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Items: 27

1.

Ribosome depurination by ricin leads to inhibition of endoplasmic reticulum stress-induced HAC1 mRNA splicing on the ribosome.

Pierce M, Vengsarkar D, McLaughlin JE, Kahn JN, Tumer NE.

J Biol Chem. 2019 Nov 22;294(47):17848-17862. doi: 10.1074/jbc.RA119.009128. Epub 2019 Oct 17.

PMID:
31624149
2.

Leucine 232 and hydrophobic residues at the ribosomal P stalk binding site are critical for biological activity of ricin.

Zhou Y, Li XP, Kahn JN, McLaughlin JE, Tumer NE.

Biosci Rep. 2019 Oct 30;39(10). pii: BSR20192022. doi: 10.1042/BSR20192022.

3.

Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding.

Li XP, Kahn JN, Tumer NE.

Toxins (Basel). 2018 Sep 13;10(9). pii: E371. doi: 10.3390/toxins10090371.

4.

Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins.

Zhou Y, Li XP, Kahn JN, Tumer NE.

Toxins (Basel). 2018 Jun 14;10(6). pii: E240. doi: 10.3390/toxins10060240. Review.

5.

Using CRISPR-Cas9-mediated genome editing to generate C. difficile mutants defective in selenoproteins synthesis.

McAllister KN, Bouillaut L, Kahn JN, Self WT, Sorg JA.

Sci Rep. 2017 Nov 7;7(1):14672. doi: 10.1038/s41598-017-15236-5.

7.

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T.

ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12.

8.

The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.

Basu D, Li XP, Kahn JN, May KL, Kahn PC, Tumer NE.

Infect Immun. 2015 Oct 19;84(1):149-61. doi: 10.1128/IAI.00994-15. Print 2016 Jan.

9.
10.

Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966. Epub 2013 Sep 3.

11.

Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.

Singh SB, Herath K, Kahn JN, Mann P, Abruzzo G, Motyl M.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3253-6. doi: 10.1016/j.bmcl.2013.03.115. Epub 2013 Apr 10.

PMID:
23623416
12.

Isolation, structure, and biological activity of Phaeofungin, a cyclic lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test.

Singh SB, Ondeyka J, Harris G, Herath K, Zink D, Vicente F, Bills G, Collado J, Platas G, González del Val A, Martin J, Reyes F, Wang H, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Roemer T, Xu D.

J Nat Prod. 2013 Mar 22;76(3):334-45. doi: 10.1021/np300704s. Epub 2012 Dec 24.

PMID:
23259972
13.

Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins.

Park JG, Kahn JN, Tumer NE, Pang YP.

Sci Rep. 2012;2:631. doi: 10.1038/srep00631. Epub 2012 Sep 5.

14.

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase.

Heasley BH, Pacofsky GJ, Mamai A, Liu H, Nelson K, Coti G, Peel MR, Balkovec JM, Greenlee ML, Liberator P, Meng D, Parker DL, Wilkening RR, Apgar JM, Racine F, Hsu MJ, Giacobbe RA, Kahn JN.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6811-6. doi: 10.1016/j.bmcl.2012.05.031. Epub 2012 May 17.

PMID:
22672801
15.

Isolation, structure, and biological activities of Fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test.

Xu D, Ondeyka J, Harris GH, Zink D, Kahn JN, Wang H, Bills G, Platas G, Wang W, Szewczak AA, Liberator P, Roemer T, Singh SB.

J Nat Prod. 2011 Aug 26;74(8):1721-30. doi: 10.1021/np2001573. Epub 2011 Jul 13.

PMID:
21761939
16.

Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach.

Pang YP, Park JG, Wang S, Vummenthala A, Mishra RK, McLaughlin JE, Di R, Kahn JN, Tumer NE, Janosi L, Davis J, Millard CB.

PLoS One. 2011 Mar 24;6(3):e17883. doi: 10.1371/journal.pone.0017883.

17.
18.

Differential Aspergillus lentulus echinocandin susceptibilities are Fksp independent.

Staab JF, Kahn JN, Marr KA.

Antimicrob Agents Chemother. 2010 Dec;54(12):4992-8. doi: 10.1128/AAC.00774-10. Epub 2010 Sep 20.

19.

Distribution of the antifungal agents sordarins across filamentous fungi.

Vicente F, Basilio A, Platas G, Collado J, Bills GF, González del Val A, Martín J, Tormo JR, Harris GH, Zink DL, Justice M, Kahn JN, Peláez F.

Mycol Res. 2009 Jun-Jul;113(Pt 6-7):754-70. doi: 10.1016/j.mycres.2009.02.011. Epub 2009 Feb 26.

PMID:
19249360
20.

Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products.

Overy D, Calati K, Kahn JN, Hsu MJ, Martín J, Collado J, Roemer T, Harris G, Parish CA.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1224-7. doi: 10.1016/j.bmcl.2008.12.081. Epub 2008 Dec 25.

PMID:
19147347
21.

Isolation, structure elucidation, and biological activity of virgineone from Lachnum Wirgineum using the genome-wide Candida albicans fitness test.

Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, Platas G, Collado J, Gonzáez A, de la Cruz M, Martin J, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Jiang B, Xu D, Roemer T, Singh SB.

J Nat Prod. 2009 Jan;72(1):136-41. doi: 10.1021/np800511r.

PMID:
19115836
22.

Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp.

Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu D, Roemer T, Singh SB.

Bioorg Med Chem. 2009 Feb 1;17(3):1361-9. doi: 10.1016/j.bmc.2008.12.009. Epub 2008 Dec 14.

PMID:
19112025
23.

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu W, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Pelaez F, Diez MT, Kauffman S, Becker J, Harris G, Liberator P, Roemer T.

Chem Biol. 2008 Apr;15(4):363-74. doi: 10.1016/j.chembiol.2008.02.016.

24.

Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase.

Kahn JN, Garcia-Effron G, Hsu MJ, Park S, Marr KA, Perlin DS.

Antimicrob Agents Chemother. 2007 May;51(5):1876-8. Epub 2007 Feb 26.

25.

Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.

Bowman JC, Abruzzo GK, Flattery AM, Gill CJ, Hickey EJ, Hsu MJ, Kahn JN, Liberator PA, Misura AS, Pelak BA, Wang TC, Douglas CM.

Antimicrob Agents Chemother. 2006 Dec;50(12):4202-5. Epub 2006 Oct 2.

26.
27.

Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.

Park S, Kelly R, Kahn JN, Robles J, Hsu MJ, Register E, Li W, Vyas V, Fan H, Abruzzo G, Flattery A, Gill C, Chrebet G, Parent SA, Kurtz M, Teppler H, Douglas CM, Perlin DS.

Antimicrob Agents Chemother. 2005 Aug;49(8):3264-73.

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