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Ancient complement and lineage-specific evolution of the Sec7 ARF GEF proteins in eukaryotes.

Pipaliya SV, Schlacht A, Klinger CM, Kahn RA, Dacks J.

Mol Biol Cell. 2019 Jul 15;30(15):1846-1863. doi: 10.1091/mbc.E19-01-0073. Epub 2019 May 29.


ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA.

Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820.


Reply to: foundation and clinical exigency of cerebral oximetry.

Kahn RA, Anyanwu A.

Eur J Anaesthesiol. 2019 May;36(5):376-377. doi: 10.1097/EJA.0000000000000971. No abstract available.


ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2.

Schiavon CR, Turn RE, Newman LE, Kahn RA.

Mol Biol Cell. 2019 May 1;30(10):1198-1213. doi: 10.1091/mbc.E18-12-0804. Epub 2019 Mar 13.


Constraining chemical transport PM2.5 modeling outputs using surface monitor measurements and satellite retrievals: application over the San Joaquin Valley.

Friberg MD, Kahn RA, Limbacher JA, Appel KW, Mulholland JA.

Atmos Chem Phys. 2018 Jul 9;18(17):12891-12913. doi: 10.5194/acp-18-12891-2018.


Compositional complexity of rods and rings.

Schiavon CR, Griffin ME, Pirozzi M, Parashuraman R, Zhou W, Jinnah HA, Reines D, Kahn RA.

Mol Biol Cell. 2018 Sep 15;29(19):2303-2316. doi: 10.1091/mbc.E18-05-0274. Epub 2018 Jul 19.


Near-infrared spectroscopy in vegetables and humans: An observational study.

Kahn RA, Anyanwu A.

Eur J Anaesthesiol. 2018 Dec;35(12):907-910. doi: 10.1097/EJA.0000000000000855.


Karymsky volcano eruptive plume properties based on MISR multi-angle imagery, and volcanological implications.

Flower VJB, Kahn RA.

Atmos Chem Phys. 2018;18(6):3903-3918. doi: 10.5194/acp-18-3903-2018. Epub 2018 Mar 20.


Distinguishing remobilized ash from erupted volcanic plumes using space-borne multi-angle imaging.

Flower VJB, Kahn RA.

Geophys Res Lett. 2017 Oct 28;44(20):10772-10779. doi: 10.1002/2017GL074740. Epub 2017 Oct 11.


The ARF guanine nucleotide exchange factor GBF1 is targeted to Golgi membranes through a PIP-binding domain.

Meissner JM, Bhatt JM, Lee E, Styers ML, Ivanova AA, Kahn RA, Sztul E.

J Cell Sci. 2018 Feb 5;131(3). pii: jcs210245. doi: 10.1242/jcs.210245.


SAM-CAAM: A Concept for Acquiring Systematic Aircraft Measurements to Characterize Aerosol Air Masses.

Kahn RA, Berkoff TA, Brock C, Chen G, Ferrare RA, Ghan S, Hansico TF, Hegg DA, Martins JV, McNaughton CS, Murphy DM, Ogren JA, Penner JE, Pilewskie P, Seinfeld JH, Worsnop DR.

Bull Am Meteorol Soc. 2017 Oct;98(No 10):2215-2228. doi: 10.1175/BAMS-D-16-0003.1. Epub 2017 Oct 30.


Aerosol Absorption: Progress Towards Global and Regional Constraints.

Samset BH, Stjern CW, Andrews E, Kahn RA, Myhre G, Schulz M, Schuster GL.

Curr Clim Change Rep. 2018;4(2):65-83. doi: 10.1007/s40641-018-0091-4. Epub 2018 Apr 3. Review.


A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.

Rafiullah R, Long AB, Ivanova AA, Ali H, Berkel S, Mustafa G, Paramasivam N, Schlesner M, Wiemann S, Wade RC, Bolthauser E, Blum M, Kahn RA, Caspary T, Rappold GA.

Eur J Hum Genet. 2017 Dec;25(12):1324-1334. doi: 10.1038/s41431-017-0031-0. Epub 2017 Nov 15.


Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA.

J Mol Biol. 2017 Nov 24;429(23):3696-3716. doi: 10.1016/j.jmb.2017.09.016. Epub 2017 Sep 29.


The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space.

Newman LE, Schiavon CR, Turn RE, Kahn RA.

Cell Logist. 2017 Jun 23;7(3):e1340104. doi: 10.1080/21592799.2017.1340104. eCollection 2017.


Mistakes in translation: Reflections on mechanism.

Liu Y, Sharp JS, Do DH, Kahn RA, Schwalbe H, Buhr F, Prestegard JH.

PLoS One. 2017 Jun 29;12(6):e0180566. doi: 10.1371/journal.pone.0180566. eCollection 2017.


Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).

Ivanova AA, Caspary T, Seyfried NT, Duong DM, West AB, Liu Z, Kahn RA.

J Biol Chem. 2017 Jun 30;292(26):11091-11108. doi: 10.1074/jbc.M117.784025. Epub 2017 May 9.


The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors.

Newman LE, Schiavon CR, Zhou C, Kahn RA.

PLoS One. 2017 Apr 5;12(4):e0175164. doi: 10.1371/journal.pone.0175164. eCollection 2017.


A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network.

Francis JW, Newman LE, Cunningham LA, Kahn RA.

J Biol Chem. 2017 Mar 10;292(10):4336-4349. doi: 10.1074/jbc.M116.770909. Epub 2017 Jan 26.


Plasmids for variable expression of proteins targeted to the mitochondrial matrix or intermembrane space.

Newman LE, Schiavon C, Kahn RA.

Cell Logist. 2016 Oct 13;6(4):e1247939. doi: 10.1080/21592799.2016.1247939. eCollection 2016.


Special Issue: GTPases in trafficking, autophagy, and disease (FASEB SRC).

Kahn RA, Lambright D, De Matteis A.

Small GTPases. 2016 Oct;7(4):187. No abstract available.


Arl13b regulates Shh signaling from both inside and outside the cilium.

Mariani LE, Bijlsma MF, Ivanova AA, Suciu SK, Kahn RA, Caspary T.

Mol Biol Cell. 2016 Sep 28. pii: mbc.E16-03-0189. [Epub ahead of print] Erratum in: Mol Biol Cell. 2017 Apr 1;28(7):996. Ivanova, Anna I [corrected to Ivanova, Anna A].


Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy.

Flex E, Niceta M, Cecchetti S, Thiffault I, Au MG, Capuano A, Piermarini E, Ivanova AA, Francis JW, Chillemi G, Chandramouli B, Carpentieri G, Haaxma CA, Ciolfi A, Pizzi S, Douglas GV, Levine K, Sferra A, Dentici ML, Pfundt RR, Le Pichon JB, Farrow E, Baas F, Piemonte F, Dallapiccola B, Graham JM Jr, Saunders CJ, Bertini E, Kahn RA, Koolen DA, Tartaglia M.

Am J Hum Genet. 2016 Oct 6;99(4):962-973. doi: 10.1016/j.ajhg.2016.08.003. Epub 2016 Sep 22.


Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions.

Francis JW, Turn RE, Newman LE, Schiavon C, Kahn RA.

Small GTPases. 2016 Oct;7(4):188-196. Epub 2016 Jul 11. Review.


A Reappraisal of Prediabetes.

Davidson MB, Kahn RA.

J Clin Endocrinol Metab. 2016 Jul;101(7):2628-35. doi: 10.1210/jc.2016-1370. Review. No abstract available.


Use of a Grant Writing Class in Training PhD Students.

Kahn RA, Conn GL, Pavlath GK, Corbett AH.

Traffic. 2016 Jul;17(7):803-14. doi: 10.1111/tra.12398. Epub 2016 May 3.


Global Estimates of Fine Particulate Matter using a Combined Geophysical-Statistical Method with Information from Satellites, Models, and Monitors.

van Donkelaar A, Martin RV, Brauer M, Hsu NC, Kahn RA, Levy RC, Lyapustin A, Sayer AM, Winker DM.

Environ Sci Technol. 2016 Apr 5;50(7):3762-72. doi: 10.1021/acs.est.5b05833. Epub 2016 Mar 24.


Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation.

Bhatt JM, Viktorova EG, Busby T, Wyrozumska P, Newman LE, Lin H, Lee E, Wright J, Belov GA, Kahn RA, Sztul E.

Am J Physiol Cell Physiol. 2016 Mar 15;310(6):C456-69. doi: 10.1152/ajpcell.00185.2015. Epub 2015 Dec 30.


Arl13b and the exocyst interact synergistically in ciliogenesis.

Seixas C, Choi SY, Polgar N, Umberger NL, East MP, Zuo X, Moreiras H, Ghossoub R, Benmerah A, Kahn RA, Fogelgren B, Caspary T, Lipschutz JH, Barral DC.

Mol Biol Cell. 2016 Jan 15;27(2):308-20. doi: 10.1091/mbc.E15-02-0061. Epub 2015 Nov 18.


A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1.

Kahn RA, Lambright DG.

Structure. 2015 Nov 3;23(11):1971-3. doi: 10.1016/j.str.2015.10.002.


LRRK2 autophosphorylation enhances its GTPase activity.

Liu Z, Mobley JA, DeLucas LJ, Kahn RA, West AB.

FASEB J. 2016 Jan;30(1):336-47. doi: 10.1096/fj.15-277095. Epub 2015 Sep 22.


Transesophageal Echocardiographic Assessment of Left Ventricular Mass.

Weiner MM, Kahn RA, Evans AS.

Anesth Analg. 2015 Aug;121(2):323-8. doi: 10.1213/ANE.0000000000000778. No abstract available.


Reverse two-hybrid techniques in the yeast Saccharomyces cerevisiae.

Bennett MA, Shern JF, Kahn RA.

Methods Mol Biol. 2015;1278:433-46. doi: 10.1007/978-1-4939-2425-7_28.


The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.

Newman LE, Zhou CJ, Mudigonda S, Mattheyses AL, Paradies E, Marobbio CM, Kahn RA.

PLoS One. 2014 Jun 9;9(6):e99270. doi: 10.1371/journal.pone.0099270. eCollection 2014.


Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation.

Wright J, Kahn RA, Sztul E.

Cell Mol Life Sci. 2014 Sep;71(18):3419-38. doi: 10.1007/s00018-014-1602-7. Epub 2014 Apr 13. Review.


Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases.

Ivanova AA, East MP, Yi SL, Kahn RA.

J Biol Chem. 2014 Apr 18;289(16):11111-21. doi: 10.1074/jbc.M114.548529. Epub 2014 Mar 10.


Interaction of Fapp1 with Arf1 and PI4P at a membrane surface: an example of coincidence detection.

Liu Y, Kahn RA, Prestegard JH.

Structure. 2014 Mar 4;22(3):421-30. doi: 10.1016/j.str.2013.12.011. Epub 2014 Jan 23.


Meeting report - Arf and Rab family G proteins.

Casanova JE, Hsu VW, Jackson CL, Kahn RA, Roy CR, Stow JL, Wandinger-Ness A, Sztul E.

J Cell Sci. 2013 Dec 1;126(Pt 23):5313-6. doi: 10.1242/jcs.143610.


An alteration in ELMOD3, an Arl2 GTPase-activating protein, is associated with hearing impairment in humans.

Jaworek TJ, Richard EM, Ivanova AA, Giese AP, Choo DI, Khan SN, Riazuddin S, Kahn RA, Riazuddin S.

PLoS Genet. 2013;9(9):e1003774. doi: 10.1371/journal.pgen.1003774. Epub 2013 Sep 5.


Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex.

Caster AH, Kahn RA.

J Biol Chem. 2013 Oct 4;288(40):28567-80. doi: 10.1074/jbc.M113.481101. Epub 2013 Aug 21.


Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.

Davidson AE, Schwarz N, Zelinger L, Stern-Schneider G, Shoemark A, Spitzbarth B, Gross M, Laxer U, Sosna J, Sergouniotis PI, Waseem NH, Wilson R, Kahn RA, Plagnol V, Wolfrum U, Banin E, Hardcastle AJ, Cheetham ME, Sharon D, Webster AR.

Am J Hum Genet. 2013 Aug 8;93(2):321-9. doi: 10.1016/j.ajhg.2013.06.003. Epub 2013 Jul 11.


Dryness of ephemeral lakes and consequences for dust activity: the case of the Hamoun drainage basin, southeastern Iran.

Rashki A, Kaskaoutis DG, Goudie AS, Kahn RA.

Sci Total Environ. 2013 Oct 1;463-464:552-64. doi: 10.1016/j.scitotenv.2013.06.045. Epub 2013 Jul 5.


A role for cargo in Arf-dependent adaptor recruitment.

Caster AH, Sztul E, Kahn RA.

J Biol Chem. 2013 May 24;288(21):14788-804. doi: 10.1074/jbc.M113.453621. Epub 2013 Apr 9.


Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins.

Schlacht A, Mowbrey K, Elias M, Kahn RA, Dacks JB.

Traffic. 2013 Jun;14(6):636-49. doi: 10.1111/tra.12063. Epub 2013 Mar 20.


Kinetic and cell-based analyses of GTPase regulators.

Segev N, Kahn RA.

Cell Logist. 2012 Jul 1;2(3):138-139.


The capping domain in RalF regulates effector functions.

Alix E, Chesnel L, Bowzard BJ, Tucker AM, Delprato A, Cherfils J, Wood DO, Kahn RA, Roy CR.

PLoS Pathog. 2012;8(11):e1003012. doi: 10.1371/journal.ppat.1003012. Epub 2012 Nov 15.


ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases.

East MP, Bowzard JB, Dacks JB, Kahn RA.

J Biol Chem. 2012 Nov 16;287(47):39538-53. doi: 10.1074/jbc.M112.417477. Epub 2012 Sep 26.

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