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Items: 1 to 50 of 338

1.

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).

Kaestner KH, Powers AC, Naji A; HPAP Consortium, Atkinson MA.

Diabetes. 2019 Jul;68(7):1394-1402. doi: 10.2337/db19-0058. Epub 2019 May 24. Review.

PMID:
31127054
2.

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J.

JCI Insight. 2019 Apr 23;5. pii: 127994. doi: 10.1172/jci.insight.127994.

3.

The Intestinal Stem Cell Niche: A Central Role for Foxl1-Expressing Subepithelial Telocytes.

Kaestner KH.

Cell Mol Gastroenterol Hepatol. 2019;8(1):111-117. doi: 10.1016/j.jcmgh.2019.04.001. Epub 2019 Apr 6. Review.

4.

Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence.

Zheng D, McLaughlin SA, Kaestner KH, Li Z.

Am J Cancer Res. 2019 Feb 1;9(2):424-428. eCollection 2019.

5.

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Wang YJ, Traum D, Schug J, Gao L, Liu C; HPAP Consortium, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH.

Cell Metab. 2019 Mar 5;29(3):769-783.e4. doi: 10.1016/j.cmet.2019.01.003. Epub 2019 Jan 31.

PMID:
30713110
6.

Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?

Wang YJ, Kaestner KH.

Cell Metab. 2019 Mar 5;29(3):539-544. doi: 10.1016/j.cmet.2018.11.016. Epub 2018 Dec 20. Review.

PMID:
30581120
7.

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.

Camolotto SA, Pattabiraman S, Mosbruger TL, Jones A, Belova VK, Orstad G, Streiff M, Salmond L, Stubben C, Kaestner KH, Snyder EL.

Elife. 2018 Nov 26;7. pii: e38579. doi: 10.7554/eLife.38579.

8.

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally.

Cyphert HA, Walker EM, Hang Y, Dhawan S, Haliyur R, Bonatakis L, Avrahami D, Brissova M, Kaestner KH, Bhushan A, Powers AC, Stein R.

Diabetes. 2019 Feb;68(2):337-348. doi: 10.2337/db18-0903. Epub 2018 Nov 13.

PMID:
30425060
9.

Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication.

Ou K, Yu M, Moss NG, Wang YJ, Wang AW, Nguyen SC, Jiang C, Feleke E, Kameswaran V, Joyce EF, Naji A, Glaser B, Avrahami D, Kaestner KH.

J Clin Invest. 2019 Jan 2;129(1):209-214. doi: 10.1172/JCI99170. Epub 2018 Nov 26.

10.

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K.

Diabetes. 2018 Oct;67(10):1923-1931. doi: 10.2337/db18-0537.

11.

The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs.

Kameswaran V, Golson ML, Ramos-Rodríguez M, Ou K, Wang YJ, Zhang J, Pasquali L, Kaestner KH.

Diabetes. 2018 Sep;67(9):1807-1815. doi: 10.2337/db17-0682. Epub 2018 Jul 3.

12.

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo.

Ackermann AM, Moss NG, Kaestner KH.

Cell Metab. 2018 Nov 6;28(5):787-792.e3. doi: 10.1016/j.cmet.2018.07.002. Epub 2018 Jul 26.

PMID:
30057067
13.

Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.

Cohen-Tayar Y, Cohen H, Mitiagin Y, Abravanel Z, Levy C, Idelson M, Reubinoff B, Itzkovitz S, Raviv S, Kaestner KH, Blinder P, Elkon R, Ashery-Padan R.

Development. 2018 Aug 9;145(15). pii: dev163691. doi: 10.1242/dev.163691.

14.

Author Correction: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massasa EE, Itzkovitz S, Kaestner KH.

Nature. 2018 Aug;560(7718):E29. doi: 10.1038/s41586-018-0286-9.

PMID:
29977061
15.

Lipid malabsorption from altered hormonal signaling changes early gut microbial responses.

Terry NA, Ngaba LV, Wilkins BJ, Pi D, Gheewala N, Kaestner KH.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G580-G591. doi: 10.1152/ajpgi.00135.2018. Epub 2018 Jun 28.

PMID:
29953253
16.

Postnatal DNA demethylation and its role in tissue maturation.

Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, Wang A, Kieckhaefer J, Li C, Pikarsky E, Levin-Klein R, Goren A, Rajewsky K, Kaestner KH, Cedar H.

Nat Commun. 2018 May 23;9(1):2040. doi: 10.1038/s41467-018-04456-6.

17.

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massasa EE, Itzkovitz S, Kaestner KH.

Nature. 2018 May;557(7704):242-246. doi: 10.1038/s41586-018-0084-4. Epub 2018 May 2. Erratum in: Nature. 2018 Aug;560(7718):E29.

18.

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH.

Mol Metab. 2018 May;11:212-217. doi: 10.1016/j.molmet.2018.03.009. Epub 2018 Mar 23.

19.

TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury.

Wang AW, Wangensteen KJ, Wang YJ, Zahm AM, Moss NG, Erez N, Kaestner KH.

J Clin Invest. 2018 Jun 1;128(6):2297-2309. doi: 10.1172/JCI95120. Epub 2018 Apr 30.

20.

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity.

Abu-Gazala S, Horwitz E, Ben-Haroush Schyr R, Bardugo A, Israeli H, Hija A, Schug J, Shin S, Dor Y, Kaestner KH, Ben-Zvi D.

Diabetes. 2018 Jun;67(6):1079-1085. doi: 10.2337/db17-1028. Epub 2018 Feb 23.

21.

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.

Serr I, Scherm MG, Zahm AM, Schug J, Flynn VK, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, Gerlach K, Liebsch N, Loretz B, Lehr CM, Kirchner B, Spornraft M, Haase B, Segars J, Küper C, Palmisano R, Waisman A, Willis RA, Kim WU, Weigmann B, Kaestner KH, Ziegler AG, Daniel C.

Sci Transl Med. 2018 Jan 3;10(422). pii: eaag1782. doi: 10.1126/scitranslmed.aag1782. Erratum in: Sci Transl Med. 2019 Feb 20;11(480):.

22.

Transcriptional Noise and Somatic Mutations in the Aging Pancreas.

Swisa A, Kaestner KH, Dor Y.

Cell Metab. 2017 Dec 5;26(6):809-811. doi: 10.1016/j.cmet.2017.11.009.

23.

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH.

Hepatology. 2018 Aug;68(2):663-676. doi: 10.1002/hep.29626. Epub 2018 May 14.

PMID:
29091290
24.

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.

Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11739-11744. doi: 10.1073/pnas.1712616114. Epub 2017 Oct 16.

25.

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.

Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N.

Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1.

26.

Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.

Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.

27.

Islet biology.

Lickert H, Kaestner KH.

Mol Metab. 2017 Jun 13;6(9):vi. doi: 10.1016/j.molmet.2017.06.005. eCollection 2017 Sep. No abstract available.

28.

Epigenetics in formation, function, and failure of the endocrine pancreas.

Golson ML, Kaestner KH.

Mol Metab. 2017 May 31;6(9):1066-1076. doi: 10.1016/j.molmet.2017.05.015. eCollection 2017 Sep. Review.

29.

β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells.

Avrahami D, Wang YJ, Klochendler A, Dor Y, Glaser B, Kaestner KH.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:147-152. doi: 10.1111/dom.13019. Review.

30.

Reprogramming human gallbladder cells into insulin-producing β-like cells.

Galivo F, Benedetti E, Wang Y, Pelz C, Schug J, Kaestner KH, Grompe M.

PLoS One. 2017 Aug 16;12(8):e0181812. doi: 10.1371/journal.pone.0181812. eCollection 2017.

31.

WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE.

Nat Commun. 2017 Jun 7;8:15397. doi: 10.1038/ncomms15397.

32.

Insights From the Crypt: Regionalization, Adaptation, and Renewal of the Intestinal Epithelium.

Kaestner KH.

Cell Mol Gastroenterol Hepatol. 2017 Mar 31;3(3):297-298. doi: 10.1016/j.jcmgh.2017.03.001. eCollection 2017 May. No abstract available.

33.

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets.

Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, Dunne MJ, Stanley CA, De León DD.

Diabetes. 2017 Jul;66(7):1901-1913. doi: 10.2337/db17-0029. Epub 2017 Apr 25.

34.

Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.

van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO.

Cell Metab. 2017 Apr 4;25(4):911-926.e6. doi: 10.1016/j.cmet.2017.03.017.

35.

High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting.

Ackermann AM, Zhang J, Heller A, Briker A, Kaestner KH.

Mol Metab. 2017 Jan 12;6(3):236-244. doi: 10.1016/j.molmet.2017.01.003. eCollection 2017 Mar.

36.

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.

McFadden VC, Shalaby RE, Iram S, Oropeza CE, Landolfi JA, Lyubimov AV, Maienschein-Cline M, Green SJ, Kaestner KH, McLachlan A.

PLoS Pathog. 2017 Feb 24;13(2):e1006239. doi: 10.1371/journal.ppat.1006239. eCollection 2017 Feb.

37.

The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice.

Kieckhaefer J, Lukovac S, Ye DZ, Lee D, Beetler DJ, Pack M, Kaestner KH.

Cell Mol Gastroenterol Hepatol. 2016 Nov;2(6):783-795. doi: 10.1016/j.jcmgh.2016.08.003.

38.

Fox transcription factors: from development to disease.

Golson ML, Kaestner KH.

Development. 2016 Dec 15;143(24):4558-4570. Review.

39.

Pancreatic β cell identity requires continual repression of non-β cell programs.

Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L.

J Clin Invest. 2017 Jan 3;127(1):244-259. doi: 10.1172/JCI88017. Epub 2016 Dec 12.

40.

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.

Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA.

J Clin Invest. 2017 Jan 3;127(1):215-229. doi: 10.1172/JCI88016. Epub 2016 Dec 12.

41.

PAX6 maintains β cell identity by repressing genes of alternative islet cell types.

Swisa A, Avrahami D, Eden N, Zhang J, Feleke E, Dahan T, Cohen-Tayar Y, Stolovich-Rain M, Kaestner KH, Glaser B, Ashery-Padan R, Dor Y.

J Clin Invest. 2017 Jan 3;127(1):230-243. doi: 10.1172/JCI88015. Epub 2016 Dec 12.

42.

Epigenetic control of β-cell function and failure.

Bernstein D, Golson ML, Kaestner KH.

Diabetes Res Clin Pract. 2017 Jan;123:24-36. doi: 10.1016/j.diabres.2016.11.009. Epub 2016 Nov 21. Review.

43.

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.

Kim R, Sheaffer KL, Choi I, Won KJ, Kaestner KH.

Genes Dev. 2016 Nov 1;30(21):2433-2442. Epub 2016 Nov 17.

44.

Epigenetic Analysis of Endocrine Cell Subtypes from Human Pancreatic Islets.

Zhang J, Kaestner KH.

Methods Mol Biol. 2017;1507:95-111.

PMID:
27832535
45.

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.

Cell Metab. 2016 Oct 11;24(4):616-626. doi: 10.1016/j.cmet.2016.09.007.

46.

Effects of ageing and senescence on pancreatic β-cell function.

Helman A, Avrahami D, Klochendler A, Glaser B, Kaestner KH, Ben-Porath I, Dor Y.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:58-62. doi: 10.1111/dom.12719. Review.

PMID:
27615132
47.

Human islets contain four distinct subtypes of β cells.

Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M.

Nat Commun. 2016 Jul 11;7:11756. doi: 10.1038/ncomms11756.

48.

The next generation of target capture technologies - large DNA fragment enrichment and sequencing determines regional genomic variation of high complexity.

Dapprich J, Ferriola D, Mackiewicz K, Clark PM, Rappaport E, D'Arcy M, Sasson A, Gai X, Schug J, Kaestner KH, Monos D.

BMC Genomics. 2016 Jul 9;17:486. doi: 10.1186/s12864-016-2836-6.

49.

Single-Cell Transcriptomics of the Human Endocrine Pancreas.

Wang YJ, Schug J, Won KJ, Liu C, Naji A, Avrahami D, Golson ML, Kaestner KH.

Diabetes. 2016 Oct;65(10):3028-38. doi: 10.2337/db16-0405. Epub 2016 Jun 30.

50.

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice.

Shin S, Wangensteen KJ, Teta-Bissett M, Wang YJ, Mosleh-Shirazi E, Buza EL, Greenbaum LE, Kaestner KH.

Hepatology. 2016 Oct;64(4):1163-1177. doi: 10.1002/hep.28602. Epub 2016 May 28.

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