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Items: 14

1.

Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.

Kühnle S, Martínez-Noël G, Leclere F, Hayes SD, Harper JW, Howley PM.

J Biol Chem. 2018 Nov 23;293(47):18387-18399. doi: 10.1074/jbc.RA118.004653. Epub 2018 Sep 26.

2.

Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.

Martínez-Noël G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M, Howley PM.

J Mol Biol. 2018 Mar 30;430(7):1024-1050. doi: 10.1016/j.jmb.2018.01.021. Epub 2018 Feb 6.

3.

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination.

Mortensen F, Schneider D, Barbic T, Sladewska-Marquardt A, Kühnle S, Marx A, Scheffner M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9872-7. doi: 10.1073/pnas.1505923112. Epub 2015 Jul 27.

4.

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

French CA, Rahman S, Walsh EM, Kühnle S, Grayson AR, Lemieux ME, Grunfeld N, Rubin BP, Antonescu CR, Zhang S, Venkatramani R, Dal Cin P, Howley PM.

Cancer Discov. 2014 Aug;4(8):928-41. doi: 10.1158/2159-8290.CD-14-0014. Epub 2014 May 29.

5.

Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc.

Kühnle S, Mothes B, Matentzoglu K, Scheffner M.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8888-93. doi: 10.1073/pnas.1302792110. Epub 2013 May 13.

6.

Mutation of HERC2 causes developmental delay with Angelman-like features.

Harlalka GV, Baple EL, Cross H, Kühnle S, Cubillos-Rojas M, Matentzoglu K, Patton MA, Wagner K, Coblentz R, Ford DL, Mackay DJ, Chioza BA, Scheffner M, Rosa JL, Crosby AH.

J Med Genet. 2013 Feb;50(2):65-73. doi: 10.1136/jmedgenet-2012-101367. Epub 2012 Dec 14.

PMID:
23243086
7.

Development of auditory localization accuracy and auditory spatial discrimination in children and adolescents.

Kühnle S, Ludwig AA, Meuret S, Küttner C, Witte C, Scholbach J, Fuchs M, Rübsamen R.

Audiol Neurootol. 2013;18(1):48-62. doi: 10.1159/000342904. Epub 2012 Oct 20.

PMID:
23095333
8.

Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2.

Kühnle S, Kogel U, Glockzin S, Marquardt A, Ciechanover A, Matentzoglu K, Scheffner M.

J Biol Chem. 2011 Jun 3;286(22):19410-6. doi: 10.1074/jbc.M110.205211. Epub 2011 Apr 14.

9.

GM-CSF restores innate, but not adaptive, immune responses in glucocorticoid-immunosuppressed human blood in vitro.

Xu J, Lucas R, Schuchmann M, Kühnle S, Meergans T, Barreiros AP, Lohse AW, Otto G, Wendel A.

J Immunol. 2003 Jul 15;171(2):938-47.

10.

Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice.

Kühnle S, Nicotera P, Wendel A, Leist M.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):433-8.

PMID:
10491311
11.

Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis.

Leist M, Single B, Naumann H, Fava E, Simon B, Kühnle S, Nicotera P.

Exp Cell Res. 1999 Jun 15;249(2):396-403.

PMID:
10366439
12.

Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release.

Leist M, Single B, Naumann H, Fava E, Simon B, Kühnle S, Nicotera P.

Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21.

PMID:
10222263
13.

Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide.

Leist M, Volbracht C, Kühnle S, Fava E, Ferrando-May E, Nicotera P.

Mol Med. 1997 Nov;3(11):750-64.

14.

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis.

Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P.

J Exp Med. 1997 Apr 21;185(8):1481-6.

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