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PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.

Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB.

J Clin Invest. 2019 Oct 1;129(10):4138-4150. doi: 10.1172/JCI127092.


PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

Syed I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB.

J Clin Invest. 2019 Aug 5;129:3717-3731. doi: 10.1172/JCI122445. eCollection 2019 Aug 5.


Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.

Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A.

J Am Chem Soc. 2019 Jun 5;141(22):8798-8806. doi: 10.1021/jacs.9b00045. Epub 2019 May 13.


Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.

Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U.

Sci Rep. 2018 Oct 25;8(1):15757. doi: 10.1038/s41598-018-34113-3.


Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell Metab. 2018 Oct 2;28(4):543-546. doi: 10.1016/j.cmet.2018.09.007. Epub 2018 Sep 20.


Metabolites as regulators of insulin sensitivity and metabolism.

Yang Q, Vijayakumar A, Kahn BB.

Nat Rev Mol Cell Biol. 2018 Oct;19(10):654-672. doi: 10.1038/s41580-018-0044-8. Review.


Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED.

Cell Metab. 2018 Oct 2;28(4):631-643.e3. doi: 10.1016/j.cmet.2018.07.004. Epub 2018 Aug 2.


Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.

Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A.

Anal Chem. 2018 Apr 17;90(8):5358-5365. doi: 10.1021/acs.analchem.8b00503. Epub 2018 Mar 26.


Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB.

Cell Metab. 2018 Feb 6;27(2):419-427.e4. doi: 10.1016/j.cmet.2018.01.001.


Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.

Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.

Cell Rep. 2018 Jan 16;22(3):706-721. doi: 10.1016/j.celrep.2017.11.102.


Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.


Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.

Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D.

J Am Chem Soc. 2017 Apr 5;139(13):4943-4947. doi: 10.1021/jacs.7b01269. Epub 2017 Mar 28.


GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle.

McMillin SL, Schmidt DL, Kahn BB, Witczak CA.

Diabetes. 2017 Jun;66(6):1491-1500. doi: 10.2337/db16-1075. Epub 2017 Mar 9.


Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.

Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U.

Sci Rep. 2017 Feb 27;7:43515. doi: 10.1038/srep43515.


Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation.

Reno CM, Puente EC, Sheng Z, Daphna-Iken D, Bree AJ, Routh VH, Kahn BB, Fisher SJ.

Diabetes. 2017 Mar;66(3):587-597. doi: 10.2337/db16-0917. Epub 2016 Oct 17.


Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice.

Lee SA, Yuen JJ, Jiang H, Kahn BB, Blaner WS.

Hepatology. 2016 Nov;64(5):1534-1546. doi: 10.1002/hep.28659. Epub 2016 Jul 4.


Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids.

Smith U, Kahn BB.

J Intern Med. 2016 Nov;280(5):465-475. doi: 10.1111/joim.12540. Epub 2016 Oct 3. Review.


Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.

Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB.

J Biol Chem. 2016 Oct 14;291(42):22207-22217. Epub 2016 Aug 29.


Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A.

Biochemistry. 2016 Aug 23;55(33):4636-41. doi: 10.1021/acs.biochem.6b00565. Epub 2016 Aug 10.


A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons.

Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB.

Neuron. 2016 Jul 6;91(1):25-33. doi: 10.1016/j.neuron.2016.05.025. Epub 2016 Jun 16.


GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.

Moraes-Vieira PM, Saghatelian A, Kahn BB.

Diabetes. 2016 Jul;65(7):1808-15. doi: 10.2337/db16-0221. Epub 2016 Jun 10. Review.


Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE.

Diabetes. 2016 Jun;65(6):1577-89. doi: 10.2337/db15-1128. Epub 2016 Mar 25.


AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

Parsons WH, Kolar MJ, Kamat SS, Cognetta AB 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF.

Nat Chem Biol. 2016 May;12(5):367-372. doi: 10.1038/nchembio.2051. Epub 2016 Mar 28.


A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids.

Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A.

Nat Protoc. 2016 Apr;11(4):747-63. doi: 10.1038/nprot.2016.040. Epub 2016 Mar 17.


Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.

Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB.

Diabetes. 2016 May;65(5):1317-27. doi: 10.2337/db15-1696. Epub 2016 Mar 2.


PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK.

J Biol Chem. 2016 Mar 11;291(11):5664-75. doi: 10.1074/jbc.M115.696849. Epub 2016 Jan 21.


Novel role for retinol-binding protein 4 in the regulation of blood pressure.

Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jiang H, Michel T, Kahn BB.

FASEB J. 2015 Aug;29(8):3133-40. doi: 10.1096/fj.14-266064. Epub 2015 Apr 24.


Leptin and insulin act on POMC neurons to promote the browning of white fat.

Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T.

Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022.


Lipid Extraction from Mouse Feces.

Kraus D, Yang Q, Kahn BB.

Bio Protoc. 2015 Jan 5;5(1). pii: e1375.


Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.

Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB.

Diabetes. 2015 May;64(5):1603-14. doi: 10.2337/db14-0970. Epub 2014 Dec 18.


Data-driven synthesis of proteolysis-resistant peptide hormones.

Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A.

J Am Chem Soc. 2014 Dec 24;136(51):17710-3. doi: 10.1021/ja5065735. Epub 2014 Dec 12.


Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035.


Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.

Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB.

J Clin Invest. 2014 Sep;124(9):3781-92. doi: 10.1172/JCI68585. Epub 2014 Aug 1.


Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.

Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.


RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.

Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB.

Cell Metab. 2014 Mar 4;19(3):512-26. doi: 10.1016/j.cmet.2014.01.018.


Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.

Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB.

Mol Cell Biol. 2014 Mar;34(6):1170-86. doi: 10.1128/MCB.01106-13. Epub 2014 Jan 13.


Leptin, GABA, and glucose control.

Kahn BB, Minokoshi Y.

Cell Metab. 2013 Sep 3;18(3):304-6. doi: 10.1016/j.cmet.2013.08.015.


Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM.

Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20.


Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS.

Ann N Y Acad Sci. 2013 May;1287:1-16. doi: 10.1111/nyas.12116. Epub 2013 May 9.


Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study.

Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, Manson JE, Albert CM, Rexrode KM.

Circulation. 2013 May 14;127(19):1938-47. doi: 10.1161/CIRCULATIONAHA.113.002073. Epub 2013 Apr 12.


AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC.

Mol Cell. 2013 Mar 28;49(6):1167-75. doi: 10.1016/j.molcel.2013.01.035. Epub 2013 Feb 28.


Lessons on conditional gene targeting in mouse adipose tissue.

Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR.

Diabetes. 2013 Mar;62(3):864-74. doi: 10.2337/db12-1089. Epub 2013 Jan 15.


Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.

Hammarstedt A, Graham TE, Kahn BB.

Diabetol Metab Syndr. 2012 Sep 19;4(1):42. doi: 10.1186/1758-5996-4-42.


p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB.

Cell Metab. 2012 Jul 3;16(1):104-12. doi: 10.1016/j.cmet.2012.05.010. Epub 2012 Jun 21.


Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.

Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB.

PLoS One. 2012;7(5):e36335. doi: 10.1371/journal.pone.0036335. Epub 2012 May 10.


A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.

Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB.

Nature. 2012 Apr 19;484(7394):333-8. doi: 10.1038/nature10986.


Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.

Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB.

Mol Cell Biol. 2012 May;32(10):2010-9. doi: 10.1128/MCB.06193-11. Epub 2012 Mar 19.


Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.

Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M.

PLoS One. 2012;7(2):e32700. doi: 10.1371/journal.pone.0032700. Epub 2012 Feb 28.


Challenges and opportunities of defining clinical leptin resistance.

Myers MG Jr, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA.

Cell Metab. 2012 Feb 8;15(2):150-6. doi: 10.1016/j.cmet.2012.01.002.

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