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Items: 1 to 50 of 749

1.

Viral Hormones: Expanding Dimensions in Endocrinology.

Huang Q, Kahn CR, Altindis E.

Endocrinology. 2019 Jul 16. pii: en.2019-00271. doi: 10.1210/en.2019-00271. [Epub ahead of print]

PMID:
31310273
2.

The insulin receptor goes nuclear.

Batista TM, Cederquist CT, Kahn CR.

Cell Res. 2019 Jul;29(7):509-511. doi: 10.1038/s41422-019-0185-0. No abstract available.

PMID:
31160720
3.

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.

Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Pasquale Nigro, Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY, Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ.

Nat Metab. 2019 Feb;1(2):291-303. doi: 10.1038/s42255-018-0030-7. Epub 2019 Feb 11.

PMID:
31032475
4.

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.

Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR.

Mol Cell. 2019 May 16;74(4):844-857.e7. doi: 10.1016/j.molcel.2019.03.021. Epub 2019 Apr 15.

PMID:
31000437
5.

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.

Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, Kahn CR.

Nat Commun. 2019 Apr 5;10(1):1582. doi: 10.1038/s41467-019-09418-0.

6.

Insulin/IGF1 signalling mediates the effects of β2 -adrenergic agonist on muscle proteostasis and growth.

Gonçalves DA, Silveira WA, Manfredi LH, Graça FA, Armani A, Bertaggia E, O Neill BT, Lautherbach N, Machado J, Nogara L, Pereira MG, Arcidiacono D, Realdon S, Kahn CR, Sandri M, Kettelhut IC, Navegantes LCC.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):455-475. doi: 10.1002/jcsm.12395. Epub 2019 Apr 1.

7.

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.

Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, Kahn CR.

Cell Rep. 2019 Mar 19;26(12):3429-3443.e3. doi: 10.1016/j.celrep.2019.02.081.

8.

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes.

Ramirez AK, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR.

Mol Metab. 2019 Apr;22:21-36. doi: 10.1016/j.molmet.2019.01.006. Epub 2019 Jan 25.

9.

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.

Soto M, Cai W, Konishi M, Kahn CR.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6379-6384. doi: 10.1073/pnas.1817391116. Epub 2019 Feb 14.

PMID:
30765523
10.

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain.

Wardelmann K, Blümel S, Rath M, Alfine E, Chudoba C, Schell M, Cai W, Hauffe R, Warnke K, Flore T, Ritter K, Weiß J, Kahn CR, Kleinridders A.

Mol Metab. 2019 Mar;21:68-81. doi: 10.1016/j.molmet.2019.01.001. Epub 2019 Jan 6.

11.

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M.

J Clin Invest. 2019 Jan 2;129(1):437. doi: 10.1172/JCI126191. Epub 2019 Jan 2. No abstract available.

12.

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.

Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B.

PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018.

13.

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.

O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR.

Diabetes. 2019 Mar;68(3):556-570. doi: 10.2337/db18-0416. Epub 2018 Dec 6.

PMID:
30523026
14.

Developmental and functional heterogeneity of white adipocytes within a single fat depot.

Lee KY, Luong Q, Sharma R, Dreyfuss JM, Ussar S, Kahn CR.

EMBO J. 2019 Feb 1;38(3). pii: e99291. doi: 10.15252/embj.201899291. Epub 2018 Dec 10.

PMID:
30530479
15.

Fatty liver disease: is it nonalcoholic fatty liver disease or obesity-associated fatty liver disease?

Softic S, Kahn CR.

Eur J Gastroenterol Hepatol. 2019 Jan;31(1):143. doi: 10.1097/MEG.0000000000001279. No abstract available.

PMID:
30507644
16.

TRPV1 neurons regulate β-cell function in a sex-dependent manner.

Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, Homan EP, Dirice E, Kahn CR, El Ouaamari A.

Mol Metab. 2018 Dec;18:60-67. doi: 10.1016/j.molmet.2018.10.002. Epub 2018 Oct 5.

17.

Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.

Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ.

EMBO J. 2018 Dec 14;37(24). pii: e100409. doi: 10.15252/embj.2018100409. Epub 2018 Nov 16.

18.

Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly.

Weingarten G, Ben Yaakov A, Dror E, Russ J, Magin TM, Kahn CR, Wertheimer E.

FASEB J. 2019 Feb;33(2):2241-2251. doi: 10.1096/fj.201800847R. Epub 2018 Oct 17.

PMID:
30332298
19.

Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity.

Chaudhari A, Ejeskär K, Wettergren Y, Kahn CR, Rotter Sopasakis V.

Version 2. F1000Res. 2017 Aug 30 [revised 2018 Jan 1];6:1600. doi: 10.12688/f1000research.12418.2. eCollection 2017.

20.

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.

Soto M, Herzog C, Pacheco JA, Fujisaka S, Bullock K, Clish CB, Kahn CR.

Mol Psychiatry. 2018 Dec;23(12):2287-2301. doi: 10.1038/s41380-018-0086-5. Epub 2018 Jun 18.

21.

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI.

Elife. 2018 May 31;7. pii: e34469. doi: 10.7554/eLife.34469.

22.

Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes.

Solheim MH, Winnay JN, Batista TM, Molven A, Njølstad PR, Kahn CR.

Diabetes. 2018 Jul;67(7):1297-1309. doi: 10.2337/db17-1509. Epub 2018 May 3.

23.

Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

Kleinridders A, Ferris HA, Reyzer ML, Rath M, Soto M, Manier ML, Spraggins J, Yang Z, Stanton RC, Caprioli RM, Kahn CR.

Mol Metab. 2018 Jun;12:113-121. doi: 10.1016/j.molmet.2018.03.013. Epub 2018 Apr 6.

24.

Insulin regulates astrocyte gliotransmission and modulates behavior.

Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR.

J Clin Invest. 2018 Jul 2;128(7):2914-2926. doi: 10.1172/JCI99366. Epub 2018 Jun 4.

25.

Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action.

Rabiee A, Krüger M, Ardenkjær-Larsen J, Kahn CR, Emanuelli B.

Cell Signal. 2018 Jul;47:1-15. doi: 10.1016/j.cellsig.2018.03.003. Epub 2018 Mar 14.

26.

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.

Fujisaka S, Avila-Pacheco J, Soto M, Kostic A, Dreyfuss JM, Pan H, Ussar S, Altindis E, Li N, Bry L, Clish CB, Kahn CR.

Cell Rep. 2018 Mar 13;22(11):3072-3086. doi: 10.1016/j.celrep.2018.02.060.

27.

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR.

J Clin Invest. 2018 Mar 1;128(3):1199. doi: 10.1172/JCI99009. Epub 2018 Mar 1. No abstract available.

28.

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.

Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2461-2466. doi: 10.1073/pnas.1721117115. Epub 2018 Feb 21.

29.

Pyruvate induces torpor in obese mice.

Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):810-815. doi: 10.1073/pnas.1717507115. Epub 2018 Jan 8.

30.

Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes.

Ramirez AK, Lynes MD, Shamsi F, Xue R, Tseng YH, Kahn CR, Kasif S, Dreyfuss JM.

Cell Rep. 2017 Dec 12;21(11):3040-3048. doi: 10.1016/j.celrep.2017.11.065.

31.

Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.

Viana-Huete V, Guillén C, García G, Fernández S, García-Aguilar A, Kahn CR, Benito M.

Endocrinology. 2018 Jan 1;159(1):323-340. doi: 10.1210/en.2017-00738.

32.

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.

Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV.

Neurobiol Aging. 2018 Jan;61:225-237. doi: 10.1016/j.neurobiolaging.2017.09.001. Epub 2017 Sep 15.

33.

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241c.

PMID:
28985207
34.

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR.

J Clin Invest. 2017 Nov 1;127(11):4059-4074. doi: 10.1172/JCI94585. Epub 2017 Oct 3. Erratum in: J Clin Invest. 2018 Mar 1;128(3):1199.

35.

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice.

Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8478-E8487. doi: 10.1073/pnas.1710625114. Epub 2017 Sep 18.

36.

Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.

Lee KY, Sharma R, Gase G, Ussar S, Li Y, Welch L, Berryman DE, Kispert A, Bluher M, Kahn CR.

Diabetes. 2017 Nov;66(11):2822-2829. doi: 10.2337/db17-0218. Epub 2017 Aug 28.

37.

Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase.

Solheim MH, Clermont AC, Winnay JN, Hallstensen E, Molven A, Njølstad PR, Rødahl E, Kahn CR.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3100-3106. doi: 10.1167/iovs.16-21347.

38.

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. Erratum in: Nat Med. 2017 Oct 6;23 (10 ):1241.

39.

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K.

Aging Cell. 2017 Aug;16(4):761-772. doi: 10.1111/acel.12610. Epub 2017 May 22.

40.
41.

Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 May 10;545(7653):252. doi: 10.1038/nature22319. No abstract available.

PMID:
28492253
42.

Insulin resistance in vascular endothelial cells promotes intestinal tumour formation.

Wang X, Häring MF, Rathjen T, Lockhart SM, Sørensen D, Ussar S, Rasmussen LM, Bertagnolli MM, Kahn CR, Rask-Madsen C.

Oncogene. 2017 Aug 31;36(35):4987-4996. doi: 10.1038/onc.2017.107. Epub 2017 May 1.

43.

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.

Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS.

Nat Cell Biol. 2017 May;19(5):445-456. doi: 10.1038/ncb3517. Epub 2017 Apr 24.

44.

Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR.

J Biol Chem. 2017 Mar 31;292(13):5608. doi: 10.1074/jbc.A117.305602. No abstract available.

45.

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.

Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR.

Nat Commun. 2017 Mar 27;8:14892. doi: 10.1038/ncomms14892.

46.

Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 Feb 23;542(7642):450-455. doi: 10.1038/nature21365. Epub 2017 Feb 15. Erratum in: Nature. 2017 May 10;545(7653):252.

47.

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1189-1194. doi: 10.1073/pnas.1620506114. Epub 2017 Jan 17.

48.

Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor.

Ussar S, Haering MF, Fujisaka S, Lutter D, Lee KY, Li N, Gerber GK, Bry L, Kahn CR.

Diabetes. 2017 Apr;66(4):886-896. doi: 10.2337/db15-1349. Epub 2017 Jan 17.

49.

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR.

Cell Metab. 2017 Feb 7;25(2):448-462. doi: 10.1016/j.cmet.2016.12.008. Epub 2017 Jan 5.

50.

Bi-directional regulation of brown fat adipogenesis by the insulin receptor.

Entingh AJ, Taniguchi CM, Kahn CR.

J Biol Chem. 2016 Dec 30;291(53):27434. doi: 10.1074/jbc.A116.303056. No abstract available.

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