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Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.

Heras V, Sangiao-Alvarellos S, Manfredi-Lozano M, Sanchez-Tapia MJ, Ruiz-Pino F, Roa J, Lara-Chica M, Morrugares-Carmona R, Jouy N, Abreu AP, Prevot V, Belsham D, Vazquez MJ, Calzado MA, Pinilla L, Gaytan F, Latronico AC, Kaiser UB, Castellano JM, Tena-Sempere M.

PLoS Biol. 2019 Nov 7;17(11):e3000532. doi: 10.1371/journal.pbio.3000532. [Epub ahead of print]


GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers.

Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YG.

Cell Rep. 2019 Jun 18;27(12):3522-3532.e3. doi: 10.1016/j.celrep.2019.05.062.


The Impact of High-Dose Glucocorticoids on the Outcome of Immune-Checkpoint Inhibitor-Related Thyroid Disorders.

Ma C, Hodi FS, Giobbie-Hurder A, Wang X, Zhou J, Zhang A, Zhou Y, Mao F, Angell TE, Andrews CP, Hu J, Barroso-Sousa R, Kaiser UB, Tolaney SM, Min L.

Cancer Immunol Res. 2019 Jul;7(7):1214-1220. doi: 10.1158/2326-6066.CIR-18-0613. Epub 2019 May 14.


MKRN3 Mutations in Central Precocious Puberty: A Systematic Review and Meta-Analysis.

Valadares LP, Meireles CG, De Toledo IP, Santarem de Oliveira R, Gonçalves de Castro LC, Abreu AP, Carroll RS, Latronico AC, Kaiser UB, Guerra ENS, Lofrano-Porto A.

J Endocr Soc. 2019 Mar 25;3(5):979-995. doi: 10.1210/js.2019-00041. eCollection 2019 May 1.


Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice.

Lee JA, Kuchakulla M, Arora H, Kulandavelu S, Gonzalez E, Masterson TA, Hare JM, Kaiser UB, Ramasamy R.

Front Endocrinol (Lausanne). 2019 Mar 28;10:190. doi: 10.3389/fendo.2019.00190. eCollection 2019.


GnRH-A Key Regulator of FSH.

Stamatiades GA, Carroll RS, Kaiser UB.

Endocrinology. 2019 Jan 1;160(1):57-67. doi: 10.1210/en.2018-00889.


GnRH Transactivates Human AMH Receptor Gene via Egr1 and FOXO1 in Gonadotrope Cells.

Garrel G, Denoyelle C, L'Hôte D, Picard JY, Teixeira J, Kaiser UB, Laverrière JN, Cohen-Tannoudji J.

Neuroendocrinology. 2019;108(2):65-83. doi: 10.1159/000494890. Epub 2018 Oct 28.


Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.

Chang LS, Barroso-Sousa R, Tolaney SM, Hodi FS, Kaiser UB, Min L.

Endocr Rev. 2019 Feb 1;40(1):17-65. doi: 10.1210/er.2018-00006. Review.


PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse.

Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM.

Elife. 2018 Jun 15;7. pii: e35960. doi: 10.7554/eLife.35960.


Central Precocious Puberty Caused by a Heterozygous Deletion in the MKRN3 Promoter Region.

Macedo DB, França MM, Montenegro LR, Cunha-Silva M, Best DS, Abreu AP, Kaiser UB, Mendonca BB, Jorge AAL, Brito VN, Latronico AC.

Neuroendocrinology. 2018;107(2):127-132. doi: 10.1159/000490059. Epub 2018 May 15.


Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators.

Rich-Edwards JW, Kaiser UB, Chen GL, Manson JE, Goldstein JM.

Endocr Rev. 2018 Aug 1;39(4):424-439. doi: 10.1210/er.2017-00246. Review.


S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.

Masterson TA, Arora H, Kulandavelu S, Carroll RS, Kaiser UB, Gultekin SH, Hare JM, Ramasamy R.

J Sex Med. 2018 May;15(5):654-661. doi: 10.1016/j.jsxm.2018.03.002. Epub 2018 Mar 30.


Endocrine dysfunction induced by immune checkpoint inhibitors: Practical recommendations for diagnosis and clinical management.

Barroso-Sousa R, Ott PA, Hodi FS, Kaiser UB, Tolaney SM, Min L.

Cancer. 2018 Mar 15;124(6):1111-1121. doi: 10.1002/cncr.31200. Epub 2018 Jan 3. Review.


Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression.

Stamatiades GA, Kaiser UB.

Mol Cell Endocrinol. 2018 Mar 5;463:131-141. doi: 10.1016/j.mce.2017.10.015. Epub 2017 Nov 2. Review.


Characterization of Thyroid Disorders in Patients Receiving Immune Checkpoint Inhibition Therapy.

Lee H, Hodi FS, Giobbie-Hurder A, Ott PA, Buchbinder EI, Haq R, Tolaney S, Barroso-Sousa R, Zhang K, Donahue H, Davis M, Gargano ME, Kelley KM, Carroll RS, Kaiser UB, Min L.

Cancer Immunol Res. 2017 Dec;5(12):1133-1140. doi: 10.1158/2326-6066.CIR-17-0208. Epub 2017 Oct 27.


Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice.

Maguire CA, León S, Carroll RS, Kaiser UB, Navarro VM.

Int J Obes (Lond). 2017 Dec;41(12):1798-1804. doi: 10.1038/ijo.2017.185. Epub 2017 Aug 4.


Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors.

Bi WL, Greenwald NF, Ramkissoon SH, Abedalthagafi M, Coy SM, Ligon KL, Mei Y, MacConaill L, Ducar M, Min L, Santagata S, Kaiser UB, Beroukhim R, Laws ER Jr, Dunn IF.

Endocrinology. 2017 Jul 1;158(7):2284-2291. doi: 10.1210/en.2016-1967.


Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse.

Maguire CA, Song YB, Wu M, León S, Carroll RS, Alreja M, Kaiser UB, Navarro VM.

Endocrinology. 2017 Jul 1;158(7):2319-2329. doi: 10.1210/en.2016-1807.


Pulsatile GnRH Therapy May Restore Hypothalamus-Pituitary-Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial.

Zheng J, Mao J, Xu H, Wang X, Huang B, Liu Z, Cui M, Xiong S, Ma W, Min L, Kaiser UB, Nie M, Wu X.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2291-2300. doi: 10.1210/jc.2016-3990.


Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.

Dauber A, Cunha-Silva M, Macedo DB, Brito VN, Abreu AP, Roberts SA, Montenegro LR, Andrew M, Kirby A, Weirauch MT, Labilloy G, Bessa DS, Carroll RS, Jacobs DC, Chappell PE, Mendonca BB, Haig D, Kaiser UB, Latronico AC.

J Clin Endocrinol Metab. 2017 May 1;102(5):1557-1567. doi: 10.1210/jc.2016-3677.


Estrogens regulate glycosylation of IgG in women and men.

Ercan A, Kohrt WM, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, Nigrovic PA.

JCI Insight. 2017 Feb 23;2(4):e89703. doi: 10.1172/jci.insight.89703.


Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism.

Mao JF, Liu ZX, Nie M, Wang X, Xu HL, Huang BK, Zheng JJ, Min L, Kaiser UB, Wu XY.

Asian J Androl. 2017 Nov-Dec;19(6):680-685. doi: 10.4103/1008-682X.193568.


Reproductive endocrinology: The emotional cost of contraception.

Ross RA, Kaiser UB.

Nat Rev Endocrinol. 2016 Dec 8;13(1):7-9. doi: 10.1038/nrendo.2016.194. No abstract available.


Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors.

Mei Y, Bi WL, Greenwald NF, Du Z, Agar NY, Kaiser UB, Woodmansee WW, Reardon DA, Freeman GJ, Fecci PE, Laws ER Jr, Santagata S, Dunn GP, Dunn IF.

Oncotarget. 2016 Nov 22;7(47):76565-76576. doi: 10.18632/oncotarget.12088.


Time Course of Central Precocious Puberty Development Caused by an MKRN3 Gene Mutation: A Prismatic Case.

Stecchini MF, Macedo DB, Reis AC, Abreu AP, Moreira AC, Castro M, Kaiser UB, Latronico AC, Antonini SR.

Horm Res Paediatr. 2016;86(2):126-130. Epub 2016 Jul 16.


High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic.

Bessa DS, Macedo DB, Brito VN, França MM, Montenegro LR, Cunha-Silva M, Silveira LG, Hummel T, Bergadá I, Braslavsky D, Abreu AP, Dauber A, Mendonca BB, Kaiser UB, Latronico AC.

Neuroendocrinology. 2017;105(1):17-25. doi: 10.1159/000446963. Epub 2016 May 26.


Candidate gene analysis in a case of congenital absence of the endometrium.

Simavli S, Abreu AP, Kwaan MR, Dluhy RG, Yanushpolsky EH, Feltmate C, Cerda SR, Carroll RS, Kaiser UB, Kuohung W.

Fertil Res Pract. 2016 Feb 9;2:3. doi: 10.1186/s40738-016-0015-8. eCollection 2016.


Pubertal development and regulation.

Abreu AP, Kaiser UB.

Lancet Diabetes Endocrinol. 2016 Mar;4(3):254-264. doi: 10.1016/S2213-8587(15)00418-0. Epub 2016 Feb 4. Review.


GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.

Thompson IR, Ciccone NA, Zhou Q, Xu S, Khogeer A, Carroll RS, Kaiser UB.

Mol Endocrinol. 2016 Mar;30(3):348-60. doi: 10.1210/me.2015-1222. Epub 2016 Feb 2.


Functional Gonadotroph Adenomas: Case Series and Report of Literature.

Cote DJ, Smith TR, Sandler CN, Gupta T, Bale TA, Bi WL, Dunn IF, De Girolami U, Woodmansee WW, Kaiser UB, Laws ER Jr.

Neurosurgery. 2016 Dec;79(6):823-831. Review.


Decade in review-reproductive endocrinology: Understanding reproductive endocrine disorders.

Kaiser UB.

Nat Rev Endocrinol. 2015 Nov;11(11):640-1. doi: 10.1038/nrendo.2015.179. Epub 2015 Oct 13. No abstract available.


RF9 Acts as a KISS1R Agonist In Vivo and In Vitro.

Min L, Leon S, Li H, Pinilla L, Carroll RS, Tena-Sempere M, Kaiser UB.

Endocrinology. 2015 Dec;156(12):4639-48. doi: 10.1210/en.2015-1635. Epub 2015 Sep 29.


GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.

Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB.

J Neurosci. 2015 Sep 16;35(37):12903-16. doi: 10.1523/JNEUROSCI.0041-15.2015.


Corticosteroids and immune checkpoint blockade.

Min L, Hodi FS, Kaiser UB.

Aging (Albany NY). 2015 Aug;7(8):521-2. No abstract available.


Editorial: The Rise of the Asterisk: One Step to Facilitate Team Science.

Goldberg MA, Kaiser UB.

Mol Endocrinol. 2015 Jul;29(7):943-5. doi: 10.1210/me.2015-1140. No abstract available.


Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction.

Min L, Nie M, Zhang A, Wen J, Noel SD, Lee V, Carroll RS, Kaiser UB.

Neuroendocrinology. 2016;103(3-4):230-9. doi: 10.1159/000435884. Epub 2015 Jun 18.


A new pathway in the control of the initiation of puberty: the MKRN3 gene.

Abreu AP, Macedo DB, Brito VN, Kaiser UB, Latronico AC.

J Mol Endocrinol. 2015 Jun;54(3):R131-9. doi: 10.1530/JME-14-0315. Review.


Cushing's disease: towards precision medicine.

Kaiser UB.

Cell Res. 2015 Jun;25(6):649-50. doi: 10.1038/cr.2015.53. Epub 2015 May 1.


Substance p regulates puberty onset and fertility in the female mouse.

Simavli S, Thompson IR, Maguire CA, Gill JC, Carroll RS, Wolfe A, Kaiser UB, Navarro VM.

Endocrinology. 2015 Jun;156(6):2313-22. doi: 10.1210/en.2014-2012. Epub 2015 Apr 9.


Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study.

Min L, Hodi FS, Giobbie-Hurder A, Ott PA, Luke JJ, Donahue H, Davis M, Carroll RS, Kaiser UB.

Clin Cancer Res. 2015 Feb 15;21(4):749-55. doi: 10.1158/1078-0432.CCR-14-2353. Epub 2014 Dec 23.


The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.

Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB.

Endocrinology. 2015 Feb;156(2):627-37. doi: 10.1210/en.2014-1651. Epub 2014 Nov 25.


Editorial: advances in neuroscience: the BRAIN initiative and implications for neuroendocrinology.

Kaiser UB.

Mol Endocrinol. 2014 Oct;28(10):1589-91. doi: 10.1210/me.2014-1288. No abstract available.


KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse.

Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV.

Endocrinology. 2014 Nov;155(11):4433-46. doi: 10.1210/en.2014-1304. Epub 2014 Aug 22.


Role of gonadotropin-releasing hormone receptor mutations in patients with a wide spectrum of pubertal delay.

Beneduzzi D, Trarbach EB, Min L, Jorge AA, Garmes HM, Renk AC, Fichna M, Fichna P, Arantes KA, Costa EM, Zhang A, Adeola O, Wen J, Carroll RS, Mendonça BB, Kaiser UB, Latronico AC, Silveira LF.

Fertil Steril. 2014 Sep;102(3):838-846.e2. doi: 10.1016/j.fertnstert.2014.05.044. Epub 2014 Jul 10.


Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.

Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB.

J Neurosci. 2014 Apr 23;34(17):6047-56. doi: 10.1523/JNEUROSCI.3003-13.2014.


Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3.

Macedo DB, Abreu AP, Reis AC, Montenegro LR, Dauber A, Beneduzzi D, Cukier P, Silveira LF, Teles MG, Carroll RS, Junior GG, Filho GG, Gucev Z, Arnhold IJ, de Castro M, Moreira AC, Martinelli CE Jr, Hirschhorn JN, Mendonca BB, Brito VN, Antonini SR, Kaiser UB, Latronico AC.

J Clin Endocrinol Metab. 2014 Jun;99(6):E1097-103. doi: 10.1210/jc.2013-3126. Epub 2014 Mar 14.


TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.

Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB.

FASEB J. 2014 Apr;28(4):1924-37. doi: 10.1096/fj.13-240630. Epub 2013 Dec 27.


Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling.

Min L, Soltis K, Reis AC, Xu S, Kuohung W, Jain M, Carroll RS, Kaiser UB.

Mol Endocrinol. 2014 Jan;28(1):16-27. doi: 10.1210/me.2013-1165. Epub 2013 Dec 2.


A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells.

Magill JC, Ciccone NA, Kaiser UB.

Math Biosci. 2013 Nov;246(1):38-46. doi: 10.1016/j.mbs.2013.09.006. Epub 2013 Oct 3.


GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression.

Thompson IR, Kaiser UB.

Mol Cell Endocrinol. 2014 Mar 25;385(1-2):28-35. doi: 10.1016/j.mce.2013.09.012. Epub 2013 Sep 19. Review.

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