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Structure, mechanism, and regulation of the chloroplast ATP synthase.

Hahn A, Vonck J, Mills DJ, Meier T, Kühlbrandt W.

Science. 2018 May 11;360(6389). pii: eaat4318. doi: 10.1126/science.aat4318.


Structural basis for energy transduction by respiratory alternative complex III.

Sousa JS, Calisto F, Langer JD, Mills DJ, Refojo PN, Teixeira M, Kühlbrandt W, Vonck J, Pereira MM.

Nat Commun. 2018 Apr 30;9(1):1728. doi: 10.1038/s41467-018-04141-8.


Structure of the catalytic F1 head of the F1-Fo ATP synthase from Trypanosoma brucei.

Davies KM, Kühlbrandt W.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2906-E2907. doi: 10.1073/pnas.1801103115. Epub 2018 Mar 9. No abstract available.


Conserved in situ arrangement of complex I and III2 in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants.

Davies KM, Blum TB, Kühlbrandt W.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3024-3029. doi: 10.1073/pnas.1720702115. Epub 2018 Mar 8.


Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus.

D'Imprima E, Salzer R, Bhaskara RM, Sánchez R, Rose I, Kirchner L, Hummer G, Kühlbrandt W, Vonck J, Averhoff B.

Elife. 2017 Dec 27;6. pii: e30483. doi: 10.7554/eLife.30483.


Structure of outer membrane protein G in lipid bilayers.

Retel JS, Nieuwkoop AJ, Hiller M, Higman VA, Barbet-Massin E, Stanek J, Andreas LB, Franks WT, van Rossum BJ, Vinothkumar KR, Handel L, de Palma GG, Bardiaux B, Pintacuda G, Emsley L, Kühlbrandt W, Oschkinat H.

Nat Commun. 2017 Dec 12;8(1):2073. doi: 10.1038/s41467-017-02228-2.


Structural basis of proton translocation and force generation in mitochondrial ATP synthase.

Klusch N, Murphy BJ, Mills DJ, Yildiz Ö, Kühlbrandt W.

Elife. 2017 Dec 6;6. pii: e33274. doi: 10.7554/eLife.33274.


Cryo-EM Structure of the TOM Core Complex from Neurospora crassa.

Bausewein T, Mills DJ, Langer JD, Nitschke B, Nussberger S, Kühlbrandt W.

Cell. 2017 Aug 10;170(4):693-700.e7. doi: 10.1016/j.cell.2017.07.012.


Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.

Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W.

Elife. 2017 Jul 12;6. pii: e24662. doi: 10.7554/eLife.24662.


Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery.

Daum B, Vonck J, Bellack A, Chaudhury P, Reichelt R, Albers SV, Rachel R, Kühlbrandt W.

Elife. 2017 Jun 27;6. pii: e27470. doi: 10.7554/eLife.27470.


Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy.

Scherr J, Parey K, Klusch N, Murphy BJ, Balser S, Neuhaus A, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D.

ACS Nano. 2017 Jun 27;11(6):6467-6473. doi: 10.1021/acsnano.7b03099. Epub 2017 Jun 15.


CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin.

van Pee K, Neuhaus A, D'Imprima E, Mills DJ, Kühlbrandt W, Yildiz Ö.

Elife. 2017 Mar 21;6. pii: e23644. doi: 10.7554/eLife.23644.


Molecular architecture of the N-type ATPase rotor ring from Burkholderia pseudomallei.

Schulz S, Wilkes M, Mills DJ, Kühlbrandt W, Meier T.

EMBO Rep. 2017 Apr;18(4):526-535. doi: 10.15252/embr.201643374. Epub 2017 Mar 10.


In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits.

Mühleip AW, Dewar CE, Schnaufer A, Kühlbrandt W, Davies KM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):992-997. doi: 10.1073/pnas.1612386114. Epub 2017 Jan 17.


Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.

Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C.

Nat Struct Mol Biol. 2017 Feb;24(2):123-130. doi: 10.1038/nsmb.3357. Epub 2017 Jan 16.


Functional asymmetry and electron flow in the bovine respirasome.

Sousa JS, Mills DJ, Vonck J, Kühlbrandt W.

Elife. 2016 Nov 10;5. pii: e21290. doi: 10.7554/eLife.21290.


Electrogenic Cation Binding in the Electroneutral Na+/H+ Antiporter of Pyrococcus abyssi.

Călinescu O, Linder M, Wöhlert D, Yildiz Ö, Kühlbrandt W, Fendler K.

J Biol Chem. 2016 Dec 23;291(52):26786-26793. doi: 10.1074/jbc.M116.761080. Epub 2016 Nov 7.


Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism.

D'Imprima E, Mills DJ, Parey K, Brandt U, Kühlbrandt W, Zickermann V, Vonck J.

Biochim Biophys Acta. 2016 Dec;1857(12):1935-1942. doi: 10.1016/j.bbabio.2016.09.014. Epub 2016 Sep 30.


Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria.

Mühleip AW, Joos F, Wigge C, Frangakis AS, Kühlbrandt W, Davies KM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8442-7. doi: 10.1073/pnas.1525430113. Epub 2016 Jul 11.


Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology.

Hahn A, Parey K, Bublitz M, Mills DJ, Zickermann V, Vonck J, Kühlbrandt W, Meier T.

Mol Cell. 2016 Aug 4;63(3):445-56. doi: 10.1016/j.molcel.2016.05.037. Epub 2016 Jun 30.


A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro.

Brandt T, Cavellini L, Kühlbrandt W, Cohen MM.

Elife. 2016 Jun 2;5. pii: e14618. doi: 10.7554/eLife.14618.


Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane.

Daum B, Auerswald A, Gruber T, Hause G, Balbach J, Kühlbrandt W, Meister A.

J Struct Biol. 2016 Jun;194(3):375-82. doi: 10.1016/j.jsb.2016.03.017. Epub 2016 Mar 22.


Three in a row-how sodium ions cross the channel.

Kühlbrandt W.

EMBO J. 2016 Apr 15;35(8):793-5. doi: 10.15252/embj.201694094. Epub 2016 Mar 21. No abstract available.


CryoEM at IUCrJ: a new era.

Subramaniam S, Kühlbrandt W, Henderson R.

IUCrJ. 2016 Jan 1;3(Pt 1):3-7. doi: 10.1107/S2052252515023738. eCollection 2016 Jan 1.


Rotary ATPases: A New Twist to an Ancient Machine.

Kühlbrandt W, Davies KM.

Trends Biochem Sci. 2016 Jan;41(1):106-116. doi: 10.1016/j.tibs.2015.10.006. Epub 2015 Dec 4. Review.


Mechanism of Na(+)-dependent citrate transport from the structure of an asymmetrical CitS dimer.

Wöhlert D, Grötzinger MJ, Kühlbrandt W, Yildiz Ö.

Elife. 2015 Dec 4;4:e09375. doi: 10.7554/eLife.09375.


Structure and function of mitochondrial membrane protein complexes.

Kühlbrandt W.

BMC Biol. 2015 Oct 29;13:89. doi: 10.1186/s12915-015-0201-x. Review.


Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.

Kukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11288-93. doi: 10.1073/pnas.1512131112. Epub 2015 Aug 24.


Structure of a type IV pilus machinery in the open and closed state.

Gold VA, Salzer R, Averhoff B, Kühlbrandt W.

Elife. 2015 May 21;4. doi: 10.7554/eLife.07380.


Central role of Mic10 in the mitochondrial contact site and cristae organizing system.

Bohnert M, Zerbes RM, Davies KM, Mühleip AW, Rampelt H, Horvath SE, Boenke T, Kram A, Perschil I, Veenhuis M, Kühlbrandt W, van der Klei IJ, Pfanner N, van der Laan M.

Cell Metab. 2015 May 5;21(5):747-55. doi: 10.1016/j.cmet.2015.04.007.


Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals.

Jiko C, Davies KM, Shinzawa-Itoh K, Tani K, Maeda S, Mills DJ, Tsukihara T, Fujiyoshi Y, Kühlbrandt W, Gerle C.

Elife. 2015 Mar 27;4:e06119. doi: 10.7554/eLife.06119.


Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase.

Allegretti M, Klusch N, Mills DJ, Vonck J, Kühlbrandt W, Davies KM.

Nature. 2015 May 14;521(7551):237-40. doi: 10.1038/nature14185. Epub 2015 Feb 23.


Towards an optimum design for electrostatic phase plates.

Walter A, Steltenkamp S, Schmitz S, Holik P, Pakanavicius E, Sachser R, Huth M, Rhinow D, Kühlbrandt W.

Ultramicroscopy. 2015 Jun;153:22-31. doi: 10.1016/j.ultramic.2015.01.005. Epub 2015 Feb 3.


Protein dynamics tunes excited state positions in light-harvesting complex II.

Vrandecic K, Rätsep M, Wilk L, Rusevich L, Golub M, Reppert M, Irrgang KD, Kühlbrandt W, Pieper J.

J Phys Chem B. 2015 Mar 12;119(10):3920-30. doi: 10.1021/jp5112873. Epub 2015 Feb 26.


Light-induced helix movements in channelrhodopsin-2.

Müller M, Bamann C, Bamberg E, Kühlbrandt W.

J Mol Biol. 2015 Jan 30;427(2):341-9. doi: 10.1016/j.jmb.2014.11.004. Epub 2014 Nov 9.


Structure and transport mechanism of the sodium/proton antiporter MjNhaP1.

Paulino C, Wöhlert D, Kapotova E, Yildiz Ö, Kühlbrandt W.

Elife. 2014 Nov 26;3:e03583. doi: 10.7554/eLife.03583.


Structure and substrate ion binding in the sodium/proton antiporter PaNhaP.

Wöhlert D, Kühlbrandt W, Yildiz O.

Elife. 2014 Nov 26;3:e03579. doi: 10.7554/eLife.03579.


A 3D cellular context for the macromolecular world.

Patwardhan A, Ashton A, Brandt R, Butcher S, Carzaniga R, Chiu W, Collinson L, Doux P, Duke E, Ellisman MH, Franken E, Grünewald K, Heriche JK, Koster A, Kühlbrandt W, Lagerstedt I, Larabell C, Lawson CL, Saibil HR, Sanz-García E, Subramaniam S, Verkade P, Swedlow JR, Kleywegt GJ.

Nat Struct Mol Biol. 2014 Oct;21(10):841-5. doi: 10.1038/nsmb.2897. No abstract available.


Visualization of ATP synthase dimers in mitochondria by electron cryo-tomography.

Davies KM, Daum B, Gold VA, Mühleip AW, Brandt T, Blum TB, Mills DJ, Kühlbrandt W.

J Vis Exp. 2014 Sep 14;(91):51228. doi: 10.3791/51228.


Cryo-EM enters a new era.

Kühlbrandt W.

Elife. 2014 Aug 13;3:e03678. doi: 10.7554/eLife.03678.


Visualizing active membrane protein complexes by electron cryotomography.

Gold VA, Ieva R, Walter A, Pfanner N, van der Laan M, Kühlbrandt W.

Nat Commun. 2014 Jun 19;5:4129. doi: 10.1038/ncomms5129.


Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation.

Köster S, van Pee K, Hudel M, Leustik M, Rhinow D, Kühlbrandt W, Chakraborty T, Yildiz Ö.

Nat Commun. 2014 Apr 22;5:3690. doi: 10.1038/ncomms4690.


Biochemistry. The resolution revolution.

Kühlbrandt W.

Science. 2014 Mar 28;343(6178):1443-4. doi: 10.1126/science.1251652. No abstract available.


Keeping it simple, transport mechanism and pH regulation in Na+/H+ exchangers.

Călinescu O, Paulino C, Kühlbrandt W, Fendler K.

J Biol Chem. 2014 May 9;289(19):13168-76. doi: 10.1074/jbc.M113.542993. Epub 2014 Mar 18.


Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector.

Allegretti M, Mills DJ, McMullan G, Kühlbrandt W, Vonck J.

Elife. 2014 Feb 25;3:e01963. doi: 10.7554/eLife.01963.


Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids.

Daum B, Quax TE, Sachse M, Mills DJ, Reimann J, Yildiz Ö, Häder S, Saveanu C, Forterre P, Albers SV, Kühlbrandt W, Prangishvili D.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3829-34. doi: 10.1073/pnas.1319245111. Epub 2014 Feb 24.


pH- and sodium-induced changes in a sodium/proton antiporter.

Paulino C, Kühlbrandt W.

Elife. 2014 Jan 28;3:e01412. doi: 10.7554/eLife.01412.


Loss of LRPPRC causes ATP synthase deficiency.

Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG.

Hum Mol Genet. 2014 May 15;23(10):2580-92. doi: 10.1093/hmg/ddt652. Epub 2014 Jan 6.


Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiT.

Kalayil S, Schulze S, Kühlbrandt W.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17296-301. doi: 10.1073/pnas.1309071110. Epub 2013 Oct 7.


First insights into the entry process of hyperthermophilic archaeal viruses.

Quemin ER, Lucas S, Daum B, Quax TE, Kühlbrandt W, Forterre P, Albers SV, Prangishvili D, Krupovic M.

J Virol. 2013 Dec;87(24):13379-85. doi: 10.1128/JVI.02742-13. Epub 2013 Oct 2.

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