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Items: 1 to 50 of 189

1.

Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae.

Chen KL, Ven TN, Crane MM, Brunner MLC, Pun AK, Helget KL, Brower K, Chen DE, Doan H, Dillard-Telm JD, Huynh E, Feng YC, Yan Z, Golubeva A, Hsu RA, Knight R, Levin J, Mobasher V, Muir M, Omokehinde V, Screws C, Tunali E, Tran RK, Valdez L, Yang E, Kennedy SR, Herr AJ, Kaeberlein M, Wasko BM.

Geroscience. 2020 Jan 23. doi: 10.1007/s11357-020-00159-3. [Epub ahead of print]

PMID:
31975050
2.

Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins.

Burnaevskiy N, Sands B, Yun S, Tedesco PM, Johnson TE, Kaeberlein M, Brent R, Mendenhall A.

Nat Commun. 2019 Dec 16;10(1):5725. doi: 10.1038/s41467-019-13664-7.

3.

Desexing Dogs: A Review of the Current Literature.

Urfer SR, Kaeberlein M.

Animals (Basel). 2019 Dec 5;9(12). pii: E1086. doi: 10.3390/ani9121086. Review.

4.

Latest advances in aging research and drug discovery.

Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Reason, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2019 Nov 21;11(22):9971-9981. doi: 10.18632/aging.102487. Epub 2019 Nov 21.

5.

WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans.

Pitt JN, Strait NL, Vayndorf EM, Blue BW, Tran CH, Davis BEM, Huang K, Johnson BJ, Lim KM, Liu S, Nikjoo A, Vaid A, Wu JZ, Kaeberlein M.

Geroscience. 2019 Dec;41(6):961-973. doi: 10.1007/s11357-019-00124-9. Epub 2019 Nov 14.

6.

DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging.

Crane MM, Russell AE, Schafer BJ, Blue BW, Whalen R, Almazan J, Hong MG, Nguyen B, Goings JE, Chen KL, Kelly R, Kaeberlein M.

Elife. 2019 Nov 12;8. pii: e50778. doi: 10.7554/eLife.50778.

7.

Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples.

Urfer SR, Latimer CS, Ladiges W, Keene CD, Benbow S, Harrison B, Promislow DEL, Kaeberlein M, Kraemer BC, Wang A, Guscetti F, Darvas M.

Pathobiol Aging Age Relat Dis. 2019 Sep 3;9(1):1657768. doi: 10.1080/20010001.2019.1657768. eCollection 2019.

8.

An inexpensive microscopy system for microfluidic studies in budding yeast.

Chen KL, Ven TN, Crane MM, Chen DE, Feng YC, Suzuki N, Russell AE, de Moraes D, Kaeberlein M.

Transl Med Aging. 2019;3:52-56. doi: 10.1016/j.tma.2019.05.001. Epub 2019 Jun 7.

9.

Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging.

Crane MM, Chen KL, Blue BW, Kaeberlein M.

Proteomics. 2019 Aug 5:e1800420. doi: 10.1002/pmic.201800420. [Epub ahead of print] Review.

PMID:
31385433
10.

Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae.

Sanchez JC, Ollodart A, Large CRL, Clough C, Alvino GM, Tsuchiya M, Crane M, Kwan EX, Kaeberlein M, Dunham MJ, Raghuraman MK, Brewer BJ.

Genetics. 2019 Sep;213(1):229-249. doi: 10.1534/genetics.119.302351. Epub 2019 Jul 10.

11.

In vivo measurements reveal a single 5'-intron is sufficient to increase protein expression level in Caenorhabditis elegans.

Crane MM, Sands B, Battaglia C, Johnson B, Yun S, Kaeberlein M, Brent R, Mendenhall A.

Sci Rep. 2019 Jun 24;9(1):9192. doi: 10.1038/s41598-019-45517-0.

12.

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics.

Rempel IL, Crane MM, Thaller DJ, Mishra A, Jansen DP, Janssens G, Popken P, Ak┼čit A, Kaeberlein M, van der Giessen E, Steen A, Onck PR, Lusk CP, Veenhoff LM.

Elife. 2019 Jun 3;8. pii: e48186. doi: 10.7554/eLife.48186.

13.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Lee MB, Dowsett IT, Carr DT, Wasko BM, Stanton SG, Chung MS, Ghodsian N, Bode A, Kiflezghi MG, Uppal PA, Grayden KA, Elala YC, Tang TT, Tran NHB, Tran THB, Diep AB, Hope M, Promislow DEL, Kennedy SR, Kaeberlein M, Herr AJ.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3062-3071. doi: 10.1073/pnas.1815966116. Epub 2019 Feb 4.

14.

Rapamycin and Alzheimer's disease: Time for a clinical trial?

Kaeberlein M, Galvan V.

Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Review.

15.

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.

Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, Legendre C, Suh Y, Canaud G.

Kidney Int. 2019 Feb;95(2):455-466. doi: 10.1016/j.kint.2018.08.038. Epub 2018 Nov 22.

16.

Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective.

Wilfond BS, Porter KM, Creevy KE, Kaeberlein M, Promislow D.

Am J Bioeth. 2018 Oct;18(10):64-65. doi: 10.1080/15265161.2018.1513591. No abstract available.

17.

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9586-9591. doi: 10.1073/pnas.1804264115. Epub 2018 Sep 5.

18.

How healthy is the healthspan concept?

Kaeberlein M.

Geroscience. 2018 Aug;40(4):361-364. doi: 10.1007/s11357-018-0036-9. Epub 2018 Aug 6. No abstract available.

19.

Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans.

Burnaevskiy N, Chen S, Mailig M, Reynolds A, Karanth S, Mendenhall A, Van Gilst M, Kaeberlein M.

Elife. 2018 Aug 2;7. pii: e36194. doi: 10.7554/eLife.36194.

20.

The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells.

Crane MM, Kaeberlein M.

Curr Opin Syst Biol. 2018 Apr;8:25-31. doi: 10.1016/j.coisb.2017.11.010. Epub 2017 Dec 6.

21.

Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Dec 22;8:221. doi: 10.3389/fgene.2017.00221. eCollection 2017.

22.

Oral health in geroscience: animal models and the aging oral cavity.

An JY, Darveau R, Kaeberlein M.

Geroscience. 2018 Feb;40(1):1-10. doi: 10.1007/s11357-017-0004-9. Epub 2017 Dec 27. Review.

23.

Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants.

Russell JC, Burnaevskiy N, Ma B, Mailig MA, Faust F, Crane M, Kaeberlein M, Mendenhall A.

J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1173-1179. doi: 10.1093/gerona/glx230.

24.

Genetic interaction with temperature is an important determinant of nematode longevity.

Miller H, Fletcher M, Primitivo M, Leonard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF.

Aging Cell. 2017 Dec;16(6):1425-1429. doi: 10.1111/acel.12658. Epub 2017 Sep 21.

25.

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113. eCollection 2017. Erratum in: Front Genet. 2017 Dec 22;8:221.

26.

Rapamycin treatment attenuates age-associated periodontitis in mice.

An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M.

Geroscience. 2017 Aug;39(4):457-463. doi: 10.1007/s11357-017-9994-6. Epub 2017 Sep 9.

27.

A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae.

Lee MB, Carr DT, Kiflezghi MG, Zhao YT, Kim DB, Thon S, Moore MD, Li MAK, Kaeberlein M.

Geroscience. 2017 Aug;39(4):419-428. doi: 10.1007/s11357-017-9988-4. Epub 2017 Jul 13.

28.

Inter-organ regulation of haem homeostasis.

Pitt JN, Kaeberlein M.

Nat Cell Biol. 2017 Jun 29;19(7):756-758. doi: 10.1038/ncb3568.

PMID:
28659637
29.

Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes.

Rossner R, Kaeberlein M, Leiser SF.

J Biol Chem. 2017 Jul 7;292(27):11138-11146. doi: 10.1074/jbc.R117.779678. Epub 2017 May 17. Review.

30.

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M.

Geroscience. 2017 Apr;39(2):117-127. doi: 10.1007/s11357-017-9972-z. Epub 2017 Apr 3.

31.

Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans.

Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1033-1037. doi: 10.1093/gerona/glx017.

32.

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.

Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M.

PLoS Genet. 2017 Mar 29;13(3):e1006695. doi: 10.1371/journal.pgen.1006695. eCollection 2017 Mar.

33.

Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging.

Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DE, Kaeberlein M.

Geroscience. 2017 Feb;39(1):43-50. doi: 10.1007/s11357-016-9956-4. Epub 2017 Jan 14.

34.

Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.

Mukherjee S, Russell JC, Carr DT, Burgess JD, Allen M, Serie DJ, Boehme KL, Kauwe JSK, Naj AC, Fardo DW, Dickson DW, Montine TJ, Ertekin-Taner N, Kaeberlein MR, Crane PK.

Alzheimers Dement. 2017 Oct;13(10):1133-1142. doi: 10.1016/j.jalz.2017.01.016. Epub 2017 Feb 24.

35.

CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM.

Cell Rep. 2017 Feb 21;18(8):1884-1892. doi: 10.1016/j.celrep.2017.01.077.

36.

Dietary restriction and lifespan: Lessons from invertebrate models.

Kapahi P, Kaeberlein M, Hansen M.

Ageing Res Rev. 2017 Oct;39:3-14. doi: 10.1016/j.arr.2016.12.005. Epub 2016 Dec 19. Review.

37.

Rapamycin enhances survival in a Drosophila model of mitochondrial disease.

Wang A, Mouser J, Pitt J, Promislow D, Kaeberlein M.

Oncotarget. 2016 Dec 6;7(49):80131-80139. doi: 10.18632/oncotarget.12560.

38.

Age-associated vulval integrity is an important marker of nematode healthspan.

Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M.

Age (Dordr). 2016 Dec;38(5-6):419-431. doi: 10.1007/s11357-016-9936-8. Epub 2016 Aug 26.

39.

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M.

Elife. 2016 Aug 23;5. pii: e16351. doi: 10.7554/eLife.16351.

40.

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects.

Johnson SC, Kaeberlein M.

Oncotarget. 2016 Jul 19;7(29):44876-44878. doi: 10.18632/oncotarget.10381.

41.

New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response.

Leiser SF, Rossner R, Kaeberlein M.

Worm. 2016 Apr 12;5(2):e1176823. doi: 10.1080/21624054.2016.1176823. eCollection 2016 Apr-Jun.

42.

New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans.

Jafari G, Wasko BM, Kaeberlein M, Crofts AR.

Worm. 2016 Apr 11;5(2):e1174803. doi: 10.1080/21624054.2016.1174803. eCollection 2016 Apr-Jun.

43.

The dog aging project: translational geroscience in companion animals.

Kaeberlein M, Creevy KE, Promislow DE.

Mamm Genome. 2016 Aug;27(7-8):279-88. doi: 10.1007/s00335-016-9638-7. Epub 2016 May 3. Review.

44.

Microfluidic technologies for yeast replicative lifespan studies.

Chen KL, Crane MM, Kaeberlein M.

Mech Ageing Dev. 2017 Jan;161(Pt B):262-269. doi: 10.1016/j.mad.2016.03.009. Epub 2016 Mar 23. Review.

45.

Healthy aging: The ultimate preventative medicine.

Kaeberlein M, Rabinovitch PS, Martin GM.

Science. 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267. Review.

46.

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae.

Sunshine AB, Ong GT, Nickerson DP, Carr D, Murakami CJ, Wasko BM, Shemorry A, Merz AJ, Kaeberlein M, Dunham MJ.

Aging Cell. 2016 Apr;15(2):317-24. doi: 10.1111/acel.12443. Epub 2016 Jan 13.

47.

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.

Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M.

Science. 2015 Dec 11;350(6266):1375-1378. doi: 10.1126/science.aac9257. Epub 2015 Nov 19.

48.

Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans.

Chandler-Brown D, Choi H, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M.

Front Genet. 2015 Oct 27;6:316. doi: 10.3389/fgene.2015.00316. eCollection 2015.

49.

Biochemical Genetic Pathways that Modulate Aging in Multiple Species.

Bitto A, Wang AM, Bennett CF, Kaeberlein M.

Cold Spring Harb Perspect Med. 2015 Nov 2;5(11). pii: a025114. doi: 10.1101/cshperspect.a025114. Review.

50.

Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.

Jafari G, Wasko BM, Tonge A, Schurman N, Dong C, Li Z, Peters R, Kayser EB, Pitt JN, Morgan PG, Sedensky MM, Crofts AR, Kaeberlein M.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6148-57. doi: 10.1073/pnas.1509416112. Epub 2015 Oct 26.

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