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Items: 1 to 50 of 80

1.

A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding.

Robinson CM, Poon BPK, Kano Y, Pluthero FG, Kahr WHA, Ohh M.

Mol Cancer Res. 2019 Aug 19. doi: 10.1158/1541-7786.MCR-19-0461. [Epub ahead of print]

PMID:
31427440
2.

Recent advances in inherited platelet disorders.

Pluthero FG, Kahr WHA.

Curr Opin Hematol. 2019 Sep;26(5):313-319. doi: 10.1097/MOH.0000000000000525.

PMID:
31348050
3.

Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency.

Egan G, Pluthero FG, Bouskill V, Hilliard P, Drury LJ, Carcao MD, Kahr WHA.

Br J Haematol. 2019 Sep;186(6):e198-e201. doi: 10.1111/bjh.16077. Epub 2019 Jul 8. No abstract available.

PMID:
31282989
4.

NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by α-Granules During Their Production by Megakaryocytes.

Lo RW, Li L, Leung R, Pluthero FG, Kahr WHA.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2435-2447. doi: 10.1161/ATVBAHA.118.311270.

PMID:
30354215
5.

Imaging Platelets and Megakaryocytes by High-Resolution Laser Fluorescence Microscopy.

Pluthero FG, Kahr WHA.

Methods Mol Biol. 2018;1812:13-31. doi: 10.1007/978-1-4939-8585-2_2.

PMID:
30171570
6.

NBEAL2 mutations and bleeding in patients with gray platelet syndrome.

Pluthero FG, Di Paola J, Carcao MD, Kahr WHA.

Platelets. 2018 Sep;29(6):632-635. doi: 10.1080/09537104.2018.1478405. Epub 2018 Jun 5. Review.

PMID:
29869935
7.

The Birth and Death of Platelets in Health and Disease.

Pluthero FG, Kahr WHA.

Physiology (Bethesda). 2018 May 1;33(3):225-234. doi: 10.1152/physiol.00005.2018. Review.

8.

Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria.

Azzouz L, Cherry A, Riedl M, Khan M, Pluthero FG, Kahr WHA, Palaniyar N, Licht C.

Mol Immunol. 2018 May;97:71-81. doi: 10.1016/j.molimm.2018.02.019. Epub 2018 Mar 20.

PMID:
29571059
9.

Balancing the yin and yang of SINE.

Pluthero FG, Kahr WHA.

Blood. 2017 Aug 31;130(9):1077-1078. doi: 10.1182/blood-2017-07-793398. No abstract available.

PMID:
28860324
10.

Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions.

Al-Battat S, Rand ML, Bouskill V, Lau W, Blanchette VS, Kahr WHA, Rivard GE, Carcao MD.

Br J Haematol. 2018 May;181(3):410-413. doi: 10.1111/bjh.14623. Epub 2017 May 3. No abstract available.

PMID:
28466602
11.

Discrepant platelet and plasma von Willebrand factor in von Willebrand disease patients with p.Pro2808Leufs*24.

Bowman ML, Pluthero FG, Tuttle A, Casey L, Li L, Christensen H, Robinson KS, Lillicrap D, Kahr WHA, James P.

J Thromb Haemost. 2017 Jul;15(7):1403-1411. doi: 10.1111/jth.13722. Epub 2017 Jun 6.

12.

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.

Kahr WH, Pluthero FG, Elkadri A, Warner N, Drobac M, Chen CH, Lo RW, Li L, Li R, Li Q, Thoeni C, Pan J, Leung G, Lara-Corrales I, Murchie R, Cutz E, Laxer RM, Upton J, Roifman CM, Yeung RS, Brumell JH, Muise AM.

Nat Commun. 2017 Apr 3;8:14816. doi: 10.1038/ncomms14816.

13.

α-granule biogenesis: from disease to discovery.

Chen CH, Lo RW, Urban D, Pluthero FG, Kahr WH.

Platelets. 2017 Mar;28(2):147-154. doi: 10.1080/09537104.2017.1280599. Epub 2017 Feb 22. Review.

PMID:
28277061
14.

Effect of moderate intensity exercise on haemostatic capacity in adults with haemophilia A and B: pilot study.

Sholzberg M, Floros G, Schneiderman JE, Kahr WH, Rand M, Pluthero F, Hossain T, Mahamad S, Nisenbaum R, Zhang C, O'Neill NE, Teitel J, Carcao M.

Haemophilia. 2017 Mar;23(2):e162-e165. doi: 10.1111/hae.13181. Epub 2017 Jan 22. No abstract available.

PMID:
28111839
15.

The Association Between Cyanosis and Thromboelastometry (ROTEM) in Children With Congenital Heart Defects: A Retrospective Cohort Study.

Laskine-Holland ML, Kahr WH, Crawford-Lean L, Humpl T, Honjo O, Foreman C, Jain M, O'Leary JD.

Anesth Analg. 2017 Jan;124(1):23-29.

PMID:
27861436
16.

Decreased numbers of dense granules in fetal and neonatal platelets.

Urban D, Pluthero FG, Christensen H, Baidya S, Rand ML, Das A, Shah PS, Chitayat D, Blanchette VS, Kahr WH.

Haematologica. 2017 Feb;102(2):e36-e38. doi: 10.3324/haematol.2016.152421. Epub 2016 Nov 3. No abstract available.

17.

Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants.

Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT.

J Thromb Haemost. 2016 Nov;14(11):2230-2240. doi: 10.1111/jth.13500. Epub 2016 Oct 20.

18.

Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells.

Riedl M, Noone DG, Khan MA, Pluthero FG, Kahr WHA, Palaniyar N, Licht C.

Kidney Int Rep. 2016 Aug 31;2(1):66-75. doi: 10.1016/j.ekir.2016.08.015. eCollection 2017 Jan.

19.

Von Willebrand factor regulates complement on endothelial cells.

Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C.

Kidney Int. 2016 Jul;90(1):123-34. doi: 10.1016/j.kint.2016.03.023. Epub 2016 May 25.

20.

NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways.

Yuen J, Pluthero FG, Douda DN, Riedl M, Cherry A, Ulanova M, Kahr WH, Palaniyar N, Licht C.

Front Immunol. 2016 Apr 14;7:137. doi: 10.3389/fimmu.2016.00137. eCollection 2016.

21.

Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency.

Wang TF, Dawson JE, Forman-Kay JD, Kahr WHA, Williams S, Chan AK, Kumar R.

Br J Haematol. 2017 May;177(4):654-656. doi: 10.1111/bjh.14090. Epub 2016 Apr 21. No abstract available.

PMID:
27098850
22.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E.

Blood. 2016 Jun 9;127(23):2791-803. doi: 10.1182/blood-2015-12-688267. Epub 2016 Apr 15.

23.

Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. doi: 10.1161/ATVBAHA.116.307461. Epub 2016 Apr 14.

24.

Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia.

Kumar R, Bouskill V, Schneiderman JE, Pluthero FG, Kahr WH, Craik A, Clark D, Whitney K, Zhang C, Rand ML, Carcao M.

Thromb Haemost. 2016 Jun 2;115(6):1120-8. doi: 10.1160/TH15-09-0757. Epub 2016 Feb 25.

PMID:
26917411
25.

Platelet production: new players in the field.

Pluthero FG, Kahr WH.

Blood. 2016 Feb 18;127(7):797-9. doi: 10.1182/blood-2016-01-687707. No abstract available.

PMID:
26893396
26.

Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets.

Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz H.

J Thromb Haemost. 2016 May;14(5):1082-94. doi: 10.1111/jth.13281. Epub 2016 Mar 22.

27.

FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H.

Blood. 2015 Jul 2;126(1):80-8. doi: 10.1182/blood-2014-07-587600. Epub 2015 Apr 2.

28.

Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.

Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini C, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WHA, Porter CC, Di Paola J.

Nat Genet. 2015 May;47(5):535-538. doi: 10.1038/ng.3253. Epub 2015 Mar 25.

29.

c.1058C>T variant in the SERPINC1 gene is pathogenic for antithrombin deficiency.

Kumar R, Dawson JE, Chan AK, Forman-Kay JD, Kahr WH, Williams S.

Br J Haematol. 2015 Jul;170(1):123-5. doi: 10.1111/bjh.13261. Epub 2014 Dec 19. No abstract available.

PMID:
25522812
30.

Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.

Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H.

Blood. 2015 Feb 5;125(6):1014-24. doi: 10.1182/blood-2014-07-587857. Epub 2014 Dec 2.

31.

Inherited macrothrombocytopenias on the rise.

Landolt-Marticorena C, Kahr WH.

Blood. 2014 Oct 16;124(16):2473-5. doi: 10.1182/blood-2014-08-592329.

PMID:
25323684
32.

Proteasome function is required for platelet production.

Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS.

J Clin Invest. 2014 Sep;124(9):3757-66. doi: 10.1172/JCI75247. Epub 2014 Jul 25.

33.

Postthrombotic syndrome following upper extremity deep vein thrombosis in children.

Avila ML, Duan L, Cipolla A, Kim A, Kahr WH, Williams S, Brandão LR.

Blood. 2014 Aug 14;124(7):1166-73. doi: 10.1182/blood-2014-04-570531. Epub 2014 Jun 23.

PMID:
24957144
34.

Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study.

Kumar R, Chan AK, Dawson JE, Forman-Kay JD, Kahr WH, Williams S.

Br J Haematol. 2014 Jul;166(1):130-9. doi: 10.1111/bjh.12842. Epub 2014 Mar 29.

PMID:
24684277
35.

MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on genotype-phenotype correlations.

Pecci A, Klersy C, Gresele P, Lee KJ, De Rocco D, Bozzi V, Russo G, Heller PG, Loffredo G, Ballmaier M, Fabris F, Beggiato E, Kahr WH, Pujol-Moix N, Platokouki H, Van Geet C, Noris P, Yerram P, Hermans C, Gerber B, Economou M, De Groot M, Zieger B, De Candia E, Fraticelli V, Kersseboom R, Piccoli GB, Zimmermann S, Fierro T, Glembotsky AC, Vianello F, Zaninetti C, Nicchia E, Güthner C, Baronci C, Seri M, Knight PJ, Balduini CL, Savoia A.

Hum Mutat. 2014 Feb;35(2):236-47. doi: 10.1002/humu.22476. Epub 2013 Dec 12.

36.

Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.

Chen Y, Aardema J, Kale S, Whichard ZL, Awomolo A, Blanchard E, Chang B, Myers DR, Ju L, Tran R, Reece D, Christensen H, Boukour S, Debili N, Strom TS, Rawlings D, Vázquez FX, Voth GA, Zhu C, Kahr WH, Lam WA, Corey SJ.

Blood. 2013 Sep 5;122(10):1695-706. doi: 10.1182/blood-2013-03-484550. Epub 2013 Jul 23.

37.

Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice.

Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross PL.

Blood. 2013 Nov 7;122(19):3349-58. doi: 10.1182/blood-2013-04-499491. Epub 2013 Jul 16.

38.

Congenital thrombocytopenia: clinical manifestations, laboratory abnormalities, and molecular defects of a heterogeneous group of conditions.

Kumar R, Kahr WH.

Hematol Oncol Clin North Am. 2013 Jun;27(3):465-94. doi: 10.1016/j.hoc.2013.02.004. Review.

PMID:
23714308
39.

Intracranial haemorrhage in von Willebrand disease: a report on six cases.

Labarque V, Stain AM, Blanchette V, Kahr WH, Carcao MD.

Haemophilia. 2013 Jul;19(4):602-6. doi: 10.1111/hae.12142. Epub 2013 Apr 5.

PMID:
23556472
40.

Coagulation assessment in children with diabetic ketoacidosis.

Tran TH, Al-Harfi I, Harle CC, Kahr WH, Morrison GC, Kornecki A.

Pediatr Crit Care Med. 2013 Mar;14(3):256-60. doi: 10.1097/PCC.0b013e318271fcb7.

PMID:
23392364
41.

Gray platelet syndrome: macrothrombocytopenia with deficient α-granules.

Kahr WH, Dror Y.

Blood. 2012 Sep 27;120(13):2543. No abstract available.

PMID:
23193541
42.

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.

Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS.

Blood. 2012 Dec 13;120(25):5014-20. doi: 10.1182/blood-2012-04-420661. Epub 2012 Oct 18.

43.

The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis.

Urban D, Li L, Christensen H, Pluthero FG, Chen SZ, Puhacz M, Garg PM, Lanka KK, Cummings JJ, Kramer H, Wasmuth JD, Parkinson J, Kahr WH.

Blood. 2012 Dec 13;120(25):5032-40. doi: 10.1182/blood-2012-05-431205. Epub 2012 Sep 21.

44.

Interstitial deletion of 11q-implicating the KIRREL3 gene in the neurocognitive delay associated with Jacobsen syndrome.

Guerin A, Stavropoulos DJ, Diab Y, Chénier S, Christensen H, Kahr WH, Babul-Hirji R, Chitayat D.

Am J Med Genet A. 2012 Oct;158A(10):2551-6. doi: 10.1002/ajmg.a.35621. Epub 2012 Sep 10.

PMID:
22965935
45.

The cell motility modulator Slit2 is a potent inhibitor of platelet function.

Patel S, Huang YW, Reheman A, Pluthero FG, Chaturvedi S, Mukovozov IM, Tole S, Liu GY, Li L, Durocher Y, Ni H, Kahr WH, Robinson LA.

Circulation. 2012 Sep 11;126(11):1385-95. doi: 10.1161/CIRCULATIONAHA.112.105452. Epub 2012 Aug 3.

PMID:
22865890
46.

Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab.

Noone D, Al-Matrafi J, Tinckam K, Zipfel PF, Herzenberg AM, Thorner PS, Pluthero FG, Kahr WH, Filler G, Hebert D, Harvey E, Licht C.

Am J Transplant. 2012 Sep;12(9):2546-53. doi: 10.1111/j.1600-6143.2012.04124.x. Epub 2012 Jun 8.

47.

Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene.

Mendoza-Londono R, Chitayat D, Kahr WH, Hinek A, Blaser S, Dupuis L, Goh E, Badilla-Porras R, Howard A, Mittaz L, Superti-Furga A, Unger S, Nishimura G, Bonafe L.

Am J Med Genet A. 2012 Jun;158A(6):1344-54. doi: 10.1002/ajmg.a.35339. Epub 2012 May 11.

PMID:
22581468
48.

The role of prothrombotic factors in the ocular manifestations of abusive and non-abusive head trauma: a feasibility study.

Yu A, Stephens D, Feldman BM, Parkin PC, Kahr WH, Brandão LR, Shouldice M, Levin AV.

Child Abuse Negl. 2012 Apr;36(4):333-41. doi: 10.1016/j.chiabu.2011.11.009. Epub 2012 May 8.

PMID:
22575907
49.

Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation.

Rand ML, Wang H, Pluthero FG, Stafford AR, Ni R, Vaezzadeh N, Allison AC, Kahr WH, Weitz JI, Gross PL.

J Thromb Haemost. 2012 Jun;10(6):1109-19. doi: 10.1111/j.1538-7836.2012.04716.x.

50.

Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored with anti-factor Xa levels.

Schechter T, Finkelstein Y, Ali M, Kahr WH, Williams S, Chan AK, Deveber G, Brandão LR.

J Thromb Haemost. 2012 Mar;10(3):368-74. doi: 10.1111/j.1538-7836.2012.04624.x.

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