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Items: 1 to 50 of 218

1.

Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability.

Kaczmarek LK.

Neuron. 2019 Aug 21;103(4):551-553. doi: 10.1016/j.neuron.2019.07.032.

PMID:
31437449
2.

An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents.

Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK.

J Neurosci. 2019 Sep 11;39(37):7438-7449. doi: 10.1523/JNEUROSCI.1628-18.2019. Epub 2019 Jul 26.

PMID:
31350261
3.

Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.

El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK.

J Neurosci. 2019 Jun 12;39(24):4797-4813. doi: 10.1523/JNEUROSCI.0839-18.2019. Epub 2019 Apr 1.

PMID:
30936239
4.

C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity.

Khare S, Galeano K, Zhang Y, Nick JA, Nick HS, Subramony SH, Sampson J, Kaczmarek LK, Waters MF.

Cerebellum. 2018 Oct;17(5):692-697. doi: 10.1007/s12311-018-0950-5.

PMID:
29949095
5.

Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage.

Chambers AR, Pilati N, Balaram P, Large CH, Kaczmarek LK, Polley DB.

Sci Rep. 2017 Dec 13;7(1):17496. doi: 10.1038/s41598-017-17406-x.

6.

Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.

Kaczmarek LK, Zhang Y.

Physiol Rev. 2017 Oct 1;97(4):1431-1468. doi: 10.1152/physrev.00002.2017. Review.

7.

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.

Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF.

PLoS One. 2017 May 3;12(5):e0173565. doi: 10.1371/journal.pone.0173565. eCollection 2017.

8.

International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.

Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H.

Pharmacol Rev. 2017 Jan;69(1):1-11. doi: 10.1124/pr.116.012864. Epub 2016 Nov 15. Review.

PMID:
28267675
9.

An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons.

Zhang Y, Ni W, Horwich AL, Kaczmarek LK.

J Neurosci. 2017 Feb 22;37(8):2258-2265. doi: 10.1523/JNEUROSCI.3102-16.2017. Epub 2017 Jan 24.

10.

The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.

Gribkoff VK, Kaczmarek LK.

Neuropharmacology. 2017 Jul 1;120:11-19. doi: 10.1016/j.neuropharm.2016.03.021. Epub 2016 Mar 12. Review.

11.

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.

Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N.

Cell Rep. 2016 Sep 6;16(10):2576-2592. doi: 10.1016/j.celrep.2016.08.038. Epub 2016 Aug 24.

12.

Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.

Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK.

Cell Rep. 2016 Aug 30;16(9):2281-8. doi: 10.1016/j.celrep.2016.07.024. Epub 2016 Aug 18.

13.

Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.

Brown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK.

J Neurophysiol. 2016 Jul 1;116(1):106-21. doi: 10.1152/jn.00174.2016. Epub 2016 Apr 6.

14.

Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.

Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK.

Cell. 2016 Apr 7;165(2):434-448. doi: 10.1016/j.cell.2016.02.009. Epub 2016 Mar 17.

15.

T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels.

Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA.

PLoS One. 2016 Jan 27;11(1):e0147379. doi: 10.1371/journal.pone.0147379. eCollection 2016.

16.

Kv3.3 potassium channels and spinocerebellar ataxia.

Zhang Y, Kaczmarek LK.

J Physiol. 2016 Aug 15;594(16):4677-84. doi: 10.1113/JP271343. Epub 2015 Nov 15. Review.

17.

The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice.

Bausch AE, Dieter R, Nann Y, Hausmann M, Meyerdierks N, Kaczmarek LK, Ruth P, Lukowski R.

Learn Mem. 2015 Jun 15;22(7):323-35. doi: 10.1101/lm.037820.114. Print 2015 Jul.

18.

Human slack potassium channel mutations increase positive cooperativity between individual channels.

Kim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK.

Cell Rep. 2014 Dec 11;9(5):1661-1672. doi: 10.1016/j.celrep.2014.11.015. Epub 2014 Dec 4.

19.

More than a pore: ion channel signaling complexes.

Lee A, Fakler B, Kaczmarek LK, Isom LL.

J Neurosci. 2014 Nov 12;34(46):15159-69. doi: 10.1523/JNEUROSCI.3275-14.2014. Review.

20.

Emerging role of the KCNT1 Slack channel in intellectual disability.

Kim GE, Kaczmarek LK.

Front Cell Neurosci. 2014 Jul 28;8:209. doi: 10.3389/fncel.2014.00209. eCollection 2014. Review.

21.

Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors.

Fleming MR, Shamah SM, Kaczmarek LK.

J Vis Exp. 2014 Feb 10;(84):e51307. doi: 10.3791/51307.

22.

Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.

El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF.

Biol Psychiatry. 2014 Sep 15;76(6):476-85. doi: 10.1016/j.biopsych.2013.12.019. Epub 2014 Jan 20.

23.

Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis.

Martin HC, Kim GE, Pagnamenta AT, Murakami Y, Carvill GL, Meyer E, Copley RR, Rimmer A, Barcia G, Fleming MR, Kronengold J, Brown MR, Hudspith KA, Broxholme J, Kanapin A, Cazier JB, Kinoshita T, Nabbout R; WGS500 Consortium, Bentley D, McVean G, Heavin S, Zaiwalla Z, McShane T, Mefford HC, Shears D, Stewart H, Kurian MA, Scheffer IE, Blair E, Donnelly P, Kaczmarek LK, Taylor JC.

Hum Mol Genet. 2014 Jun 15;23(12):3200-11. doi: 10.1093/hmg/ddu030. Epub 2014 Jan 25.

24.

The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments.

Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M.

Front Cell Neurosci. 2013 Dec 9;7:246. doi: 10.3389/fncel.2013.00246. eCollection 2013.

25.

Slack, Slick and Sodium-Activated Potassium Channels.

Kaczmarek LK.

ISRN Neurosci. 2013 Apr 18;2013(2013). pii: 354262.

26.

Expression of Kv1.3 potassium channels regulates density of cortical interneurons.

Duque A, Gazula VR, Kaczmarek LK.

Dev Neurobiol. 2013 Nov;73(11):841-55. doi: 10.1002/dneu.22105. Epub 2013 Sep 11.

27.

A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude.

Markham MR, Kaczmarek LK, Zakon HH.

J Neurophysiol. 2013 Apr;109(7):1713-23. doi: 10.1152/jn.00875.2012. Epub 2013 Jan 16.

28.

An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels.

Cotella D, Hernandez-Enriquez B, Duan Z, Wu X, Gazula VR, Brown MR, Kaczmarek LK, Sesti F.

FASEB J. 2013 Apr;27(4):1381-93. doi: 10.1096/fj.12-222778. Epub 2012 Dec 11.

29.

Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.

Zhang Y, Brown MR, Hyland C, Chen Y, Kronengold J, Fleming MR, Kohn AB, Moroz LL, Kaczmarek LK.

J Neurosci. 2012 Oct 31;32(44):15318-27. doi: 10.1523/JNEUROSCI.2162-12.2012.

30.

De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy.

Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R.

Nat Genet. 2012 Nov;44(11):1255-9. doi: 10.1038/ng.2441. Epub 2012 Oct 21.

31.

Gradients and modulation of K(+) channels optimize temporal accuracy in networks of auditory neurons.

Kaczmarek LK.

PLoS Comput Biol. 2012;8(3):e1002424. doi: 10.1371/journal.pcbi.1002424. Epub 2012 Mar 15.

32.

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.

33.

Potassium channel modulation and auditory processing.

Brown MR, Kaczmarek LK.

Hear Res. 2011 Sep;279(1-2):32-42. doi: 10.1016/j.heares.2011.03.004. Epub 2011 Mar 21. Review.

34.

Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.

Strumbos JG, Brown MR, Kronengold J, Polley DB, Kaczmarek LK.

J Neurosci. 2010 Aug 4;30(31):10263-71. doi: 10.1523/JNEUROSCI.1125-10.2010.

35.

A less flexible BK channel opens more easily.

Kronengold J, Kaczmarek LK.

Neuron. 2010 Jun 24;66(6):817-8. doi: 10.1016/j.neuron.2010.06.013.

36.

Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.

Gazula VR, Strumbos JG, Mei X, Chen H, Rahner C, Kaczmarek LK.

J Comp Neurol. 2010 Aug 15;518(16):3205-20. doi: 10.1002/cne.22393.

37.

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.

Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK.

Nat Neurosci. 2010 Jul;13(7):819-21. doi: 10.1038/nn.2563. Epub 2010 May 30.

38.

Controlling auditory excitability: the benefits of a cultured environment.

Kaczmarek LK.

J Physiol. 2010 May 1;588(Pt 9):1387-8. doi: 10.1113/jphysiol.2010.189712. No abstract available.

39.

The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice.

Lu S, Das P, Fadool DA, Kaczmarek LK.

J Neurophysiol. 2010 Jun;103(6):3311-9. doi: 10.1152/jn.00607.2009. Epub 2010 Apr 14.

40.

Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.

McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut-Smith MP.

J Physiol. 2010 May 1;588(Pt 9):1399-406. doi: 10.1113/jphysiol.2010.188136. Epub 2010 Mar 22.

41.

Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat.

Strumbos JG, Polley DB, Kaczmarek LK.

Neuroscience. 2010 May 19;167(3):567-72. doi: 10.1016/j.neuroscience.2010.02.046. Epub 2010 Feb 26.

42.

Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors.

Fleming MR, Kaczmarek LK.

J Recept Signal Transduct Res. 2009;29(3-4):173-81. doi: 10.1080/10799890903056883.

43.

The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.

Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK.

J Neurosci. 2009 Apr 29;29(17):5654-65. doi: 10.1523/JNEUROSCI.5978-08.2009.

44.

Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission.

Nanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, El Manira A.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20941-6. doi: 10.1073/pnas.0806403106. Epub 2008 Dec 18.

45.

Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.

Brown MR, Kronengold J, Gazula VR, Spilianakis CG, Flavell RA, von Hehn CA, Bhattacharjee A, Kaczmarek LK.

J Physiol. 2008 Nov 1;586(21):5161-79. doi: 10.1113/jphysiol.2008.160861. Epub 2008 Sep 11.

46.

Protein kinase C modulates inactivation of Kv3.3 channels.

Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LK.

J Biol Chem. 2008 Aug 8;283(32):22283-94. doi: 10.1074/jbc.M801663200. Epub 2008 Jun 6.

47.

PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.

Zhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA.

J Neurosci. 2008 Mar 5;28(10):2601-12. doi: 10.1523/JNEUROSCI.4314-07.

48.

Repetitive firing triggers clustering of Kv2.1 potassium channels in Aplysia neurons.

Zhang Y, McKay SE, Bewley B, Kaczmarek LK.

J Biol Chem. 2008 Apr 18;283(16):10632-41. doi: 10.1074/jbc.M800253200. Epub 2008 Feb 13.

49.

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

Hickman JA, Hardwick JM, Kaczmarek LK, Jonas EA.

J Neurophysiol. 2008 Mar;99(3):1515-22. Epub 2007 Dec 26.

50.

Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons.

Knox RJ, Keen KL, Luchansky L, Terasawa E, Freyer H, Barbee SJ, Kaczmarek LK.

Biochem Biophys Res Commun. 2008 Feb 1;366(1):48-53. Epub 2007 Nov 29.

PMID:
18053804

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