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Items: 1 to 50 of 53

1.

The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.

Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C.

J Biol Chem. 2019 Aug 2;294(31):11741-11750. doi: 10.1074/jbc.RA118.006357. Epub 2019 Jun 11.

PMID:
31186352
2.

A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways.

Behrendt L, Kurth I, Kaether C.

Cell Mol Life Sci. 2019 Apr;76(7):1433-1445. doi: 10.1007/s00018-019-03010-x. Epub 2019 Jan 21.

3.

Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle.

Ahrens HE, Huettemeister J, Schmidt M, Kaether C, von Maltzahn J.

Skelet Muscle. 2018 Jul 4;8(1):20. doi: 10.1186/s13395-018-0166-x.

4.

Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.

Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H, von Maltzahn J.

Stem Cell Reports. 2018 Jun 5;10(6):1959-1974. doi: 10.1016/j.stemcr.2018.03.021. Epub 2018 Apr 26.

5.

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

Valkova C, Liebmann L, Krämer A, Hübner CA, Kaether C.

Sci Rep. 2017 Jan 24;7:41248. doi: 10.1038/srep41248.

6.

The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.

Port SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, Kehlenbach RH.

J Biol Chem. 2016 Oct 28;291(44):23068-23083. Epub 2016 Sep 9.

7.

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.

Yonemura Y, Futai E, Yagishita S, Kaether C, Ishiura S.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1751-7. doi: 10.1016/j.bbrc.2016.09.018. Epub 2016 Sep 5.

8.

Inhibition of cargo export at ER exit sites and the trans-Golgi network by the secretion inhibitor FLI-06.

Yonemura Y, Li X, Müller K, Krämer A, Atigbire P, Mentrup T, Feuerhake T, Kroll T, Shomron O, Nohl R, Arndt HD, Hoischen C, Hemmerich P, Hirschberg K, Kaether C.

J Cell Sci. 2016 Oct 15;129(20):3868-3877. Epub 2016 Sep 1.

9.

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.

Marthandan S, Menzel U, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Kaether C, Diekmann S.

Biol Res. 2016 Jul 28;49(1):34. doi: 10.1186/s40659-016-0095-2.

10.

Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.

Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, Guthke R, Cellerino A, Platzer M, Diekmann S, Hemmerich P.

PLoS One. 2016 May 3;11(5):e0154531. doi: 10.1371/journal.pone.0154531. eCollection 2016.

11.

Internalization of Near-Infrared Fluorescently Labeled Activatable Cell-Penetrating Peptide and of Proteins into Human Fibrosarcoma Cell Line HT-1080.

Tansi F, Kallweit E, Kaether C, Kappe K, Schumann C, Hilger I, Reissmann S.

J Cell Biochem. 2015 Jul;116(7):1222-31. doi: 10.1002/jcb.25075.

PMID:
25546737
12.

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.

Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, Menche D, Müller R, Pergola C, Werz O.

Biochem Pharmacol. 2014 Oct 15;91(4):490-500. doi: 10.1016/j.bcp.2014.07.028. Epub 2014 Aug 12.

PMID:
25107704
13.

A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model.

Wang S, Yu Y, Geng S, Wang D, Zhang L, Xie X, Wu B, Li C, Xu H, Li X, Hu Y, Zhang L, Kaether C, Wang B.

Alzheimers Res Ther. 2014 May 12;6(3):26. doi: 10.1186/alzrt256. eCollection 2014.

14.

Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3.

Kornak U, Mademan I, Schinke M, Voigt M, Krawitz P, Hecht J, Barvencik F, Schinke T, Gießelmann S, Beil FT, Pou-Serradell A, Vílchez JJ, Beetz C, Deconinck T, Timmerman V, Kaether C, De Jonghe P, Hübner CA, Gal A, Amling M, Mundlos S, Baets J, Kurth I.

Brain. 2014 Mar;137(Pt 3):683-92. doi: 10.1093/brain/awt357. Epub 2014 Jan 22.

PMID:
24459106
15.

Small molecules intercept Notch signaling and the early secretory pathway.

Krämer A, Mentrup T, Kleizen B, Rivera-Milla E, Reichenbach D, Enzensperger C, Nohl R, Täuscher E, Görls H, Ploubidou A, Englert C, Werz O, Arndt HD, Kaether C.

Nat Chem Biol. 2013 Nov;9(11):731-8. doi: 10.1038/nchembio.1356. Epub 2013 Sep 29.

PMID:
24077179
16.

Trafficking and proteolytic processing of APP.

Haass C, Kaether C, Thinakaran G, Sisodia S.

Cold Spring Harb Perspect Med. 2012 May;2(5):a006270. doi: 10.1101/cshperspect.a006270. Review.

17.

Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.

Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J.

J Neurosci. 2012 Jan 11;32(2):738-45. doi: 10.1523/JNEUROSCI.5036-11.2012.

18.
19.

Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.

Valkova C, Albrizio M, Röder IV, Schwake M, Betto R, Rudolf R, Kaether C.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):621-5. doi: 10.1073/pnas.1001624108. Epub 2010 Dec 27.

20.

Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.

Juenemann K, Weisse C, Reichmann D, Kaether C, Calkhoven CF, Schilling G.

Neurotox Res. 2011 Aug;20(2):120-33. doi: 10.1007/s12640-010-9227-6. Epub 2010 Nov 30.

21.

NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner.

Kramer M, Boeck J, Reichenbach D, Kaether C, Schreiber S, Platzer M, Rosenstiel P, Huse K.

BMC Res Notes. 2010 Aug 10;3:224. doi: 10.1186/1756-0500-3-224.

22.

Notch1 signaling is mediated by importins alpha 3, 4, and 7.

Huenniger K, Krämer A, Soom M, Chang I, Köhler M, Depping R, Kehlenbach RH, Kaether C.

Cell Mol Life Sci. 2010 Sep;67(18):3187-96. doi: 10.1007/s00018-010-0378-7. Epub 2010 May 8.

23.

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.

Friedrich RP, Tepper K, Rönicke R, Soom M, Westermann M, Reymann K, Kaether C, Fändrich M.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1942-7. doi: 10.1073/pnas.0904532106. Epub 2010 Jan 19.

24.

Masking of transmembrane-based retention signals controls ER export of gamma-secretase.

Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C.

Traffic. 2010 Feb;11(2):250-8. doi: 10.1111/j.1600-0854.2009.01014.x. Epub 2009 Nov 5.

25.

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy.

Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK, Rotthier A, Baets J, Senderek J, Topaloglu H, Farrell SA, Nürnberg G, Nürnberg P, De Jonghe P, Gal A, Kaether C, Timmerman V, Hübner CA.

Nat Genet. 2009 Nov;41(11):1179-81. doi: 10.1038/ng.464. Epub 2009 Oct 18.

PMID:
19838196
26.

Klotho is a substrate for alpha-, beta- and gamma-secretase.

Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, Kaether C.

FEBS Lett. 2009 Oct 6;583(19):3221-4. doi: 10.1016/j.febslet.2009.09.009. Epub 2009 Sep 6.

27.

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C.

EMBO Rep. 2007 Aug;8(8):743-8. Epub 2007 Jul 6.

28.

Assembly, trafficking and function of gamma-secretase.

Kaether C, Haass C, Steiner H.

Neurodegener Dis. 2006;3(4-5):275-83. Review.

PMID:
17047368
29.

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.

Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM.

Traffic. 2006 Jul;7(7):873-88. Epub 2006 May 25.

30.

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H.

J Neurosci. 2006 Apr 5;26(14):3821-8.

31.
32.

Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment.

Straub T, Neumann MF, Prestel M, Kremmer E, Kaether C, Haass C, Becker PB.

Chromosoma. 2005 Nov;114(5):352-64. Epub 2005 Nov 12.

PMID:
16179989
33.

Gamma-secretase complex assembly within the early secretory pathway.

Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C.

J Biol Chem. 2005 Feb 25;280(8):6471-8. Epub 2004 Dec 10.

34.

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation.

Kaether C, Haass C.

J Cell Biol. 2004 Dec 6;167(5):809-12. Review.

35.

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C.

EMBO J. 2004 Dec 8;23(24):4738-48. Epub 2004 Nov 18.

36.

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

Edbauer D, Kaether C, Steiner H, Haass C.

J Biol Chem. 2004 Sep 3;279(36):37311-5. Epub 2004 Jun 21.

37.

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C.

J Biol Chem. 2003 Dec 26;278(52):52519-23. Epub 2003 Nov 5.

38.

Monitoring of protein secretion with green fluorescent protein.

Kaether C, Gerdes HH.

Methods Enzymol. 1999;302:11-9. No abstract available.

PMID:
12876757
39.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.

40.

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.

J Cell Biol. 2002 Aug 5;158(3):551-61. Epub 2002 Jul 29.

41.

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8025-30. Epub 2002 Jun 4.

42.

Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells.

Rustom A, Bajohrs M, Kaether C, Keller P, Toomre D, Corbeil D, Gerdes HH.

Traffic. 2002 Apr;3(4):279-88.

43.

The cell biology of Alzheimer's disease: uncovering the secrets of secretases.

Walter J, Kaether C, Steiner H, Haass C.

Curr Opin Neurobiol. 2001 Oct;11(5):585-90. Review.

PMID:
11595492
44.

Phosphorylation regulates intracellular trafficking of beta-secretase.

Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2001 May 4;276(18):14634-41. Epub 2001 Jan 29.

46.

Fast, convenient, and effective method to transiently transfect primary hippocampal neurons.

Köhrmann M, Haubensak W, Hemraj I, Kaether C, Lessmann VJ, Kiebler MA.

J Neurosci Res. 1999 Dec 15;58(6):831-5.

PMID:
10583914
47.
48.

Time-resolved analysis and visualization of dynamic processes in living cells.

Tvaruskó W, Bentele M, Misteli T, Rudolf R, Kaether C, Spector DL, Gerdes HH, Eils R.

Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7950-5.

49.
50.

Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein.

Wacker I, Kaether C, Krömer A, Migala A, Almers W, Gerdes HH.

J Cell Sci. 1997 Jul;110 ( Pt 13):1453-63.

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