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Items: 1 to 50 of 270

1.

The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance.

Wedel J, Nakayama H, Kochupurakkal NM, Koch J, Klagsbrun M, Bielenberg DR, Briscoe DM.

Curr Opin Organ Transplant. 2017 Feb;22(1):55-63. doi: 10.1097/MOT.0000000000000373. Review.

2.

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.

Mucka P, Levonyak N, Geretti E, Zwaans BMM, Li X, Adini I, Klagsbrun M, Adam RM, Bielenberg DR.

Am J Pathol. 2016 Nov;186(11):2803-2812. doi: 10.1016/j.ajpath.2016.07.022. Epub 2016 Oct 14.

3.

Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo.

Boneschansker L, Nakayama H, Eisenga M, Wedel J, Klagsbrun M, Irimia D, Briscoe DM.

J Immunol. 2016 Aug 15;197(4):1389-98. doi: 10.4049/jimmunol.1502432. Epub 2016 Jul 18.

4.

Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus.

Shim JW, Sandlund J, Hameed MQ, Blazer-Yost B, Zhou FC, Klagsbrun M, Madsen JR.

Sci Rep. 2016 May 31;6:26794. doi: 10.1038/srep26794.

5.

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.

Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK.

Biol Open. 2015 Jul 24;4(9):1063-76. doi: 10.1242/bio.010918.

6.

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.

Nakayama H, Bruneau S, Kochupurakkal N, Coma S, Briscoe DM, Klagsbrun M.

Sci Rep. 2015 Jul 9;5:11789. doi: 10.1038/srep11789.

7.

Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.

Nakayama H, Huang L, Kelly RP, Oudenaarden CR, Dagher A, Hofmann NA, Moses MA, Bischoff J, Klagsbrun M.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):126-32. doi: 10.1016/j.bbrc.2015.06.087. Epub 2015 Jun 15.

8.

The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis.

Hofmann NA, Yang J, Trauger SA, Nakayama H, Huang L, Strunk D, Moses MA, Klagsbrun M, Bischoff J, Graier WF.

Br J Pharmacol. 2015 Aug;172(16):4107-18. doi: 10.1111/bph.13196. Epub 2015 Jun 26.

9.

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.

Adapala RK, Thoppil RJ, Ghosh K, Cappelli HC, Dudley AC, Paruchuri S, Keshamouni V, Klagsbrun M, Meszaros JG, Chilian WM, Ingber DE, Thodeti CK.

Oncogene. 2016 Jan 21;35(3):314-22. doi: 10.1038/onc.2015.83. Epub 2015 Apr 13.

10.

AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.

Boscolo E, Coma S, Luks VL, Greene AK, Klagsbrun M, Warman ML, Bischoff J.

Angiogenesis. 2015 Apr;18(2):151-62. doi: 10.1007/s10456-014-9453-2. Epub 2014 Nov 26.

11.

Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells.

Huang L, Nakayama H, Klagsbrun M, Mulliken JB, Bischoff J.

Stem Cells. 2015 Jan;33(1):133-45. doi: 10.1002/stem.1841.

12.

Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration.

Panigrahy D, Adini I, Mamluk R, Levonyak N, Bruns CJ, D'Amore PA, Klagsbrun M, Bielenberg DR.

Pathology. 2014 Aug;46(5):416-23. doi: 10.1097/PAT.0000000000000121.

13.

Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma.

Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, Klagsbrun M, Smith E.

Cancer Res. 2014 Jul 15;74(14):3716-26. doi: 10.1158/0008-5472.CAN-13-3116. Epub 2014 May 8.

14.

Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility.

Procaccia V, Nakayama H, Shimizu A, Klagsbrun M.

Biochem Biophys Res Commun. 2014 May 30;448(2):134-8. doi: 10.1016/j.bbrc.2014.04.063. Epub 2014 Apr 20.

15.

RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.

Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B, Kazerounian S, Kurschat P, Blachon S, Khedkar S, Bagchi M, Sherris D, Prendergast GC, Klagsbrun M, Stuhlmann H, Rigby AC, Nagy JA, Benjamin LE.

Nat Commun. 2013;4:2824. doi: 10.1038/ncomms3824.

16.

GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.

Coma S, Allard-Ratick M, Akino T, van Meeteren LA, Mammoto A, Klagsbrun M.

Angiogenesis. 2013 Oct;16(4):939-52. doi: 10.1007/s10456-013-9370-9. Epub 2013 Jul 28.

17.

Semaphorin 3F forms an anti-angiogenic barrier in outer retina.

Buehler A, Sitaras N, Favret S, Bucher F, Berger S, Pielen A, Joyal JS, Juan AM, Martin G, Schlunck G, Agostini HT, Klagsbrun M, Smith LE, Sapieha P, Stahl A.

FEBS Lett. 2013 Jun 5;587(11):1650-5. doi: 10.1016/j.febslet.2013.04.008. Epub 2013 Apr 18.

18.

VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats.

Shim JW, Sandlund J, Han CH, Hameed MQ, Connors S, Klagsbrun M, Madsen JR, Irwin N.

Exp Neurol. 2013 Sep;247:703-9. doi: 10.1016/j.expneurol.2013.03.011. Epub 2013 Mar 19.

PMID:
23518418
19.

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.

Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK.

Cell. 2013 Feb 28;152(5):1065-76. doi: 10.1016/j.cell.2013.01.036.

20.

Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.

Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M.

J Biol Chem. 2013 Jan 25;288(4):2210-22. doi: 10.1074/jbc.M112.397398. Epub 2012 Nov 29.

21.

Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.

Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, Moses MA, Demichelis F, Lisanti MP, Wu H, Klagsbrun M, Bhowmick NA, Rubin MA, D'Souza-Schorey C, Freeman MR.

Am J Pathol. 2012 Nov;181(5):1573-84. doi: 10.1016/j.ajpath.2012.07.030. Epub 2012 Sep 27.

22.

Increased smooth muscle contractility in mice deficient for neuropilin 2.

Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM.

Am J Pathol. 2012 Aug;181(2):548-59. doi: 10.1016/j.ajpath.2012.04.013. Epub 2012 Jun 9.

23.

Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis.

Wagner M, Bjerkvig R, Wiig H, Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley AC.

Angiogenesis. 2012 Sep;15(3):481-95. doi: 10.1007/s10456-012-9276-y. Epub 2012 May 22.

24.

Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.

Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK.

Neoplasia. 2012 Feb;14(2):84-94.

25.

Forty-year journey of angiogenesis translational research.

Cao Y, Arbiser J, D'Amato RJ, D'Amore PA, Ingber DE, Kerbel R, Klagsbrun M, Lim S, Moses MA, Zetter B, Dvorak H, Langer R.

Sci Transl Med. 2011 Dec 21;3(114):114rv3. doi: 10.1126/scitranslmed.3003149. Review.

PMID:
22190240
26.

Neuropilin-2 expression promotes TGF-β1-mediated epithelial to mesenchymal transition in colorectal cancer cells.

Grandclement C, Pallandre JR, Valmary Degano S, Viel E, Bouard A, Balland J, Rémy-Martin JP, Simon B, Rouleau A, Boireau W, Klagsbrun M, Ferrand C, Borg C.

PLoS One. 2011;6(7):e20444. doi: 10.1371/journal.pone.0020444. Epub 2011 Jul 1.

28.

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P.

Blood. 2011 Jun 2;117(22):6024-35. doi: 10.1182/blood-2010-10-311589. Epub 2011 Feb 25.

29.

Semaphorin 3E, an exception to the rule.

Klagsbrun M, Shimizu A.

J Clin Invest. 2010 Aug;120(8):2658-60. doi: 10.1172/JCI44110. Epub 2010 Jul 26.

30.

A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression.

Geretti E, van Meeteren LA, Shimizu A, Dudley AC, Claesson-Welsh L, Klagsbrun M.

Mol Cancer Res. 2010 Aug;8(8):1063-73. doi: 10.1158/1541-7786.MCR-10-0157. Epub 2010 Jul 22.

31.

Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors.

Dudley AC, Udagawa T, Melero-Martin JM, Shih SC, Curatolo A, Moses MA, Klagsbrun M.

Blood. 2010 Oct 28;116(17):3367-71. doi: 10.1182/blood-2010-02-271122. Epub 2010 May 7.

32.

Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F.

Coma S, Amin DN, Shimizu A, Lasorella A, Iavarone A, Klagsbrun M.

Cancer Res. 2010 May 1;70(9):3823-32. doi: 10.1158/0008-5472.CAN-09-3048. Epub 2010 Apr 13.

33.

Isolated tumor endothelial cells maintain specific character during long-term culture.

Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):947-54. doi: 10.1016/j.bbrc.2010.03.089. Epub 2010 Mar 17.

PMID:
20302845
34.

Host myeloid cells are necessary for creating bioengineered human vascular networks in vivo.

Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J.

Tissue Eng Part A. 2010 Aug;16(8):2457-66. doi: 10.1089/ten.TEA.2010.0024.

35.

Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors.

Akino T, Hida K, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Akiyama K, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M.

Am J Pathol. 2009 Dec;175(6):2657-67. doi: 10.2353/ajpath.2009.090202. Epub 2009 Oct 29.

36.

Novel svVEGF isoforms from Macrovipera lebetina venom interact with neuropilins.

Aloui Z, Hoos S, Geretti E, Kharmachi H, Haumont PY, Mejdoub H, Klagsbrun M, England P, Gasmi A.

Biochem Biophys Res Commun. 2009 Nov 6;389(1):10-5. doi: 10.1016/j.bbrc.2009.08.068. Epub 2009 Aug 18.

PMID:
19695228
37.

Tumor endothelial cells join the resistance.

Dudley AC, Klagsbrun M.

Clin Cancer Res. 2009 Aug 1;15(15):4787-9. doi: 10.1158/1078-0432.CCR-09-0902. Epub 2009 Jul 28.

38.

Tumor endothelial cells have features of adult stem cells.

Dudley AC, Klagsbrun M.

Cell Cycle. 2009 Jan 15;8(2):236-8. Epub 2009 Jan 14.

39.

Advanced glycation end-products suppress neuropilin-1 expression in podocytes.

Bondeva T, Rüster C, Franke S, Hammerschmid E, Klagsbrun M, Cohen CD, Wolf G.

Kidney Int. 2009 Mar;75(6):605-16. doi: 10.1038/ki.2008.603. Epub 2008 Nov 26.

40.

Calcification of multipotent prostate tumor endothelium.

Dudley AC, Khan ZA, Shih SC, Kang SY, Zwaans BM, Bischoff J, Klagsbrun M.

Cancer Cell. 2008 Sep 9;14(3):201-11. doi: 10.1016/j.ccr.2008.06.017.

41.

Semaphorin-induced cytoskeletal collapse and repulsion of endothelial cells.

Bielenberg DR, Shimizu A, Klagsbrun M.

Methods Enzymol. 2008;443:299-314. doi: 10.1016/S0076-6879(08)02015-6.

PMID:
18772022
42.

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro.

Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11305-10. doi: 10.1073/pnas.0800835105. Epub 2008 Aug 6.

43.

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization.

Kawamura H, Li X, Goishi K, van Meeteren LA, Jakobsson L, Cébe-Suarez S, Shimizu A, Edholm D, Ballmer-Hofer K, Kjellén L, Klagsbrun M, Claesson-Welsh L.

Blood. 2008 Nov 1;112(9):3638-49. doi: 10.1182/blood-2007-12-125856. Epub 2008 Jul 29.

44.

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.

Shimizu A, Mammoto A, Italiano JE Jr, Pravda E, Dudley AC, Ingber DE, Klagsbrun M.

J Biol Chem. 2008 Oct 3;283(40):27230-8. doi: 10.1074/jbc.M804520200. Epub 2008 Jul 25.

45.

Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine.

Dudley AC, Shih SC, Cliffe AR, Hida K, Klagsbrun M.

Br J Cancer. 2008 Jul 8;99(1):118-25. doi: 10.1038/sj.bjc.6604465.

46.

Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.

Amin DN, Bielenberg DR, Lifshits E, Heymach JV, Klagsbrun M.

Microvasc Res. 2008 May;76(1):15-22. doi: 10.1016/j.mvr.2008.01.002. Epub 2008 Mar 18.

PMID:
18440031
47.

Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis.

Geretti E, Shimizu A, Klagsbrun M.

Angiogenesis. 2008;11(1):31-9. doi: 10.1007/s10456-008-9097-1. Epub 2008 Feb 19. Review.

PMID:
18283547
48.

Obituary: M. Judah Folkman (1933-2008).

Klagsbrun M, Moses MA.

Nature. 2008 Feb 14;451(7180):781. doi: 10.1038/451781a. No abstract available.

PMID:
18273010
49.

Targeting endothelial and tumor cells with semaphorins.

Bielenberg DR, Klagsbrun M.

Cancer Metastasis Rev. 2007 Dec;26(3-4):421-31. Review.

PMID:
17768598
50.

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish.

Bahary N, Goishi K, Stuckenholz C, Weber G, Leblanc J, Schafer CA, Berman SS, Klagsbrun M, Zon LI.

Blood. 2007 Nov 15;110(10):3627-36. Epub 2007 Aug 14.

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