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Items: 39


Users' Experiences With Home Mechanical Ventilation: A Review of Qualitative Studies.

Ørtenblad L, Carstensen K, Væggemose U, Løvschall C, Sprehn M, Küchen S, Nørregaard O, Jensen LG.

Respir Care. 2019 Sep;64(9):1157-1168. doi: 10.4187/respcare.06855. Epub 2019 Jul 23. Review.


Treatment of severe periodontitis may improve clinical disease activity in otherwise treatment-refractory rheumatoid arthritis patients.

Möller B, Bender P, Eick S, Kuchen S, Maldonado A, Potempa J, Reichenbach S, Sculean A, Schwenzer A, Villiger PM, Wong A, Midwood KS.

Rheumatology (Oxford). 2019 Jul 10. pii: kez287. doi: 10.1093/rheumatology/kez287. [Epub ahead of print] No abstract available.


Human "TH9" cells are a subpopulation of PPAR-γ+ TH2 cells.

Micossé C, von Meyenn L, Steck O, Kipfer E, Adam C, Simillion C, Seyed Jafari SM, Olah P, Yawlkar N, Simon D, Borradori L, Kuchen S, Yerly D, Homey B, Conrad C, Snijder B, Schmidt M, Schlapbach C.

Sci Immunol. 2019 Jan 18;4(31). pii: eaat5943. doi: 10.1126/sciimmunol.aat5943.


Coincidence of NOD2-Associated Autoinflammatory Disease (Yao Syndrome) and HCV Infection With Fatal Consequences: Interaction Between Genes and Environment.

Trueb B, Zhuang L, Keller I, von Köckritz L, Kuchen S, Dufour JF, Villiger PM.

J Clin Rheumatol. 2018 Dec 28. doi: 10.1097/RHU.0000000000000963. [Epub ahead of print] No abstract available.


Increased cardiovascular comorbidities in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia presenting with systemic inflammatory and autoimmune manifestations.

Kipfer B, Daikeler T, Kuchen S, Hallal M, Andina N, Allam R, Bonadies N.

Semin Hematol. 2018 Oct;55(4):242-247. doi: 10.1053/j.seminhematol.2018.05.002. Epub 2018 May 28.


Immuno-monitoring reveals an extended subclinical disease activity in tocilizumab-treated giant cell arteritis.

Gloor AD, Yerly D, Adler S, Reichenbach S, Kuchen S, Seitz M, Villiger PM.

Rheumatology (Oxford). 2018 Oct 1;57(10):1795-1801. doi: 10.1093/rheumatology/key158.


Magnetic resonance angiography in giant cell arteritis: results of a randomized controlled trial of tocilizumab in giant cell arteritis.

Reichenbach S, Adler S, Bonel H, Cullmann JL, Kuchen S, Bütikofer L, Seitz M, Villiger PM.

Rheumatology (Oxford). 2018 Jun 1;57(6):982-986. doi: 10.1093/rheumatology/key015.


[Indentations and discolorations on arms and legs].

Maurer M, Kuchen S.

MMW Fortschr Med. 2015 Nov 5;157(19):5. German. No abstract available.


Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial.

Villiger PM, Adler S, Kuchen S, Wermelinger F, Dan D, Fiege V, Bütikofer L, Seitz M, Reichenbach S.

Lancet. 2016 May 7;387(10031):1921-7. doi: 10.1016/S0140-6736(16)00560-2. Epub 2016 Mar 4.


Deletion of exon 8 from the EXT1 gene causes multiple osteochondromas (MO) in a family with three affected members.

Zhuang L, Gerber SD, Kuchen S, Villiger PM, Trueb B.

Springerplus. 2016 Jan 22;5:71. doi: 10.1186/s40064-016-1695-6. eCollection 2016.


A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.

Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.


A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection.

Brandes M, Klauschen F, Kuchen S, Germain RN.

Cell. 2013 Jul 3;154(1):197-212. doi: 10.1016/j.cell.2013.06.013.


Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.

Snow AL, Xiao W, Stinson JR, Lu W, Chaigne-Delalande B, Zheng L, Pittaluga S, Matthews HF, Schmitz R, Jhavar S, Kuchen S, Kardava L, Wang W, Lamborn IT, Jing H, Raffeld M, Moir S, Fleisher TA, Staudt LM, Su HC, Lenardo MJ.

J Exp Med. 2012 Nov 19;209(12):2247-61. doi: 10.1084/jem.20120831. Epub 2012 Nov 5.


The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.

Baba M, Keller JR, Sun HW, Resch W, Kuchen S, Suh HC, Hasumi H, Hasumi Y, Kieffer-Kwon KR, Gonzalez CG, Hughes RM, Klein ME, Oh HF, Bible P, Southon E, Tessarollo L, Schmidt LS, Linehan WM, Casellas R.

Blood. 2012 Aug 9;120(6):1254-61. doi: 10.1182/blood-2012-02-410407. Epub 2012 Jun 18.


TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

Takahashi H, Kanno T, Nakayamada S, Hirahara K, Sciumè G, Muljo SA, Kuchen S, Casellas R, Wei L, Kanno Y, O'Shea JJ.

Nat Immunol. 2012 Apr 29;13(6):587-95. doi: 10.1038/ni.2286.


Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.

Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride K, Nussenzweig MC, Casellas R.

Nat Immunol. 2011 Jan;12(1):62-9. doi: 10.1038/ni.1964. Epub 2010 Nov 28.


Regulation of microRNA expression and abundance during lymphopoiesis.

Kuchen S, Resch W, Yamane A, Kuo N, Li Z, Chakraborty T, Wei L, Laurence A, Yasuda T, Peng S, Hu-Li J, Lu K, Dubois W, Kitamura Y, Charles N, Sun HW, Muljo S, Schwartzberg PL, Paul WE, O'Shea J, Rajewsky K, Casellas R.

Immunity. 2010 Jun 25;32(6):828-39. doi: 10.1016/j.immuni.2010.05.009. Epub 2010 Jun 3.


The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.

Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, Henke N, Li Z, Hoffmann TK, Kim YM, Hofmann WK, Jumaa H, Groffen J, Heisterkamp N, Martinelli G, Lieber MR, Casellas R, Müschen M.

Cancer Cell. 2009 Sep 8;16(3):232-45. doi: 10.1016/j.ccr.2009.07.030.


Identification and characterization of a human CD5+ pre-naive B cell population.

Lee J, Kuchen S, Fischer R, Chang S, Lipsky PE.

J Immunol. 2009 Apr 1;182(7):4116-26. doi: 10.4049/jimmunol.0803391.


Interleukin 21 as a target of intervention in autoimmune disease.

Ettinger R, Kuchen S, Lipsky PE.

Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii83-6. doi: 10.1136/ard.2008.098400. Review.


The role of IL-21 in regulating B-cell function in health and disease.

Ettinger R, Kuchen S, Lipsky PE.

Immunol Rev. 2008 Jun;223:60-86. doi: 10.1111/j.1600-065X.2008.00631.x. Review.


In situ hybridization of synovial tissue.

Kuchen S, Seemayer CA, Neidhart M, Gay RE, Gay S.

Methods Mol Med. 2007;135:65-75.


Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.

Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R.

J Immunol. 2007 Nov 1;179(9):5886-96.


IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.

Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE.

J Immunol. 2007 Mar 1;178(5):2872-82.


Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis.

Pap T, Nawrath M, Heinrich J, Bosse M, Baier A, Hummel KM, Petrow P, Kuchen S, Michel BA, Gay RE, Müller-Ladner U, Moelling K, Gay S.

Arthritis Rheum. 2004 Sep;50(9):2794-802.


The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.

Studýnková JT, Kuchen S, Jeisy E, Schedel J, Charvát F, Jarosová K, Sprott H, Matucci-Cerinic M, Gay RE, Michel BA, Pavelka K, Vencovský J, Gay S.

Clin Exp Rheumatol. 2004 Jul-Aug;22(4):395-402.


Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.

Schedel J, Seemayer CA, Pap T, Neidhart M, Kuchen S, Michel BA, Gay RE, Müller-Ladner U, Gay S, Zacharias W.

Gene Ther. 2004 Jul;11(13):1040-7.


The L1 retroelement-related p40 protein induces p38delta MAP kinase.

Kuchen S, Seemayer CA, Rethage J, von Knoch R, Kuenzler P, Beat AM, Gay RE, Gay S, Neidhart M.

Autoimmunity. 2004 Feb;37(1):57-65.


p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.

Seemayer CA, Kuchen S, Neidhart M, Kuenzler P, Rihosková V, Neumann E, Pruschy M, Aicher WK, Müller-Ladner U, Gay RE, Michel BA, Firestein GS, Gay S.

Ann Rheum Dis. 2003 Dec;62(12):1139-44.


Galectin 3 and its binding protein in rheumatoid arthritis.

Ohshima S, Kuchen S, Seemayer CA, Kyburz D, Hirt A, Klinzing S, Michel BA, Gay RE, Liu FT, Gay S, Neidhart M.

Arthritis Rheum. 2003 Oct;48(10):2788-95.


Induction of p16 at sites of cartilage invasion in the SCID mouse coimplantation model of rheumatoid arthritis.

Kuenzler P, Kuchen S, Rihosková V, Michel BA, Gay RE, Neidhart M, Gay S, Seemayer CA.

Arthritis Rheum. 2003 Jul;48(7):2069-73. No abstract available.


Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.

Seemayer CA, Kuchen S, Kuenzler P, Rihosková V, Rethage J, Aicher WK, Michel BA, Gay RE, Kyburz D, Neidhart M, Gay S.

Am J Pathol. 2003 May;162(5):1549-57.


Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts.

Aicher WK, Alexander D, Haas C, Kuchen S, Pagenstecher A, Gay S, Peter HH, Eibel H.

Arthritis Rheum. 2003 Feb;48(2):348-59.


Cartilage destruction in rheumatoid arthritis.

Gay S, Kuchen S, Gay RE, Neidhart M.

Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii87. Review. No abstract available.


[Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts].

Seemayer CA, Distler O, Kuchen S, Müller-Ladner U, Michel BA, Neidhart M, Gay RE, Gay S.

Z Rheumatol. 2001 Oct;60(5):309-18. Review. German.


Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression.

Neidhart M, Rethage J, Kuchen S, Künzler P, Crowl RM, Billingham ME, Gay RE, Gay S.

Arthritis Rheum. 2000 Dec;43(12):2634-47.


Gene transfer in rheumatoid arthritis: a novel therapeutic approach.

Kuchen S, Pap T, Müller-Ladner U, Gay RE, Gay S.

Clin Exp Rheumatol. 2000 Sep-Oct;18(5):543-5. Review. No abstract available.


Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis.

Pap T, Shigeyama Y, Kuchen S, Fernihough JK, Simmen B, Gay RE, Billingham M, Gay S.

Arthritis Rheum. 2000 Jun;43(6):1226-32.


Increased serum levels of antibodies against human cytomegalovirus and prevalence of autoantibodies in systemic sclerosis.

Neidhart M, Kuchen S, Distler O, Brühlmann P, Michel BA, Gay RE, Gay S.

Arthritis Rheum. 1999 Feb;42(2):389-92. No abstract available.

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