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Items: 19


Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.

Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10798-10803. doi: 10.1073/pnas.1819309116. Epub 2019 May 10.


A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A.

Mol Cell. 2017 Aug 3;67(3):498-511.e6. doi: 10.1016/j.molcel.2017.06.024. Epub 2017 Jul 20.


An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J.

Elife. 2016 Oct 4;5. pii: e20105. doi: 10.7554/eLife.20105.


A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM.

J Exp Med. 2016 Feb 8;213(2):155-65. doi: 10.1084/jem.20150888. Epub 2016 Jan 18.


The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A.

Sci Signal. 2015 May 19;8(377):ra49. doi: 10.1126/scisignal.2005596.


Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.

Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J.

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12. Epub 2013 Mar 25.


Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.

Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A.

Sci Signal. 2013 Jan 1;6(256):ra1. doi: 10.1126/scisignal.2003220.


ZAP-70: an essential kinase in T-cell signaling.

Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A.

Cold Spring Harb Perspect Biol. 2010 May;2(5):a002279. doi: 10.1101/cshperspect.a002279. Review.


Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.

Deindl S, Kadlecek TA, Cao X, Kuriyan J, Weiss A.

Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20699-704. doi: 10.1073/pnas.0911512106. Epub 2009 Nov 17.


Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.

Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A.

J Biol Chem. 2008 May 30;283(22):15419-30. doi: 10.1074/jbc.M709000200. Epub 2008 Mar 31.


Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.

Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J.

Cell. 2007 May 18;129(4):735-46.


Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A.

Mol Cell Biol. 2005 Jun;25(12):4924-33.


Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.

Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A.

Mol Cell Biol. 2004 Mar;24(6):2455-66.


Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.

Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A.

J Immunol. 2001 Jan 1;166(1):656-61.


Differential requirements for ZAP-70 in TCR signaling and T cell development.

Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A.

J Immunol. 1998 Nov 1;161(9):4688-94.


Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.

Taylor N, Bacon KB, Smith S, Jahn T, Kadlecek TA, Uribe L, Kohn DB, Gelfand EW, Weiss A, Weinberg K.

J Exp Med. 1996 Nov 1;184(5):2031-6.


Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes.

Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A.

J Exp Med. 1995 Oct 1;182(4):1057-65.


ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.

Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A.

Science. 1994 Jun 10;264(5165):1599-601.


Molecular and genetic insights into T cell antigen receptor signal transduction.

Weiss A, Iwashima M, Irving B, van Oers NS, Kadlecek TA, Straus D, Chan A.

Adv Exp Med Biol. 1994;365:53-62. No abstract available.


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