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Traveler Exposures to Animals: A GeoSentinel Analysis.

Muehlenbein MP, Angelo KM, Schlagenhauf P, Chen L, Grobusch MP, Gautret P, Duvignaud A, Chappuis F, Kain KC, Bottieau E, Epelboin L, Shaw M, Hynes N, Hamer DH; GeoSentinel Surveillance Network .

J Travel Med. 2020 Jan 28. pii: taaa010. doi: 10.1093/jtm/taaa010. [Epub ahead of print]


Malaria in Pregnancy and Adverse Birth Outcomes: New Mechanisms and Therapeutic Opportunities.

Ngai M, Weckman AM, Erice C, McDonald CR, Cahill LS, Sled JG, Kain KC.

Trends Parasitol. 2020 Feb;36(2):127-137. doi: 10.1016/ Epub 2019 Dec 18. Review.


Anemia and transfusion requirements among Ugandan children with severe malaria treated with intravenous artesunate.

Hawkes MT, Opoka RO, Conroy AL, Elphinstone RE, Hume HA, Namasopo S, Kain KC.

Pediatr Hematol Oncol. 2019 Dec 12:1-13. doi: 10.1080/08880018.2019.1701161. [Epub ahead of print]


Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study.

Kalinjuma AV, Darling AM, Sudfeld CR, Mugusi F, Wright J, Abioye AI, Aboud S, McDonald C, Hertzmark E, Kain KC, Fawzi WW.

Nutrients. 2019 Dec 2;11(12). pii: E2906. doi: 10.3390/nu11122906.


New insights into microvascular injury to inform enhanced diagnostics and therapeutics for severe malaria.

Erice C, Kain KC.

Virulence. 2019 Dec;10(1):1034-1046. doi: 10.1080/21505594.2019.1696621.


Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study.

Elphinstone RE, Weckman AM, McDonald CR, Tran V, Zhong K, Madanitsa M, Kalilani-Phiri L, Khairallah C, Taylor SM, Meshnick SR, Mwapasa V, Ter Kuile FO, Conroy AL, Kain KC.

PLoS Med. 2019 Oct 1;16(10):e1002914. doi: 10.1371/journal.pmed.1002914. eCollection 2019 Oct.


Cutaneous and mucocutaneous leishmaniasis in travellers and migrants: a 20-year GeoSentinel Surveillance Network analysis.

Boggild AK, Caumes E, Grobusch MP, Schwartz E, Hynes NA, Libman M, Connor BA, Chakrabarti S, Parola P, Keystone JS, Nash T, Showler AJ, Schunk M, Asgeirsson H, Hamer DH, Kain KC; GeoSentinel Surveillance Network .

J Travel Med. 2019 Dec 23;26(8). pii: taz055. doi: 10.1093/jtm/taz055.


The Impact of Infection in Pregnancy on Placental Vascular Development and Adverse Birth Outcomes.

Weckman AM, Ngai M, Wright J, McDonald CR, Kain KC.

Front Microbiol. 2019 Aug 22;10:1924. doi: 10.3389/fmicb.2019.01924. eCollection 2019. Review.


Erratum for Bansal et al., "Rectal and Naris Swabs: Practical and Informative Samples for Analyzing the Microbiota of Critically Ill Patients".

Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B.

mSphere. 2018 Jun 27;3(3). pii: e00328-18. doi: 10.1128/mSphere.00328-18. eCollection 2018 May-Jun.


Prognostic accuracy of sTREM-1-based algorithms in febrile adults presenting to Tanzanian outpatient clinics.

Richard-Greenblatt M, Boillat-Blanco N, Zhong K, Mbarack Z, Samaka J, Mlaganile T, Kazimoto T, D'Acremont V, Kain KC.

Clin Infect Dis. 2019 May 18. pii: ciz419. doi: 10.1093/cid/ciz419. [Epub ahead of print]


Fever in returning travellers and migrants: disease severity markers to improve triage and management.

Ngai M, Kain KC.

J Travel Med. 2019 May 16. pii: taz038. doi: 10.1093/jtm/taz038. [Epub ahead of print] No abstract available.


Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings.

Weckman AM, McDonald CR, Baxter JB, Fawzi WW, Conroy AL, Kain KC.

Adv Nutr. 2019 Sep 1;10(5):765-777. doi: 10.1093/advances/nmz015.


Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.

McDonald CR, Weckman AM, Conroy AL, Olwoch P, Natureeba P, Kamya MR, Havlir DV, Dorsey G, Kain KC.

Sci Rep. 2019 May 1;9(1):6758. doi: 10.1038/s41598-019-43191-w.


Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

Clark DV, Banura P, Bandeen-Roche K, Liles WC, Kain KC, Scheld WM, Moss WJ, Jacob ST.

JCI Insight. 2019 Apr 23;5. pii: 127623. doi: 10.1172/jci.insight.127623.


A Direct from Blood/Plasma Reverse Transcription-Polymerase Chain Reaction for Dengue Virus Detection in Point-of-Care Settings.

Mehta N, Perrais B, Martin K, Kumar A, Hobman TC, Cabalfin-Chua MN, Donaldo ME, Siose Painaga MS, Gaite JY, Tran V, Kain KC, Hawkes MT, Yanow SK.

Am J Trop Med Hyg. 2019 Jun;100(6):1534-1540. doi: 10.4269/ajtmh.19-0138.


Dysregulation of solute carrier transporters in malaria-infected pregnant mice.

Najjar N, McColl ER, Weckman A, Kain KC, Piquette-Miller M.

Parasite Immunol. 2019 Apr;41(4):e12614. doi: 10.1111/pim.12614. Epub 2019 Feb 20.


Single-dose radical cure for Plasmodium vivax.

Kain KC.

J Travel Med. 2019 Jun 1;26(4). pii: tay127. doi: 10.1093/jtm/tay127. No abstract available.


Rabies post-exposure prophylaxis started during or after travel: A GeoSentinel analysis.

Gautret P, Angelo KM, Asgeirsson H, Lalloo DG, Shaw M, Schwartz E, Libman M, Kain KC, Piyaphanee W, Murphy H, Leder K, Vincelette J, Jensenius M, Waggoner J, Leung D, Borwein S, Blumberg L, Schlagenhauf P, Barnett ED, Hamer DH; GeoSentinel Global Surveillance Network.

PLoS Negl Trop Dis. 2018 Nov 13;12(11):e0006951. doi: 10.1371/journal.pntd.0006951. eCollection 2018 Nov.


Spectrum of illness in migrants to Canada: sentinel surveillance through CanTravNet.

Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, Hajek J, Ghesquiere W, Mirzanejad Y, Vincelette J, Kuhn S, Plourde PJ, Chakrabarti S, Greenaway C, Hamer DH, Kain KC.

J Travel Med. 2019 Feb 1;26(2). pii: tay117. doi: 10.1093/jtm/tay117.


Plasmodium falciparum-CD36 Structure-Function Relationships Defined by Ortholog Scanning Mutagenesis.

Cabrera A, Neculai D, Tran V, Lavstsen T, Turner L, Kain KC.

J Infect Dis. 2019 Feb 23;219(6):945-954. doi: 10.1093/infdis/jiy607.


Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness.

McDonald CR, Weckman A, Richard-Greenblatt M, Leligdowicz A, Kain KC.

Malar J. 2018 Oct 10;17(1):353. doi: 10.1186/s12936-018-2488-x.


Rectal and Naris Swabs: Practical and Informative Samples for Analyzing the Microbiota of Critically Ill Patients.

Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B.

mSphere. 2018 Jun 13;3(3). pii: e00219-18. doi: 10.1128/mSphere.00219-18. Erratum in: mSphere. 2018 Jun 27;3(3):.


Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial.

Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO.

JAMA Pediatr. 2018 Jul 1;172(7):694-696. doi: 10.1001/jamapediatrics.2018.0228. No abstract available.


Endothelial Activation: The Ang/Tie Axis in Sepsis.

Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, Kain KC.

Front Immunol. 2018 Apr 24;9:838. doi: 10.3389/fimmu.2018.00838. eCollection 2018. Review.


Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study.

Wright JK, Hayford K, Tran V, Al Kibria GM, Baqui A, Manajjir A, Mahmud A, Begum N, Siddiquee M, Kain KC, Farzin A.

BMC Pediatr. 2018 Mar 23;18(1):118. doi: 10.1186/s12887-018-1087-x.


Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.

McDonald CR, Cahill LS, Gamble JL, Elphinstone R, Gazdzinski LM, Zhong KJY, Philson AC, Madanitsa M, Kalilani-Phiri L, Mwapasa V, Ter Kuile FO, Sled JG, Conroy AL, Kain KC.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaan6007. doi: 10.1126/scitranslmed.aan6007.


Rocaglates as dual-targeting agents for experimental cerebral malaria.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375. doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20.


Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria.

Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC.

Malar J. 2018 Feb 15;17(1):82. doi: 10.1186/s12936-018-2225-5.


Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC.

PLoS One. 2018 Jan 25;13(1):e0191550. doi: 10.1371/journal.pone.0191550. eCollection 2018.


Adjunctive therapy for severe malaria: a review and critical appraisal.

Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q.

Malar J. 2018 Jan 24;17(1):47. doi: 10.1186/s12936-018-2195-7. Review.


Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.

Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC.

Malar J. 2017 Nov 14;16(1):463. doi: 10.1186/s12936-017-2109-0.


Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy.

McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L.

Clin Infect Dis. 2018 Jan 18;66(3):428-436. doi: 10.1093/cid/cix772.


Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.

Conroy AL, McDonald CR, Gamble JL, Olwoch P, Natureeba P, Cohan D, Kamya MR, Havlir DV, Dorsey G, Kain KC.

Am J Obstet Gynecol. 2017 Dec;217(6):684.e1-684.e17. doi: 10.1016/j.ajog.2017.10.003. Epub 2017 Oct 12.


Maternal Dietary L-Arginine and Adverse Birth Outcomes in Dar es Salaam, Tanzania.

Darling AM, McDonald CR, Urassa WS, Kain KC, Mwiru RS, Fawzi WW.

Am J Epidemiol. 2017 Sep 1;186(5):603-611. doi: 10.1093/aje/kwx080.


Malaria after international travel: a GeoSentinel analysis, 2003-2016.

Angelo KM, Libman M, Caumes E, Hamer DH, Kain KC, Leder K, Grobusch MP, Hagmann SH, Kozarsky P, Lalloo DG, Lim PL, Patimeteeporn C, Gautret P, Odolini S, Chappuis F, Esposito DH; GeoSentinel Network.

Malar J. 2017 Jul 20;16(1):293. doi: 10.1186/s12936-017-1936-3.


S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.

Elphinstone RE, Besla R, Shikatani EA, Lu Z, Hausladen A, Davies M, Robbins CS, Husain M, Stamler JS, Kain KC.

Infect Immun. 2017 Aug 18;85(9). pii: e00371-17. doi: 10.1128/IAI.00371-17. Print 2017 Sep.


Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria.

Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H, Mayor A, Bassat Q, Kain KC.

Malar J. 2017 May 23;16(1):215. doi: 10.1186/s12936-017-1858-0.


Response to "Selection bias".

Boggild AK, Libman M, Yansouni CP, Freedman DO, Kuhn S, Plourde P, Mirzanejad Y, Hajek J, Chakrabarti S, Geduld J, McCarthy AE, Vincelette J, Ghesquiere W, Kain KC.

CMAJ. 2017 May 8;189(18):E674. doi: 10.1503/cmaj.732964. No abstract available.


Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection.

Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC.

PLoS One. 2017 Apr 18;12(4):e0175130. doi: 10.1371/journal.pone.0175130. eCollection 2017.


Surveillance report of Zika virus among Canadian travellers returning from the Americas.

Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, Hajek J, Ghesquiere W, Mirzanejad Y, Vincelette J, Kuhn S, Plourde PJ, Chakrabarti S, Freedman DO, Kain KC.

CMAJ. 2017 Mar 6;189(9):E334-E340. doi: 10.1503/cmaj.161241.


miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria.

Barker KR, Lu Z, Kim H, Zheng Y, Chen J, Conroy AL, Hawkes M, Cheng HS, Njock MS, Fish JE, Harlan JM, López JA, Liles WC, Kain KC.

Mol Med. 2017 Mar;23:24-33. doi: 10.2119/molmed.2016.00139. Epub 2017 Feb 2.


Underestimate of annual malaria imports to Canada.

Boggild AK, McCarthy AE, Libman MD, Freedman DO, Kain KC.

Lancet Infect Dis. 2017 Feb;17(2):141-142. doi: 10.1016/S1473-3099(17)30010-5. No abstract available.


Vitamin A and Zinc Supplementation Among Pregnant Women to Prevent Placental Malaria: A Randomized, Double-Blind, Placebo-Controlled Trial in Tanzania.

Darling AM, Mugusi FM, Etheredge AJ, Gunaratna NS, Abioye AI, Aboud S, Duggan C, Mongi R, Spiegelman D, Roberts D, Hamer DH, Kain KC, Fawzi WW.

Am J Trop Med Hyg. 2017 Apr;96(4):826-834. doi: 10.4269/ajtmh.16-0599. Epub 2017 Jan 23.


Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania.

McDonald CR, Darling AM, Liu E, Tran V, Cabrera A, Aboud S, Urassa W, Kain KC, Fawzi WW.

PLoS One. 2016 Dec 9;11(12):e0167716. doi: 10.1371/journal.pone.0167716. eCollection 2016.


Low prevalence of laboratory-confirmed malaria in clinically diagnosed adult women from the Wakiso district of Uganda.

Yegorov S, Galiwango RM, Ssemaganda A, Muwanga M, Wesonga I, Miiro G, Drajole DA, Kain KC, Kiwanuka N, Bagaya BS, Kaul R.

Malar J. 2016 Nov 14;15(1):555.


Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC.

BMC Pediatr. 2016 Nov 4;16(1):177.


Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria.

McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC.

Pediatr Infect Dis J. 2017 Feb;36(2):146-150. doi: 10.1097/INF.0000000000001382.


Malaria in travellers returning or migrating to Canada: surveillance report from CanTravNet surveillance data, 2004-2014.

Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, Hajek J, Ghesquiere W, Vincelette J, Kuhn S, Freedman DO, Kain KC.

CMAJ Open. 2016 Jul 6;4(3):E352-E358. eCollection 2016 Jul-Sep.


Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw134. eCollection 2016 Sep.


Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.

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