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Items: 1 to 50 of 307

1.

Rectal and Naris Swabs: Practical and Informative Samples for Analyzing the Microbiota of Critically Ill Patients.

Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B.

mSphere. 2018 Jun 13;3(3). pii: e00219-18. doi: 10.1128/mSphere.00219-18.

2.

Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial.

Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO.

JAMA Pediatr. 2018 Jul 1;172(7):694-696. doi: 10.1001/jamapediatrics.2018.0228. No abstract available.

PMID:
29800014
3.

Endothelial Activation: The Ang/Tie Axis in Sepsis.

Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, Kain KC.

Front Immunol. 2018 Apr 24;9:838. doi: 10.3389/fimmu.2018.00838. eCollection 2018. Review.

4.

Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study.

Wright JK, Hayford K, Tran V, Al Kibria GM, Baqui A, Manajjir A, Mahmud A, Begum N, Siddiquee M, Kain KC, Farzin A.

BMC Pediatr. 2018 Mar 23;18(1):118. doi: 10.1186/s12887-018-1087-x.

5.

Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.

McDonald CR, Cahill LS, Gamble JL, Elphinstone R, Gazdzinski LM, Zhong KJY, Philson AC, Madanitsa M, Kalilani-Phiri L, Mwapasa V, Ter Kuile FO, Sled JG, Conroy AL, Kain KC.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaan6007. doi: 10.1126/scitranslmed.aan6007.

PMID:
29514999
6.

Rocaglates as dual-targeting agents for experimental cerebral malaria.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375. doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20.

PMID:
29463745
7.

Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria.

Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC.

Malar J. 2018 Feb 15;17(1):82. doi: 10.1186/s12936-018-2225-5.

8.

Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC.

PLoS One. 2018 Jan 25;13(1):e0191550. doi: 10.1371/journal.pone.0191550. eCollection 2018.

9.

Adjunctive therapy for severe malaria: a review and critical appraisal.

Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q.

Malar J. 2018 Jan 24;17(1):47. doi: 10.1186/s12936-018-2195-7. Review.

10.

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.

Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC.

Malar J. 2017 Nov 14;16(1):463. doi: 10.1186/s12936-017-2109-0.

11.

Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy.

McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L.

Clin Infect Dis. 2018 Jan 18;66(3):428-436. doi: 10.1093/cid/cix772.

PMID:
29136115
12.

Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.

Conroy AL, McDonald CR, Gamble JL, Olwoch P, Natureeba P, Cohan D, Kamya MR, Havlir DV, Dorsey G, Kain KC.

Am J Obstet Gynecol. 2017 Dec;217(6):684.e1-684.e17. doi: 10.1016/j.ajog.2017.10.003. Epub 2017 Oct 12.

13.

Maternal Dietary L-Arginine and Adverse Birth Outcomes in Dar es Salaam, Tanzania.

Darling AM, McDonald CR, Urassa WS, Kain KC, Mwiru RS, Fawzi WW.

Am J Epidemiol. 2017 Sep 1;186(5):603-611. doi: 10.1093/aje/kwx080.

PMID:
28911008
14.

Malaria after international travel: a GeoSentinel analysis, 2003-2016.

Angelo KM, Libman M, Caumes E, Hamer DH, Kain KC, Leder K, Grobusch MP, Hagmann SH, Kozarsky P, Lalloo DG, Lim PL, Patimeteeporn C, Gautret P, Odolini S, Chappuis F, Esposito DH; GeoSentinel Network.

Malar J. 2017 Jul 20;16(1):293. doi: 10.1186/s12936-017-1936-3.

15.

S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.

Elphinstone RE, Besla R, Shikatani EA, Lu Z, Hausladen A, Davies M, Robbins CS, Husain M, Stamler JS, Kain KC.

Infect Immun. 2017 Aug 18;85(9). pii: e00371-17. doi: 10.1128/IAI.00371-17. Print 2017 Sep.

16.

Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria.

Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H, Mayor A, Bassat Q, Kain KC.

Malar J. 2017 May 23;16(1):215. doi: 10.1186/s12936-017-1858-0.

17.

Response to "Selection bias".

Boggild AK, Libman M, Yansouni CP, Freedman DO, Kuhn S, Plourde P, Mirzanejad Y, Hajek J, Chakrabarti S, Geduld J, McCarthy AE, Vincelette J, Ghesquiere W, Kain KC.

CMAJ. 2017 May 8;189(18):E674. doi: 10.1503/cmaj.732964. No abstract available.

18.

Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection.

Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC.

PLoS One. 2017 Apr 18;12(4):e0175130. doi: 10.1371/journal.pone.0175130. eCollection 2017.

19.

Surveillance report of Zika virus among Canadian travellers returning from the Americas.

Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, Hajek J, Ghesquiere W, Mirzanejad Y, Vincelette J, Kuhn S, Plourde PJ, Chakrabarti S, Freedman DO, Kain KC.

CMAJ. 2017 Mar 6;189(9):E334-E340. doi: 10.1503/cmaj.161241.

20.

miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria.

Barker KR, Lu Z, Kim H, Zheng Y, Chen J, Conroy AL, Hawkes M, Cheng HS, Njock MS, Fish JE, Harlan JM, López JA, Liles WC, Kain KC.

Mol Med. 2017 Feb 2;23. doi: 10.2119/molmed.2016.00139. [Epub ahead of print]

21.

Underestimate of annual malaria imports to Canada.

Boggild AK, McCarthy AE, Libman MD, Freedman DO, Kain KC.

Lancet Infect Dis. 2017 Feb;17(2):141-142. doi: 10.1016/S1473-3099(17)30010-5. No abstract available.

PMID:
28134112
22.

Vitamin A and Zinc Supplementation Among Pregnant Women to Prevent Placental Malaria: A Randomized, Double-Blind, Placebo-Controlled Trial in Tanzania.

Darling AM, Mugusi FM, Etheredge AJ, Gunaratna NS, Abioye AI, Aboud S, Duggan C, Mongi R, Spiegelman D, Roberts D, Hamer DH, Kain KC, Fawzi WW.

Am J Trop Med Hyg. 2017 Apr;96(4):826-834. doi: 10.4269/ajtmh.16-0599. Epub 2017 Jan 23.

23.

Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania.

McDonald CR, Darling AM, Liu E, Tran V, Cabrera A, Aboud S, Urassa W, Kain KC, Fawzi WW.

PLoS One. 2016 Dec 9;11(12):e0167716. doi: 10.1371/journal.pone.0167716. eCollection 2016.

24.

Low prevalence of laboratory-confirmed malaria in clinically diagnosed adult women from the Wakiso district of Uganda.

Yegorov S, Galiwango RM, Ssemaganda A, Muwanga M, Wesonga I, Miiro G, Drajole DA, Kain KC, Kiwanuka N, Bagaya BS, Kaul R.

Malar J. 2016 Nov 14;15(1):555.

25.

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC.

BMC Pediatr. 2016 Nov 4;16(1):177.

26.

Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria.

McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC.

Pediatr Infect Dis J. 2017 Feb;36(2):146-150. doi: 10.1097/INF.0000000000001382.

PMID:
27798544
27.

Malaria in travellers returning or migrating to Canada: surveillance report from CanTravNet surveillance data, 2004-2014.

Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, Hajek J, Ghesquiere W, Vincelette J, Kuhn S, Freedman DO, Kain KC.

CMAJ Open. 2016 Jul 6;4(3):E352-E358. eCollection 2016 Jul-Sep.

28.

Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw134. eCollection 2016 Sep.

29.

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.

PMID:
27683553
30.

Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria.

Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC.

J Infect Dis. 2016 Oct 15;214(8):1268-75. doi: 10.1093/infdis/jiw357. Epub 2016 Aug 11.

31.

Illness in Canadian travellers and migrants from Brazil: CanTravNet surveillance data, 2013-2016.

Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, Hajek J, Ghesquiere W, Vincelette J, Kuhn S, Plourde PJ, Freedman DO, Kain KC.

Can Commun Dis Rep. 2016 Aug 4;42(8):153-157. eCollection 2016 Aug 4.

32.

Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality.

Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Feb 26;3(2):ofw046. doi: 10.1093/ofid/ofw046. eCollection 2016 Mar.

33.

CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo.

Ayi K, Lu Z, Serghides L, Ho JM, Finney C, Wang JCY, Liles WC, Kain KC.

Infect Immun. 2016 Jun 23;84(7):2002-2011. doi: 10.1128/IAI.01426-15. Print 2016 Jul.

34.

Solar-powered oxygen delivery: proof of concept.

Turnbull H, Conroy A, Opoka RO, Namasopo S, Kain KC, Hawkes M.

Int J Tuberc Lung Dis. 2016 May;20(5):696-703. doi: 10.5588/ijtld.15.0796.

PMID:
27084827
35.

Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study.

Barker KR, Conroy AL, Hawkes M, Murphy H, Pandey P, Kain KC.

J Travel Med. 2016 Mar 16;23(3). pii: taw005. doi: 10.1093/jtm/taw005. Print 2016 Mar.

36.

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.

37.

Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial.

Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC.

Malar J. 2016 Feb 2;15:56. doi: 10.1186/s12936-016-1106-z.

38.

A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria.

Hahn WO, Harju-Baker S, Erdman LK, Krudsood S, Kain KC, Wurfel MM, Liles WC.

Malar J. 2016 Jan 6;15:12. doi: 10.1186/s12936-015-1071-y.

39.

Complement Activation in Placental Malaria.

McDonald CR, Tran V, Kain KC.

Front Microbiol. 2015 Dec 21;6:1460. doi: 10.3389/fmicb.2015.01460. eCollection 2015.

40.

Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children.

Elphinstone RE, Riley F, Lin T, Higgins S, Dhabangi A, Musoke C, Cserti-Gazdewich C, Regan RF, Warren HS, Kain KC.

Malar J. 2015 Dec 21;14:511. doi: 10.1186/s12936-015-1028-1.

41.

Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial.

Hawkes MT, Conroy AL, Opoka RO, Hermann L, Thorpe KE, McDonald C, Kim H, Higgins S, Namasopo S, John C, Miller C, Liles WC, Kain KC.

Malar J. 2015 Oct 29;14:421. doi: 10.1186/s12936-015-0946-2.

42.

Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness.

Mikacenic C, Hahn WO, Price BL, Harju-Baker S, Katz R, Kain KC, Himmelfarb J, Liles WC, Wurfel MM.

PLoS One. 2015 Oct 22;10(10):e0141251. doi: 10.1371/journal.pone.0141251. eCollection 2015.

43.

Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.

McDonald CR, Cahill LS, Ho KT, Yang J, Kim H, Silver KL, Ward PA, Mount HT, Liles WC, Sled JG, Kain KC.

PLoS Pathog. 2015 Sep 24;11(9):e1005140. doi: 10.1371/journal.ppat.1005140. eCollection 2015 Sep.

44.

Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study.

Erdman LK, D'Acremont V, Hayford K, Rajwans N, Kilowoko M, Kyungu E, Hongoa P, Alamo L, Streiner DL, Genton B, Kain KC.

PLoS One. 2015 Sep 14;10(9):e0137592. doi: 10.1371/journal.pone.0137592. eCollection 2015.

45.

Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study.

Conroy AL, Gélvez M, Hawkes M, Rajwans N, Tran V, Liles WC, Villar-Centeno LA, Kain KC.

Int J Infect Dis. 2015 Nov;40:45-53. doi: 10.1016/j.ijid.2015.07.027. Epub 2015 Aug 6.

46.

Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.

McDonald CR, Darling AM, Conroy AL, Tran V, Cabrera A, Liles WC, Wang M, Aboud S, Urassa W, Fawzi WW, Kain KC.

PLoS One. 2015 Aug 6;10(8):e0134619. doi: 10.1371/journal.pone.0134619. eCollection 2015.

47.

Solar-powered oxygen delivery: study protocol for a randomized controlled trial.

Nyende S, Conroy A, Opoka RO, Namasopo S, Kain KC, Mpimbaza A, Bhargava R, Hawkes M.

Trials. 2015 Jul 9;16:297. doi: 10.1186/s13063-015-0814-y.

48.

Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC.

Emerg Infect Dis. 2015 Jul;21(7):1237-9. doi: 10.3201/eid2107.150213.

49.

Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness.

Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Crit Care. 2015 Feb 23;19:47. doi: 10.1186/s13054-015-0773-4.

50.

Dermatoses among returned Canadian travellers and immigrants: surveillance report based on CanTravNet data, 2009-2012.

Stevens MS, Geduld J, Libman M, Ward BJ, McCarthy AE, Vincelette J, Ghesquiere W, Hajek J, Kuhn S, Freedman DO, Kain KC, Boggild AK.

CMAJ Open. 2015 Jan 13;3(1):E119-26. doi: 10.9778/cmajo.20140082. eCollection 2015 Jan-Mar.

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