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Items: 1 to 50 of 178

1.

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics.

Rempel IL, Crane MM, Thaller DJ, Mishra A, Jansen DP, Janssens G, Popken P, Ak┼čit A, Kaeberlein M, van der Giessen E, Steen A, Onck PR, Lusk CP, Veenhoff LM.

Elife. 2019 Jun 3;8. pii: e48186. doi: 10.7554/eLife.48186.

2.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Lee MB, Dowsett IT, Carr DT, Wasko BM, Stanton SG, Chung MS, Ghodsian N, Bode A, Kiflezghi MG, Uppal PA, Grayden KA, Elala YC, Tang TT, Tran NHB, Tran THB, Diep AB, Hope M, Promislow DEL, Kennedy SR, Kaeberlein M, Herr AJ.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3062-3071. doi: 10.1073/pnas.1815966116. Epub 2019 Feb 4.

PMID:
30718408
3.

Rapamycin and Alzheimer's disease: Time for a clinical trial?

Kaeberlein M, Galvan V.

Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Review.

PMID:
30674654
4.

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.

Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, Legendre C, Suh Y, Canaud G.

Kidney Int. 2019 Feb;95(2):455-466. doi: 10.1016/j.kint.2018.08.038. Epub 2018 Nov 22.

PMID:
30471880
5.

Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective.

Wilfond BS, Porter KM, Creevy KE, Kaeberlein M, Promislow D.

Am J Bioeth. 2018 Oct;18(10):64-65. doi: 10.1080/15265161.2018.1513591. No abstract available.

PMID:
30339074
6.

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9586-9591. doi: 10.1073/pnas.1804264115. Epub 2018 Sep 5.

7.

How healthy is the healthspan concept?

Kaeberlein M.

Geroscience. 2018 Aug;40(4):361-364. doi: 10.1007/s11357-018-0036-9. Epub 2018 Aug 6. No abstract available.

8.

Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans.

Burnaevskiy N, Chen S, Mailig M, Reynolds A, Karanth S, Mendenhall A, Van Gilst M, Kaeberlein M.

Elife. 2018 Aug 2;7. pii: e36194. doi: 10.7554/eLife.36194.

9.

The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells.

Crane MM, Kaeberlein M.

Curr Opin Syst Biol. 2018 Apr;8:25-31. doi: 10.1016/j.coisb.2017.11.010. Epub 2017 Dec 6.

10.

Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Dec 22;8:221. doi: 10.3389/fgene.2017.00221. eCollection 2017.

11.

Oral health in geroscience: animal models and the aging oral cavity.

An JY, Darveau R, Kaeberlein M.

Geroscience. 2018 Feb;40(1):1-10. doi: 10.1007/s11357-017-0004-9. Epub 2017 Dec 27. Review.

12.

Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants.

Russell JC, Burnaevskiy N, Ma B, Mailig MA, Faust F, Crane M, Kaeberlein M, Mendenhall A.

J Gerontol A Biol Sci Med Sci. 2017 Nov 18. doi: 10.1093/gerona/glx230. [Epub ahead of print]

PMID:
29165668
13.

Genetic interaction with temperature is an important determinant of nematode longevity.

Miller H, Fletcher M, Primitivo M, Leonard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF.

Aging Cell. 2017 Dec;16(6):1425-1429. doi: 10.1111/acel.12658. Epub 2017 Sep 21.

14.

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113. eCollection 2017. Erratum in: Front Genet. 2017 Dec 22;8:221.

15.

Rapamycin treatment attenuates age-associated periodontitis in mice.

An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M.

Geroscience. 2017 Aug;39(4):457-463. doi: 10.1007/s11357-017-9994-6. Epub 2017 Sep 9.

16.

A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae.

Lee MB, Carr DT, Kiflezghi MG, Zhao YT, Kim DB, Thon S, Moore MD, Li MAK, Kaeberlein M.

Geroscience. 2017 Aug;39(4):419-428. doi: 10.1007/s11357-017-9988-4. Epub 2017 Jul 13.

17.

Inter-organ regulation of haem homeostasis.

Pitt JN, Kaeberlein M.

Nat Cell Biol. 2017 Jun 29;19(7):756-758. doi: 10.1038/ncb3568.

PMID:
28659637
18.

Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes.

Rossner R, Kaeberlein M, Leiser SF.

J Biol Chem. 2017 Jul 7;292(27):11138-11146. doi: 10.1074/jbc.R117.779678. Epub 2017 May 17. Review.

19.

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M.

Geroscience. 2017 Apr;39(2):117-127. doi: 10.1007/s11357-017-9972-z. Epub 2017 Apr 3.

20.

Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans.

Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1033-1037. doi: 10.1093/gerona/glx017.

21.

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.

Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M.

PLoS Genet. 2017 Mar 29;13(3):e1006695. doi: 10.1371/journal.pgen.1006695. eCollection 2017 Mar.

22.

Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging.

Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DE, Kaeberlein M.

Geroscience. 2017 Feb;39(1):43-50. doi: 10.1007/s11357-016-9956-4. Epub 2017 Jan 14.

23.

Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.

Mukherjee S, Russell JC, Carr DT, Burgess JD, Allen M, Serie DJ, Boehme KL, Kauwe JSK, Naj AC, Fardo DW, Dickson DW, Montine TJ, Ertekin-Taner N, Kaeberlein MR, Crane PK.

Alzheimers Dement. 2017 Oct;13(10):1133-1142. doi: 10.1016/j.jalz.2017.01.016. Epub 2017 Feb 24.

24.

CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM.

Cell Rep. 2017 Feb 21;18(8):1884-1892. doi: 10.1016/j.celrep.2017.01.077.

25.

Dietary restriction and lifespan: Lessons from invertebrate models.

Kapahi P, Kaeberlein M, Hansen M.

Ageing Res Rev. 2017 Oct;39:3-14. doi: 10.1016/j.arr.2016.12.005. Epub 2016 Dec 19. Review.

26.

Rapamycin enhances survival in a Drosophila model of mitochondrial disease.

Wang A, Mouser J, Pitt J, Promislow D, Kaeberlein M.

Oncotarget. 2016 Dec 6;7(49):80131-80139. doi: 10.18632/oncotarget.12560.

27.

Age-associated vulval integrity is an important marker of nematode healthspan.

Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M.

Age (Dordr). 2016 Dec;38(5-6):419-431. doi: 10.1007/s11357-016-9936-8. Epub 2016 Aug 26.

28.

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M.

Elife. 2016 Aug 23;5. pii: e16351. doi: 10.7554/eLife.16351.

29.

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects.

Johnson SC, Kaeberlein M.

Oncotarget. 2016 Jul 19;7(29):44876-44878. doi: 10.18632/oncotarget.10381.

30.

New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response.

Leiser SF, Rossner R, Kaeberlein M.

Worm. 2016 Apr 12;5(2):e1176823. doi: 10.1080/21624054.2016.1176823. eCollection 2016 Apr-Jun.

31.

New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans.

Jafari G, Wasko BM, Kaeberlein M, Crofts AR.

Worm. 2016 Apr 11;5(2):e1174803. doi: 10.1080/21624054.2016.1174803. eCollection 2016 Apr-Jun.

32.

The dog aging project: translational geroscience in companion animals.

Kaeberlein M, Creevy KE, Promislow DE.

Mamm Genome. 2016 Aug;27(7-8):279-88. doi: 10.1007/s00335-016-9638-7. Epub 2016 May 3. Review.

33.

Microfluidic technologies for yeast replicative lifespan studies.

Chen KL, Crane MM, Kaeberlein M.

Mech Ageing Dev. 2017 Jan;161(Pt B):262-269. doi: 10.1016/j.mad.2016.03.009. Epub 2016 Mar 23. Review.

34.

Healthy aging: The ultimate preventative medicine.

Kaeberlein M, Rabinovitch PS, Martin GM.

Science. 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267. Review.

35.

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae.

Sunshine AB, Ong GT, Nickerson DP, Carr D, Murakami CJ, Wasko BM, Shemorry A, Merz AJ, Kaeberlein M, Dunham MJ.

Aging Cell. 2016 Apr;15(2):317-24. doi: 10.1111/acel.12443. Epub 2016 Jan 13.

36.

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.

Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M.

Science. 2015 Dec 11;350(6266):1375-1378. doi: 10.1126/science.aac9257. Epub 2015 Nov 19.

37.

Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans.

Chandler-Brown D, Choi H, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M.

Front Genet. 2015 Oct 27;6:316. doi: 10.3389/fgene.2015.00316. eCollection 2015.

38.

Biochemical Genetic Pathways that Modulate Aging in Multiple Species.

Bitto A, Wang AM, Bennett CF, Kaeberlein M.

Cold Spring Harb Perspect Med. 2015 Nov 2;5(11). pii: a025114. doi: 10.1101/cshperspect.a025114. Review.

39.

Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.

Jafari G, Wasko BM, Tonge A, Schurman N, Dong C, Li Z, Peters R, Kayser EB, Pitt JN, Morgan PG, Sedensky MM, Crofts AR, Kaeberlein M.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6148-57. doi: 10.1073/pnas.1509416112. Epub 2015 Oct 26.

40.

Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan.

Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA.

Nat Commun. 2015 Oct 14;6:8738. doi: 10.1038/ncomms9738. No abstract available.

PMID:
26465398
41.

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.

McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK.

Cell Metab. 2015 Nov 3;22(5):895-906. doi: 10.1016/j.cmet.2015.09.008. Epub 2015 Oct 8.

42.

Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.

Yang J, McCormick MA, Zheng J, Xie Z, Tsuchiya M, Tsuchiyama S, El-Samad H, Ouyang Q, Kaeberlein M, Kennedy BK, Li H.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11977-82. doi: 10.1073/pnas.1506054112. Epub 2015 Sep 8.

43.

Transcription errors induce proteotoxic stress and shorten cellular lifespan.

Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA.

Nat Commun. 2015 Aug 25;6:8065. doi: 10.1038/ncomms9065. Erratum in: Nat Commun. 2015;6:8738. Thompson, William J and Mosely, Arthur M [Corrected to Thompson, J Will and Moseley, M Arthur].

44.

Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M.

Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015.

45.

H3K36 methylation promotes longevity by enhancing transcriptional fidelity.

Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL.

Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115.

46.

The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.

Kaeberlein M.

Vet Pathol. 2016 Mar;53(2):291-8. doi: 10.1177/0300985815591082. Epub 2015 Jun 15. Review.

47.

MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts.

Xiong XD, Jung HJ, Gombar S, Park JY, Zhang CL, Zheng H, Ruan J, Li JB, Kaeberlein M, Kennedy BK, Zhou Z, Liu X, Suh Y.

Mutat Res. 2015 Jul;777:69-78. doi: 10.1016/j.mrfmmm.2015.04.010. Epub 2015 Apr 24.

48.

Correction: Why Is Aging Conserved and What Can We Do about it?

Pitt JN, Kaeberlein M.

PLoS Biol. 2015 May 15;13(5):e1002176. doi: 10.1371/journal.pbio.1002176. eCollection 2015 May.

49.

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.

Cui HJ, Liu XG, McCormick M, Wasko BM, Zhao W, He X, Yuan Y, Fang BX, Sun XR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Feng WL.

Age (Dordr). 2015 Jun;37(3):9788. doi: 10.1007/s11357-015-9788-7. Epub 2015 May 4.

50.

Why is aging conserved and what can we do about it?

Pitt JN, Kaeberlein M.

PLoS Biol. 2015 Apr 29;13(4):e1002131. doi: 10.1371/journal.pbio.1002131. eCollection 2015 Apr. Erratum in: PLoS Biol. 2015 May;13(5):e1002176.

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