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Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines.

Šošić L, Selbo PK, Kotkowska ZK, Kündig TM, Høgset A, Johansen P.

Cancers (Basel). 2020 Jan 9;12(1). pii: E165. doi: 10.3390/cancers12010165. Review.


Vaccine against peanut allergy based on engineered Virus-Like-Particles displaying single major peanut allergens.

Storni F, Zeltins A, Balke I, Heath MD, Kramer MF, Skinner MA, Zha L, Roesti E, Engeroff P, Muri L, von Werdt D, Gruber T, Cragg M, Mlynarczyk M, Kündig TM, Vogel M, Bachmann MF.

J Allergy Clin Immunol. 2019 Dec 19. pii: S0091-6749(19)31709-9. doi: 10.1016/j.jaci.2019.12.007. [Epub ahead of print]


Interleukin 31 in insect bite hypersensitivity - Alleviating clinical symptoms by active vaccination against itch.

Olomski F, Fettelschoss V, Jonsdottir S, Birkmann K, Thoms F, Marti E, Bachmann MF, Kündig TM, Fettelschoss-Gabriel A.

Allergy. 2019 Dec 9. doi: 10.1111/all.14145. [Epub ahead of print]


State-of-the-art in marketed adjuvants and formulations in Allergen Immunotherapy: a position paper of the European Academy of Allergy and Clinical Immunology (EAACI).

Jensen-Jarolim E, Bachmann M, Bonini S, Jacobsen L, Jutel M, Klimek L, Mahler V, Mösges R, Moingeon P, O Hehir RE, Palomares O, Pfaar O, Renz H, Rhyner C, Roth-Walter F, Rudenko M, Savolainen J, Schmidt-Weber C, Traidl-Hoffmann C, Kündig T.

Allergy. 2019 Nov 27. doi: 10.1111/all.14134. [Epub ahead of print]


Apremilast in Treatment-Refractory Recurrent Aphthous Stomatitis.

Kolios AGA, Yawalkar N, Feusi A, Kündig T, Boyman O, Nilsson J.

N Engl J Med. 2019 Nov 14;381(20):1975-1977. doi: 10.1056/NEJMc1901987. No abstract available.


Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help.

Varypataki EM, Hasler F, Waeckerle-Men Y, Vogel-Kindgen S, Høgset A, Kündig TM, Gander B, Halin C, Johansen P.

Front Immunol. 2019 Jul 5;10:1548. doi: 10.3389/fimmu.2019.01548. eCollection 2019.


Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine.

Mohsen MO, Vogel M, Riether C, Muller J, Salatino S, Ternette N, Gomes AC, Cabral-Miranda G, El-Turabi A, Ruedl C, Kundig TM, Dermime S, Knuth A, Speiser DE, Bachmann MF.

Front Immunol. 2019 May 15;10:1015. doi: 10.3389/fimmu.2019.01015. eCollection 2019.


Correction to: Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.

Mohsen MO, Heath MD, Cabral-Miranda G, Lipp C, Zeltins A, Sande M, Stein JV, Riether C, Roesti E, Zha L, Engeroff P, El-Turabi A, Kundig TM, Vogel M, Skinner MA, Speiser DE, Knuth A, Kramer MF, Bachmann MF.

J Immunother Cancer. 2019 May 23;7(1):137. doi: 10.1186/s40425-019-0616-y.


Design of in vitro Transcribed mRNA Vectors for Research and Therapy.

Tusup M, French LE, De Matos M, Gatfield D, Kundig T, Pascolo S.

Chimia (Aarau). 2019 May 29;73(6):391-394. doi: 10.2533/chimia.2019.391. Review.


Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects.

Thoms F, Jennings GT, Maudrich M, Vogel M, Haas S, Zeltins A, Hofmann-Lehmann R, Riond B, Grossmann J, Hunziker P, Fettelschoss-Gabriel A, Senti G, Kündig TM, Bachmann MF.

J Allergy Clin Immunol. 2019 Jul;144(1):193-203. doi: 10.1016/j.jaci.2019.01.050. Epub 2019 May 2.


Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.

Mohsen MO, Heath MD, Cabral-Miranda G, Lipp C, Zeltins A, Sande M, Stein JV, Riether C, Roesti E, Zha L, Engeroff P, El-Turabi A, Kundig TM, Vogel M, Skinner MA, Speiser DE, Knuth A, Kramer MF, Bachmann MF.

J Immunother Cancer. 2019 Apr 26;7(1):114. doi: 10.1186/s40425-019-0587-z. Erratum in: J Immunother Cancer. 2019 May 23;7(1):137.


Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases.

Klimek L, Kündig T, Kramer MF, Guethoff S, Jensen-Jarolim E, Schmidt-Weber CB, Palomares O, Mohsen MO, Jakob T, Bachmann M.

Allergo J Int. 2018;27(8):245-255. doi: 10.1007/s40629-018-0074-y. Epub 2018 Jul 9. Review.


Letter to the Editor: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II.

Wüthrich B, Senti G, Kündig TM.

J Eur Acad Dermatol Venereol. 2019 Apr;33(4):e151-e153. doi: 10.1111/jdv.15382. Epub 2019 Jan 15. No abstract available.


Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses.

Fettelschoss-Gabriel A, Fettelschoss V, Olomski F, Birkmann K, Thoms F, Bühler M, Kummer M, Zeltins A, Kündig TM, Bachmann MF.

Allergy. 2019 Mar;74(3):572-582. doi: 10.1111/all.13659. Epub 2018 Nov 25.


Intralymphatic Immunotherapy: Update and Unmet Needs.

Senti G, Freiburghaus AU, Larenas-Linnemann D, Hoffmann HJ, Patterson AM, Klimek L, Di Bona D, Pfaar O, Ahlbeck L, Akdis M, Weinfeld D, Contreras-Verduzco FA, Pedroza-Melendez A, Skaarup SH, Lee SM, Cardell LO, Schmid JM, Westin U, Dollner R, Kündig TM.

Int Arch Allergy Immunol. 2019;178(2):141-149. doi: 10.1159/000493647. Epub 2018 Nov 2. Review.


Epitranscriptomics of cancer.

Tusup M, Kundig T, Pascolo S.

World J Clin Oncol. 2018 Jun 10;9(3):42-55. doi: 10.5306/wjco.v9.i3.42. Review.


Treating insect-bite hypersensitivity in horses with active vaccination against IL-5.

Fettelschoss-Gabriel A, Fettelschoss V, Thoms F, Giese C, Daniel M, Olomski F, Kamarachev J, Birkmann K, Bühler M, Kummer M, Zeltins A, Marti E, Kündig TM, Bachmann MF.

J Allergy Clin Immunol. 2018 Oct;142(4):1194-1205.e3. doi: 10.1016/j.jaci.2018.01.041. Epub 2018 Apr 4.


Microcrystalline Tyrosine and Aluminum as Adjuvants in Allergen-Specific Immunotherapy Protect from IgE-Mediated Reactivity in Mouse Models and Act Independently of Inflammasome and TLR Signaling.

Leuthard DS, Duda A, Freiberger SN, Weiss S, Dommann I, Fenini G, Contassot E, Kramer MF, Skinner MA, Kündig TM, Heath MD, Johansen P.

J Immunol. 2018 May 1;200(9):3151-3159. doi: 10.4049/jimmunol.1800035. Epub 2018 Mar 28.


PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.

Spalinger MR, Manzini R, Hering L, Riggs JB, Gottier C, Lang S, Atrott K, Fettelschoss A, Olomski F, Kündig TM, Fried M, McCole DF, Rogler G, Scharl M.

Cell Rep. 2018 Feb 13;22(7):1835-1848. doi: 10.1016/j.celrep.2018.01.052.


Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.

Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C.

Stem Cell Res. 2018 Mar;27:121-130. doi: 10.1016/j.scr.2018.01.019. Epub 2018 Jan 28.


Intraperitoneal administration of aluminium-based adjuvants produces severe transient systemic adverse events in mice.

Freiberger SN, Leuthard DS, Duda A, Contassot E, Thallmair M, Kündig TM, Johansen P.

Eur J Pharm Sci. 2018 Mar 30;115:362-368. doi: 10.1016/j.ejps.2018.01.042. Epub 2018 Feb 2.


Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540-543.

Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW.

J Immunol. 2017 Dec 1;199(11):3717-3720. No abstract available.


Clinical Disease Patterns in a Regional Swiss Cohort of 34 Pyoderma Gangrenosum Patients.

Kolios AGA, Gübeli A, Meier B, Maul JT, Kündig T, Nilsson J, Hafner J, Guenova E, Kerl K, Anliker M, Kempf W, Navarini AA, French LE, Cozzio A.

Dermatology. 2017;233(4):268-276. doi: 10.1159/000481432. Epub 2017 Nov 7.


Cutaneous Corynebacterium Infection Presenting with Disseminated Skin Nodules and Ulceration.

Kolios AGA, Cozzio A, Zinkernagel AS, French LE, Kündig TM.

Case Rep Dermatol. 2017 May 16;9(2):8-12. doi: 10.1159/000476054. eCollection 2017 May-Aug.


Allergen immunotherapy in allergic rhinitis: current use and future trends.

Klimek L, Pfaar O, Bousquet J, Senti G, Kündig T.

Expert Rev Clin Immunol. 2017 Sep;13(9):897-906. doi: 10.1080/1744666X.2017.1333423. Epub 2017 Jun 15. Review.


Topical azithromycin for the prevention of Lyme borreliosis: a randomised, placebo-controlled, phase 3 efficacy trial.

Schwameis M, Kündig T, Huber G, von Bidder L, Meinel L, Weisser R, Aberer E, Härter G, Weinke T, Jelinek T, Fätkenheuer G, Wollina U, Burchard GD, Aschoff R, Nischik R, Sattler G, Popp G, Lotte W, Wiechert D, Eder G, Maus O, Staubach-Renz P, Gräfe A, Geigenberger V, Naudts I, Sebastian M, Reider N, Weber R, Heckmann M, Reisinger EC, Klein G, Wantzen J, Jilma B.

Lancet Infect Dis. 2017 Mar;17(3):322-329. doi: 10.1016/S1473-3099(16)30529-1. Epub 2016 Dec 20. Erratum in: Lancet Infect Dis. 2017 Nov 21;:.


IL-12 protects from psoriasiform skin inflammation.

Kulig P, Musiol S, Freiberger SN, Schreiner B, Gyülveszi G, Russo G, Pantelyushin S, Kishihara K, Alessandrini F, Kündig T, Sallusto F, Hofbauer GF, Haak S, Becher B.

Nat Commun. 2016 Nov 28;7:13466. doi: 10.1038/ncomms13466.


Distinct T helper cell dependence of memory B-cell proliferation versus plasma cell differentiation.

Zabel F, Fettelschoss A, Vogel M, Johansen P, Kündig TM, Bachmann MF.

Immunology. 2017 Mar;150(3):329-342. doi: 10.1111/imm.12688. Epub 2017 Jan 5.


Allergen-specific immunotherapy: is it vaccination against toxins after all?

Bachmann MF, Kündig TM.

Allergy. 2017 Jan;72(1):13-23. doi: 10.1111/all.12890. Epub 2016 Sep 28. Review.


IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT-Feld1 in human.

Freiberger SN, Zehnder M, Gafvelin G, Grönlund H, Kündig TM, Johansen P.

Allergy. 2016 Sep;71(9):1366-70. doi: 10.1111/all.12946. Epub 2016 Jun 17.


Novel Delivery Routes for Allergy Immunotherapy: Intralymphatic, Epicutaneous, and Intradermal.

Senti G, Kündig TM.

Immunol Allergy Clin North Am. 2016 Feb;36(1):25-37. doi: 10.1016/j.iac.2015.08.006. Review.


Dosing intervals in intralymphatic immunotherapy.

Hjálmsdóttir Á, Wäckerle-Men Y, Duda A, Kündig TM, Johansen P.

Clin Exp Allergy. 2016 Mar;46(3):504-7. doi: 10.1111/cea.12657. No abstract available.


Allergen immunotherapy on the way to product-based evaluation-a WAO statement.

Bachert C, Larché M, Bonini S, Canonica GW, Kündig T, Larenas-Linnemann D, Ledford D, Neffen H, Pawankar R, Passalacqua G.

World Allergy Organ J. 2015 Sep 16;8(1):29. doi: 10.1186/s40413-015-0078-8. eCollection 2015.


Comparison of microneedles and adhesive-tape stripping in skin preparation for epicutaneous allergen delivery.

Spina L, Weisskopf M, von Moos S, Graf N, Kündig TM, Senti G.

Int Arch Allergy Immunol. 2015;167(2):103-9. doi: 10.1159/000434681. Epub 2015 Aug 12.


A bizarre attack on the freedom of scientific expression.

Senti G, Johansen P, von Moos S, Kündig TM.

Allergy. 2015 Sep;70(9):1037-8. doi: 10.1111/all.12660. No abstract available.


Photosensitizer and Light Pave the Way for Cytosolic Targeting and Generation of Cytosolic CD8 T Cells Using PLGA Vaccine Particles.

Bruno C, Waeckerle-Men Y, Håkerud M, Kündig TM, Gander B, Johansen P.

J Immunol. 2015 Jul 1;195(1):166-73. doi: 10.4049/jimmunol.1500431. Epub 2015 May 27.


[Allergen specific immunotherapy for rhinitis allergica : New applications].

Klimek L, Kündig T, Senti G.

HNO. 2015 May;63(5):343-51. doi: 10.1007/s00106-015-0003-z. German.


Intralymphatic immunotherapy.

Senti G, Kündig TM.

World Allergy Organ J. 2015 Mar 7;8(1):9. doi: 10.1186/s40413-014-0047-7. eCollection 2015.


Is The Allergen Really Needed in Allergy Immunotherapy?

Kündig TM, Klimek L, Schendzielorz P, Renner WA, Senti G, Bachmann MF.

Curr Treat Options Allergy. 2015;2(1):72-82. Review.


Determinants of efficacy and safety in epicutaneous allergen immunotherapy: summary of three clinical trials.

Senti G, von Moos S, Tay F, Graf N, Johansen P, Kündig TM.

Allergy. 2015 Jun;70(6):707-10. doi: 10.1111/all.12600. Epub 2015 Mar 13.


Photosensitisation facilitates cross-priming of adjuvant-free protein vaccines and stimulation of tumour-suppressing CD8 T cells.

Håkerud M, Selbo PK, Waeckerle-Men Y, Contassot E, Dziunycz P, Kündig TM, Høgset A, Johansen P.

J Control Release. 2015 Jan 28;198:10-7. doi: 10.1016/j.jconrel.2014.11.032. Epub 2014 Dec 4.


[Transcutaneous applications for vaccination and immunotherapy].

Krämer I, Zabel F, Kündig TM, Johansen P.

Praxis (Bern 1994). 2014 Oct 15;103(21):1247-55. doi: 10.1024/1661-8157/a001802. Review. German.


Comparing safety of abrasion and tape-stripping as skin preparation in allergen-specific epicutaneous immunotherapy.

von Moos S, Johansen P, Tay F, Graf N, Kündig TM, Senti G.

J Allergy Clin Immunol. 2014 Oct;134(4):965-7.e4. doi: 10.1016/j.jaci.2014.07.037. No abstract available.


Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine.

Zaleska A, Eiwegger T, Soyer O, van de Veen W, Rhyner C, Soyka MB, Bekpen C, Demiröz D, Treis A, Söllner S, Palomares O, Kwok WW, Rose H, Senti G, Kündig TM, Ozoren N, Jutel M, Akdis CA, Crameri R, Akdis M.

Allergy. 2014 Sep;69(9):1162-70. doi: 10.1111/all.12461. Epub 2014 Jul 12. Erratum in: Allergy. 2016 Jan;71(1):129.


A critical appraisal of analyzing nasal provocation test results in allergen immunotherapy trials.

Graf N, Dinkel B, Rose H, Hothorn LA, Gerhard D, Johansen P, Kundig TM, Klimek L, Senti G.

Rhinology. 2014 Jun;52(2):137-41. doi: 10.4193/Rhin13.145.


Epicutaneous Immunotherapy for Aeroallergen and Food Allergy.

Senti G, von Moos S, Kündig TM.

Curr Treat Options Allergy. 2013 Dec 17;1:68-78. eCollection 2014. Review.


Immunotherapy of type-1 allergies with virus-like particles and CpG-motifs.

Klimek L, Bachmann MF, Senti G, Kündig TM.

Expert Rev Clin Immunol. 2014 Aug;10(8):1059-67. doi: 10.1586/1744666X.2014.924854. Epub 2014 Jun 5. Review.


Induction or exacerbation of psoriasis in patients with Crohn's disease under treatment with anti-TNF antibodies.

Barthel C, Biedermann L, Frei P, Vavricka SR, Kündig T, Fried M, Rogler G, Scharl M.

Digestion. 2014;89(3):209-15. doi: 10.1159/000358288. Epub 2014 May 21.


Viral particles drive rapid differentiation of memory B cells into secondary plasma cells producing increased levels of antibodies.

Zabel F, Mohanan D, Bessa J, Link A, Fettelschoss A, Saudan P, Kündig TM, Bachmann MF.

J Immunol. 2014 Jun 15;192(12):5499-508. doi: 10.4049/jimmunol.1400065. Epub 2014 May 12.


Intralymphatic immunotherapy and vaccination in mice.

Johansen P, Kündig TM.

J Vis Exp. 2014 Feb 2;(84):e51031. doi: 10.3791/51031.

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