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Human Mast Cell Sensitization with IgE Increases miRNA-210 Expression.

Just J, Munk Ipsen P, Kruhøffer M, Lykkemark S, Skjold T, Schiøtz PO, Hoffmann HJ.

Int Arch Allergy Immunol. 2019;179(2):102-107. doi: 10.1159/000496513. Epub 2019 Apr 9.


Biomarkers for monitoring pre-analytical quality variation of mRNA in blood samples.

Zhang H, Korenková V, Sjöback R, Švec D, Björkman J, Kruhøffer M, Verderio P, Pizzamiglio S, Ciniselli CM, Wyrich R, Oelmueller U, Kubista M, Lindahl T, Lönneborg A, Rian E.

PLoS One. 2014 Nov 4;9(11):e111644. doi: 10.1371/journal.pone.0111644. eCollection 2014.


miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan.

Schou JV, Rossi S, Jensen BV, Nielsen DL, Pfeiffer P, Høgdall E, Yilmaz M, Tejpar S, Delorenzi M, Kruhøffer M, Johansen JS.

PLoS One. 2014 Jun 18;9(6):e99886. doi: 10.1371/journal.pone.0099886. eCollection 2014.


Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue.

Hedegaard J, Thorsen K, Lund MK, Hein AM, Hamilton-Dutoit SJ, Vang S, Nordentoft I, Birkenkamp-Demtröder K, Kruhøffer M, Hager H, Knudsen B, Andersen CL, Sørensen KD, Pedersen JS, Ørntoft TF, Dyrskjøt L.

PLoS One. 2014 May 30;9(5):e98187. doi: 10.1371/journal.pone.0098187. eCollection 2014.


Data resource profile: the Aarhus birth cohort biobank (ABC biobank).

Mortensen LM, Bech BH, Nohr EA, Kruhøffer M, Kjærgaard S, Uldbjerg N, Olsen J, Henriksen TB.

Int J Epidemiol. 2013 Dec;42(6):1697-701. doi: 10.1093/ije/dyt199.


DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.

Pedersen JM, Fredsoe J, Roedgaard M, Andreasen L, Mundbjerg K, Kruhøffer M, Brinch M, Schierup MH, Bjergbaek L, Andersen AH.

PLoS Genet. 2012;8(12):e1003128. doi: 10.1371/journal.pgen.1003128. Epub 2012 Dec 20.


Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas.

Schultz NA, Roslind A, Christensen IJ, Horn T, Høgdall E, Pedersen LN, Kruhøffer M, Burcharth F, Wøjdemann M, Johansen JS.

Pancreas. 2012 Jul;41(5):759-66. doi: 10.1097/MPA.0b013e31823cd9df.


Ischemic pre- and postconditioning has pronounced effects on gene expression profiles in the rat liver after ischemia/reperfusion.

Knudsen AR, Kannerup AS, Dich R, Funch-Jensen P, Grønbaek H, Kruhøffer M, Mortensen FV.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G482-9. doi: 10.1152/ajpgi.00337.2011. Epub 2012 Jun 7.


Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer.

Bertini I, Cacciatore S, Jensen BV, Schou JV, Johansen JS, Kruhøffer M, Luchinat C, Nielsen DL, Turano P.

Cancer Res. 2012 Jan 1;72(1):356-64. doi: 10.1158/0008-5472.CAN-11-1543. Epub 2011 Nov 11.


Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.

Liaset B, Hao Q, Jørgensen H, Hallenborg P, Du ZY, Ma T, Marschall HU, Kruhøffer M, Li R, Li Q, Yde CC, Criales G, Bertram HC, Mellgren G, Ofjord ES, Lock EJ, Espe M, Frøyland L, Madsen L, Kristiansen K.

J Biol Chem. 2011 Aug 12;286(32):28382-95. doi: 10.1074/jbc.M111.234732. Epub 2011 Jun 16.


Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.

Baandrup JD, Markvardsen LH, Peters CD, Schou UK, Jensen JL, Magnusson NE, Ørntoft TF, Kruhøffer M, Simonsen U.

PLoS One. 2011 Jan 5;6(1):e15859. doi: 10.1371/journal.pone.0015859.


Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.

Neess D, Bloksgaard M, Bek S, Marcher AB, Elle IC, Helledie T, Due M, Pagmantidis V, Finsen B, Wilbertz J, Kruhøffer M, Færgeman N, Mandrup S.

J Biol Chem. 2011 Feb 4;286(5):3460-72. doi: 10.1074/jbc.M110.161109. Epub 2010 Nov 24.


Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males.

Marteau JB, Rigaud O, Brugat T, Gault N, Vallat L, Kruhoffer M, Orntoft TF, Nguyen-Khac F, Chevillard S, Merle-Beral H, Delic J.

BMC Med Genomics. 2010 Nov 10;3:53. doi: 10.1186/1755-8794-3-53.


Expression of genes involved in rat liver angiogenesis after ischaemia and reperfusion: effects of ischaemic pre- and post-conditioning.

Knudsen AR, Kannerup AS, Dich R, Kruhøffer M, Funch-Jensen P, Grønbaek H, Mortensen FV.

HPB (Oxford). 2010 Oct;12(8):554-60. doi: 10.1111/j.1477-2574.2010.00215.x.


1Identification of genes differentially expressed in the embryonic pig cerebral cortex before and after appearance of gyration.

Nielsen KB, Kruhøffer M, Holm IE, Jørgensen AL, Nielsen AL.

BMC Res Notes. 2010 May 5;3:127. doi: 10.1186/1756-0500-3-127.


Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.

Jorissen RN, Gibbs P, Christie M, Prakash S, Lipton L, Desai J, Kerr D, Aaltonen LA, Arango D, Kruhøffer M, Orntoft TF, Andersen CL, Gruidl M, Kamath VP, Eschrich S, Yeatman TJ, Sieber OM.

Clin Cancer Res. 2009 Dec 15;15(24):7642-7651.


IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes.

Berchtold LA, Larsen CM, Vaag A, Faulenbach M, Workman CT, Kruhøffer M, Donath M, Mandrup-Poulsen T.

Eur Cytokine Netw. 2009 Jun;20(2):81-7. doi: 10.1684/ecn.2009.0152.


Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.

Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sørensen FB, Verspaget HW, Simon R, Kruhøffer M, Aaltonen LA, Laurberg S, Ørntoft TF.

Br J Cancer. 2009 Feb 10;100(3):511-23. doi: 10.1038/sj.bjc.6604884. Epub 2009 Jan 20.


Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression.

Jensen SA, Vainer B, Kruhøffer M, Sørensen JB.

BMC Cancer. 2009 Jan 20;9:25. doi: 10.1186/1471-2407-9-25.


DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.

Jorissen RN, Lipton L, Gibbs P, Chapman M, Desai J, Jones IT, Yeatman TJ, East P, Tomlinson IP, Verspaget HW, Aaltonen LA, Kruhøffer M, Orntoft TF, Andersen CL, Sieber OM.

Clin Cancer Res. 2008 Dec 15;14(24):8061-9. doi: 10.1158/1078-0432.CCR-08-1431.


Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.

Mansilla F, da Costa KA, Wang S, Kruhøffer M, Lewin TM, Orntoft TF, Coleman RA, Birkenkamp-Demtröder K.

J Mol Med (Berl). 2009 Jan;87(1):85-97. doi: 10.1007/s00109-008-0409-0. Epub 2008 Oct 31.


Diagnostic and prognostic microRNAs in stage II colon cancer.

Schepeler T, Reinert JT, Ostenfeld MS, Christensen LL, Silahtaroglu AN, Dyrskjøt L, Wiuf C, Sørensen FJ, Kruhøffer M, Laurberg S, Kauppinen S, Ørntoft TF, Andersen CL.

Cancer Res. 2008 Aug 1;68(15):6416-24. doi: 10.1158/0008-5472.CAN-07-6110.


Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy.

Strøm CC, Kruhøffer M, Knudsen S, Stensgaard-Hansen F, Jonassen TE, Orntoft TF, Haunsø S, Sheikh SP.

Comp Funct Genomics. 2004;5(6-7):459-70. doi: 10.1002/cfg.428.


The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.

Bross P, Naundrup S, Hansen J, Nielsen MN, Christensen JH, Kruhøffer M, Palmfeldt J, Corydon TJ, Gregersen N, Ang D, Georgopoulos C, Nielsen KL.

J Biol Chem. 2008 Jun 6;283(23):15694-700. doi: 10.1074/jbc.M800548200. Epub 2008 Apr 8.


Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.

Thorsen K, Sørensen KD, Brems-Eskildsen AS, Modin C, Gaustadnes M, Hein AM, Kruhøffer M, Laurberg S, Borre M, Wang K, Brunak S, Krainer AR, Tørring N, Dyrskjøt L, Andersen CL, Orntoft TF.

Mol Cell Proteomics. 2008 Jul;7(7):1214-24. doi: 10.1074/mcp.M700590-MCP200. Epub 2008 Mar 18.


The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation.

Reusens B, Sparre T, Kalbe L, Bouckenooghe T, Theys N, Kruhøffer M, Orntoft TF, Nerup J, Remacle C.

Diabetologia. 2008 May;51(5):836-45. doi: 10.1007/s00125-008-0956-5. Epub 2008 Mar 3.


Adaptive differences in gene expression in European flounder (Platichthys flesus).

Larsen PF, Nielsen EE, Williams TD, Hemmer-Hansen J, Chipman JK, Kruhøffer M, Grønkjaer P, George SG, Dyrskjøt L, Loeschcke V.

Mol Ecol. 2007 Nov;16(22):4674-83. Epub 2007 Oct 8.


The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.

De Martino I, Visone R, Palmieri D, Cappabianca P, Chieffi P, Forzati F, Barbieri A, Kruhoffer M, Lombardi G, Fusco A, Fedele M.

Endocr Relat Cancer. 2007 Sep;14(3):875-86.


Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.

Niemelä AM, Hynninen P, Mecklin JP, Kuopio T, Kokko A, Aaltonen L, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Orntoft TF, Kruhøffer M, Haapasalo H, Parkkila S, Kivelä AJ.

Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6.


Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.

Birkenkamp-Demtroder K, Mansilla F, Sørensen FB, Kruhøffer M, Cabezón T, Christensen LL, Aaltonen LA, Verspaget HW, Ørntoft TF.

Mol Oncol. 2007 Sep;1(2):181-95. doi: 10.1016/j.molonc.2007.05.005. Epub 2007 Jun 3.


Isolation of microarray-grade total RNA, microRNA, and DNA from a single PAXgene blood RNA tube.

Kruhøffer M, Dyrskjøt L, Voss T, Lindberg RL, Wyrich R, Thykjaer T, Orntoft TF.

J Mol Diagn. 2007 Sep;9(4):452-8. Epub 2007 Aug 9.


Transcriptional profile of Ki-Ras-induced transformation of thyroid cells.

Visconti R, Federico A, Coppola V, Pentimalli F, Berlingieri MT, Pallante P, Kruhoffer M, Orntoft TF, Fusco A.

Cancer Invest. 2007 Jun;25(4):256-66.


Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups.

Mansilla F, Birkenkamp-Demtroder K, Kruhøffer M, Sørensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW, Orntoft TF.

Br J Cancer. 2007 Jun 18;96(12):1896-903. Epub 2007 May 22.


Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.

Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhøffer M, Orntoft T, Wang H, Wollheim CB, Nerup J, Pociot F.

Genes Immun. 2007 Apr;8(3):232-8. Epub 2007 Mar 1.


Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance.

Nielsen MM, Sørensen JG, Kruhøffer M, Justesen J, Loeschcke V.

Cell Stress Chaperones. 2006 Winter;11(4):325-33.


Frequent occurrence of uniparental disomy in colorectal cancer.

Andersen CL, Wiuf C, Kruhøffer M, Korsgaard M, Laurberg S, Ørntoft TF.

Carcinogenesis. 2007 Jan;28(1):38-48. Epub 2006 Jun 13.


Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes.

Ebbesen LS, Olesen SH, Kruhøffer M, Ingerslev J, Ørntoft TF.

Blood Coagul Fibrinolysis. 2006 Jun;17(4):293-301.


Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster.

Kristensen TN, Sørensen P, Pedersen KS, Kruhøffer M, Loeschcke V.

Genetics. 2006 Jul;173(3):1329-36. Epub 2006 Apr 19.


Identification of tryptase- and chymase-related gene clusters in human mast cells using microarrays.

Dahl C, Saito H, Kruhøffer M, Schiøtz PO.

Allergy. 2006 Mar;61(3):276-80.


Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis.

Magnusson NE, Cardozo AK, Kruhøffer M, Eizirik DL, Ørntoft TF, Jensen JL.

BMC Bioinformatics. 2005 Dec 29;6:311.


Full genome gene expression analysis of the heat stress response in Drosophila melanogaster.

Sørensen JG, Nielsen MM, Kruhøffer M, Justesen J, Loeschcke V.

Cell Stress Chaperones. 2005 Winter;10(4):312-28.


Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.

Vanharanta S, Pollard PJ, Lehtonen HJ, Laiho P, Sjöberg J, Leminen A, Aittomäki K, Arola J, Kruhoffer M, Orntoft TF, Tomlinson IP, Kiuru M, Arango D, Aaltonen LA.

Hum Mol Genet. 2006 Jan 1;15(1):97-103. Epub 2005 Nov 30.


UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.

Pallante P, Berlingieri MT, Troncone G, Kruhoffer M, Orntoft TF, Viglietto G, Caleo A, Migliaccio I, Decaussin-Petrucci M, Santoro M, Palombini L, Fusco A.

Br J Cancer. 2005 Aug 22;93(4):464-71.


Gene expression signatures for colorectal cancer microsatellite status and HNPCC.

Kruhøffer M, Jensen JL, Laiho P, Dyrskjøt L, Salovaara R, Arango D, Birkenkamp-Demtroder K, Sørensen FB, Christensen LL, Buhl L, Mecklin JP, Järvinen H, Thykjaer T, Wikman FP, Bech-Knudsen F, Juhola M, Nupponen NN, Laurberg S, Andersen CL, Aaltonen LA, Ørntoft TF.

Br J Cancer. 2005 Jun 20;92(12):2240-8.


Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster.

Kristensen TN, Sørensen P, Kruhøffer M, Pedersen KS, Loeschcke V.

Genetics. 2005 Sep;171(1):157-67. Epub 2005 Jun 8.


A molecular signature in superficial bladder carcinoma predicts clinical outcome.

Dyrskjøt L, Zieger K, Kruhøffer M, Thykjaer T, Jensen JL, Primdahl H, Aziz N, Marcussen N, Møller K, Orntoft TF.

Clin Cancer Res. 2005 Jun 1;11(11):4029-36.


Gene expression changes induced by bismuth in a macrophage cell line.

Magnusson NE, Larsen A, Rungby J, Kruhøffer M, Orntoft TF, Stoltenberg M.

Cell Tissue Res. 2005 Aug;321(2):195-210. Epub 2005 May 24.


Molecular staging for survival prediction of colorectal cancer patients.

Eschrich S, Yang I, Bloom G, Kwong KY, Boulware D, Cantor A, Coppola D, Kruhøffer M, Aaltonen L, Orntoft TF, Quackenbush J, Yeatman TJ.

J Clin Oncol. 2005 May 20;23(15):3526-35.


Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation.

Kalbe L, Leunda A, Sparre T, Meulemans C, Ahn MT, Orntoft T, Kruhoffer M, Reusens B, Nerup J, Remacle C.

Br J Nutr. 2005 Mar;93(3):309-16.


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