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Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.

Stanifer ML, Mukenhirn M, Muenchau S, Pervolaraki K, Kanaya T, Albrecht D, Odendall C, Hielscher T, Haucke V, Kagan JC, Bartfeld S, Ohno H, Boulant S.

Nat Microbiol. 2019 Nov 4. doi: 10.1038/s41564-019-0594-3. [Epub ahead of print]


A randomized evaluation of on-site monitoring nested in a multinational randomized trial.

Wyman Engen N, Huppler Hullsiek K, Belloso WH, Finley E, Hudson F, Denning E, Carey C, Pearson M, Kagan J.

Clin Trials. 2019 Oct 24:1740774519881616. doi: 10.1177/1740774519881616. [Epub ahead of print]


Gasdermin D activity in inflammation and host defense.

Lieberman J, Wu H, Kagan JC.

Sci Immunol. 2019 Sep 6;4(39). pii: eaav1447. doi: 10.1126/sciimmunol.aav1447. Review.


Inflammasomes: Threat-Assessment Organelles of the Innate Immune System.

Evavold CL, Kagan JC.

Immunity. 2019 Oct 15;51(4):609-624. doi: 10.1016/j.immuni.2019.08.005. Epub 2019 Aug 28. Review.


Patterns, dynamics and consequences of microplastic ingestion by the temperate coral, Astrangia poculata.

Rotjan RD, Sharp KH, Gauthier AE, Yelton R, Lopez EMB, Carilli J, Kagan JC, Urban-Rich J.

Proc Biol Sci. 2019 Jun 26;286(1905):20190726. doi: 10.1098/rspb.2019.0726. Epub 2019 Jun 26.


Lipids that directly regulate innate immune signal transduction.

Barnett KC, Kagan JC.

Innate Immun. 2019 Jun 10:1753425919852695. doi: 10.1177/1753425919852695. [Epub ahead of print]


Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World.

Odendall C, Kagan JC.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0011-2019.


Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ.

Cell Rep. 2019 Apr 23;27(4):1165-1175.e5. doi: 10.1016/j.celrep.2019.03.098.


Cost of peripheral neuropathy in patients receiving treatment for multiple myeloma: a US administrative claims analysis.

Song X, Wilson KL, Kagan J, Panjabi S.

Ther Adv Hematol. 2019 Apr 1;10:2040620719839025. doi: 10.1177/2040620719839025. eCollection 2019.


Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.

Tan Y, Kagan JC.

Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7.


Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.

Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28.


Defying Death: The (W)hole Truth about the Fate of GSDMD Pores.

Evavold CL, Kagan JC.

Immunity. 2019 Jan 15;50(1):15-17. doi: 10.1016/j.immuni.2018.12.032.


Carrier-Assisted Single-Tube Processing Approach for Targeted Proteomics Analysis of Low Numbers of Mammalian Cells.

Zhang P, Gaffrey MJ, Zhu Y, Chrisler WB, Fillmore TL, Yi L, Nicora CD, Zhang T, Wu H, Jacobs J, Tang K, Kagan J, Srivastava S, Rodland KD, Qian WJ, Smith RD, Liu T, Wiley HS, Shi T.

Anal Chem. 2019 Jan 15;91(2):1441-1451. doi: 10.1021/acs.analchem.8b04258. Epub 2018 Dec 28.


The Fly Way of Antiviral Resistance and Disease Tolerance.

Chow J, Kagan JC.

Adv Immunol. 2018;140:59-93. doi: 10.1016/ Epub 2018 Sep 18. Review.


Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance.

Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF.

Trends Immunol. 2018 Nov;39(11):862-873. doi: 10.1016/ Epub 2018 Oct 6. Review.


An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication.

Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC.

Mol Cell. 2018 Sep 6;71(5):825-840.e6. doi: 10.1016/j.molcel.2018.07.009. Epub 2018 Aug 9.


The Making of a PreCancer Atlas: Promises, Challenges, and Opportunities.

Srivastava S, Ghosh S, Kagan J, Mazurchuk R; National Cancer Institute’s HTAN Implementation.

Trends Cancer. 2018 Aug;4(8):523-536. doi: 10.1016/j.trecan.2018.06.007. Epub 2018 Jul 21. Review.


The PreCancer Atlas (PCA).

Srivastava S, Ghosh S, Kagan J, Mazurchuk R.

Trends Cancer. 2018 Aug;4(8):513-514. doi: 10.1016/j.trecan.2018.06.003. Epub 2018 Jul 3.


Kinds of individuals defined by patterns of variables.

Kagan J.

Dev Psychopathol. 2018 Oct;30(4):1197-1209. doi: 10.1017/S095457941800055X. Epub 2018 Jul 18.


Evidence-Based Causal Chains for Linking Health, Development, and Conservation Actions.

Qiu J, Game ET, Tallis H, Olander LP, Glew L, Kagan JS, Kalies EL, Michanowicz D, Phelan J, Polasky S, Reed J, Sills EO, Urban D, Weaver SK.

Bioscience. 2018 Mar 1;68(3):182-193. doi: 10.1093/biosci/bix167. Epub 2018 Feb 21.


Achromobacter endocarditis in native cardiac valves - an autopsy case report and review of the literature.

Xia R, Otto C, Zeng J, Momeni-Boroujeni A, Kagan J, Meleney K, Libien J.

Cardiovasc Pathol. 2018 Sep - Oct;36:6-10. doi: 10.1016/j.carpath.2018.05.003. Epub 2018 May 22. Review. No abstract available.


Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2018 Apr 11;23(4):571. doi: 10.1016/j.chom.2018.03.005. No abstract available.


Three Unresolved Issues in Human Morality.

Kagan J.

Perspect Psychol Sci. 2018 May;13(3):346-358. doi: 10.1177/1745691617727862. Epub 2018 Mar 28.


Perspectives on two temperamental biases.

Kagan J.

Philos Trans R Soc Lond B Biol Sci. 2018 Apr 19;373(1744). pii: 20170158. doi: 10.1098/rstb.2017.0158. Review.


STING-dependent translation inhibition restricts RNA virus replication.

Franz KM, Neidermyer WJ, Tan YJ, Whelan SPJ, Kagan JC.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2058-E2067. doi: 10.1073/pnas.1716937115. Epub 2018 Feb 12.


PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma.

Ghannam-Shahbari D, Jacob E, Kakun RR, Wasserman T, Korsensky L, Sternfeld O, Kagan J, Bublik DR, Aviel-Ronen S, Levanon K, Sabo E, Larisch S, Oren M, Hershkovitz D, Perets R.

Oncogene. 2018 Apr;37(17):2213-2224. doi: 10.1038/s41388-017-0040-z. Epub 2018 Jan 30.


The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC.

Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28.


Biochemical Isolation of the Myddosome from Murine Macrophages.

Tan Y, Kagan JC.

Methods Mol Biol. 2018;1714:79-95. doi: 10.1007/978-1-4939-7519-8_6.


A Neurobehavioral Mechanism Linking Behaviorally Inhibited Temperament and Later Adolescent Social Anxiety.

Buzzell GA, Troller-Renfree SV, Barker TV, Bowman LC, Chronis-Tuscano A, Henderson HA, Kagan J, Pine DS, Fox NA.

J Am Acad Child Adolesc Psychiatry. 2017 Dec;56(12):1097-1105. doi: 10.1016/j.jaac.2017.10.007. Epub 2017 Oct 13.


By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation.

Zanoni I, Tan Y, Di Gioia M, Springstead JR, Kagan JC.

Immunity. 2017 Oct 17;47(4):697-709.e3. doi: 10.1016/j.immuni.2017.09.010.


Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.

Edison N, Curtz Y, Paland N, Mamriev D, Chorubczyk N, Haviv-Reingewertz T, Kfir N, Morgenstern D, Kupervaser M, Kagan J, Kim HT, Larisch S.

Cell Rep. 2017 Oct 10;21(2):442-454. doi: 10.1016/j.celrep.2017.09.052.


How Inflammasomes Inform Adaptive Immunity.

Evavold CL, Kagan JC.

J Mol Biol. 2018 Jan 19;430(2):217-237. doi: 10.1016/j.jmb.2017.09.019. Epub 2017 Oct 5. Review.


Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection.

Odendall C, Voak AA, Kagan JC.

J Immunol. 2017 Nov 1;199(9):3270-3279. doi: 10.4049/jimmunol.1700250. Epub 2017 Sep 27.


Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics.

Wang H, Barbieri CE, He J, Gao Y, Shi T, Wu C, Schepmoes AA, Fillmore TL, Chae SS, Huang D, Mosquera JM, Qian WJ, Smith RD, Srivastava S, Kagan J, Camp DG 2nd, Rodland KD, Rubin MA, Liu T.

J Transl Med. 2017 Aug 15;15(1):175. doi: 10.1186/s12967-017-1276-7.


A one-protein signaling pathway in the innate immune system.

Orzalli MH, Kagan JC.

Sci Immunol. 2016 Aug 19;1(2):eaah6184. doi: 10.1126/sciimmunol.aah6184. Epub 2016 Aug 19. Review.


Predicting Prostate Cancer Progression as a Function of ETS-related Gene Status, Race, and Obesity in a Longitudinal Patient Cohort.

Cullen J, Young D, Chen Y, Degon M, Farrell J, Sedarsky J, Baptiste W, Rosen P, Tolstikov V, Kiebish M, Kagan J, Srivastava S, Kuo HC, Moncur JT, Rosner IL, Narain N, Akmaev V, Petrovics G, Dobi A, McLeod DG, Srivastava S, Sesterhenn IA.

Eur Urol Focus. 2018 Dec;4(6):818-824. doi: 10.1016/j.euf.2017.02.016. Epub 2017 Mar 11.


Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections.

Chow J, Márka Z, Bartos I, Márka S, Kagan JC.

Cell Host Microbe. 2017 Jul 12;22(1):48-60.e5. doi: 10.1016/j.chom.2017.06.010.


Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection.

Orzalli MH, Kagan JC.

Trends Cell Biol. 2017 Nov;27(11):800-809. doi: 10.1016/j.tcb.2017.05.007. Epub 2017 Jun 19. Review.


Innate Immune Receptors as Competitive Determinants of Cell Fate.

Franz KM, Kagan JC.

Mol Cell. 2017 Jun 15;66(6):750-760. doi: 10.1016/j.molcel.2017.05.009. Review.


Lipopolysaccharide Detection across the Kingdoms of Life.

Kagan JC.

Trends Immunol. 2017 Oct;38(10):696-704. doi: 10.1016/ Epub 2017 May 24. Review.


Association Between Combined TMPRSS2:ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer.

Sanda MG, Feng Z, Howard DH, Tomlins SA, Sokoll LJ, Chan DW, Regan MM, Groskopf J, Chipman J, Patil DH, Salami SS, Scherr DS, Kagan J, Srivastava S, Thompson IM Jr, Siddiqui J, Fan J, Joon AY, Bantis LE, Rubin MA, Chinnayian AM, Wei JT; and the EDRN-PCA3 Study Group, Bidair M, Kibel A, Lin DW, Lotan Y, Partin A, Taneja S.

JAMA Oncol. 2017 Aug 1;3(8):1085-1093. doi: 10.1001/jamaoncol.2017.0177.


Significance of pigmented urothelial and non-urothelial cells in voided urine specimens: A case report and review.

Kagan JA, Wu S, Bardarov S.

J Cytol. 2017 Apr-Jun;34(2):101-103. doi: 10.4103/0970-9371.203578.


Multi-receptor detection of individual bacterial products by the innate immune system.

Kieser KJ, Kagan JC.

Nat Rev Immunol. 2017 Jun;17(6):376-390. doi: 10.1038/nri.2017.25. Epub 2017 May 2. Review.


Reversible Capture and Release of Cl2 and Br2 with a Redox-Active Metal-Organic Framework.

Tulchinsky Y, Hendon CH, Lomachenko KA, Borfecchia E, Melot BC, Hudson MR, Tarver JD, Korzyński MD, Stubbs AW, Kagan JJ, Lamberti C, Brown CM, Dincă M.

J Am Chem Soc. 2017 Apr 26;139(16):5992-5997. doi: 10.1021/jacs.7b02161. Epub 2017 Apr 14.


Autoantibodies against oncogenic ERG protein in prostate cancer: potential use in diagnosis and prognosis in a panel with C-MYC, AMACR and HERV-K Gag.

Rastogi A, Ali A, Tan SH, Banerjee S, Chen Y, Cullen J, Xavier CP, Mohamed AA, Ravindranath L, Srivastav J, Young D, Sesterhenn IA, Kagan J, Srivastava S, McLeod DG, Rosner IL, Petrovics G, Dobi A, Srivastava S, Srinivasan A.

Genes Cancer. 2016 Nov;7(11-12):394-413. doi: 10.18632/genesandcancer.126.


Activation and pathogenic manipulation of the sensors of the innate immune system.

Odendall C, Kagan JC.

Microbes Infect. 2017 Apr - May;19(4-5):229-237. doi: 10.1016/j.micinf.2017.01.003. Epub 2017 Jan 14. Review.


Early innate immune responses to bacterial LPS.

Rosadini CV, Kagan JC.

Curr Opin Immunol. 2017 Feb;44:14-19. doi: 10.1016/j.coi.2016.10.005. Epub 2016 Nov 12. Review.


Microbe-inducible trafficking pathways that control Toll-like receptor signaling.

Tan Y, Kagan JC.

Traffic. 2017 Jan;18(1):6-17. doi: 10.1111/tra.12454. Epub 2016 Nov 23. Review.


Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil.

Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, Guedes MM, Moore SR, Petri WA, Havt A, Lima IF, Prata MM, Michaleckyj JC, Scharf RJ, Sturgeon C, Fasano A, Lima AA.

PLoS One. 2016 Sep 30;11(9):e0158772. doi: 10.1371/journal.pone.0158772. eCollection 2016.


Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.

Blouin CM, Hamon Y, Gonnord P, Boularan C, Kagan J, Viaris de Lesegno C, Ruez R, Mailfert S, Bertaux N, Loew D, Wunder C, Johannes L, Vogt G, Contreras FX, Marguet D, Casanova JL, Galès C, He HT, Lamaze C.

Cell. 2016 Aug 11;166(4):920-934. doi: 10.1016/j.cell.2016.07.003. Epub 2016 Aug 4.

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