, Kassouf N, Gibbins JM, Authi KS.

Cell Signal. 2014 Mar;26(3):502-11. doi: 10.1016/j.cellsig.2013.11.025. Epub 2013 Dec 2.

37.

Context-driven, prescription-based personal activity classification: methodology, architecture, and end-to-end implementation.

Xu JY, Chang HI, Chien C, Kaiser WJ, Pottie GJ.

IEEE J Biomed Health Inform. 2014 May;18(3):1015-25. doi: 10.1109/JBHI.2013.2282812. Epub 2013 Sep 20.

PMID:
24107984
38.

Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells.

Antonopoulos C, El Sanadi C, Kaiser WJ, Mocarski ES, Dubyak GR.

J Immunol. 2013 Nov 1;191(9):4789-803. doi: 10.4049/jimmunol.1300645. Epub 2013 Sep 27.

39.

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES.

J Biol Chem. 2013 Oct 25;288(43):31268-79. doi: 10.1074/jbc.M113.462341. Epub 2013 Sep 9.

40.

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.

Long AB, Kaiser WJ, Mocarski ES, Caspary T.

Cell Death Differ. 2013 Nov;20(11):1510-20. doi: 10.1038/cdd.2013.97. Epub 2013 Jul 26.

41.

Viral modulation of programmed necrosis.

Kaiser WJ, Upton JW, Mocarski ES.

Curr Opin Virol. 2013 Jun;3(3):296-306. doi: 10.1016/j.coviro.2013.05.019. Epub 2013 Jun 15. Review.

42.

The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function.

Wright B, Stanley RG, Kaiser WJ, Gibbins JM.

Proteomics Clin Appl. 2013 Jan;7(1-2):144-54. doi: 10.1002/prca.201200095. Review.

PMID:
23184887
43.

Karyotype polymorphism and chromosomal rearrangement in populations of the phytopathogenic fungus, Ascochyta rabiei.

Akamatsu HO, Chilvers MI, Kaiser WJ, Peever TL.

Fungal Biol. 2012 Nov;116(11):1119-33. doi: 10.1016/j.funbio.2012.07.001. Epub 2012 Jul 14.

PMID:
23153803
44.

Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.

Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E.

J Immunol. 2012 Dec 15;189(12):5508-12. doi: 10.4049/jimmunol.1202121. Epub 2012 Nov 9.

45.

Enabling large-scale ground-truth acquisition and system evaluation in wireless health.

Xu JY, Pottie GJ, Kaiser WJ.

IEEE Trans Biomed Eng. 2013 Jan;60(1):174-8. doi: 10.1109/TBME.2012.2208111. Epub 2012 Jul 11.

PMID:
22801488
46.

Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.

Vaiyapuri S, Jones CI, Sasikumar P, Moraes LA, Munger SJ, Wright JR, Ali MS, Sage T, Kaiser WJ, Tucker KL, Stain CJ, Bye AP, Jones S, Oviedo-Orta E, Simon AM, Mahaut-Smith MP, Gibbins JM.

Circulation. 2012 May 22;125(20):2479-91. doi: 10.1161/CIRCULATIONAHA.112.101246. Epub 2012 Apr 23.

47.

Energy-efficient context classification with dynamic sensor control.

Au LK, Bui AA, Batalin MA, Kaiser WJ.

IEEE Trans Biomed Circuits Syst. 2012 Apr;6(2):167-78. doi: 10.1109/TBCAS.2011.2166073.

48.

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

Upton JW, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2012 Mar 15;11(3):290-7. doi: 10.1016/j.chom.2012.01.016.

49.

CARER: efficient dynamic sensing for continuous activity monitoring.

Au LK, Bui AA, Batalin MA, Xu X, Kaiser WJ.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2228-32. doi: 10.1109/IEMBS.2011.6090422.

50.

Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways.

Mocarski ES, Upton JW, Kaiser WJ.

Nat Rev Immunol. 2011 Dec 23;12(2):79-88. doi: 10.1038/nri3131. Review.

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