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Items: 1 to 50 of 63

1.

Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear.

Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Alzheimers Dis. 2018;66(4):1371-1378. doi: 10.3233/JAD-180618.

2.

Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.

Cavini IA, Munte CE, Erlach MB, van Groen T, Kadish I, Zhang T, Ziehm T, Nagel-Steger L, Kutzsche J, Kremer W, Willbold D, Kalbitzer HR.

Chem Commun (Camb). 2018 Mar 27;54(26):3294-3297. doi: 10.1039/c8cc01458b.

PMID:
29537428
3.

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.

Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2018 Jan 24;38(4):1030-1041. doi: 10.1523/JNEUROSCI.2234-17.2017. Epub 2017 Dec 18.

4.

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.

Campbell SL, van Groen T, Kadish I, Smoot LHM, Bolger GB.

BMC Neurosci. 2017 Dec 2;18(1):77. doi: 10.1186/s12868-017-0396-6.

5.

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.

6.

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D.

ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23.

PMID:
28581708
7.

Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice.

Ramani M, van Groen T, Kadish I, Ambalavanan N, McMahon LL.

Neurobiol Learn Mem. 2017 May;141:209-216. doi: 10.1016/j.nlm.2017.04.013. Epub 2017 Apr 27.

PMID:
28458035
8.

Observational research rigour alone does not justify causal inference.

Ejima K, Li P, Smith DL Jr, Nagy TR, Kadish I, van Groen T, Dawson JA, Yang Y, Patki A, Allison DB.

Eur J Clin Invest. 2016 Dec;46(12):985-993. doi: 10.1111/eci.12681. Epub 2016 Oct 28.

9.

Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide.

Jiang N, Frenzel D, Schartmann E, van Groen T, Kadish I, Shah NJ, Langen KJ, Willbold D, Willuweit A.

Biochim Biophys Acta. 2016 Nov;1858(11):2717-2724. doi: 10.1016/j.bbamem.2016.07.002. Epub 2016 Jul 14.

10.

Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice.

Jansone B, Kadish I, van Groen T, Beitnere U, Plotniece A, Pajuste K, Klusa V.

Pharmacol Res. 2016 Nov;113(Pt B):781-787. doi: 10.1016/j.phrs.2016.06.020. Epub 2016 Jun 21.

11.

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D.

ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9.

PMID:
27240424
12.

Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice.

Kadish I, Kumar A, Beitnere U, Jennings E, McGilberry W, van Groen T.

Exp Gerontol. 2016 Dec 15;86:39-49. doi: 10.1016/j.exger.2016.05.003. Epub 2016 May 7.

13.

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.

Kumar A, Zhang J, Tallaksen-Greene S, Crowley MR, Crossman DK, Morton AJ, Van Groen T, Kadish I, Albin RL, Lesort M, Detloff PJ.

Hum Mol Genet. 2016 Apr 15;25(8):1619-36. doi: 10.1093/hmg/ddw040. Epub 2016 Feb 14.

14.

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.

Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D.

Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222.

15.

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2015 Jul 29;35(30):10878-87. doi: 10.1523/JNEUROSCI.1248-15.2015.

16.

Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse model.

Kunath N, van Groen T, Allison DB, Kumar A, Dozier-Sharpe M, Kadish I.

Sci Rep. 2015 Jun 19;5:11452. doi: 10.1038/srep11452.

17.

A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweDI Mice.

Jansone B, Kadish I, van Groen T, Beitnere U, Moore DR, Plotniece A, Pajuste K, Klusa V.

PLoS One. 2015 Jun 4;10(6):e0127686. doi: 10.1371/journal.pone.0127686. eCollection 2015.

18.
19.

FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW.

Eur J Pharmacol. 2014 Sep 15;739:74-82. doi: 10.1016/j.ejphar.2013.10.070. Epub 2013 Nov 28. Review.

20.

Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice.

Beitnere U, van Groen T, Kumar A, Jansone B, Klusa V, Kadish I.

J Neurosci Res. 2014 Mar;92(3):338-46. doi: 10.1002/jnr.23315. Epub 2013 Nov 22.

21.

Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging.

Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW.

Endocrinology. 2013 Aug;154(8):2807-20. doi: 10.1210/en.2013-1139. Epub 2013 Jun 4.

22.

In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology.

Handattu SP, Monroe CE, Nayyar G, Palgunachari MN, Kadish I, van Groen T, Anantharamaiah GM, Garber DW.

J Alzheimers Dis. 2013;36(2):335-47. doi: 10.3233/JAD-122377.

23.

Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer's disease pathology in a mouse model.

Dhurandhar EJ, Allison DB, van Groen T, Kadish I.

PLoS One. 2013;8(4):e60437. doi: 10.1371/journal.pone.0060437. Epub 2013 Apr 2.

24.

Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats.

Pancani T, Anderson KL, Brewer LD, Kadish I, DeMoll C, Landfield PW, Blalock EM, Porter NM, Thibault O.

Neurobiol Aging. 2013 Aug;34(8):1977-87. doi: 10.1016/j.neurobiolaging.2013.02.019. Epub 2013 Mar 29.

25.

Treatment with D3 removes amyloid deposits, reduces inflammation, and improves cognition in aged AβPP/PS1 double transgenic mice.

van Groen T, Kadish I, Funke SA, Bartnik D, Willbold D.

J Alzheimers Dis. 2013;34(3):609-20. doi: 10.3233/JAD-121792.

26.

Neurodevelopmental impairment following neonatal hyperoxia in the mouse.

Ramani M, van Groen T, Kadish I, Bulger A, Ambalavanan N.

Neurobiol Dis. 2013 Feb;50:69-75. doi: 10.1016/j.nbd.2012.10.005. Epub 2012 Oct 12.

27.

Treatment with Aβ42 binding D-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic mice.

van Groen T, Kadish I, Funke A, Bartnik D, Willbold D.

Adv Protein Chem Struct Biol. 2012;88:133-52. doi: 10.1016/B978-0-12-398314-5.00005-2.

PMID:
22814708
28.

Insufficient DNA methylation affects healthy aging and promotes age-related health problems.

Liu L, van Groen T, Kadish I, Li Y, Wang D, James SR, Karpf AR, Tollefsbol TO.

Clin Epigenetics. 2011 Aug;2(2):349-60. doi: 10.1007/s13148-011-0042-6. Epub 2011 Jun 12.

29.

Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.

Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O.

J Alzheimers Dis. 2012;30(4):943-61. doi: 10.3233/JAD-2012-111661.

30.

Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Neurosci. 2011 Feb 2;31(5):1693-703. doi: 10.1523/JNEUROSCI.4805-10.2011.

31.

Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology.

van Groen T, Miettinen P, Kadish I.

J Alzheimers Dis. 2011;24(2):301-13. doi: 10.3233/JAD-2011-101479.

PMID:
21239852
32.

Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.

Aileen Funke S, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AH, Müller-Schiffmann A, Korth C, Sticht H, Willbold D.

ACS Chem Neurosci. 2010 Sep 15;1(9):639-48. doi: 10.1021/cn100057j. Epub 2010 Aug 2.

33.

Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology.

van Groen T, Kadish I, Popović N, Popović M, Caballero-Bleda M, Baño-Otálora B, Vivanco P, Rol MÁ, Madrid JA.

Neurobiol Aging. 2011 Sep;32(9):1651-61. doi: 10.1016/j.neurobiolaging.2009.10.008. Epub 2009 Nov 11.

PMID:
19910078
34.

Lesion-induced hippocampal plasticity in transgenic Alzheimer's disease mouse models: influences of age, genotype, and estrogen.

Kadish I, van Groen T.

J Alzheimers Dis. 2009;18(2):429-45. doi: 10.3233/JAD-2009-1157.

PMID:
19584452
35.

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease.

Handattu SP, Garber DW, Monroe CE, van Groen T, Kadish I, Nayyar G, Cao D, Palgunachari MN, Li L, Anantharamaiah GM.

Neurobiol Dis. 2009 Jun;34(3):525-34. doi: 10.1016/j.nbd.2009.03.007. Epub 2009 Apr 1.

36.

Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW.

J Neurosci. 2009 Feb 11;29(6):1805-16. doi: 10.1523/JNEUROSCI.4599-08.2009.

37.

Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.

Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Van Groen T, Grizzle WE, Ponnazhagan S, Fallon MB.

Gastroenterology. 2009 Mar;136(3):1070-80. doi: 10.1053/j.gastro.2008.12.001. Epub 2008 Dec 3.

38.

In vitro and in vivo staining characteristics of small, fluorescent, Abeta42-binding D-enantiomeric peptides in transgenic AD mouse models.

van Groen T, Kadish I, Wiesehan K, Funke SA, Willbold D.

ChemMedChem. 2009 Feb;4(2):276-82. doi: 10.1002/cmdc.200800289.

PMID:
19072935
39.

Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, A D-enantiomeric peptide identified by mirror image phage display.

van Groen T, Wiesehan K, Funke SA, Kadish I, Nagel-Steger L, Willbold D.

ChemMedChem. 2008 Dec;3(12):1848-52. doi: 10.1002/cmdc.200800273. No abstract available.

PMID:
19016284
40.

Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice.

Popović M, Caballero-Bleda M, Kadish I, Van Groen T.

Neuroscience. 2008 Jul 31;155(1):182-91. doi: 10.1016/j.neuroscience.2008.05.023. Epub 2008 May 24.

41.

DNA methylation impacts on learning and memory in aging.

Liu L, van Groen T, Kadish I, Tollefsbol TO.

Neurobiol Aging. 2009 Apr;30(4):549-60. Epub 2007 Sep 11. Review.

42.

Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats.

Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW.

J Neurosci. 2007 Mar 21;27(12):3098-110.

43.

Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.

van Groen T, Kiliaan AJ, Kadish I.

Neurobiol Dis. 2006 Sep;23(3):653-62. Epub 2006 Jul 10.

PMID:
16829076
44.

Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation.

Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, Landfield PW.

Ageing Res Rev. 2005 Nov;4(4):481-512. Epub 2005 Oct 27. Review.

PMID:
16257272
45.

Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.

Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD.

J Neurosci. 2005 May 4;25(18):4649-58.

46.

Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology.

van Groen T, Kadish I.

Brain Res Brain Res Rev. 2005 Apr;48(2):370-8.

PMID:
15850676
47.

Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the rat.

van Groen T, Kadish I, Wyss JM.

Behav Brain Res. 2004 Oct 5;154(2):483-91.

PMID:
15313037
48.

Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice.

Wang J, Tanila H, Puoliväli J, Kadish I, van Groen T.

Neurobiol Dis. 2003 Dec;14(3):318-27. Erratum in: Neurobiol Dis. 2004 Jun;16(1):following 289.

PMID:
14678749
49.

Age-related decline in spatial learning and memory: attenuation by captopril.

Wyss JM, Kadish I, van Groen T.

Clin Exp Hypertens. 2003 Oct;25(7):455-74.

PMID:
14596369
50.

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