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lncRNA HOXB-AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K-AKT pathway.

Jiang W, Kai J, Li D, Wei Z, Wang Y, Wang W.

J Cell Physiol. 2020 Feb 10. doi: 10.1002/jcp.29618. [Epub ahead of print]


Targeting Ku86 enhances X-ray-induced radiotherapy sensitivity in serous ovarian cancer cells.

Ma Q, Kai J, Liu Y, Tong Y, Xie S, Zheng H, Wang Y, Guo L, Lu R.

Int J Biochem Cell Biol. 2020 Feb 3;121:105705. doi: 10.1016/j.biocel.2020.105705. [Epub ahead of print]


Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.

Lee SI, Qureshi N, Dutton B, Kai J, Weng S.

J Community Genet. 2020 Jan 22. doi: 10.1007/s12687-020-00452-w. [Epub ahead of print]


Recent progress on elucidating the molecular mechanism of plasmid-mediated colistin resistance and drug design.

Kai J, Wang S.

Int Microbiol. 2019 Dec 23. doi: 10.1007/s10123-019-00112-1. [Epub ahead of print] Review.


Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study.

Patel M, Lee SI, Levell NJ, Smart P, Kai J, Thomas KS, Leighton P.

Br J Gen Pract. 2020 Jan 30;70(691):e130-e137. doi: 10.3399/bjgp19X707909. Print 2020 Feb.


Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Maula A, Kai J, Woolley AK, Weng S, Dhalwani N, Griffiths FE, Khunti K, Kendrick D.

Diabet Med. 2019 Nov 30. doi: 10.1111/dme.14193. [Epub ahead of print] Review.


Metronidazole versus lactic acid for treating bacterial vaginosis (VITA): protocol for a randomised controlled trial to assess the clinical and cost effectiveness of topical lactic acid gel for treating second and subsequent episodes of bacterial vaginosis.

Armstrong-Buisseret L, Brittain C, David M, Dean G, Griffiths F, Hepburn T, Jackson L, Kai J, Montgomery A, Roberts T, Thandi S, Ross JDC.

Trials. 2019 Nov 27;20(1):648. doi: 10.1186/s13063-019-3731-7.


Diffusion dispersion imaging: Mapping oscillating gradient spin-echo frequency dependence in the human brain.

Arbabi A, Kai J, Khan AR, Baron CA.

Magn Reson Med. 2019 Nov 25. doi: 10.1002/mrm.28083. [Epub ahead of print]


Acceptability of and treatment preferences for recurrent bacterial vaginosis-Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial.

Anstey Watkins J, Ross JDC, Thandi S, Brittain C, Kai J, Griffiths F.

PLoS One. 2019 Nov 15;14(11):e0224964. doi: 10.1371/journal.pone.0224964. eCollection 2019.


Hierarchical nanostructured aluminum alloy with ultrahigh strength and large plasticity.

Wu G, Liu C, Sun L, Wang Q, Sun B, Han B, Kai JJ, Luan J, Liu CT, Cao K, Lu Y, Cheng L, Lu J.

Nat Commun. 2019 Nov 8;10(1):5099. doi: 10.1038/s41467-019-13087-4.


Downregulation of XBP1 decreases serous ovarian cancer cell viability and enhances sensitivity to oxidative stress by increasing intracellular ROS levels.

Zhang GH, Kai JY, Chen MM, Ma Q, Zhong AL, Xie SH, Zheng H, Wang YC, Tong Y, Tian Y, Lu RQ, Guo L.

Oncol Lett. 2019 Oct;18(4):4194-4202. doi: 10.3892/ol.2019.10772. Epub 2019 Aug 22.


ASAP3 is a downstream target of HIF-1α and is critical for progression of lung adenocarcinoma.

Zhang P, Sun J, Kai J, Peng Y, Liu X, Zhou F, Wu J.

Onco Targets Ther. 2019 Jul 17;12:5793-5803. doi: 10.2147/OTT.S199603. eCollection 2019.


Users' experiences of a pragmatic diabetes prevention intervention implemented in primary care: qualitative study.

Aujla N, Yates T, Dallosso H, Kai J.

BMJ Open. 2019 Aug 2;9(8):e028491. doi: 10.1136/bmjopen-2018-028491.


LDL cholesterol response to statins and future risk of cardiovascular disease.

Akyea RK, Kai J, Qureshi N, Iyen B, Weng SF.

Heart. 2019 Aug;105(16):1290-1291. doi: 10.1136/heartjnl-2019-315461. No abstract available.


Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach.

Cabral C, Horwood J, Symonds J, Ingram J, Lucas PJ, Redmond NM, Kai J, Hay AD, Barnes RK.

BMC Fam Pract. 2019 Jul 19;20(1):102. doi: 10.1186/s12875-019-0993-9.


Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.

Iyen B, Qureshi N, Kai J, Akyea RK, Leonardi-Bee J, Roderick P, Humphries SE, Weng S.

Atherosclerosis. 2019 Aug;287:8-15. doi: 10.1016/j.atherosclerosis.2019.05.017. Epub 2019 May 24.


A framework for evaluating correspondence between brain images using anatomical fiducials.

Lau JC, Parrent AG, Demarco J, Gupta G, Kai J, Stanley OW, Kuehn T, Park PJ, Ferko K, Khan AR, Peters TM.

Hum Brain Mapp. 2019 Oct 1;40(14):4163-4179. doi: 10.1002/hbm.24693. Epub 2019 Jun 7.


Molecular profiling of mucinous epithelial ovarian cancer by weighted gene co-expression network analysis.

Zhang GH, Chen MM, Kai JY, Ma Q, Zhong AL, Xie SH, Zheng H, Wang YC, Tong Y, Lu RQ, Guo L.

Gene. 2019 Aug 15;709:56-64. doi: 10.1016/j.gene.2019.05.034. Epub 2019 May 17.


Secondary prevention of cardiovascular disease: Time to rethink stratification of disease severity?

Akyea RK, Kai J, Qureshi N, Abdul Hamid H, Weng SF.

Eur J Prev Cardiol. 2019 Nov;26(16):1778-1780. doi: 10.1177/2047487319850957. Epub 2019 May 15. No abstract available.


TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study.

Ridd MJ, Edwards L, Santer M, Chalmers JR, Waddell L, Marriage D, Muller I, Roberts K, Garfield K, Coast J, Selman L, Clement C, Shaw ARG, Angier E, Blair PS, Turner NL, Taylor J, Kai J, Boyle RJ.

BMJ Open. 2019 May 9;9(5):e028428. doi: 10.1136/bmjopen-2018-028428.


Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care.

Weng S, Kai J, Akyea R, Qureshi N.

Lancet Public Health. 2019 May;4(5):e256-e264. doi: 10.1016/S2468-2667(19)30061-1. Erratum in: Lancet Public Health. 2019 Jul;4(7):e325.


Different knockout genotypes of OsIAA23 in rice using CRISPR/Cas9 generating different phenotypes.

Jiang M, Hu H, Kai J, Traw MB, Yang S, Zhang X.

Plant Mol Biol. 2019 Jul;100(4-5):467-479. doi: 10.1007/s11103-019-00871-5. Epub 2019 Apr 19.


Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.

Akyea RK, Kai J, Qureshi N, Iyen B, Weng SF.

Heart. 2019 Jul;105(13):975-981. doi: 10.1136/heartjnl-2018-314253. Epub 2019 Apr 15.


Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches.

Weng SF, Vaz L, Qureshi N, Kai J.

PLoS One. 2019 Mar 27;14(3):e0214365. doi: 10.1371/journal.pone.0214365. eCollection 2019.


A systematic review showing the lack of diagnostic criteria and tools developed for lower-limb cellulitis.

Patel M, Lee SI, Akyea RK, Grindlay D, Francis N, Levell NJ, Smart P, Kai J, Thomas KS.

Br J Dermatol. 2019 Dec;181(6):1156-1165. doi: 10.1111/bjd.17857. Epub 2019 Jun 28. Review.


PAX3 Promotes Proliferation of Human Glioma Cells by WNT/β-Catenin Signaling Pathways.

Liang X, Dong Z, Bin W, Dekang N, Xuhang Z, Shuyuan Z, Liwen L, Kai J, Caixing S.

J Mol Neurosci. 2019 May;68(1):66-77. doi: 10.1007/s12031-019-01283-2. Epub 2019 Mar 2.


Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial.

Morriss R, Patel S, Malins S, Guo B, Higton F, James M, Wu M, Brown P, Boycott N, Kaylor-Hughes C, Morris M, Rowley E, Simpson J, Smart D, Stubley M, Kai J, Tyrer H.

BMC Med. 2019 Jan 23;17(1):16. doi: 10.1186/s12916-019-1253-5.


Elevated serum HER-2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression.

Zheng H, Zhong A, Xie S, Wang Y, Sun J, Zhang J, Tong Y, Chen M, Zhang G, Ma Q, Kai J, Guo L, Lu R.

Cancer Med. 2019 Feb;8(2):679-685. doi: 10.1002/cam4.1859. Epub 2019 Jan 19.


Multicomponent intermetallic nanoparticles and superb mechanical behaviors of complex alloys.

Yang T, Zhao YL, Tong Y, Jiao ZB, Wei J, Cai JX, Han XD, Chen D, Hu A, Kai JJ, Lu K, Liu Y, Liu CT.

Science. 2018 Nov 23;362(6417):933-937. doi: 10.1126/science.aas8815.


Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.

Chen M, Zhang H, Zhang G, Zhong A, Ma Q, Kai J, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):74-82. doi: 10.1016/j.bbrc.2018.10.164. Epub 2018 Nov 16.


The red leg dilemma: a scoping review of the challenges of diagnosing lower-limb cellulitis.

Patel M, Lee SI, Thomas KS, Kai J.

Br J Dermatol. 2019 May;180(5):993-1000. doi: 10.1111/bjd.17415. Epub 2018 Dec 21. Review.


Genetic and pharmacological inhibition of eIF4E effectively targets esophageal cancer cells and augments 5-FU's efficacy.

Kai J, Wang Y, Xiong F, Wang S.

J Thorac Dis. 2018 Jul;10(7):3983-3991. doi: 10.21037/jtd.2018.06.43.


[Historical Oncomelania hupensis snail environments in Baoshan District, Shanghai City].

Jing-Xin Z, Yu-Chao Z, Yan-Jun J, Kai J, Lun-Hui X.

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2018 May 28;30(3):343-345. doi: 10.16250/j.32.1374.2017228. Chinese.


Effectiveness of low dose of rapamycin in preventing seizure-induced anxiety-like behaviour, cognitive impairment, and defects in neurogenesis in developing rats.

Liu F, Wu M, Kai J, Dong J, Zhang B, Liu L, Zhu F, Zeng LH.

Int J Neurosci. 2020 Jan;130(1):9-18. doi: 10.1080/00207454.2018.1486827. Epub 2019 Oct 10.


Nanoscale Structural Evolution and Anomalous Mechanical Response of Nanoglasses by Cryogenic Thermal Cycling.

Liu WH, Sun BA, Gleiter H, Lan S, Tong Y, Wang XL, Hahn H, Yang Y, Kai JJ, Liu CT.

Nano Lett. 2018 Jul 11;18(7):4188-4194. doi: 10.1021/acs.nanolett.8b01007. Epub 2018 Jun 5.


Post-radiotherapy maintenance treatment with fluticasone propionate and salmeterol for lung cancer patients with grade III radiation pneumonitis: A case report.

Zhang P, Yan H, Wang S, Kai J, Pi G, Peng Y, Liu X, Sun J.

Medicine (Baltimore). 2018 May;97(21):e10681. doi: 10.1097/MD.0000000000010681.


Improving identification and management of familial hypercholesterolaemia in primary care: Pre- and post-intervention study.

Weng S, Kai J, Tranter J, Leonardi-Bee J, Qureshi N.

Atherosclerosis. 2018 Jul;274:54-60. doi: 10.1016/j.atherosclerosis.2018.04.037. Epub 2018 Apr 30.


Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Hussein N, Weng SF, Kai J, Kleijnen J, Qureshi N.

Cochrane Database Syst Rev. 2018 Mar 14;3:CD010849. doi: 10.1002/14651858.CD010849.pub3. Review.


Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats.

Wu M, Zhang H, Kai J, Zhu F, Dong J, Xu Z, Wong M, Zeng LH.

Ann Clin Transl Neurol. 2017 Dec 27;5(2):138-146. doi: 10.1002/acn3.507. eCollection 2018 Feb.


[Inhibiting mammalian target of rapamycin signaling pathway improves cognitive function in mice with chronic cerebral ischemia].

Zhang B, Wu M, Liu L, Zhu Y, Kai J, Zeng L.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Jul 25;46(4):405-412. Chinese.


Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway.

Chen X, Bian M, Zhang C, Kai J, Yao Z, Jin H, Lu C, Shao J, Chen A, Zhang F, Zheng S.

Biomed Pharmacother. 2018 Jan;97:975-984. doi: 10.1016/j.biopha.2017.11.010. Epub 2017 Nov 7.


Atomic Configuration of Point Defect Clusters in Ion-Irradiated Silicon Carbide.

Lin YR, Chen LG, Hsieh CY, Chang MT, Fung KY, Hu A, Lo SC, Chen FR, Kai JJ.

Sci Rep. 2017 Nov 7;7(1):14635. doi: 10.1038/s41598-017-15037-w.


Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy.

Zhu F, Kai J, Chen L, Wu M, Dong J, Wang Q, Zeng LH.

Neurosci Bull. 2018 Apr;34(2):283-290. doi: 10.1007/s12264-017-0165-7. Epub 2017 Aug 7.


Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis.

Shen J, Pu ZJ, Kai J, Kang A, Tang YP, Shang LL, Zhou GS, Zhu ZH, Shang EX, Li SP, Cao YJ, Tao WW, Su SL, Zhang L, Zhou H, Qian DW, Duan JA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:40-45. doi: 10.1016/j.jchromb.2017.04.042. Epub 2017 Apr 26.


Can machine-learning improve cardiovascular risk prediction using routine clinical data?

Weng SF, Reps J, Kai J, Garibaldi JM, Qureshi N.

PLoS One. 2017 Apr 4;12(4):e0174944. doi: 10.1371/journal.pone.0174944. eCollection 2017.


Venous thromboembolism in adults screened for sickle cell trait: a population-based cohort study with nested case-control analysis.

Little I, Vinogradova Y, Orton E, Kai J, Qureshi N.

BMJ Open. 2017 Mar 29;7(3):e012665. doi: 10.1136/bmjopen-2016-012665.


Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term randomised pragmatic trial in primary care.

Kai J, Middleton L, Daniels J, Pattison H, Tryposkiadis K, Gupta J; ECLIPSE trial collaborative group.

Br J Gen Pract. 2016 Dec;66(653):e861-e870. Epub 2016 Oct 10.


Protocol investigating the clinical outcomes and cost-effectiveness of cognitive-behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Patel S, Malins S, Guo B, James M, Kai J, Kaylor-Hughes C, Rowley E, Simpson J, Smart D, Stubley M, Tyrer H, Morriss R.

BJPsych Open. 2016 Feb 25;2(1):81-87. eCollection 2016 Jan.


Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure-Induced Behavioral Abnormalities.

Chen LL, Wu ML, Zhu F, Kai JJ, Dong JY, Wu XM, Zeng LH.

CNS Neurosci Ther. 2016 Dec;22(12):1000-1008. doi: 10.1111/cns.12607. Epub 2016 Sep 28.


Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study.

Malins S, Kai J, Atha C, Avery A, Guo B, James M, Patel S, Sampson C, Stubley M, Morriss R.

Br J Gen Pract. 2016 Oct;66(651):e729-36. doi: 10.3399/bjgp16X686569. Epub 2016 Jul 18.

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