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Items: 1 to 50 of 101

1.

AsthmaMap: An expert-driven computational representation of disease mechanisms.

Mazein A, Knowles RG, Adcock I, Chung KF, Wheelock CE, Maitland-van der Zee AH, Sterk PJ, Auffray C; AsthmaMap Project Team.

Clin Exp Allergy. 2018 Aug;48(8):916-918. doi: 10.1111/cea.13211. No abstract available.

PMID:
30133857
2.

Translational models of lung disease.

Mercer PF, Abbott-Banner K, Adcock IM, Knowles RG.

Clin Sci (Lond). 2015 Feb;128(4):235-56. doi: 10.1042/CS20140373. Review.

PMID:
25328010
3.

Development of anti-inflammatory drugs - the research and development process.

Knowles RG.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):7-12. doi: 10.1111/bcpt.12130. Epub 2013 Sep 18. Review.

4.

In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action.

Slack RJ, Barrett VJ, Morrison VS, Sturton RG, Emmons AJ, Ford AJ, Knowles RG.

J Pharmacol Exp Ther. 2013 Jan;344(1):218-30. doi: 10.1124/jpet.112.198481. Epub 2012 Nov 6.

PMID:
23131596
5.

A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma.

Evans RL, Nials AT, Knowles RG, Kidd EJ, Ford WR, Broadley KJ.

Pulm Pharmacol Ther. 2012 Dec;25(6):453-64. doi: 10.1016/j.pupt.2012.08.004. Epub 2012 Aug 23.

PMID:
23046662
6.

Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

Young RJ, Alderton W, Angell AD, Beswick PJ, Brown D, Chambers CL, Crowe MC, Dawson J, Hamlett CC, Hodgson ST, Kleanthous S, Knowles RG, Russell LJ, Stocker R, Woolven JM.

Bioorg Med Chem Lett. 2011 May 15;21(10):3037-40. doi: 10.1016/j.bmcl.2011.03.038. Epub 2011 Mar 21.

PMID:
21482467
7.
8.

In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor.

Nials AT, Tralau-Stewart CJ, Gascoigne MH, Ball DI, Ranshaw LE, Knowles RG.

J Pharmacol Exp Ther. 2011 Apr;337(1):137-44. doi: 10.1124/jpet.110.173641. Epub 2011 Jan 4.

PMID:
21205924
9.

GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization.

Tralau-Stewart CJ, Williamson RA, Nials AT, Gascoigne M, Dawson J, Hart GJ, Angell AD, Solanke YE, Lucas FS, Wiseman J, Ward P, Ranshaw LE, Knowles RG.

J Pharmacol Exp Ther. 2011 Apr;337(1):145-54. doi: 10.1124/jpet.110.173690. Epub 2011 Jan 4.

PMID:
21205923
10.

House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?

De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA.

Eur Respir J. 2010 Jun;35(6):1377-87. doi: 10.1183/09031936.00022908. Epub 2009 Oct 19.

11.

The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

Davis TG, Peterson JJ, Kou JP, Capper-Spudich EA, Ball D, Nials AT, Wiseman J, Solanke YE, Lucas FS, Williamson RA, Ferrari L, Wren P, Knowles RG, Barnette MS, Podolin PL.

J Pharmacol Exp Ther. 2009 Sep;330(3):922-31. doi: 10.1124/jpet.109.152454. Epub 2009 Jun 4.

PMID:
19498103
13.

The role of nitric oxide in osteoarthritis.

Vuolteenaho K, Moilanen T, Knowles RG, Moilanen E.

Scand J Rheumatol. 2007 Jul-Aug;36(4):247-58. Review.

PMID:
17853003
14.

Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma.

Singh D, Richards D, Knowles RG, Schwartz S, Woodcock A, Langley S, O'Connor BJ.

Am J Respir Crit Care Med. 2007 Nov 15;176(10):988-93. Epub 2007 Aug 23.

PMID:
17717202
15.

y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages.

Baydoun AR, Bertran J, Thakur S, Dawson J, Palacín M, Knowles RG.

Amino Acids. 2006 Sep;31(2):101-9. Epub 2006 May 15.

PMID:
16699825
16.

GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.

De Alba J, Clayton NM, Collins SD, Colthup P, Chessell I, Knowles RG.

Pain. 2006 Jan;120(1-2):170-81. Epub 2005 Dec 19.

PMID:
16360270
17.

GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.

Alderton WK, Angell AD, Craig C, Dawson J, Garvey E, Moncada S, Monkhouse J, Rees D, Russell LJ, Russell RJ, Schwartz S, Waslidge N, Knowles RG.

Br J Pharmacol. 2005 Jun;145(3):301-12.

18.

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD.

Mol Pharmacol. 2005 Jun;67(6):1920-34. Epub 2005 Feb 28.

PMID:
15738310
19.

Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia.

Pérez-Asensio FJ, Hurtado O, Burguete MC, Moro MA, Salom JB, Lizasoain I, Torregrosa G, Leza JC, Alborch E, Castillo J, Knowles RG, Lorenzo P.

Neurobiol Dis. 2005 Mar;18(2):375-84.

PMID:
15686966
20.

Inducible nitric oxide synthase is involved in the mechanisms of cocaine enhanced neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat.

Bagetta G, Piccirilli S, Del Duca C, Morrone LA, Rombolà L, Nappi G, De Alba J, Knowles RG, Corasaniti MT.

Neurosci Lett. 2004 Feb 19;356(3):183-6.

PMID:
15036625
21.

Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.

McCarthy LC, Hosford DA, Riley JH, Bird MI, White NJ, Hewett DR, Peroutka SJ, Griffiths LR, Boyd PR, Lea RA, Bhatti SM, Hosking LK, Hood CM, Jones KW, Handley AR, Rallan R, Lewis KF, Yeo AJ, Williams PM, Priest RC, Khan P, Donnelly C, Lumsden SM, O'Sullivan J, See CG, Smart DH, Shaw-Hawkins S, Patel J, Langrish TC, Feniuk W, Knowles RG, Thomas M, Libri V, Montgomery DS, Manasco PK, Xu CF, Dykes C, Humphrey PP, Roses AD, Purvis IJ.

Genomics. 2001 Dec;78(3):135-49. Erratum in: Genomics 2002 Feb;79(2):271.

PMID:
11735220
22.

Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage.

Vuolteenaho K, Moilanen T, Al-Saffar N, Knowles RG, Moilanen E.

Osteoarthritis Cartilage. 2001 Oct;9(7):597-605.

23.

Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine.

Kankuri E, Vaali K, Knowles RG, Lähde M, Korpela R, Vapaatalo H, Moilanen E.

J Pharmacol Exp Ther. 2001 Sep;298(3):1128-32.

PMID:
11504810
24.

Nitric oxide synthases: structure, function and inhibition.

Alderton WK, Cooper CE, Knowles RG.

Biochem J. 2001 Aug 1;357(Pt 3):593-615. Review.

26.

A microtiter-plate assay of human NOS isoforms.

Dawson J, Knowles RG.

Methods Mol Biol. 1998;100:237-42. No abstract available.

PMID:
10907009
27.

Measurement of NOS activity by conversion of radiolabeled arginine to citrulline using ion-exchange separation.

Knowles RG, Salter M.

Methods Mol Biol. 1998;100:67-73. No abstract available.

PMID:
10906994
28.

Assay of NOS activity by the measurement of conversion of oxyhemoglobin to methemoglobin by NO.

Salter M, Knowles RG.

Methods Mol Biol. 1998;100:61-5. No abstract available.

PMID:
10906993
29.

Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.

Young RJ, Beams RM, Carter K, Clark HA, Coe DM, Chambers CL, Davies PI, Dawson J, Drysdale MJ, Franzman KW, French C, Hodgson ST, Hodson HF, Kleanthous S, Rider P, Sanders D, Sawyer DA, Scott KJ, Shearer BG, Stocker R, Smith S, Tackley MC, Knowles RG.

Bioorg Med Chem Lett. 2000 Mar 20;10(6):597-600.

PMID:
10741561
30.

A microtiter-plate assay of nitric oxide synthase activity.

Dawson J, Knowles RG.

Mol Biotechnol. 1999 Oct;12(3):275-9.

PMID:
10631684
32.

Factors affecting the DNA damaging activity of superoxide and nitric oxide.

Thomas S, Lowe JE, Knowles RG, Green IC, Green MH.

Mutat Res. 1998 Jun 18;402(1-2):77-84. Review.

PMID:
9675248
33.

Use of the Comet assay to investigate the role of superoxide in glutathione-induced DNA damage.

Thomas S, Lowe JE, Hadjivassiliou V, Knowles RG, Green IC, Green MH.

Biochem Biophys Res Commun. 1998 Feb 4;243(1):241-5.

PMID:
9473511
34.

Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid.

Moilanen E, Thomsen LL, Miles DW, Happerfield DW, Knowles RG, Moncada S.

Br J Cancer. 1998;77(3):426-33.

35.

Nitric oxide biochemistry.

Knowles RG.

Biochem Soc Trans. 1997 Aug;25(3):895-901. Review. No abstract available.

PMID:
9388568
36.

Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.

Thomsen LL, Scott JM, Topley P, Knowles RG, Keerie AJ, Frend AJ.

Cancer Res. 1997 Aug 1;57(15):3300-4.

38.

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo.

Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG.

J Biol Chem. 1997 Feb 21;272(8):4959-63.

39.

Metabolic control analysis of purine biosynthesis from serine in Molt-4 cells.

Bolton MC, Knowles RG, Salter M, Pogson CI, Snell K.

Biochem Soc Trans. 1996 Aug;24(3):483S. No abstract available.

PMID:
8879027
40.

Nitric oxide synthases.

Knowles RG.

Biochem Soc Trans. 1996 Aug;24(3):875-8. Review. No abstract available.

PMID:
8878865
41.

The ontogeny of cerebral and cerebellar nitric oxide synthase in the guinea pig and rat.

Lizasoain I, Weiner CP, Knowles RG, Moncada S.

Pediatr Res. 1996 May;39(5):779-83.

PMID:
8726228
42.

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.

Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, Moncada S.

Biochem J. 1996 Mar 15;314 ( Pt 3):877-80.

43.

Myometrial arginase activity increases with advancing pregnancy in the guinea pig.

Weiner CP, Knowles RG, Stegink LD, Dawson J, Moncada S.

Am J Obstet Gynecol. 1996 Feb;174(2):779-82.

PMID:
8623821
44.

Expression of human nitric oxide synthase isozymes.

Charles IG, Scorer CA, Moro MA, Fernàndez C, Chubb A, Dawson J, Foxwell N, Knowles RG, Baylis SA.

Methods Enzymol. 1996;268:449-60. No abstract available.

PMID:
8782611
45.

Mechanism of inhibition of hepatic gluconeogenesis by bacterial endotoxin: a role for nitric oxide?

Titheradge MA, Knowles RG, Smith FS, Horton RA, Ceppi ED.

Biochem Soc Trans. 1995 Nov;23(4):1002-8. No abstract available.

PMID:
8654670
46.

The formation of nitric oxide donors from peroxynitrite.

Moro MA, Darley-Usmar VM, Lizasoain I, Su Y, Knowles RG, Radomski MW, Moncada S.

Br J Pharmacol. 1995 Oct;116(3):1999-2004.

47.

Nitric oxide synthase activity in human breast cancer.

Thomsen LL, Miles DW, Happerfield L, Bobrow LG, Knowles RG, Moncada S.

Br J Cancer. 1995 Jul;72(1):41-4.

48.

Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis and gluconeogenesis.

Horton RA, Knowles RG, Titheradge MA.

Biochem Soc Trans. 1995 May;23(2):322S. No abstract available.

PMID:
7545614
49.

Inhibition by lamotrigine of the generation of nitric oxide in rat forebrain slices.

Lizasoain I, Knowles RG, Moncada S.

J Neurochem. 1995 Feb;64(2):636-42.

PMID:
7830056
50.

The role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-gamma in vivo.

Burke F, Knowles RG, East N, Balkwill FR.

Int J Cancer. 1995 Jan 3;60(1):115-22.

PMID:
7814143

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