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Items: 1 to 50 of 258

1.

A Case of Drug-induced Cutaneous Toxicity Observed in Cynomolgus Monkeys.

Kikkawa R.

Toxicol Pathol. 2016 Jun;44(4):601-6. doi: 10.1177/0192623316637710.

PMID:
27222497
2.

Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2'-O-Methoxyethyl Modified Antisense Oligonucleotide.

Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP.

Nucleic Acid Ther. 2016 Aug;26(4):236-49. doi: 10.1089/nat.2015.0584. Epub 2016 May 3.

PMID:
27140858
3.

Effects of low-dose G-CSF formulation on hematology in healthy horses after long-distance transportation.

Endo Y, Hobo S, Korosue K, Ootsuka K, Kitauchi A, Kikkawa R, Hidaka Y, Hagio M, Tsuzuki N.

J Vet Med Sci. 2015 Apr;77(4):507-9. doi: 10.1292/jvms.14-0586. Epub 2015 Jan 19.

4.

Formations of hydroxyapatite and inositol hexakisphosphate in poultry litter during the composting period: sequential fractionation, P K-edge XANES and solution (31)P NMR investigations.

Hashimoto Y, Takamoto A, Kikkawa R, Murakami K, Yamaguchi N.

Environ Sci Technol. 2014 May 20;48(10):5486-92. doi: 10.1021/es404875j. Epub 2014 Apr 29.

PMID:
24735189
5.

Non-high-density lipoprotein cholesterol: an important predictor of stroke and diabetes-related mortality in Japanese elderly diabetic patients.

Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, Ito H; Japanese Elderly Intervention Trial Research Group.

Geriatr Gerontol Int. 2012 Apr;12 Suppl 1:18-28. doi: 10.1111/j.1447-0594.2011.00809.x.

PMID:
22435937
6.

Long-term multiple risk factor interventions in Japanese elderly diabetic patients: the Japanese Elderly Diabetes Intervention Trial--study design, baseline characteristics and effects of intervention.

Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, Ito H; Japanese Elderly Diabetes Intervention Trial Study Group.

Geriatr Gerontol Int. 2012 Apr;12 Suppl 1:7-17. doi: 10.1111/j.1447-0594.2011.00808.x.

PMID:
22435936
7.

The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria.

Uzu T, Kida Y, Yamauchi A, Kume S, Isshiki K, Araki S, Koya D, Haneda M, Kashiwagi A, Maegawa H, Kikkawa R.

J Am Soc Hypertens. 2012 Mar-Apr;6(2):124-31. doi: 10.1016/j.jash.2011.11.001. Epub 2011 Dec 22.

PMID:
22197317
8.

Causes of death in Japanese diabetics: A questionnaire survey of 18,385 diabetics over a 10-year period.

Hotta N, Nakamura J, Iwamoto Y, Ohno Y, Kasuga M, Kikkawa R, Toyota T.

J Diabetes Investig. 2010 Apr 22;1(1-2):66-76. doi: 10.1111/j.2040-1124.2010.00019.x.

9.

Cerebral microvascular disease predicts renal failure in type 2 diabetes.

Uzu T, Kida Y, Shirahashi N, Harada T, Yamauchi A, Nomura M, Isshiki K, Araki S, Sugimoto T, Koya D, Haneda M, Kashiwagi A, Kikkawa R.

J Am Soc Nephrol. 2010 Mar;21(3):520-6. doi: 10.1681/ASN.2009050558. Epub 2010 Jan 28.

10.

Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial.

Koya D, Haneda M, Inomata S, Suzuki Y, Suzuki D, Makino H, Shikata K, Murakami Y, Tomino Y, Yamada K, Araki SI, Kashiwagi A, Kikkawa R; Low-Protein Diet Study Group.

Diabetologia. 2009 Oct;52(10):2037-45. doi: 10.1007/s00125-009-1467-8. Epub 2009 Aug 4.

11.

Steroid-induced crisis and rhabdomyolysis in a patient with pheochromocytoma: a case report and review.

Takahashi N, Shimada T, Tanabe K, Yoshitomi H, Murakami Y, Ishibashi Y, Kikkawa R, Yano S, Araki A, Inoue A.

Int J Cardiol. 2011 Jan 21;146(2):e41-5. doi: 10.1016/j.ijcard.2008.12.183. Epub 2009 Feb 1. Review.

PMID:
19187985
12.

Experience with laparoscopic sleeve gastrectomy for morbid versus super morbid obesity.

Tagaya N, Kasama K, Kikkawa R, Kanahira E, Umezawa A, Oshiro T, Negishi Y, Kurokawa Y, Nakazato T, Kubota K.

Obes Surg. 2009 Oct;19(10):1371-6. doi: 10.1007/s11695-008-9774-6. Epub 2008 Dec 9.

PMID:
19067089
13.

International Symposium on Diabetic Nephropathy. Preface.

Kikkawa R.

Diabetes Res Clin Pract. 2008 Nov 13;82 Suppl 1:S1. doi: 10.1016/j.diabres.2008.09.015. No abstract available.

PMID:
18994671
14.

Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus.

Araki S, Haneda M, Koya D, Kashiwagi A, Uzu T, Kikkawa R.

Diabetes Res Clin Pract. 2008 Nov 13;82 Suppl 1:S54-8. doi: 10.1016/j.diabres.2008.09.031. Epub 2008 Oct 22. Review.

PMID:
18947896
15.

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.

Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jørgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S.

Nat Genet. 2008 Sep;40(9):1098-102. doi: 10.1038/ng.208.

PMID:
18711366
16.

Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population.

Maeda S, Osawa N, Hayashi T, Tsukada S, Kobayashi M, Kikkawa R.

Kidney Int Suppl. 2007 Aug;(106):S43-8.

PMID:
17653210
17.

Genomic cluster and network analysis for predictive screening for hepatotoxicity.

Fukushima T, Kikkawa R, Hamada Y, Horii I.

J Toxicol Sci. 2006 Dec;31(5):419-32.

18.
19.

In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system.

Kikkawa R, Fujikawa M, Yamamoto T, Hamada Y, Yamada H, Horii I.

J Toxicol Sci. 2006 Feb;31(1):23-34.

20.
21.

Effects of male reproductive toxicants on gene expression in rat testes.

Fukushima T, Yamamoto T, Kikkawa R, Hamada Y, Komiyama M, Mori C, Horii I.

J Toxicol Sci. 2005 Aug;30(3):195-206.

22.

MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells.

Guo B, Inoki K, Isono M, Mori H, Kanasaki K, Sugimoto T, Akiba S, Sato T, Yang B, Kikkawa R, Kashiwagi A, Haneda M, Koya D.

Kidney Int. 2005 Sep;68(3):972-84.

23.

Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.

Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, Koya D, Maegawa H, Kashiwagi A, Babazono T, Matsuda M, Tanaka Y, Fujioka T, Hirose H, Eguchi T, Ohno Y, Groves CJ, Hattersley AT, Hitman GA, Walker M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Kamatani N, McCarthy MI, Nakamura Y.

J Hum Genet. 2005;50(6):283-92. Epub 2005 Jun 7.

PMID:
15940393
24.

Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.

Kanazawa A, Kawamura Y, Sekine A, Iida A, Tsunoda T, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kawai K, Iiizumi T, Fujioka T, Imanishi M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S.

Diabetologia. 2005 Jul;48(7):1315-22. Epub 2005 Jun 4.

PMID:
15937668
25.

Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.

Yamamoto T, Fukushima T, Kikkawa R, Yamada H, Horii I.

J Toxicol Sci. 2005 May;30(2):111-26.

27.

Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy.

Shimazaki A, Kawamura Y, Kanazawa A, Sekine A, Saito S, Tsunoda T, Koya D, Babazono T, Tanaka Y, Matsuda M, Kawai K, Iiizumi T, Imanishi M, Shinosaki T, Yanagimoto T, Ikeda M, Omachi S, Kashiwagi A, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakajima M, Nakamura Y, Maeda S.

Diabetes. 2005 Apr;54(4):1171-8.

29.

Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes.

Kanazawa A, Tsukada S, Sekine A, Tsunoda T, Takahashi A, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S.

Am J Hum Genet. 2004 Nov;75(5):832-43. Epub 2004 Sep 21.

30.

Antiproteinuric effect of candesartan cilexetil in Japanese subjects with type 2 diabetes and nephropathy.

Haneda M, Kikkawa R, Sakai H, Kawamori R; Candesartan in Diabetic Nephropathy Study Group.

Diabetes Res Clin Pract. 2004 Oct;66(1):87-95.

PMID:
15364166
31.

Characteristics of pancreas transplantation currently performed in japan.

Ishibashi M, Ito T, Sugitani A, Nakajima K, Abe T, Matsuno N, Hirao Y, Gotoh M, Tanaka M, Teraoka S, Matsuda H, Taniguchi H, Fukao T, Kikkawa R, Idezuki Y, Kanazawa Y.

Transplant Proc. 2004 May;36(4):1086-9.

PMID:
15194378
32.

A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay.

Ye F, Maegawa H, Morino K, Kashiwagi A, Kikkawa R, Xie M, Shen Z.

J Biochem Biophys Methods. 2004 Jun 30;59(3):201-8.

PMID:
15165751
33.

Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms.

Tanaka N, Babazono T, Saito S, Sekine A, Tsunoda T, Haneda M, Tanaka Y, Fujioka T, Kaku K, Kawamori R, Kikkawa R, Iwamoto Y, Nakamura Y, Maeda S.

Diabetes. 2003 Nov;52(11):2848-53.

34.

[Diabetic nephropathy--progress in its preclinical and clinical studies].

Kikkawa R, Koya D, Haneda M.

Nihon Naika Gakkai Zasshi. 2003 Sep 10;92(9):1650-61. Review. Japanese. No abstract available.

PMID:
14560599
35.
36.

APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study.

Araki S, Koya D, Makiishi T, Sugimoto T, Isono M, Kikkawa R, Kashiwagi A, Haneda M.

Diabetes Care. 2003 Aug;26(8):2416-20.

PMID:
12882872
37.

Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats.

Koya D, Hayashi K, Kitada M, Kashiwagi A, Kikkawa R, Haneda M.

J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S250-3.

38.

Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury.

Takikita-Suzuki M, Haneda M, Sasahara M, Owada MK, Nakagawa T, Isono M, Takikita S, Koya D, Ogasawara K, Kikkawa R.

Am J Pathol. 2003 Jul;163(1):277-86.

39.

Diabetic neuropathy and nerve regeneration.

Yasuda H, Terada M, Maeda K, Kogawa S, Sanada M, Haneda M, Kashiwagi A, Kikkawa R.

Prog Neurobiol. 2003 Mar;69(4):229-85. Review.

PMID:
12757748
40.

Overview of glucose signaling in mesangial cells in diabetic nephropathy.

Haneda M, Koya D, Isono M, Kikkawa R.

J Am Soc Nephrol. 2003 May;14(5):1374-82. Review. No abstract available.

41.

Progression of diabetic nephropathy.

Kikkawa R, Koya D, Haneda M.

Am J Kidney Dis. 2003 Mar;41(3 Suppl 1):S19-21. Review.

PMID:
12612945
42.

Antiproteinuric effect of candesartan cilexetil in patients with chronic glomerulonephritis.

Kurokawa K, Abe K, Saruta T, Arakawa M, Kikkawa R, Ueda N, Onoyama K, Tomita K, Ogawa N.

J Renin Angiotensin Aldosterone Syst. 2002 Sep;3(3):167-75.

PMID:
12563567
43.

[History of nephrology in the last 100 years: Diabetic nephropathies].

Kikkawa R.

Nihon Naika Gakkai Zasshi. 2002 May 10;91(5):1489-91. Review. Japanese. No abstract available.

PMID:
12082740
44.

15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells.

Sawano H, Haneda M, Sugimoto T, Inoki K, Koya D, Kikkawa R.

Kidney Int. 2002 Jun;61(6):1957-67.

46.

Increase in intracellular Ca(2+) and calcitonin gene-related peptide release through metabotropic P2Y receptors in rat dorsal root ganglion neurons.

Sanada M, Yasuda H, Omatsu-Kanbe M, Sango K, Isono T, Matsuura H, Kikkawa R.

Neuroscience. 2002;111(2):413-22.

PMID:
11983326
47.

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.

Kojima H, Nakamura T, Fujita Y, Kishi A, Fujimiya M, Yamada S, Kudo M, Nishio Y, Maegawa H, Haneda M, Yasuda H, Kojima I, Seno M, Wong NC, Kikkawa R, Kashiwagi A.

Diabetes. 2002 May;51(5):1398-408.

48.

Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.

Nagai Y, Nishio Y, Nakamura T, Maegawa H, Kikkawa R, Kashiwagi A.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1180-90.

49.

Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells.

Nishio T, Haneda M, Koya D, Inoki K, Maeda S, Kikkawa R.

Eur J Pharmacol. 2002 Feb 22;437(3):113-22.

PMID:
11890898
50.

Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart.

Kanazawa A, Nishio Y, Kashiwagi A, Inagaki H, Kikkawa R, Horiike K.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E778-85.

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