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Items: 18


Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.

Szakács G, Hall MD, Gottesman MM, Boumendjel A, Kachadourian R, Day BJ, Baubichon-Cortay H, Di Pietro A.

Chem Rev. 2014 Jun 11;114(11):5753-74. doi: 10.1021/cr4006236. Epub 2014 Apr 23. Review. No abstract available.


Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.

Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day BJ, Winnischofer SM, Rocha ME, Frachet V, Ronot X, Di Pietro A, Boumendjel A.

J Med Chem. 2012 Apr 12;55(7):3193-200. doi: 10.1021/jm2016528. Epub 2012 Apr 2.


A synthetic chalcone as a potent inducer of glutathione biosynthesis.

Kachadourian R, Day BJ, Pugazhenti S, Franklin CC, Genoux-Bastide E, Mahaffey G, Gauthier C, Di Pietro A, Boumendjel A.

J Med Chem. 2012 Feb 9;55(3):1382-8. doi: 10.1021/jm2016073. Epub 2012 Jan 30.


Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione.

Brechbuhl HM, Kachadourian R, Min E, Chan D, Day BJ.

Toxicol Appl Pharmacol. 2012 Jan 1;258(1):1-9. doi: 10.1016/j.taap.2011.08.004. Epub 2011 Aug 10.


2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BJ.

Free Radic Biol Med. 2011 Sep 15;51(6):1146-54. doi: 10.1016/j.freeradbiomed.2011.05.041. Epub 2011 Jun 13.


Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2.

Brechbuhl HM, Gould N, Kachadourian R, Riekhof WR, Voelker DR, Day BJ.

J Biol Chem. 2010 May 28;285(22):16582-7. doi: 10.1074/jbc.M109.090506. Epub 2010 Mar 23.


Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells.

Kachadourian R, Brechbuhl HM, Ruiz-Azuara L, Gracia-Mora I, Day BJ.

Toxicology. 2010 Feb 9;268(3):176-83. doi: 10.1016/j.tox.2009.12.010. Epub 2009 Dec 23.


Harnessing drug resistance: using ABC transporter proteins to target cancer cells.

Leitner HM, Kachadourian R, Day BJ.

Biochem Pharmacol. 2007 Dec 15;74(12):1677-85. Epub 2007 May 21.


Flavonoid-induced glutathione depletion: potential implications for cancer treatment.

Kachadourian R, Day BJ.

Free Radic Biol Med. 2006 Jul 1;41(1):65-76. Epub 2006 Mar 31.


Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice.

Velsor LW, Kariya C, Kachadourian R, Day BJ.

Am J Respir Cell Mol Biol. 2006 Nov;35(5):579-86. Epub 2006 Jun 8.


Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins.

Kachadourian R, Johnson CA, Min E, Spasojevic I, Day BJ.

Biochem Pharmacol. 2004 Jan 1;67(1):77-85.


Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin.

Kachadourian R, Flaherty MM, Crumbliss AL, Patel M, Day BJ.

J Inorg Biochem. 2003 Jul 1;95(4):240-8.


In vitro pro- and antioxidant properties of estrogens.

Thibodeau PA, Kachadourian R, Lemay R, Bisson M, Day BJ, Paquette B.

J Steroid Biochem Mol Biol. 2002 Jul;81(3):227-36.


High-performance liquid chromatography with spectrophotometric and electrochemical detection of a series of manganese(III) cationic porphyrins.

Kachadourian R, Menzeleev R, Agha B, Bocckino SB, Day BJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 5;767(1):61-7.


A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone.

Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K.

Diabetes. 2002 Feb;51(2):347-55.


2-methoxyestradiol does not inhibit superoxide dismutase.

Kachadourian R, Liochev SI, Cabelli DE, Patel MN, Fridovich I, Day BJ.

Arch Biochem Biophys. 2001 Aug 15;392(2):349-53.


Desferrioxamine-dependent iron transport in Erwinia amylovora CFBP1430: cloning of the gene encoding the ferrioxamine receptor FoxR.

Kachadourian R, Dellagi A, Laurent J, Bricard L, Kunesch G, Expert D.

Biometals. 1996 Apr;9(2):143-50.


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