Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 298

1.

Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes.

Kress JM, Dio LD, Heck L, Pulliero A, Izzotti A, Laarmann K, Fritz G, Kaina B.

Sci Rep. 2019 Sep 24;9(1):13800. doi: 10.1038/s41598-019-49953-w.

2.

Epigenetic regulation of DNA repair genes and implications for tumor therapy.

Christmann M, Kaina B.

Mutat Res. 2019 Apr - Jun;780:15-28. doi: 10.1016/j.mrrev.2017.10.001. Epub 2017 Oct 7. Review.

PMID:
31395346
3.

Corrigendum to "DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas" [DNA Repair 78 (2019) 128-141].

Kaina B, Christmann M.

DNA Repair (Amst). 2019 Aug;80:93. doi: 10.1016/j.dnarep.2019.06.003. Epub 2019 Jun 17. No abstract available.

PMID:
31221561
4.

DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.

Kaina B, Christmann M.

DNA Repair (Amst). 2019 Jun;78:128-141. doi: 10.1016/j.dnarep.2019.04.007. Epub 2019 Apr 15. Review. Erratum in: DNA Repair (Amst). 2019 Jun 17;:.

PMID:
31039537
5.

Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?

He Y, Kaina B.

Int J Mol Sci. 2019 Mar 28;20(7). pii: E1562. doi: 10.3390/ijms20071562.

6.

The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death.

He Y, Roos WP, Wu Q, Hofmann TG, Kaina B.

Mol Cancer Res. 2019 May;17(5):1129-1141. doi: 10.1158/1541-7786.MCR-18-1306. Epub 2019 Feb 22.

PMID:
30796178
7.

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.

Kraus A, McKeague M, Seiwert N, Nagel G, Geisen SM, Ziegler N, Trantakis IA, Kaina B, Thomas AD, Sturla SJ, Fahrer J.

Arch Toxicol. 2019 Feb;93(2):559-572. doi: 10.1007/s00204-018-2355-0. Epub 2018 Nov 16.

PMID:
30446773
8.

Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.

Laarmann K, Kress JM, Kaina B, Fritz G.

DNA Repair (Amst). 2019 Jan;73:17-27. doi: 10.1016/j.dnarep.2018.10.005. Epub 2018 Oct 28.

PMID:
30413344
9.

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB.

Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B, Christmann M.

Cancer Res. 2019 Jan 1;79(1):99-113. doi: 10.1158/0008-5472.CAN-18-1733. Epub 2018 Oct 25.

PMID:
30361254
10.
11.

Compromised DNA Repair and Signalling in Human Granulocytes.

Ponath V, Heylmann D, Haak T, Woods K, Becker H, Kaina B.

J Innate Immun. 2019;11(1):74-85. doi: 10.1159/000492678. Epub 2018 Oct 8.

12.

Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy.

Kaina B, Izzotti A, Xu J, Christmann M, Pulliero A, Zhao X, Dobreanu M, Au WW.

Int J Hyg Environ Health. 2018 Aug;221(7):993-1006. doi: 10.1016/j.ijheh.2018.07.003. Epub 2018 Jul 21. Review.

PMID:
30041861
13.

PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.

Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9.

14.

The impact of the IGF-1 system of cancer cells on radiation response - An in vitro study.

Venkatachalam S, Mettler E, Fottner C, Miederer M, Kaina B, Weber MM.

Clin Transl Radiat Oncol. 2017 Oct 5;7:1-8. doi: 10.1016/j.ctro.2017.09.006. eCollection 2017 Dec.

15.

XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair.

Roos WP, Frohnapfel L, Quiros S, Ringel F, Kaina B.

Cancer Lett. 2018 Jun 28;424:119-126. doi: 10.1016/j.canlet.2018.03.025. Epub 2018 Mar 22.

PMID:
29574277
16.

Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation.

Aasland D, Reich TR, Tomicic MT, Switzeny OJ, Kaina B, Christmann M.

J Neurochem. 2018 Jan;144(2):139-151. doi: 10.1111/jnc.14262. Epub 2018 Jan 1.

17.

Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases.

Tomaszowski KH, Hellmann N, Ponath V, Takatsu H, Shin HW, Kaina B.

Sci Rep. 2017 Oct 24;7(1):13925. doi: 10.1038/s41598-017-14129-x.

18.

Genotoxicity testing: Comparison of the γH2AX focus assay with the alkaline and neutral comet assays.

Nikolova T, Marini F, Kaina B.

Mutat Res. 2017 Oct;822:10-18. doi: 10.1016/j.mrgentox.2017.07.004. Epub 2017 Jul 22.

PMID:
28844237
19.

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells.

Seiwert N, Neitzel C, Stroh S, Frisan T, Audebert M, Toulany M, Kaina B, Fahrer J.

Cell Death Dis. 2017 Aug 24;8(8):e3019. doi: 10.1038/cddis.2017.418.

20.

Is there a Genotoxic Potential of Endodontic Root Materials?

Taubmann A, Willershausen B, Erbe C, Kaina B, Willershausen I.

Clin Lab. 2017 Apr 1;63(4):689-697. doi: 10.7754/Clin.Lab.2016.161102.

PMID:
28397460
21.

DNA damage in lymphocytes of patients suffering from complex traumatization.

Bergholz LM, Subic-Wrana C, Heylmann D, Beutel ME, Wiltink J, Kaina B.

DNA Repair (Amst). 2017 Apr;52:103-109. doi: 10.1016/j.dnarep.2017.02.006. Epub 2017 Feb 9.

PMID:
28254426
22.

Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling.

Nikolova T, Roos WP, Krämer OH, Strik HM, Kaina B.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):29-39. doi: 10.1016/j.bbcan.2017.01.004. Epub 2017 Jan 29. Review.

PMID:
28143714
23.

Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.

Reich TR, Switzeny OJ, Renovanz M, Sommer C, Kaina B, Christmann M, Tomicic MT.

Oncotarget. 2017 Feb 28;8(9):15071-15084. doi: 10.18632/oncotarget.14748.

24.

Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans.

Ponath V, Kaina B.

PLoS One. 2017 Jan 18;12(1):e0170347. doi: 10.1371/journal.pone.0170347. eCollection 2017.

25.

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells.

Noack K, Mahendrarajah N, Hennig D, Schmidt L, Grebien F, Hildebrand D, Christmann M, Kaina B, Sellmer A, Mahboobi S, Kubatzky K, Heinzel T, Krämer OH.

Arch Toxicol. 2017 May;91(5):2191-2208. doi: 10.1007/s00204-016-1878-5. Epub 2016 Nov 2.

26.

Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.

Berte N, Piée-Staffa A, Piecha N, Wang M, Borgmann K, Kaina B, Nikolova T.

Mol Cancer Ther. 2016 Nov;15(11):2665-2678. Epub 2016 Jul 29.

27.

Quantification of Radiation Biomarkers in Leukocytes of Breast Cancer Patients Treated with Different Modalities of 3D-CRT or IMRT.

Zahnreich S, Ebersberger A, Karle H, Kaina B, Schmidberger H.

Radiat Res. 2016 Nov;186(5):508-519. Epub 2016 Oct 27.

PMID:
27788031
28.

Past, present and future of immunology in Mainz.

Waisman A, Hövelmeyer N, Diefenbach A, Schuppan D, Reddehase MJ, Kleinert H, Kaina B, Grabbe S, Galle PR, Theobald M, Zipp F, Sahin U, Türeci Ö, Kreiter S, Langguth P, Decker H, van Zandbergen G, Schild H.

Cell Immunol. 2016 Oct;308:1-6. doi: 10.1016/j.cellimm.2016.09.001. No abstract available.

PMID:
27719802
29.

Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations.

Christmann M, Boisseau C, Kitzinger R, Berac C, Allmann S, Sommer T, Aasland D, Kaina B, Tomicic MT.

Nucleic Acids Res. 2016 Dec 15;44(22):10727-10743. Epub 2016 Sep 30.

30.

Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens.

Fahrer J, Kaina B.

Food Chem Toxicol. 2017 Aug;106(Pt B):583-594. doi: 10.1016/j.fct.2016.09.029. Epub 2016 Oct 6. Review.

PMID:
27693244
31.

Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence.

Berte N, Lokan S, Eich M, Kim E, Kaina B.

Oncotarget. 2016 Oct 11;7(41):67235-67250. doi: 10.18632/oncotarget.11972.

32.

DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP.

Mimmler M, Peter S, Kraus A, Stroh S, Nikolova T, Seiwert N, Hasselwander S, Neitzel C, Haub J, Monien BH, Nicken P, Steinberg P, Shay JW, Kaina B, Fahrer J.

Nucleic Acids Res. 2016 Dec 1;44(21):10259-10276. Epub 2016 Sep 5.

33.

Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.

Christmann M, Diesler K, Majhen D, Steigerwald C, Berte N, Freund H, Stojanović N, Kaina B, Osmak M, Ambriović-Ristov A, Tomicic MT.

Oncotarget. 2017 Apr 25;8(17):27754-27771. doi: 10.18632/oncotarget.10897.

34.

Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance.

Mikhed Y, Fahrer J, Oelze M, Kröller-Schön S, Steven S, Welschof P, Zinßius E, Stamm P, Kashani F, Roohani S, Kress JM, Ullmann E, Tran LP, Schulz E, Epe B, Kaina B, Münzel T, Daiber A.

Basic Res Cardiol. 2016 Jul;111(4):52. doi: 10.1007/s00395-016-0571-4. Epub 2016 Jun 29.

PMID:
27357950
35.

MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response.

Switzeny OJ, Christmann M, Renovanz M, Giese A, Sommer C, Kaina B.

Clin Epigenetics. 2016 May 5;8:49. doi: 10.1186/s13148-016-0204-7. eCollection 2016.

36.

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance.

Krumm A, Barckhausen C, Kücük P, Tomaszowski KH, Loquai C, Fahrer J, Krämer OH, Kaina B, Roos WP.

Cancer Res. 2016 May 15;76(10):3067-77. doi: 10.1158/0008-5472.CAN-15-2680. Epub 2016 Mar 15.

37.

The γH2AX DNA damage assay from a drop of blood.

Heylmann D, Kaina B.

Sci Rep. 2016 Mar 4;6:22682. doi: 10.1038/srep22682.

38.

The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.

Faust D, Nikolova T, Wätjen W, Kaina B, Dietrich C.

Arch Toxicol. 2017 Feb;91(2):967-982. doi: 10.1007/s00204-016-1672-4. Epub 2016 Feb 8.

PMID:
26856715
39.

DNA damage and the balance between survival and death in cancer biology.

Roos WP, Thomas AD, Kaina B.

Nat Rev Cancer. 2016 Jan;16(1):20-33. doi: 10.1038/nrc.2015.2. Epub 2015 Dec 18. Review.

PMID:
26678314
40.

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.

Tomicic MT, Meise R, Aasland D, Berte N, Kitzinger R, Krämer OH, Kaina B, Christmann M.

Oncotarget. 2015 Oct 20;6(32):33755-68. doi: 10.18632/oncotarget.5274.

41.

Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors.

Tomaszowski KH, Schirrmacher R, Kaina B.

Mol Pharm. 2015 Nov 2;12(11):3924-34. doi: 10.1021/acs.molpharmaceut.5b00341. Epub 2015 Oct 1.

PMID:
26379107
42.

Theoretical considerations for thresholds in chemical carcinogenesis.

Thomas AD, Fahrer J, Johnson GE, Kaina B.

Mutat Res Rev Mutat Res. 2015 Jul-Sep;765:56-67. doi: 10.1016/j.mrrev.2015.05.001. Epub 2015 May 27. Review.

PMID:
26281768
43.

DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

Fahrer J, Frisch J, Nagel G, Kraus A, Dörsam B, Thomas AD, Reißig S, Waisman A, Kaina B.

Carcinogenesis. 2015 Oct;36(10):1235-44. doi: 10.1093/carcin/bgv114. Epub 2015 Aug 4.

PMID:
26243310
44.

Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.

Göder A, Nagel G, Kraus A, Dörsam B, Seiwert N, Kaina B, Fahrer J.

Carcinogenesis. 2015 Aug;36(8):817-31. doi: 10.1093/carcin/bgv070. Epub 2015 May 21.

PMID:
25998848
45.

Biodosimetry Based on γ-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated Radiotherapy.

Zahnreich S, Ebersberger A, Kaina B, Schmidberger H.

Radiat Res. 2015 Apr;183(4):432-46. doi: 10.1667/RR13911.1. Epub 2015 Apr 6.

PMID:
25844946
46.

Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing.

Guérard M, Baum M, Bitsch A, Eisenbrand G, Elhajouji A, Epe B, Habermeyer M, Kaina B, Martus HJ, Pfuhler S, Schmitz C, Sutter A, Thomas AD, Ziemann C, Froetschl R.

Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:181-201. doi: 10.1016/j.mrrev.2014.11.001. Epub 2014 Nov 11. Review.

PMID:
25795120
47.

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.

Tomaszowski KH, Aasland D, Margison GP, Williams E, Pinder SI, Modesti M, Fuchs RP, Kaina B.

DNA Repair (Amst). 2015 Apr;28:14-20. doi: 10.1016/j.dnarep.2015.01.009. Epub 2015 Jan 31.

PMID:
25703834
48.

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells.

Roos WP, Quiros S, Krumm A, Merz S, Switzeny OJ, Christmann M, Loquai C, Kaina B.

Oncotarget. 2014 Dec 30;5(24):12607-20.

49.

Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.

Bopp A, Wartlick F, Henninger C, Schwarz M, Kaina B, Fritz G.

Carcinogenesis. 2015 Mar;36(3):378-89. doi: 10.1093/carcin/bgu323. Epub 2015 Jan 2.

PMID:
25556150
50.

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.

Dörsam B, Göder A, Seiwert N, Kaina B, Fahrer J.

Arch Toxicol. 2015 Oct;89(10):1829-46. doi: 10.1007/s00204-014-1434-0. Epub 2014 Dec 20.

PMID:
25526924

Supplemental Content

Support Center