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Items: 1 to 50 of 138

1.

Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century.

Kierdorf U, Olsen MT, Kahle P, Ludolphy C, Kierdorf H.

PLoS One. 2019 Apr 12;14(4):e0215401. doi: 10.1371/journal.pone.0215401. eCollection 2019.

2.

Dental anomalies and lesions in Eastern Atlantic harbor seals, Phoca vitulina vitulina (Carnivora, Phocidae), from the German North Sea.

Kahle P, Ludolphy C, Kierdorf H, Kierdorf U.

PLoS One. 2018 Oct 3;13(10):e0204079. doi: 10.1371/journal.pone.0204079. eCollection 2018.

3.

Monitoring α-synuclein multimerization in vivo.

Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A.

FASEB J. 2019 Feb;33(2):2116-2131. doi: 10.1096/fj.201800148RRR. Epub 2018 Sep 25.

PMID:
30252534
4.

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).

Hans F, Eckert M, von Zweydorf F, Gloeckner CJ, Kahle PJ.

J Biol Chem. 2018 Oct 12;293(41):16083-16099. doi: 10.1074/jbc.RA118.003440. Epub 2018 Aug 17.

PMID:
30120199
5.

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein Overexpression.

Wassouf Z, Hentrich T, Samer S, Rotermund C, Kahle PJ, Ehrlich I, Riess O, Casadei N, Schulze-Hentrich JM.

Front Cell Neurosci. 2018 Apr 24;12:112. doi: 10.3389/fncel.2018.00112. eCollection 2018.

6.
7.

Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice.

Ekmark-Lewén S, Lindström V, Gumucio A, Ihse E, Behere A, Kahle PJ, Nordström E, Eriksson M, Erlandsson A, Bergström J, Ingelsson M.

Brain Behav. 2018 Feb 4;8(3):e00915. doi: 10.1002/brb3.915. eCollection 2018 Mar.

8.

Mineral Apposition Rates in Coronal Dentine of Mandibular First Molars in Soay Sheep: Results of a Fluorochrome Labeling Study.

Kahle P, Witzel C, Kierdorf U, Frölich K, Kierdorf H.

Anat Rec (Hoboken). 2018 May;301(5):902-912. doi: 10.1002/ar.23753. Epub 2017 Dec 28.

9.

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation.

Das S, Morvan F, Morozzi G, Jourde B, Minetti GC, Kahle P, Rivet H, Brebbia P, Toussaint G, Glass DJ, Fornaro M.

Cell Rep. 2017 Dec 12;21(11):3003-3011. doi: 10.1016/j.celrep.2017.11.038.

10.

In vivo models of alpha-synuclein transmission and propagation.

Recasens A, Ulusoy A, Kahle PJ, Di Monte DA, Dehay B.

Cell Tissue Res. 2018 Jul;373(1):183-193. doi: 10.1007/s00441-017-2730-9. Epub 2017 Nov 29. Review.

PMID:
29185072
11.

LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.

Yoon JH, Mo JS, Kim MY, Ann EJ, Ahn JS, Jo EH, Lee HJ, Lee YC, Seol W, Yarmoluk SM, Gasser T, Kahle PJ, Liu GH, Belmonte JCI, Park HS.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2356-2368. doi: 10.1016/j.bbamcr.2017.09.001. Epub 2017 Sep 6.

12.

Enhanced motivation to alcohol in transgenic mice expressing human α-synuclein.

Rotermund C, Reolon GK, Leixner S, Boden C, Bilbao A, Kahle PJ.

J Neurochem. 2017 Nov;143(3):294-305. doi: 10.1111/jnc.14151. Epub 2017 Sep 12.

13.

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein.

Almandoz-Gil L, Lindström V, Sigvardson J, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J.

Cell Mol Neurobiol. 2017 Oct;37(7):1217-1226. doi: 10.1007/s10571-016-0454-0. Epub 2016 Dec 27.

14.

Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.

Wettengel J, Reautschnig P, Geisler S, Kahle PJ, Stafforst T.

Nucleic Acids Res. 2017 Mar 17;45(5):2797-2808. doi: 10.1093/nar/gkw911.

15.

Visualization of Colloid Transport Pathways in Mineral Soils Using Titanium(IV) Oxide as a Tracer.

Koch S, Kahle P, Lennartz B.

J Environ Qual. 2016 Nov;45(6):2053-2059. doi: 10.2134/jeq2016.04.0131.

PMID:
27898798
16.

α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.

Sugeno N, Jäckel S, Voigt A, Wassouf Z, Schulze-Hentrich J, Kahle PJ.

Sci Rep. 2016 Nov 3;6:36328. doi: 10.1038/srep36328.

17.

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.

Scheffold A, Holtman IR, Dieni S, Brouwer N, Katz SF, Jebaraj BM, Kahle PJ, Hengerer B, Lechel A, Stilgenbauer S, Boddeke EW, Eggen BJ, Rudolph KL, Biber K.

Acta Neuropathol Commun. 2016 Aug 22;4(1):87. doi: 10.1186/s40478-016-0364-x.

18.

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M.

Neuron. 2016 Jul 20;91(2):494-496. doi: 10.1016/j.neuron.2016.07.007. Epub 2016 Jul 20. No abstract available.

19.

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M.

Neuron. 2016 Jul 6;91(1):56-66. doi: 10.1016/j.neuron.2016.05.018. Epub 2016 Jun 9. Erratum in: Neuron. 2016 Jul 20;91(2):494-496.

20.

α-Synuclein oligomers pump it up!

Kahle PJ, Sugeno N, Skodras A.

EMBO J. 2015 Oct 1;34(19):2385-7. doi: 10.15252/embj.201592770. Epub 2015 Sep 15. No abstract available.

21.

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes.

Rannikko EH, Weber SS, Kahle PJ.

BMC Neurosci. 2015 Sep 7;16:57. doi: 10.1186/s12868-015-0192-0.

22.

ATP citrate lyase improves mitochondrial function in skeletal muscle.

Das S, Morvan F, Jourde B, Meier V, Kahle P, Brebbia P, Toussaint G, Glass DJ, Fornaro M.

Cell Metab. 2015 Jun 2;21(6):868-76. doi: 10.1016/j.cmet.2015.05.006.

23.

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.

Jäckel S, Summerer AK, Thömmes CM, Pan X, Voigt A, Schulz JB, Rasse TM, Dormann D, Haass C, Kahle PJ.

Neurobiol Dis. 2015 Feb;74:76-88. doi: 10.1016/j.nbd.2014.11.003. Epub 2014 Nov 8.

PMID:
25447237
24.

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts.

Schweighauser M, Bacioglu M, Fritschi SK, Shimshek DR, Kahle PJ, Eisele YS, Jucker M.

Acta Neuropathol. 2015 Jan;129(1):157-9. doi: 10.1007/s00401-014-1360-5. Epub 2014 Nov 4. No abstract available.

PMID:
25367384
25.

Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease.

Danielyan L, Beer-Hammer S, Stolzing A, Schäfer R, Siegel G, Fabian C, Kahle P, Biedermann T, Lourhmati A, Buadze M, Novakovic A, Proksch B, Gleiter CH, Frey WH, Schwab M.

Cell Transplant. 2014;23 Suppl 1:S123-39. doi: 10.3727/096368914X684970. Epub 2014 Oct 9.

PMID:
25302802
26.

Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses.

Kroczynska B, Mehrotra S, Majchrzak-Kita B, Arslan AD, Altman JK, Stein BL, McMahon B, Kozlowski P, Kahle PJ, Eklund EA, Fish EN, Platanias LC.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11377-82. doi: 10.1073/pnas.1405250111. Epub 2014 Jul 21.

27.

Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice.

Rotermund C, Truckenmüller FM, Schell H, Kahle PJ.

J Neurochem. 2014 Dec;131(6):848-58. doi: 10.1111/jnc.12813. Epub 2014 Aug 11.

28.

The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.

Geisler S, Vollmer S, Golombek S, Kahle PJ.

J Cell Sci. 2014 Aug 1;127(Pt 15):3280-93. doi: 10.1242/jcs.146035. Epub 2014 Jun 6.

29.

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice.

Lindström V, Fagerqvist T, Nordström E, Eriksson F, Lord A, Tucker S, Andersson J, Johannesson M, Schell H, Kahle PJ, Möller C, Gellerfors P, Bergström J, Lannfelt L, Ingelsson M.

Neurobiol Dis. 2014 Sep;69:134-43. doi: 10.1016/j.nbd.2014.05.009. Epub 2014 May 20.

PMID:
24851801
30.

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.

Hans F, Fiesel FC, Strong JC, Jäckel S, Rasse TM, Geisler S, Springer W, Schulz JB, Voigt A, Kahle PJ.

J Biol Chem. 2014 Jul 4;289(27):19164-79. doi: 10.1074/jbc.M114.561704. Epub 2014 May 13.

31.

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.

Pérez-Revuelta BI, Hettich MM, Ciociaro A, Rotermund C, Kahle PJ, Krauss S, Di Monte DA.

Cell Death Dis. 2014 May 8;5:e1209. doi: 10.1038/cddis.2014.175.

32.

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.

Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S.

Hum Mol Genet. 2014 Aug 1;23(15):3975-89. doi: 10.1093/hmg/ddu112. Epub 2014 Mar 11.

33.

Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages.

Kuss M, Adamopoulou E, Kahle PJ.

J Neurochem. 2014 Jun;129(6):980-7. doi: 10.1111/jnc.12668. Epub 2014 Feb 24.

34.

Parkinson's disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein.

Büchel F, Saliger S, Dräger A, Hoffmann S, Wrzodek C, Zell A, Kahle PJ.

BMC Neurosci. 2013 Nov 6;14:136. doi: 10.1186/1471-2202-14-136.

35.

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.

Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S.

Hum Mol Genet. 2014 Feb 1;23(3):767-81. doi: 10.1093/hmg/ddt467. Epub 2013 Sep 24.

PMID:
24064336
36.

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.

Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J.

Amyloid. 2013 Dec;20(4):233-44. doi: 10.3109/13506129.2013.835726. Epub 2013 Sep 20.

PMID:
24053224
37.

Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.

Koehler NK, Stransky E, Shing M, Gaertner S, Meyer M, Schreitmüller B, Leyhe T, Laske C, Maetzler W, Kahle P, Celej MS, Jovin TM, Fallgatter AJ, Batra A, Buchkremer G, Schott K, Richartz-Salzburger E.

PLoS One. 2013 May 31;8(5):e64649. doi: 10.1371/journal.pone.0064649. Print 2013.

38.

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy.

Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH.

PLoS One. 2013;8(1):e55243. doi: 10.1371/journal.pone.0055243. Epub 2013 Jan 25.

39.

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.

Fagerqvist T, Lindström V, Nordström E, Lord A, Tucker SM, Su X, Sahlin C, Kasrayan A, Andersson J, Welander H, Näsström T, Holmquist M, Schell H, Kahle PJ, Kalimo H, Möller C, Gellerfors P, Lannfelt L, Bergström J, Ingelsson M.

J Neurochem. 2013 Jul;126(1):131-44. doi: 10.1111/jnc.12175. Epub 2013 Feb 27.

40.

Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion.

Rannikko EH, Vesterager LB, Shaik JH, Weber SS, Cornejo Castro EM, Fog K, Jensen PH, Kahle PJ.

J Neurochem. 2013 Apr;125(2):314-27. doi: 10.1111/jnc.12126. Epub 2013 Jan 15.

41.

Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice.

Schell H, Boden C, Chagas AM, Kahle PJ.

PLoS One. 2012;7(11):e50245. doi: 10.1371/journal.pone.0050245. Epub 2012 Nov 27.

42.

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.

Robert G, Puissant A, Dufies M, Marchetti S, Jacquel A, Cluzeau T, Colosetti P, Belhacene N, Kahle P, Da Costa CA, Luciano F, Checler F, Auberger P.

Cell Death Differ. 2012 Nov;19(11):1769-78. doi: 10.1038/cdd.2012.55. Epub 2012 May 4.

43.

Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture.

Sartorius T, Lutz SZ, Hoene M, Waak J, Peter A, Weigert C, Rammensee HG, Kahle PJ, Häring HU, Hennige AM.

FASEB J. 2012 May;26(5):1799-809. doi: 10.1096/fj.11-191023. Epub 2012 Jan 25.

PMID:
22278939
44.

Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration.

Minetti GC, Feige JN, Rosenstiel A, Bombard F, Meier V, Werner A, Bassilana F, Sailer AW, Kahle P, Lambert C, Glass DJ, Fornaro M.

Sci Signal. 2011 Nov 29;4(201):ra80. doi: 10.1126/scisignal.2002038.

45.

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR.

Fiesel FC, Weber SS, Supper J, Zell A, Kahle PJ.

Nucleic Acids Res. 2012 Mar;40(6):2668-82. doi: 10.1093/nar/gkr1082. Epub 2011 Nov 25.

46.

Neuropathology in mice expressing mouse alpha-synuclein.

Rieker C, Dev KK, Lehnhoff K, Barbieri S, Ksiazek I, Kauffmann S, Danner S, Schell H, Boden C, Ruegg MA, Kahle PJ, van der Putten H, Shimshek DR.

PLoS One. 2011;6(9):e24834. doi: 10.1371/journal.pone.0024834. Epub 2011 Sep 26.

47.

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6.

Fiesel FC, Schurr C, Weber SS, Kahle PJ.

Mol Neurodegener. 2011 Aug 30;6:64. doi: 10.1186/1750-1326-6-64.

48.

TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration.

Fiesel FC, Kahle PJ.

FEBS J. 2011 Oct;278(19):3550-68. doi: 10.1111/j.1742-4658.2011.08258.x. Epub 2011 Aug 24. Review.

49.

Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.

Nuber S, Petrasch-Parwez E, Arias-Carrión O, Koch L, Kohl Z, Schneider J, Calaminus C, Dermietzel R, Samarina A, Boy J, Nguyen HP, Teismann P, Velavan TP, Kahle PJ, von Hörsten S, Fendt M, Krüger R, Riess O.

Neurobiol Dis. 2011 Nov;44(2):192-204. doi: 10.1016/j.nbd.2011.06.017. Epub 2011 Jul 5.

PMID:
21767644
50.

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease.

Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M, Roberts JL, Kahle PJ, Clark RA, Li S.

J Neurosci. 2011 Jan 5;31(1):157-63. doi: 10.1523/JNEUROSCI.1833-10.2011.

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