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Items: 1 to 50 of 55

1.

Expanding the activity spectrum of antiviral agents.

Ianevski A, Andersen PI, Merits A, Bjørås M, Kainov D.

Drug Discov Today. 2019 May;24(5):1224-1228. doi: 10.1016/j.drudis.2019.04.006. Epub 2019 Apr 10. Review.

PMID:
30980905
2.

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018.

Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE.

Viruses. 2019 Mar 1;11(3). pii: E207. doi: 10.3390/v11030207.

3.

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents.

Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE.

Viruses. 2018 Aug 12;10(8). pii: E423. doi: 10.3390/v10080423. Review.

4.

Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity.

Loevenich S, Ianevski A, Oitmaa E, Kainov DE, Anthonsen MW.

Genome Announc. 2018 May 24;6(21). pii: e00440-18. doi: 10.1128/genomeA.00440-18.

5.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
6.

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min JY, Bruzzone R, Aittokallio T, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE.

Viruses. 2017 Sep 25;9(10). pii: E271. doi: 10.3390/v9100271.

7.

Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis.

Shim JM, Kim J, Tenson T, Min JY, Kainov DE.

Viruses. 2017 Aug 12;9(8). pii: E223. doi: 10.3390/v9080223. Review.

8.

Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism.

Kuivanen S, Bespalov MM, Nandania J, Ianevski A, Velagapudi V, De Brabander JK, Kainov DE, Vapalahti O.

Antiviral Res. 2017 Mar;139:117-128. doi: 10.1016/j.antiviral.2016.12.022. Epub 2016 Dec 31.

PMID:
28049006
9.

Regulation of kynurenine biosynthesis during influenza virus infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2017 Jan;284(2):222-236. doi: 10.1111/febs.13966. Epub 2016 Dec 14.

10.

Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study.

Zinkevičienė A, Kainov D, Girkontaitė I, Lastauskienė E, Kvedarienė V, Fu Y, Anders S, Velagapudi V.

Int Arch Allergy Immunol. 2016;170(4):262-268. Epub 2016 Oct 22.

11.

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE.

Biochim Biophys Acta. 2016 Nov;1859(11):1440-1448. doi: 10.1016/j.bbagrm.2016.09.005. Epub 2016 Sep 21.

PMID:
27664935
12.

Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.

Söderholm S, Fu Y, Gaelings L, Belanov S, Yetukuri L, Berlinkov M, Cheltsov AV, Anders S, Aittokallio T, Nyman TA, Matikainen S, Kainov DE.

Viruses. 2016 Sep 29;8(10). pii: E269. Review.

13.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Söderholm S, Kainov DE, Öhman T, Denisova OV, Schepens B, Kulesskiy E, Imanishi SY, Corthals G, Hintsanen P, Aittokallio T, Saelens X, Matikainen S, Nyman TA.

Mol Cell Proteomics. 2016 Oct;15(10):3203-3219. Epub 2016 Aug 2.

14.

JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses.

Fu Y, Gaelings L, Söderholm S, Belanov S, Nandania J, Nyman TA, Matikainen S, Anders S, Velagapudi V, Kainov DE.

Antiviral Res. 2016 Sep;133:23-31. doi: 10.1016/j.antiviral.2016.07.008. Epub 2016 Jul 20.

PMID:
27451344
15.

Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study.

Fu Y, Gaelings L, Jalovaara P, Kakkola L, Kinnunen MT, Kallio-Kokko H, Valkonen M, Kantele A, Kainov DE.

Cytokine. 2016 Oct;86:10-14. doi: 10.1016/j.cyto.2016.07.003. Epub 2016 Jul 18.

PMID:
27442005
16.

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM.

PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi: 10.1371/journal.ppat.1005424. eCollection 2016 Feb.

17.

Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.

Zinkevičienė A, Kainov D, Lastauskienė E, Kvedarienė V, Bychkov D, Byrne M, Girkontaitė I.

Int Arch Allergy Immunol. 2015;168(3):161-4. doi: 10.1159/000442749. Epub 2016 Jan 21.

18.

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

Söderholm S, Anastasina M, Islam MM, Tynell J, Poranen MM, Bamford DH, Stenman J, Julkunen I, Šaulienė I, De Brabander JK, Matikainen S, Nyman TA, Saelens X, Kainov D.

Antiviral Res. 2016 Feb;126:69-80. doi: 10.1016/j.antiviral.2015.12.011. Epub 2015 Dec 29.

19.

Genome-Wide Analysis of Evolutionary Markers of Human Influenza A(H1N1)pdm09 and A(H3N2) Viruses May Guide Selection of Vaccine Strain Candidates.

Belanov SS, Bychkov D, Benner C, Ripatti S, Ojala T, Kankainen M, Kai Lee H, Wei-Tze Tang J, Kainov DE.

Genome Biol Evol. 2015 Nov 27;7(12):3472-83. doi: 10.1093/gbe/evv240.

20.

Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014.

Mishel P, Ojala T, Benner C, Lakspere T, Bychkov D, Jalovaara P, Kakkola L, Kallio-Kokko H, Kantele A, Kankainen M, Ikonen N, Ripatti S, Julkunen I, Kainov DE.

Genome Announc. 2015 Jul 30;3(4). pii: e00676-15. doi: 10.1128/genomeA.00676-15.

21.

Genetic Loci Associated with Allergic Sensitization in Lithuanians.

Šaulienė I, Greičiuvienė J, Šukienė L, Juškevičiūtė N, Benner C, Zinkevičienė A, Ripatti S, Donner K, Kainov D.

PLoS One. 2015 Jul 27;10(7):e0134188. doi: 10.1371/journal.pone.0134188. eCollection 2015.

22.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Anastasina M, Schepens B, Söderholm S, Nyman TA, Matikainen S, Saksela K, Saelens X, Kainov DE.

J Gen Virol. 2015 Aug;96(8):2086-91. doi: 10.1099/vir.0.000171. Epub 2015 May 1.

PMID:
25934792
23.

Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland.

Jalovaara P, Mishel P, Kallio-Kokko H, Valkonen M, Kantele A, Ikonen N, Julkunen I, Kakkola L, Kutsaya A, Vuorinen T, Mattila P, Almusa H, Kainov D.

Genome Announc. 2015 Mar 12;3(2). pii: e01523-14. doi: 10.1128/genomeA.01523-14.

24.

Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells.

Mishel P, Bychkov D, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Jalovaara P, Kainov D.

Genome Announc. 2014 Dec 24;2(6). pii: e01349-14. doi: 10.1128/genomeA.01349-14.

25.

Genetic Instability of Influenza pH1N1 Viruses.

Jalovaara P, Bychkov D, Ahtiainen L, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Kallioniemi O, Kainov D.

Genome Announc. 2014 Oct 2;2(5). pii: e00841-14. doi: 10.1128/genomeA.00841-14.

26.

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

Denisova OV, Söderholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE.

Antimicrob Agents Chemother. 2014 Jul;58(7):3689-96. doi: 10.1128/AAC.02798-13. Epub 2014 Apr 21.

27.

Full-Genome Sequences of Influenza H3N2 Virus Strains Isolated from Finnish Patients during the 2012-2013 Epidemic Season.

Lakspere T, Kallio-Kokko H, Kantele A, Mattila P, Almusa H, Kainov D, Kakkola L.

Genome Announc. 2014 Mar 27;2(2). pii: e00039-14. doi: 10.1128/genomeA.00039-14.

28.

A technique to increase protein yield in a rabbit reticulocyte lysate translation system.

Anastasina M, Terenin I, Butcher SJ, Kainov DE.

Biotechniques. 2014 Jan;56(1):36-9. doi: 10.2144/000114125.

29.

Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013.

Lakspere T, Tynell J, Kaloinen M, Vanlede M, Parsons A, Ikonen N, Kallio-Kokko H, Kantele A, Mattila P, Almusa H, Julkunen I, Kainov D, Kakkola L.

Genome Announc. 2014 Jan 16;2(1). pii: e01004-13. doi: 10.1128/genomeA.01004-13.

30.

Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution.

El Omari K, Meier C, Kainov D, Sutton G, Grimes JM, Poranen MM, Bamford DH, Tuma R, Stuart DI, Mancini EJ.

Nucleic Acids Res. 2013 Nov;41(20):9396-410. doi: 10.1093/nar/gkt713. Epub 2013 Aug 11.

31.

Inhibition of influenza A virus infection in vitro by saliphenylhalamide-loaded porous silicon nanoparticles.

Bimbo LM, Denisova OV, Mäkilä E, Kaasalainen M, De Brabander JK, Hirvonen J, Salonen J, Kakkola L, Kainov D, Santos HA.

ACS Nano. 2013 Aug 27;7(8):6884-93. doi: 10.1021/nn402062f. Epub 2013 Aug 1.

PMID:
23889734
32.

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.

Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE.

Cell Death Dis. 2013 Jul 25;4:e742. doi: 10.1038/cddis.2013.267.

33.

Molecular evolution and epidemiology of echovirus 6 in Finland.

Smura T, Kakkola L, Blomqvist S, Klemola P, Parsons A, Kallio-Kokko H, Savolainen-Kopra C, Kainov DE, Roivainen M.

Infect Genet Evol. 2013 Jun;16:234-47. doi: 10.1016/j.meegid.2013.02.011. Epub 2013 Feb 24.

PMID:
23462388
34.

Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.

Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T, Kuivanen S, Vapalahti O, Kantele A, Tynell J, Julkunen I, Kallio-Kokko H, Paavilainen H, Hukkanen V, Elliott RM, De Brabander JK, Saelens X, Kainov DE.

J Biol Chem. 2012 Oct 12;287(42):35324-32. doi: 10.1074/jbc.M112.392142. Epub 2012 Aug 21.

35.

Technique for strand-specific gene-expression analysis and monitoring of primer-independent cDNA synthesis in reverse transcription.

Feng L, Lintula S, Ho TH, Anastasina M, Paju A, Haglund C, Stenman UH, Hotakainen K, Orpana A, Kainov D, Stenman J.

Biotechniques. 2012 Apr;52(4):263-70. doi: 10.2144/0000113842.

36.

Emerging cellular targets for influenza antiviral agents.

Müller KH, Kakkola L, Nagaraj AS, Cheltsov AV, Anastasina M, Kainov DE.

Trends Pharmacol Sci. 2012 Feb;33(2):89-99. doi: 10.1016/j.tips.2011.10.004. Epub 2011 Dec 22. Review.

PMID:
22196854
37.

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.

Müller KH, Kainov DE, El Bakkouri K, Saelens X, De Brabander JK, Kittel C, Samm E, Muller CP.

Br J Pharmacol. 2011 Sep;164(2):344-57. doi: 10.1111/j.1476-5381.2011.01346.x.

38.

Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.

Kainov DE, Müller KH, Theisen LL, Anastasina M, Kaloinen M, Muller CP.

J Biol Chem. 2011 Mar 4;286(9):7239-47. doi: 10.1074/jbc.M110.203489. Epub 2010 Dec 16.

39.

Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.

Kainov DE, Cura V, Vitorino M, Nierengarten H, Poussin P, Kieffer B, Cavarelli J, Poterszman A.

Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):745-55. doi: 10.1107/S0907444910009844. Epub 2010 Jun 19.

PMID:
20606254
40.

Interacting partners of the Tfb2 subunit from yeast TFIIH.

Kainov DE, Selth LA, Svejstrup JQ, Egly JM, Poterzsman A.

DNA Repair (Amst). 2010 Jan 2;9(1):33-9. doi: 10.1016/j.dnarep.2009.10.002. Epub 2009 Nov 7.

PMID:
19897425
41.

Structural basis for group A trichothiodystrophy.

Kainov DE, Vitorino M, Cavarelli J, Poterszman A, Egly JM.

Nat Struct Mol Biol. 2008 Sep;15(9):980-4.

PMID:
19172752
42.

Structural basis of mechanochemical coupling in a hexameric molecular motor.

Kainov DE, Mancini EJ, Telenius J, Lísal J, Grimes JM, Bamford DH, Stuart DI, Tuma R.

J Biol Chem. 2008 Feb 8;283(6):3607-17. Epub 2007 Dec 5.

43.

Stochastic detection of motor protein-RNA complexes by single-channel current recording.

Astier Y, Kainov DE, Bayley H, Tuma R, Howorka S.

Chemphyschem. 2007 Oct 22;8(15):2189-94.

PMID:
17886244
44.

Interaction of packaging motor with the polymerase complex of dsRNA bacteriophage.

Lísal J, Kainov DE, Lam TT, Emmett MR, Wei H, Gottlieb P, Marshall AG, Tuma R.

Virology. 2006 Jul 20;351(1):73-9. Epub 2006 Apr 27.

45.

Hexameric molecular motors: P4 packaging ATPase unravels the mechanism.

Kainov DE, Tuma R, Mancini EJ.

Cell Mol Life Sci. 2006 May;63(10):1095-105. Review.

PMID:
16505972
46.

Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states.

Lísal J, Lam TT, Kainov DE, Emmett MR, Marshall AG, Tuma R.

Nat Struct Mol Biol. 2005 May;12(5):460-6. Epub 2005 Apr 17.

PMID:
15834422
47.

Crystallization and preliminary X-ray diffraction analysis of bacteriophage varphi12 packaging factor P7.

Kainov DE, Simonov V, Bamford DH, Tuma R, Gottlieb P, Wei H, Walsh MA, Belrhali H, Merckel MC.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2368-70. Epub 2004 Nov 26.

PMID:
15583391
48.

Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation.

Mancini EJ, Kainov DE, Grimes JM, Tuma R, Bamford DH, Stuart DI.

Cell. 2004 Sep 17;118(6):743-55.

49.

Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription.

Kainov DE, Lísal J, Bamford DH, Tuma R.

Nucleic Acids Res. 2004 Jul 6;32(12):3515-21. Print 2004.

50.

Production, crystallization and preliminary X-ray crystallographic studies of the bacteriophage phi 12 packaging motor.

Mancini EJ, Kainov DE, Wei H, Gottlieb P, Tuma R, Bamford DH, Stuart DI, Grimes JM.

Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):588-90. Epub 2004 Feb 25.

PMID:
14993703

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