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Items: 22


Sleep modulates haematopoiesis and protects against atherosclerosis.

McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb 13.


Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells.

Schnack L, Sohrabi Y, Lagache SMM, Kahles F, Bruemmer D, Waltenberger J, Findeisen HM.

Front Immunol. 2019 Jan 23;10:13. doi: 10.3389/fimmu.2019.00013. eCollection 2019.


mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes.

Sohrabi Y, Lagache SMM, Schnack L, Godfrey R, Kahles F, Bruemmer D, Waltenberger J, Findeisen HM.

Front Immunol. 2019 Jan 22;9:3155. doi: 10.3389/fimmu.2018.03155. eCollection 2018.


Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.


Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.

Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK.

J Exp Med. 2019 Feb 4;216(2):369-383. doi: 10.1084/jem.20180722. Epub 2019 Jan 22.


Myocardial infarction is sufficient to increase GLP-1 secretion, leading to improved left ventricular contractility and mitochondrial respiratory capacity.

Diebold S, Moellmann J, Kahles F, Haj-Yehia E, Liehn EA, Nickel A, Lebherz C, Maack C, Marx N, Lehrke M.

Diabetes Obes Metab. 2018 Dec;20(12):2911-2918. doi: 10.1111/dom.13472. Epub 2018 Aug 16.


The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE-/- mice by blocking monocyte/macrophage activation.

Kahles F, Liberman A, Halim C, Rau M, Möllmann J, Mertens RW, Rückbeil M, Diepolder I, Walla B, Diebold S, Burgmaier M, Lebherz C, Marx N, Lehrke M.

Mol Metab. 2018 Aug;14:150-157. doi: 10.1016/j.molmet.2018.05.014. Epub 2018 May 23.


In vivo quantification of amyloid burden in TTR-related cardiac amyloidosis.

Kollikowski AM, Kahles F, Kintsler S, Hamada S, Reith S, Knüchel R, Röcken C, Mottaghy FM, Marx N, Burgmaier M.

Intractable Rare Dis Res. 2017 Nov;6(4):291-294. doi: 10.5582/irdr.2017.01065.


[Non-ST-Segment Elevation Myocardial Infarction Caused by Spontaneous Coronary Thrombosis by Intimal Rupture].

Kahles F, Schuh A, Lehrke M, Burgmaier M, Marx N, Reith S.

Dtsch Med Wochenschr. 2017 Nov;142(22):1686-1689. doi: 10.1055/s-0043-118633. Epub 2017 Oct 27. German.


Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition.

Burgmaier M, Reith S, Schurgers L, Kahles F, Marx N, Reutelingsperger C.

Diab Vasc Dis Res. 2017 Sep;14(5):415-422. doi: 10.1177/1479164117710392. Epub 2017 Jun 7.


GLP-1 Levels Predict Mortality in Patients with Critical Illness as Well as End-Stage Renal Disease.

Lebherz C, Schlieper G, Möllmann J, Kahles F, Schwarz M, Brünsing J, Dimkovic N, Koch A, Trautwein C, Flöge J, Marx N, Tacke F, Lehrke M.

Am J Med. 2017 Jul;130(7):833-841.e3. doi: 10.1016/j.amjmed.2017.03.010. Epub 2017 Mar 31.


The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism.

Möllmann J, Kahles F, Lebherz C, Kappel B, Baeck C, Tacke F, Werner C, Federici M, Marx N, Lehrke M.

Diabetes Obes Metab. 2017 Apr;19(4):496-508. doi: 10.1111/dom.12839. Epub 2017 Feb 22.


Does osteopontin induce adipose tissue inflammation by local macrophage proliferation?

Kahles F, Findeisen HM.

Mol Metab. 2016 Oct 14;5(12):1147-1148. doi: 10.1016/j.molmet.2016.10.002. eCollection 2016 Dec. No abstract available.


Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice.

Kahles F, Meyer C, Diebold S, Foldenauer AC, Stöhr R, Möllmann J, Lebherz C, Findeisen HM, Marx N, Lehrke M.

Diabetes Obes Metab. 2016 Nov;18(11):1147-1151. doi: 10.1111/dom.12711. Epub 2016 Aug 4.


Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism.

Lebherz C, Kahles F, Piotrowski K, Vogeser M, Foldenauer AC, Nassau K, Kilger E, Marx N, Parhofer KG, Lehrke M.

Cardiovasc Diabetol. 2016 Feb 3;15:21. doi: 10.1186/s12933-016-0330-8.


[IL-6 dependent GLP-1 secretion during acute inflammation].

Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, Trautwein C, Koch A, Tacke F, Marx N, Lehrke M.

Med Klin Intensivmed Notfmed. 2015 Sep;110(6):462-4. doi: 10.1007/s00063-015-0059-2. German. No abstract available.


PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.

Lehrke M, Kahles F, Makowska A, Tilstam PV, Diebold S, Marx J, Stöhr R, Hess K, Endorf EB, Bruemmer D, Marx N, Findeisen HM.

J Mol Cell Cardiol. 2015 Apr;81:23-33. doi: 10.1016/j.yjmcc.2015.01.015. Epub 2015 Jan 30.


GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering.

Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, Trautwein C, Koch A, Tacke F, Marx N, Lehrke M.

Diabetes. 2014 Oct;63(10):3221-9. doi: 10.2337/db14-0100. Epub 2014 Jun 19.


Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.

Kahles F, Findeisen HM, Bruemmer D.

Mol Metab. 2014 Mar 22;3(4):384-93. doi: 10.1016/j.molmet.2014.03.004. eCollection 2014 Jul. Review.


Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe⁻/⁻ mice.

Burgmaier M, Liberman A, Möllmann J, Kahles F, Reith S, Lebherz C, Marx N, Lehrke M.

Atherosclerosis. 2013 Dec;231(2):427-35. doi: 10.1016/j.atherosclerosis.2013.08.033. Epub 2013 Sep 5.


Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.

Findeisen HM, Kahles FK, Bruemmer D.

Curr Atheroscler Rep. 2013 May;15(5):319. Review.


Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.

Findeisen HM, Kahles FK, Bruemmer D.

Curr Atheroscler Rep. 2013 Apr;15(4):319. doi: 10.1007/s11883-013-0319-7. Review.


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