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Gasdermin D activity in inflammation and host defense.

Lieberman J, Wu H, Kagan JC.

Sci Immunol. 2019 Sep 6;4(39). pii: eaav1447. doi: 10.1126/sciimmunol.aav1447. Review.


Inflammasomes: Threat-Assessment Organelles of the Innate Immune System.

Evavold CL, Kagan JC.

Immunity. 2019 Aug 23. pii: S1074-7613(19)30331-0. doi: 10.1016/j.immuni.2019.08.005. [Epub ahead of print] Review.


Patterns, dynamics and consequences of microplastic ingestion by the temperate coral, Astrangia poculata.

Rotjan RD, Sharp KH, Gauthier AE, Yelton R, Lopez EMB, Carilli J, Kagan JC, Urban-Rich J.

Proc Biol Sci. 2019 Jun 26;286(1905):20190726. doi: 10.1098/rspb.2019.0726. Epub 2019 Jun 26.


Lipids that directly regulate innate immune signal transduction.

Barnett KC, Kagan JC.

Innate Immun. 2019 Jun 10:1753425919852695. doi: 10.1177/1753425919852695. [Epub ahead of print]


Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World.

Odendall C, Kagan JC.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0011-2019.


Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ.

Cell Rep. 2019 Apr 23;27(4):1165-1175.e5. doi: 10.1016/j.celrep.2019.03.098.


Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.

Tan Y, Kagan JC.

Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7.


Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.

Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28.


Defying Death: The (W)hole Truth about the Fate of GSDMD Pores.

Evavold CL, Kagan JC.

Immunity. 2019 Jan 15;50(1):15-17. doi: 10.1016/j.immuni.2018.12.032.


The Fly Way of Antiviral Resistance and Disease Tolerance.

Chow J, Kagan JC.

Adv Immunol. 2018;140:59-93. doi: 10.1016/ Epub 2018 Sep 18. Review.


Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance.

Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF.

Trends Immunol. 2018 Nov;39(11):862-873. doi: 10.1016/ Epub 2018 Oct 6. Review.


An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication.

Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC.

Mol Cell. 2018 Sep 6;71(5):825-840.e6. doi: 10.1016/j.molcel.2018.07.009. Epub 2018 Aug 9.


Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2018 Apr 11;23(4):571. doi: 10.1016/j.chom.2018.03.005. No abstract available.


STING-dependent translation inhibition restricts RNA virus replication.

Franz KM, Neidermyer WJ, Tan YJ, Whelan SPJ, Kagan JC.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2058-E2067. doi: 10.1073/pnas.1716937115. Epub 2018 Feb 12.


The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC.

Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28.


Biochemical Isolation of the Myddosome from Murine Macrophages.

Tan Y, Kagan JC.

Methods Mol Biol. 2018;1714:79-95. doi: 10.1007/978-1-4939-7519-8_6.


By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation.

Zanoni I, Tan Y, Di Gioia M, Springstead JR, Kagan JC.

Immunity. 2017 Oct 17;47(4):697-709.e3. doi: 10.1016/j.immuni.2017.09.010.


How Inflammasomes Inform Adaptive Immunity.

Evavold CL, Kagan JC.

J Mol Biol. 2018 Jan 19;430(2):217-237. doi: 10.1016/j.jmb.2017.09.019. Epub 2017 Oct 5. Review.


Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection.

Odendall C, Voak AA, Kagan JC.

J Immunol. 2017 Nov 1;199(9):3270-3279. doi: 10.4049/jimmunol.1700250. Epub 2017 Sep 27.


A one-protein signaling pathway in the innate immune system.

Orzalli MH, Kagan JC.

Sci Immunol. 2016 Aug 19;1(2):eaah6184. doi: 10.1126/sciimmunol.aah6184. Epub 2016 Aug 19. Review.


Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections.

Chow J, Márka Z, Bartos I, Márka S, Kagan JC.

Cell Host Microbe. 2017 Jul 12;22(1):48-60.e5. doi: 10.1016/j.chom.2017.06.010.


Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection.

Orzalli MH, Kagan JC.

Trends Cell Biol. 2017 Nov;27(11):800-809. doi: 10.1016/j.tcb.2017.05.007. Epub 2017 Jun 19. Review.


Innate Immune Receptors as Competitive Determinants of Cell Fate.

Franz KM, Kagan JC.

Mol Cell. 2017 Jun 15;66(6):750-760. doi: 10.1016/j.molcel.2017.05.009. Review.


Lipopolysaccharide Detection across the Kingdoms of Life.

Kagan JC.

Trends Immunol. 2017 Oct;38(10):696-704. doi: 10.1016/ Epub 2017 May 24. Review.


Multi-receptor detection of individual bacterial products by the innate immune system.

Kieser KJ, Kagan JC.

Nat Rev Immunol. 2017 Jun;17(6):376-390. doi: 10.1038/nri.2017.25. Epub 2017 May 2. Review.


Activation and pathogenic manipulation of the sensors of the innate immune system.

Odendall C, Kagan JC.

Microbes Infect. 2017 Apr - May;19(4-5):229-237. doi: 10.1016/j.micinf.2017.01.003. Epub 2017 Jan 14. Review.


Early innate immune responses to bacterial LPS.

Rosadini CV, Kagan JC.

Curr Opin Immunol. 2017 Feb;44:14-19. doi: 10.1016/j.coi.2016.10.005. Epub 2016 Nov 12. Review.


Microbe-inducible trafficking pathways that control Toll-like receptor signaling.

Tan Y, Kagan JC.

Traffic. 2017 Jan;18(1):6-17. doi: 10.1111/tra.12454. Epub 2016 Nov 23. Review.


Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil.

Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, Guedes MM, Moore SR, Petri WA, Havt A, Lima IF, Prata MM, Michaleckyj JC, Scharf RJ, Sturgeon C, Fasano A, Lima AA.

PLoS One. 2016 Sep 30;11(9):e0158772. doi: 10.1371/journal.pone.0158772. eCollection 2016.


Editorial overview: Emerging concepts in host-virus interactions.

Kagan JC.

Curr Opin Microbiol. 2016 Aug;32:xii-xiii. doi: 10.1016/j.mib.2016.06.006. Epub 2016 Jul 11. No abstract available.


Control of the innate immune response by the mevalonate pathway.

Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D.

Nat Immunol. 2016 Aug;17(8):922-9. doi: 10.1038/ni.3487. Epub 2016 Jun 6.


Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response.

Magalhães AC, Ferreira AR, Gomes S, Vieira M, Gouveia A, Valença I, Islinger M, Nascimento R, Schrader M, Kagan JC, Ribeiro D.

Sci Rep. 2016 May 16;6:26028. doi: 10.1038/srep26028.


An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.

Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC.

Science. 2016 Jun 3;352(6290):1232-6. doi: 10.1126/science.aaf3036. Epub 2016 Apr 21.


Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response.

Ferreira AR, Magalhães AC, Camões F, Gouveia A, Vieira M, Kagan JC, Ribeiro D.

J Cell Mol Med. 2016 Apr;20(4):750-7. doi: 10.1111/jcmm.12801. Epub 2016 Feb 10.


A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC.

Cell Host Microbe. 2015 Dec 9;18(6):682-93. doi: 10.1016/j.chom.2015.11.006.


Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria.

Tan Y, Zanoni I, Cullen TW, Goodman AL, Kagan JC.

Immunity. 2015 Nov 17;43(5):909-22. doi: 10.1016/j.immuni.2015.10.008. Epub 2015 Nov 3.


PRRs are watching you: Localization of innate sensing and signaling regulators.

Chow J, Franz KM, Kagan JC.

Virology. 2015 May;479-480:104-9. doi: 10.1016/j.virol.2015.02.051. Epub 2015 Mar 20. Review.


The unique regulation and functions of type III interferons in antiviral immunity.

Odendall C, Kagan JC.

Curr Opin Virol. 2015 Jun;12:47-52. doi: 10.1016/j.coviro.2015.02.003. Epub 2015 Mar 12. Review.


Microbial strategies for antagonizing Toll-like-receptor signal transduction.

Rosadini CV, Kagan JC.

Curr Opin Immunol. 2015 Feb;32:61-70. doi: 10.1016/j.coi.2014.12.011. Epub 2015 Jan 20. Review.


Innate immune pattern recognition: a cell biological perspective.

Brubaker SW, Bonham KS, Zanoni I, Kagan JC.

Annu Rev Immunol. 2015;33:257-90. doi: 10.1146/annurev-immunol-032414-112240. Epub 2015 Jan 2. Review.


Emerging principles governing signal transduction by pattern-recognition receptors.

Kagan JC, Barton GM.

Cold Spring Harb Perspect Biol. 2014 Nov 13;7(3):a016253. doi: 10.1101/cshperspect.a016253. Review.


SMOCs: supramolecular organizing centres that control innate immunity.

Kagan JC, Magupalli VG, Wu H.

Nat Rev Immunol. 2014 Dec;14(12):821-6. doi: 10.1038/nri3757. Epub 2014 Oct 31. Review.


Common mechanisms activate plant guard receptors and TLR4.

Kagan JC.

Trends Immunol. 2014 Oct;35(10):454-6. doi: 10.1016/ Epub 2014 Sep 12.


Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.

Teigler JE, Kagan JC, Barouch DH.

J Virol. 2014 Sep;88(18):10354-63. doi: 10.1128/JVI.00936-14. Epub 2014 Jul 2.


Diverse intracellular pathogens activate type III interferon expression from peroxisomes.

Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC.

Nat Immunol. 2014 Aug;15(8):717-26. doi: 10.1038/ni.2915. Epub 2014 Jun 22.


Endosomes as platforms for NOD-like receptor signaling.

Bonham KS, Kagan JC.

Cell Host Microbe. 2014 May 14;15(5):523-5. doi: 10.1016/j.chom.2014.05.001.


A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide.

Tan Y, Kagan JC.

Mol Cell. 2014 Apr 24;54(2):212-23. doi: 10.1016/j.molcel.2014.03.012. Review.


A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity.

Brubaker SW, Gauthier AE, Mills EW, Ingolia NT, Kagan JC.

Cell. 2014 Feb 13;156(4):800-11. doi: 10.1016/j.cell.2014.01.021.


A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.

Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC.

Cell. 2014 Feb 13;156(4):705-16. doi: 10.1016/j.cell.2014.01.019.


Finding a needle in a haystack of needles - a productive hunt for interferon stimulated genes with antiviral activity.

Franz KM, Kagan JC.

Immunol Cell Biol. 2014 Mar;92(3):205-7. doi: 10.1038/icb.2013.108. Epub 2014 Jan 14. No abstract available.

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