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Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera®) requires death receptor Fas, in addition to LFA-1, to trigger cell death in T lymphocytes.

Vega BA, Schober LT, Kim T, Belinka BA Jr, Kachlany SC.

Infect Immun. 2019 May 20. pii: IAI.00309-19. doi: 10.1128/IAI.00309-19. [Epub ahead of print]


Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles.

Nice JB, Balashova NV, Kachlany SC, Koufos E, Krueger E, Lally ET, Brown AC.

Toxins (Basel). 2018 Oct 13;10(10). pii: E414. doi: 10.3390/toxins10100414.


Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model.

Samy KP, Anderson DJ, Lo DJ, Mulvihill MS, Song M, Farris AB, Parker BS, MacDonald AL, Lu C, Springer TA, Kachlany SC, Reimann KA, How T, Leopardi FV, Franke KS, Williams KD, Collins BH, Kirk AD.

Am J Transplant. 2017 May;17(5):1193-1203. doi: 10.1111/ajt.14141. Epub 2017 Jan 27.


Mechanisms of LtxA (Leukotoxin), a Potent New Anti-Inflammatory Agent for the Treatment of Alopecia Areata.

Kachlany SC.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):19-22. doi: 10.1038/jidsymp.2015.34. Review.


LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.

DiFranco KM, Johnson-Farley N, Bertino JR, Elson D, Vega BA, Belinka BA Jr, Kachlany SC.

Leuk Res. 2015 Jun;39(6):649-56. doi: 10.1016/j.leukres.2015.03.010. Epub 2015 Mar 21.


Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma.

Gupta A, Espinosa V, Galusha LE, Rahimian V, Miro KL, Rivera-Medina A, Kasinathan C, Capitle E, Aguila HA, Kachlany SC.

J Leukoc Biol. 2015 Mar;97(3):439-46. doi: 10.1189/jlb.5HI0414-196R. Epub 2014 Oct 23.


Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1.

DiFranco KM, Kaswala RH, Patel C, Kasinathan C, Kachlany SC.

Comp Med. 2013 Aug;63(4):331-7.


Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association.

Brown AC, Balashova NV, Epand RM, Epand RF, Bragin A, Kachlany SC, Walters MJ, Du Y, Boesze-Battaglia K, Lally ET.

J Biol Chem. 2013 Aug 9;288(32):23607-21. doi: 10.1074/jbc.M113.486654. Epub 2013 Jun 21.


Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells.

Dietmann A, Millonig A, Combes V, Couraud PO, Kachlany SC, Grau GE.

Microb Pathog. 2013 Aug-Sep;61-62:43-50. doi: 10.1016/j.micpath.2013.05.001. Epub 2013 May 9.


Prophage induction in lysogenic Aggregatibacter actinomycetemcomitans cells co-cultured with human gingival fibroblasts, and its effect on leukotoxin release.

Stevens RH, de Moura Martins Lobo Dos Santos C, Zuanazzi D, de Accioly Mattos MB, Ferreira DF, Kachlany SC, Tinoco EM.

Microb Pathog. 2013 Jan;54:54-9. doi: 10.1016/j.micpath.2012.09.005. Epub 2012 Sep 27.


Genome sequence of Kingella kingae septic arthritis isolate PYKK081.

Kaplan JB, Lo C, Xie G, Johnson SL, Chain PS, Donnelly R, Kachlany SC, Balashova NV.

J Bacteriol. 2012 Jun;194(11):3017. doi: 10.1128/JB.00421-12.


Leukotoxin (Leukothera®) targets active leukocyte function antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway.

DiFranco KM, Gupta A, Galusha LE, Perez J, Nguyen TV, Fineza CD, Kachlany SC.

J Biol Chem. 2012 May 18;287(21):17618-27. doi: 10.1074/jbc.M111.314674. Epub 2012 Mar 30.


Gangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysis.

Forman MS, Nishikubo JB, Han RK, Le A, Balashova NV, Kachlany SC.

Toxins (Basel). 2010 Dec;2(12):2824-36. doi: 10.3390/toxins2122824. Epub 2010 Dec 14.


HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA).

Hioe CE, Tuen M, Vasiliver-Shamis G, Alvarez Y, Prins KC, Banerjee S, Nádas A, Cho MW, Dustin ML, Kachlany SC.

PLoS One. 2011;6(8):e23202. doi: 10.1371/journal.pone.0023202. Epub 2011 Aug 5.


In vitro synergism between LFA-1 targeting leukotoxin (Leukothera™) and standard chemotherapeutic agents in leukemia cells.

Gupta A, Le A, Belinka BA, Kachlany SC.

Leuk Res. 2011 Nov;35(11):1498-505. doi: 10.1016/j.leukres.2011.05.017. Epub 2011 Jun 12.


Resolution of psoriasis by a leukocyte-targeting bacterial protein in a humanized mouse model.

Stenderup K, Rosada C, Dam TN, Salerno E, Belinka BA, Kachlany SC.

J Invest Dermatol. 2011 Oct;131(10):2033-9. doi: 10.1038/jid.2011.161. Epub 2011 Jun 9.


Broad-spectrum biofilm inhibition by Kingella kingae exopolysaccharide.

Bendaoud M, Vinogradov E, Balashova NV, Kadouri DE, Kachlany SC, Kaplan JB.

J Bacteriol. 2011 Aug;193(15):3879-86. doi: 10.1128/JB.00311-11. Epub 2011 May 20.


Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells.

Maldonado R, Wei R, Kachlany SC, Kazi M, Balashova NV.

Microb Pathog. 2011 Jul-Aug;51(1-2):22-30. doi: 10.1016/j.micpath.2011.03.005. Epub 2011 Apr 2.


Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy.

Kachlany SC.

J Dent Res. 2010 Jun;89(6):561-70. doi: 10.1177/0022034510363682. Epub 2010 Mar 3. Review.


Significance of wall structure, macromolecular composition, and surface polymers to the survival and transport of Cryptosporidium parvum oocysts.

Jenkins MB, Eaglesham BS, Anthony LC, Kachlany SC, Bowman DD, Ghiorse WC.

Appl Environ Microbiol. 2010 Mar;76(6):1926-34. doi: 10.1128/AEM.02295-09. Epub 2010 Jan 22. Erratum in: Appl Environ Microbiol. 2010 Aug;76(15):5334.


Anti-leukemia activity of a bacterial toxin with natural specificity for LFA-1 on white blood cells.

Kachlany SC, Schwartz AB, Balashova NV, Hioe CE, Tuen M, Le A, Kaur M, Mei Y, Rao J.

Leuk Res. 2010 Jun;34(6):777-85. doi: 10.1016/j.leukres.2009.08.022. Epub 2009 Sep 10.


Aggregatibacter actinomycetemcomitans LtxC is required for leukotoxin activity and initial interaction between toxin and host cells.

Balashova NV, Shah C, Patel JK, Megalla S, Kachlany SC.

Gene. 2009 Aug 15;443(1-2):42-7. doi: 10.1016/j.gene.2009.05.002. Epub 2009 May 18.


Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing.

Venketaraman V, Lin AK, Le A, Kachlany SC, Connell ND, Kaplan JB.

Microb Pathog. 2008 Sep;45(3):173-80. doi: 10.1016/j.micpath.2008.05.007. Epub 2008 Jun 5.


Screen for leukotoxin mutants in Aggregatibacter actinomycetemcomitans: genes of the phosphotransferase system are required for leukotoxin biosynthesis.

Isaza MP, Duncan MS, Kaplan JB, Kachlany SC.

Infect Immun. 2008 Aug;76(8):3561-8. doi: 10.1128/IAI.01687-07. Epub 2008 Jun 9.


A bioluminescent HL-60 cell line to assay anti-leukaemia therapeutics under physiological conditions.

Isaza MP, Chau JT, Le A, Balashova NV, Patel JK, Salerno E, Crosby JA, O'Connor A, Kachlany SC.

Luminescence. 2008 Jan-Feb;23(1):17-21. doi: 10.1002/bio.1010.


Interaction between leukotoxin and Cu,Zn superoxide dismutase in Aggregatibacter actinomycetemcomitans.

Balashova NV, Park DH, Patel JK, Figurski DH, Kachlany SC.

Infect Immun. 2007 Sep;75(9):4490-7. Epub 2007 Jul 16.


Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin.

Dileepan T, Kachlany SC, Balashova NV, Patel J, Maheswaran SK.

Infect Immun. 2007 Oct;75(10):4851-6. Epub 2007 Jul 16.


Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron.

Balashova NV, Diaz R, Balashov SV, Crosby JA, Kachlany SC.

J Bacteriol. 2006 Dec;188(24):8658-61. Epub 2006 Oct 13.


How we got attached to Actinobacillus actinomycetemcomitans: A model for infectious diseases.

Fine DH, Kaplan JB, Kachlany SC, Schreiner HC.

Periodontol 2000. 2006;42:114-57. Review. No abstract available.


Genetic analysis of the requirement for flp-2, tadV, and rcpB in Actinobacillus actinomycetemcomitans biofilm formation.

Perez BA, Planet PJ, Kachlany SC, Tomich M, Fine DH, Figurski DH.

J Bacteriol. 2006 Sep;188(17):6361-75.


Leukotoxin confers beta-hemolytic activity to Actinobacillus actinomycetemcomitans.

Balashova NV, Crosby JA, Al Ghofaily L, Kachlany SC.

Infect Immun. 2006 Apr;74(4):2015-21.


Characterization of leukotoxin from a clinical strain of Actinobacillus actinomycetemcomitans.

Diaz R, Ghofaily LA, Patel J, Balashova NV, Freitas AC, Labib I, Kachlany SC.

Microb Pathog. 2006 Feb;40(2):48-55. Epub 2006 Jan 18.


Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model.

Schreiner HC, Sinatra K, Kaplan JB, Furgang D, Kachlany SC, Planet PJ, Perez BA, Figurski DH, Fine DH.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7295-300. Epub 2003 May 19.


The Widespread Colonization Island of Actinobacillus actinomycetemcomitans.

Planet PJ, Kachlany SC, Fine DH, DeSalle R, Figurski DH.

Nat Genet. 2003 Jun;34(2):193-8.


Purification of secreted leukotoxin (LtxA) from Actinobacillus actinomycetemcomitans.

Kachlany SC, Fine DH, Figurski DH.

Protein Expr Purif. 2002 Aug;25(3):465-71.


Structure and carbohydrate analysis of the exopolysaccharide capsule of Pseudomonas putida G7.

Kachlany SC, Levery SB, Kim JS, Reuhs BL, Lion LW, Ghiorse WC.

Environ Microbiol. 2001 Dec;3(12):774-84.


Nonspecific adherence and fibril biogenesis by Actinobacillus actinomycetemcomitans: TadA protein is an ATPase.

Bhattacharjee MK, Kachlany SC, Fine DH, Figurski DH.

J Bacteriol. 2001 Oct;183(20):5927-36.


Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum.

Kachlany SC, Planet PJ, DeSalle R, Fine DH, Figurski DH.

Trends Microbiol. 2001 Sep;9(9):429-37. Review.


flp-1, the first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans.

Kachlany SC, Planet PJ, Desalle R, Fine DH, Figurski DH, Kaplan JB.

Mol Microbiol. 2001 May;40(3):542-54.


Secretion of RTX leukotoxin by Actinobacillus actinomycetemcomitans.

Kachlany SC, Fine DH, Figurski DH.

Infect Immun. 2000 Nov;68(11):6094-100.


Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea.

Kachlany SC, Planet PJ, Bhattacharjee MK, Kollia E, DeSalle R, Fine DH, Figurski DH.

J Bacteriol. 2000 Nov;182(21):6169-76.

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