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Items: 17


Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.


Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467].

Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1517. doi: 10.1016/j.bbrc.2016.11.116. Epub 2016 Nov 26. No abstract available.


Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

Chaurasia B, Kaddai VA, Lancaster GI, Henstridge DC, Sriram S, Galam DL, Gopalan V, Prakash KN, Velan SS, Bulchand S, Tsong TJ, Wang M, Siddique MM, Yuguang G, Sigmundsson K, Mellet NA, Weir JM, Meikle PJ, Bin M Yassin MS, Shabbir A, Shayman JA, Hirabayashi Y, Shiow ST, Sugii S, Summers SA.

Cell Metab. 2016 Dec 13;24(6):820-834. doi: 10.1016/j.cmet.2016.10.002. Epub 2016 Nov 3.


Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells.

Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA.

Biochem Biophys Res Commun. 2016 Nov 18;480(3):461-467. doi: 10.1016/j.bbrc.2016.10.072. Epub 2016 Oct 20. Erratum in: Biochem Biophys Res Commun. 2017 Jan 22;482(4):1517.


A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.

Park M, Kaddai V, Ching J, Fridianto KT, Sieli RJ, Sugii S, Summers SA.

J Biol Chem. 2016 Nov 11;291(46):23978-23988. Epub 2016 Oct 4.


Dihydroceramides: From Bit Players to Lead Actors.

Siddique MM, Li Y, Chaurasia B, Kaddai VA, Summers SA.

J Biol Chem. 2015 Jun 19;290(25):15371-9. doi: 10.1074/jbc.R115.653204. Epub 2015 May 6. Review.


Role of seipin in lipid droplet morphology and hepatitis C virus life cycle.

Clément S, Fauvelle C, Branche E, Kaddai V, Conzelmann S, Boldanova T, Bartosch B, Minehira K, Negro F.

J Gen Virol. 2013 Oct;94(Pt 10):2208-14. doi: 10.1099/vir.0.054593-0. Epub 2013 Aug 1.


PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism.

Peyrou M, Clément S, Maier C, Bourgoin L, Branche E, Conzelmann S, Kaddai V, Foti M, Negro F.

J Hepatol. 2013 Sep;59(3):420-6. doi: 10.1016/j.jhep.2013.04.012. Epub 2013 Apr 23.


Current understanding of insulin resistance in hepatitis C.

Kaddai V, Negro F.

Expert Rev Gastroenterol Hepatol. 2011 Aug;5(4):503-16. doi: 10.1586/egh.11.43. Review.


Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.

Cai T, Dufour JF, Muellhaupt B, Gerlach T, Heim M, Moradpour D, Cerny A, Malinverni R, Kaddai V, Bochud M, Negro F, Bochud PY.

J Hepatol. 2011 Sep;55(3):529-535. doi: 10.1016/j.jhep.2010.12.020. Epub 2011 Jan 12.


Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M.

PLoS One. 2009 Apr 17;4(4):e5257. doi: 10.1371/journal.pone.0005257.


Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

Kaddai V, Jager J, Gonzalez T, Najem-Lendom R, Bonnafous S, Tran A, Le Marchand-Brustel Y, Gual P, Tanti JF, Cormont M.

Diabetologia. 2009 May;52(5):932-40. doi: 10.1007/s00125-009-1273-3. Epub 2009 Feb 14.


The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes.

Kaddai V, Gonzalez T, Bolla M, Le Marchand-Brustel Y, Cormont M.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E162-9. doi: 10.1152/ajpendo.00622.2007. Epub 2008 May 20.


Rab proteins in endocytosis and Glut4 trafficking.

Kaddai V, Le Marchand-Brustel Y, Cormont M.

Acta Physiol (Oxf). 2008 Jan;192(1):75-88. doi: 10.1111/j.1748-1716.2007.01787.x. Review. Erratum in: Acta Physiol (Oxf). 2008 Jun;193(2): 201-2.


The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.

Mari M, Monzo P, Kaddai V, Keslair F, Gonzalez T, Le Marchand-Brustel Y, Cormont M.

J Cell Sci. 2006 Apr 1;119(Pt 7):1297-306. Epub 2006 Mar 7.


CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.

Monzo P, Mari M, Kaddai V, Gonzalez T, Le Marchand-Brustel Y, Cormont M.

Methods Enzymol. 2005;403:107-18.


Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes.

Gauthier NC, Monzo P, Kaddai V, Doye A, Ricci V, Boquet P.

Mol Biol Cell. 2005 Oct;16(10):4852-66. Epub 2005 Jul 29.

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