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Items: 1 to 50 of 195

1.

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.

Schimmel K, Jung M, Foinquinos A, San José G, Beaumont J, Bock K, Grote-Levi L, Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F, Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R, Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H, Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J, González A, Thum T.

Circulation. 2020 Jan 17. doi: 10.1161/CIRCULATIONAHA.119.042559. [Epub ahead of print]

PMID:
31948273
2.

Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype.

Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, Kaever V, Müsken M, Häussler S.

NPJ Biofilms Microbiomes. 2020 Jan 10;6:2. doi: 10.1038/s41522-019-0113-6. eCollection 2020.

3.

Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis.

de Araujo LS, Pessler K, Sühs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F.

J Transl Med. 2020 Jan 7;18(1):9. doi: 10.1186/s12967-019-02179-w.

4.

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.

Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM.

Mol Cell. 2019 Dec 5;76(5):784-796.e6. doi: 10.1016/j.molcel.2019.09.010. Epub 2019 Oct 3.

5.

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.

Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20644-20654. doi: 10.1073/pnas.1908770116. Epub 2019 Sep 23.

6.

Analysis of Brevundimonas subvibrioides Developmental Signaling Systems Reveals Inconsistencies between Phenotypes and c-di-GMP Levels.

Sperling L, Mulero Alegría MD, Kaever V, Curtis PD.

J Bacteriol. 2019 Sep 20;201(20). pii: e00447-19. doi: 10.1128/JB.00447-19. Print 2019 Oct 15.

PMID:
31383736
7.

Effects of HEMA on Nrf2-related gene expression using a newly developed 3D co-culture model of the oral mucosa.

Perduns R, Volk J, Plum M, Gutzki F, Kaever V, Geurtsen W.

Dent Mater. 2019 Sep;35(9):1214-1226. doi: 10.1016/j.dental.2019.05.006. Epub 2019 May 28.

PMID:
31146961
8.

Involvement of Plasma Endocannabinoids and the Hypothalamic Endocannabinoid System in Increasing Feed Intake after Parturition of Dairy Cows.

Kuhla B, Kaever V, Tuchscherer A, Kuhla A.

Neuroendocrinology. 2020;110(3-4):246-257. doi: 10.1159/000501208. Epub 2019 May 29.

PMID:
31141804
9.

Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae.

Koppenhöfer S, Wang H, Scharfe M, Kaever V, Wagner-Döbler I, Tomasch J.

Front Microbiol. 2019 Apr 12;10:803. doi: 10.3389/fmicb.2019.00803. eCollection 2019.

10.

Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host.

Kordes A, Grahl N, Koska M, Preusse M, Arce-Rodriguez A, Abraham WR, Kaever V, Häussler S.

ISME J. 2019 Aug;13(8):2018-2030. doi: 10.1038/s41396-019-0412-1. Epub 2019 Apr 5.

PMID:
30952997
11.

Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role.

Braun F, Thomalla L, van der Does C, Quax TEF, Allers T, Kaever V, Albers SV.

Microbiologyopen. 2019 Sep;8(9):e00829. doi: 10.1002/mbo3.829. Epub 2019 Mar 18.

12.

DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31.

Li F, Cimdins A, Rohde M, Jänsch L, Kaever V, Nimtz M, Römling U.

mBio. 2019 Mar 5;10(2). pii: e02492-18. doi: 10.1128/mBio.02492-18.

13.

Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate.

Sayner SL, Choi CS, Maulucci ME, Ramila KC, Zhou C, Scruggs AK, Yarbrough T, Blair LA, King JA, Seifert R, Kaever V, Bauer NN.

Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L691-L700. doi: 10.1152/ajplung.00282.2018. Epub 2019 Feb 13.

PMID:
30758991
14.

Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections.

Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F.

J Infect Dis. 2019 Jun 5;220(1):127-138. doi: 10.1093/infdis/jiz048.

PMID:
30721966
15.

The GGDEF Domain of the Phosphodiesterase PdeB in Shewanella putrefaciens Mediates Recruitment by the Polar Landmark Protein HubP.

Rossmann FM, Rick T, Mrusek D, Sprankel L, Dörrich AK, Leonhard T, Bubendorfer S, Kaever V, Bange G, Thormann KM.

J Bacteriol. 2019 Mar 13;201(7). pii: e00534-18. doi: 10.1128/JB.00534-18. Print 2019 Apr 1.

16.

Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.

Ratuszny D, Sühs KW, Novoselova N, Kuhn M, Kaever V, Skripuletz T, Pessler F, Stangel M.

Int J Mol Sci. 2019 Jan 15;20(2). pii: E337. doi: 10.3390/ijms20020337.

17.

Identification and Quantification of (t)RNA Modifications in Pseudomonas aeruginosa by Liquid Chromatography-Tandem Mass Spectrometry.

Grobe S, Doberenz S, Ferreira K, Krueger J, Brönstrup M, Kaever V, Häussler S.

Chembiochem. 2019 Jun 3;20(11):1430-1437. doi: 10.1002/cbic.201800741. Epub 2019 Apr 5.

PMID:
30644616
18.

Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.

Scharrenbroich J, Kaever V, Dove S, Seifert R, Schneider EH.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Feb;392(2):199-208. doi: 10.1007/s00210-018-1582-5. Epub 2018 Nov 15.

PMID:
30443663
19.

Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels.

Zhang Y, Sass A, Van Acker H, Wille J, Verhasselt B, Van Nieuwerburgh F, Kaever V, Crabbé A, Coenye T.

Front Microbiol. 2018 Aug 21;9:1952. doi: 10.3389/fmicb.2018.01952. eCollection 2018.

20.

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales.

Schäper S, Yau HCL, Krol E, Skotnicka D, Heimerl T, Gray J, Kaever V, Søgaard-Andersen L, Vollmer W, Becker A.

PLoS Genet. 2018 Aug 13;14(8):e1007594. doi: 10.1371/journal.pgen.1007594. eCollection 2018 Aug.

21.

cUMP hydrolysis by PDE3B.

Ostermeyer J, Golly F, Kaever V, Dove S, Seifert R, Schneider EH.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Sep;391(9):891-905. doi: 10.1007/s00210-018-1512-6. Epub 2018 May 28.

PMID:
29808231
22.

The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C.

Open Biol. 2018 Jan;8(1). pii: 170250. doi: 10.1098/rsob.170250.

23.

Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.

Kuhn M, Sühs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F.

J Neuroinflammation. 2018 Jan 17;15(1):20. doi: 10.1186/s12974-017-1041-0.

24.

More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli.

Sarenko O, Klauck G, Wilke FM, Pfiffer V, Richter AM, Herbst S, Kaever V, Hengge R.

mBio. 2017 Oct 10;8(5). pii: e01639-17. doi: 10.1128/mBio.01639-17.

25.

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.

Moreira RN, Dressaire C, Barahona S, Galego L, Kaever V, Jenal U, Arraiano CM.

mBio. 2017 Sep 19;8(5). pii: e00443-17. doi: 10.1128/mBio.00443-17.

26.

Identification and Quantification of Cyclic Di-Guanosine Monophosphate and Its Linear Metabolites by Reversed-Phase LC-MS/MS.

Bähre H, Kaever V.

Methods Mol Biol. 2017;1657:45-58. doi: 10.1007/978-1-4939-7240-1_5.

PMID:
28889285
27.

cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.

Paijo J, Kaever V, Kalinke U.

Methods Mol Biol. 2017;1656:153-166. doi: 10.1007/978-1-4939-7237-1_9.

PMID:
28808968
28.

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.

Blötz C, Treffon K, Kaever V, Schwede F, Hammer E, Stülke J.

Front Microbiol. 2017 Jul 13;8:1328. doi: 10.3389/fmicb.2017.01328. eCollection 2017.

29.

The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2.

Angerer V, Schwenk P, Wallner T, Kaever V, Hiltbrunner A, Wilde A.

Microbiology. 2017 Jun;163(6):920-930. doi: 10.1099/mic.0.000475. Epub 2017 Jun 21.

PMID:
28635593
30.

High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.

Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L.

Microbiology. 2017 May;163(5):754-764. doi: 10.1099/mic.0.000452. Epub 2017 May 3.

PMID:
28463102
31.

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.

Gundlach J, Herzberg C, Kaever V, Gunka K, Hoffmann T, Weiß M, Gibhardt J, Thürmer A, Hertel D, Daniel R, Bremer E, Commichau FM, Stülke J.

Sci Signal. 2017 Apr 18;10(475). pii: eaal3011. doi: 10.1126/scisignal.aal3011.

PMID:
28420751
32.

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T.

Microbiologyopen. 2017 Aug;6(4). doi: 10.1002/mbo3.480. Epub 2017 Apr 16.

33.

Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro.

Abeln M, Borst KM, Cajic S, Thiesler H, Kats E, Albers I, Kuhn M, Kaever V, Rapp E, Münster-Kühnel A, Weinhold B.

Chembiochem. 2017 Jul 4;18(13):1305-1316. doi: 10.1002/cbic.201700083. Epub 2017 May 11.

34.

Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein.

Sprecher KS, Hug I, Nesper J, Potthoff E, Mahi MA, Sangermani M, Kaever V, Schwede T, Vorholt J, Jenal U.

mBio. 2017 Mar 21;8(2). pii: e00294-17. doi: 10.1128/mBio.00294-17.

35.

Analytical Methods for the Quantification of Histamine and Histamine Metabolites.

Bähre H, Kaever V.

Handb Exp Pharmacol. 2017;241:3-19. doi: 10.1007/164_2017_22. Review.

PMID:
28321587
36.

Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles.

Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Spröer C, Kordes A, Frangipani E, Luong K, Korlach J, Heeb S, Overmann J, Kaever V, Häussler S.

mBio. 2017 Feb 21;8(1). pii: e02312-16. doi: 10.1128/mBio.02312-16.

37.

Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides.

Bähre H, Kaever V.

Handb Exp Pharmacol. 2017;238:293-306. doi: 10.1007/164_2016_5001. Review.

PMID:
28181004
38.

cUMP hydrolysis by PDE3A.

Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Mar;390(3):269-280. doi: 10.1007/s00210-016-1328-1. Epub 2016 Dec 14.

PMID:
27975297
39.

Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3',5'-cAMP in Bacteria.

Zhang Y, Agrebi R, Bellows LE, Collet JF, Kaever V, Gründling A.

J Biol Chem. 2017 Jan 6;292(1):313-327. doi: 10.1074/jbc.M116.758896. Epub 2016 Nov 23.

40.

New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus.

Bowman L, Zeden MS, Schuster CF, Kaever V, Gründling A.

J Biol Chem. 2016 Dec 30;291(53):26970-26986. doi: 10.1074/jbc.M116.747709. Epub 2016 Nov 10.

41.

Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti.

Krol E, Klaner C, Gnau P, Kaever V, Essen LO, Becker A.

Microbiology. 2016 Oct;162(10):1840-1856. doi: 10.1099/mic.0.000356. Epub 2016 Aug 16.

PMID:
27535558
42.

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T.

Microbiology. 2016 Oct;162(10):1797-1807. doi: 10.1099/mic.0.000354. Epub 2016 Aug 15.

PMID:
27526691
43.

The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone.

Bæk KT, Bowman L, Millership C, Dupont Søgaard M, Kaever V, Siljamäki P, Savijoki K, Varmanen P, Nyman TA, Gründling A, Frees D.

mBio. 2016 Aug 9;7(4). pii: e01228-16. doi: 10.1128/mBio.01228-16.

44.

Evidence for Escherichia coli Diguanylate Cyclase DgcZ Interlinking Surface Sensing and Adhesion via Multiple Regulatory Routes.

Lacanna E, Bigosch C, Kaever V, Boehm A, Becker A.

J Bacteriol. 2016 Aug 25;198(18):2524-35. doi: 10.1128/JB.00320-16. Print 2016 Sep 15.

45.

Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D.

Exp Dermatol. 2017 Jan;26(1):44-50. doi: 10.1111/exd.13118.

PMID:
27306297
46.

Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice.

Tschirner SK, Bähre H, Kaever A, Schneider EH, Seifert R, Kaever V.

Life Sci. 2016 Jul 1;156:68-73. doi: 10.1016/j.lfs.2016.05.031. Epub 2016 May 21.

PMID:
27221022
47.

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus.

Skotnicka D, Smaldone GT, Petters T, Trampari E, Liang J, Kaever V, Malone JG, Singer M, Søgaard-Andersen L.

PLoS Genet. 2016 May 23;12(5):e1006080. doi: 10.1371/journal.pgen.1006080. eCollection 2016 May.

48.

Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain.

Tschirner SK, Gutzki F, Schneider EH, Seifert R, Kaever V.

J Neurol Sci. 2016 Jun 15;365:169-74. doi: 10.1016/j.jns.2016.04.025. Epub 2016 Apr 16.

PMID:
27206901
49.

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells.

Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U.

PLoS Pathog. 2016 Apr 8;12(4):e1005546. doi: 10.1371/journal.ppat.1005546. eCollection 2016 Apr.

50.

Corrigendum: Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding.

Gaupels F, Furch AC, Zimmermann MR, Chen F, Kaever V, Buhtz A, Kehr J, Sarioglu H, Kogel KH, Durner J.

Front Plant Sci. 2016 Mar 7;7:281. doi: 10.3389/fpls.2016.00281. eCollection 2016.

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