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Items: 1 to 50 of 846

1.

Effects of Serelaxin in Patients with Acute Heart Failure.

Metra M, Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Voors AA, Adams KF, Anker SD, Arias-Mendoza A, Avendaño P, Bacal F, Böhm M, Bortman G, Cleland JGF, Cohen-Solal A, Crespo-Leiro MG, Dorobantu M, Echeverría LE, Ferrari R, Goland S, Goncalvesová E, Goudev A, Køber L, Lema-Osores J, Levy PD, McDonald K, Manga P, Merkely B, Mueller C, Pieske B, Silva-Cardoso J, Špinar J, Squire I, Stępińska J, Van Mieghem W, von Lewinski D, Wikström G, Yilmaz MB, Hagner N, Holbro T, Hua TA, Sabarwal SV, Severin T, Szecsödy P, Gimpelewicz C; RELAX-AHF-2 Committees Investigators.

N Engl J Med. 2019 Aug 22;381(8):716-726. doi: 10.1056/NEJMoa1801291.

PMID:
31433919
2.

Direct oral anticoagulant- versus vitamin K antagonist-related gastrointestinal bleeding: Insights from a nationwide cohort.

Butt JH, Li A, Xian Y, Peterson ED, Garcia D, Torp-Pedersen C, Køber L, Fosbøl EL.

Am Heart J. 2019 Jul 25;216:117-124. doi: 10.1016/j.ahj.2019.07.012. [Epub ahead of print]

PMID:
31425898
3.

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.

Kristensen SL, Rørth R, Jhund PS, Docherty KF, Sattar N, Preiss D, Køber L, Petrie MC, McMurray JJV.

Lancet Diabetes Endocrinol. 2019 Aug 14. pii: S2213-8587(19)30249-9. doi: 10.1016/S2213-8587(19)30249-9. [Epub ahead of print]

PMID:
31422062
4.

Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV.

Knudsen AD, Kofoed KF, Gelpi M, Sigvardsen PE, Mocroft A, Kühl JT, Fuchs A, Køber L, Nordestgaard BG, Benfield T, Graff C, Skov MW, Lundgren J, Nielsen SD; Copenhagen Comorbidity in HIV Infection (COCOMO) Study.

AIDS. 2019 Aug 1. doi: 10.1097/QAD.0000000000002327. [Epub ahead of print]

PMID:
31373917
5.

Increased risk of sudden death in untreated Primary Carnitine Deficiency.

Rasmussen J, Dunø M, Lund AM, Steuerwald U, Hansen SH, Joensen HD, Køber L, Nielsen OW.

J Inherit Metab Dis. 2019 Aug 1. doi: 10.1002/jimd.12158. [Epub ahead of print]

PMID:
31373028
6.

Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction.

Tromp J, Shen L, Jhund PS, Anand IS, Carson PE, Desai AS, Granger CB, Komajda M, McKelvie RS, Pfeffer MA, Solomon SD, Køber L, Swedberg K, Zile MR, Pitt B, Lam CSP, McMurray JJV.

J Am Coll Cardiol. 2019 Aug 6;74(5):601-612. doi: 10.1016/j.jacc.2019.05.052.

PMID:
31370950
7.

The economic burden of heart failure in Denmark from 1998 to 2016.

Bundgaard JS, Mogensen UM, Christensen S, Ploug U, Rørth R, Ibsen R, Kjellberg J, Køber L.

Eur J Heart Fail. 2019 Jul 29. doi: 10.1002/ejhf.1577. [Epub ahead of print]

PMID:
31359583
8.

Nucleo-cytoplasmic shuttling of Drosophila Hairless/Su(H) heterodimer as a means of regulating Notch dependent transcription.

Wolf D, Smylla TK, Reichmuth J, Hoffmeister P, Kober L, Zimmermann M, Turkiewicz A, Borggrefe T, Nagel AC, Oswald F, Preiss A, Maier D.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1520-1532. doi: 10.1016/j.bbamcr.2019.07.008. Epub 2019 Jul 19.

PMID:
31326540
9.

The effect of implantable cardioverter-defibrillator in patients with diabetes and non-ischaemic systolic heart failure.

Rørth R, Thune JJ, Nielsen JC, Haarbo J, Videbæk L, Korup E, Signorovitch J, Bruun NE, Eiskjær H, Hassager C, Svendsen JH, Høfsten DE, Torp-Pedersen C, Pehrson S, Køber L, Kristensen SL.

Europace. 2019 Apr 28. pii: euz114. doi: 10.1093/europace/euz114. [Epub ahead of print]

PMID:
31323662
10.

Interaction of ischaemic postconditioning and thrombectomy in patients with ST-elevation myocardial infarction.

Nepper-Christensen L, Høfsten DE, Helqvist S, Lassen JF, Tilsted HH, Holmvang L, Pedersen F, Joshi F, Sørensen R, Bang L, Bøtker HE, Terkelsen CJ, Maeng M, Jensen LO, Aarøe J, Kelbæk H, Køber L, Engstrøm T, Lønborg J.

Heart. 2019 Jul 17. pii: heartjnl-2019-314952. doi: 10.1136/heartjnl-2019-314952. [Epub ahead of print]

PMID:
31315939
11.

The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics.

McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD; DAPA-HF Committees and Investigators.

Eur J Heart Fail. 2019 Jul 15. doi: 10.1002/ejhf.1548. [Epub ahead of print]

PMID:
31309699
12.

Residual vegetation after treatment for left-sided infective endocarditis and subsequent risk of stroke and recurrence of endocarditis.

Østergaard L, Dahl A, Fosbøl E, Bruun NE, Oestergaard LB, Lauridsen TK, Valeur N, Køber L, Hassager C, Ihlemann N.

Int J Cardiol. 2019 Jun 22. pii: S0167-5273(19)31777-2. doi: 10.1016/j.ijcard.2019.06.059. [Epub ahead of print]

PMID:
31307845
13.

Risk Models for Prediction of Implantable Cardioverter-Defibrillator Benefit: Insights From the DANISH Trial.

Kristensen SL, Levy WC, Shadman R, Nielsen JC, Haarbo J, Videbæk L, Bruun NE, Eiskjær H, Wiggers H, Brandes A, Thøgersen AM, Hassager C, Svendsen JH, Høfsten DE, Torp-Pedersen C, Pehrson S, Signorovitch J, Køber L, Thune JJ.

JACC Heart Fail. 2019 Aug;7(8):717-724. doi: 10.1016/j.jchf.2019.03.019. Epub 2019 Jul 10.

PMID:
31302052
14.

Echocardiographic subtypes of heart failure in consecutive hospitalised patients with dyspnoea.

Nielsen OW, Valeur N, Sajadieh A, Fabricius-Bjerre A, Carlsen CM, Kober L.

Open Heart. 2019 Jun 20;6(1):e000928. doi: 10.1136/openhrt-2018-000928. eCollection 2019.

15.

Association between Type D personality and outcomes in patients with non-ischemic heart failure.

Bundgaard JS, Østergaard L, Gislason G, Thune JJ, Nielsen JC, Haarbo J, Videbæk L, Olesen LL, Thøgersen AM, Torp-Pedersen C, Pedersen SS, Køber L, Mogensen UM.

Qual Life Res. 2019 Jul 10. doi: 10.1007/s11136-019-02241-6. [Epub ahead of print]

PMID:
31292822
16.

Antithrombotic treatment and major adverse cardiac events after bleeding in patients with myocardial infarction: a retrospective analysis of nationwide registry data.

Nabi H, Rørth R, Tajchman Mb DH, Holmvang L, Torp-Pedersen C, Gislason G, Fosbøl EL, Køber L, Sørensen R.

Eur Heart J Cardiovasc Pharmacother. 2019 Jul 5. pii: pvz025. doi: 10.1093/ehjcvp/pvz025. [Epub ahead of print]

PMID:
31274145
17.

Association of Carpal Tunnel Syndrome With Amyloidosis, Heart Failure, and Adverse Cardiovascular Outcomes.

Fosbøl EL, Rørth R, Leicht BP, Schou M, Maurer MS, Kristensen SL, Kober L, Gustafsson F.

J Am Coll Cardiol. 2019 Jul 9;74(1):15-23. doi: 10.1016/j.jacc.2019.04.054.

PMID:
31272537
18.

Insulin treatment and clinical outcomes in patients with diabetes and heart failure with preserved ejection fraction.

Shen L, Rørth R, Cosmi D, Kristensen SL, Petrie MC, Cosmi F, Latini R, Køber L, Anand IS, Carson PE, Granger CB, Komajda M, McKelvie RS, Solomon SD, Staszewsky L, Swedberg K, Huynh T, Zile MR, Jhund PS, McMurray JJV.

Eur J Heart Fail. 2019 Aug;21(8):974-984. doi: 10.1002/ejhf.1535. Epub 2019 Jul 4.

PMID:
31271255
19.

Burden and Causes of Hospital Admissions in Heart Failure During the Last Year of Life.

Madelaire C, Gustafsson F, Kristensen SL, D'Souza M, Stevenson LW, Kober L, Torp-Pedersen C, Gislason G, Schou M.

JACC Heart Fail. 2019 Jul;7(7):561-570. doi: 10.1016/j.jchf.2019.03.018.

PMID:
31248567
20.

Early Discharge from the Emergency Department Based on Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels: A TRIAGE III Substudy.

Schultz M, Rasmussen LJH, Høi-Hansen T, Kjøller E, Jensen BN, Lind MN, Ravn L, Kallemose T, Lange T, Køber L, Rasmussen LS, Eugen-Olsen J, Iversen KK.

Dis Markers. 2019 May 19;2019:3403549. doi: 10.1155/2019/3403549. eCollection 2019.

21.

Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.

Kober L, Zimmermann M, Kurz M, Bayer M, Nagel AC.

Sci Rep. 2019 Jun 24;9(1):9108. doi: 10.1038/s41598-019-45655-5.

22.

Empagliflozin in heart failure patients with reduced ejection fraction: a randomized clinical trial (Empire HF).

Jensen J, Omar M, Kistorp C, Poulsen MK, Tuxen C, Gustafsson I, Køber L, Gustafsson F, Fosbøl E, Bruun NE, Videbæk L, Frederiksen PH, Møller JE, Schou M.

Trials. 2019 Jun 21;20(1):374. doi: 10.1186/s13063-019-3474-5.

23.

Associations between common ECG abnormalities and out-of-hospital cardiac arrest.

Søndergaard MM, Nielsen JB, Mortensen RN, Gislason G, Køber L, Lippert F, Graff C, Haunsø S, Svendsen JH, Kragholm KH, Pietersen AH, Lind BS, Hjortshøj SP, Holst AG, Struijk JJ, Torp-Pedersen C, Hansen SM.

Open Heart. 2019 May 21;6(1):e000905. doi: 10.1136/openhrt-2018-000905. eCollection 2019.

24.

Heart failure and the prognostic impact and incidence of new-onset of diabetes mellitus: a nationwide cohort study.

Zareini B, Rørth R, Holt A, Mogensen UM, Selmer C, Gislason G, Schou M, Køber L, Torp-Pedersen C, Lamberts M, Kristensen SL.

Cardiovasc Diabetol. 2019 Jun 12;18(1):79. doi: 10.1186/s12933-019-0883-4.

25.

Polygenic predisposition to breast cancer and the risk of coronary artery disease.

D'Souza M, Schou M, Skals R, Weeke PE, Lee C, Smedegaard L, Madelaire C, Gerds TA, Poulsen HE, Hansen T, Grarup N, Pedersen O, Stender S, Engstrøm T, Fosbøl E, Nielsen D, Gislason G, Køber L, Torp-Pedersen C, Andersson C.

Int J Cardiol. 2019 Sep 15;291:145-151. doi: 10.1016/j.ijcard.2019.05.051. Epub 2019 May 24.

PMID:
31155334
26.

Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study.

Østergaard L, Bruun NE, Voldstedlund M, Arpi M, Andersen CØ, Schønheyder HC, Lemming L, Rosenvinge F, Valeur N, Søgaard P, Andersen PS, Skov R, Chen M, Iversen K, Gill S, Lauridsen TK, Dahl A, Oestergaard LB, Povlsen JA, Moser C, Bundgaard H, Køber L, Fosbøl EL.

Eur Heart J. 2019 May 30. pii: ehz327. doi: 10.1093/eurheartj/ehz327. [Epub ahead of print]

PMID:
31145782
27.

Clinical implications of electrocardiographic bundle branch block in primary care.

Rasmussen PV, Skov MW, Ghouse J, Pietersen A, Hansen SM, Torp-Pedersen C, Køber L, Haunsø S, Olesen MS, Svendsen JH, Melgaard J, Graff C, Holst AG, Nielsen JB.

Heart. 2019 Aug;105(15):1160-1167. doi: 10.1136/heartjnl-2018-314295. Epub 2019 May 25.

PMID:
31129608
28.

Response by Kofoed et al to Letter Regarding Article, "Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome: VERDICT Randomized Controlled Trial".

Kofoed KF, Kelbæk H, Engstrøm T, Køber LV.

Circulation. 2019 May 14;139(20):e961-e962. doi: 10.1161/CIRCULATIONAHA.119.040053. No abstract available.

PMID:
31082293
29.

Unreported exclusion and sampling bias in interpretation of randomized controlled trials in patients with STEMI.

Laursen PN, Holmvang L, Lønborg J, Køber L, Høfsten DE, Helqvist S, Clemmensen P, Kelbæk H, Jørgensen E, Lassen JF, Pedersen F, Høi-Hansen T, Raungaard B, Terkelsen CJ, Jensen LO, Sadjadieh G, Engstrøm T.

Int J Cardiol. 2019 Aug 15;289:1-5. doi: 10.1016/j.ijcard.2019.04.064. Epub 2019 May 1.

PMID:
31078351
30.

Impact of Multiple Myocardial Scars Detected by CMR in Patients Following STEMI.

Ekström K, Nepper-Christensen L, Ahtarovski KA, Kyhl K, Göransson C, Bertelsen L, Ghotbi AA, Kelbæk H, Helqvist S, Høfsten DE, Køber L, Schoos MM, Vejlstrup N, Lønborg J, Engstrøm T.

JACC Cardiovasc Imaging. 2019 Apr 10. pii: S1936-878X(19)30241-4. doi: 10.1016/j.jcmg.2019.01.032. [Epub ahead of print]

PMID:
31005537
31.

Risk of stroke subsequent to infective endocarditis: A nationwide study.

Østergaard L, Andersson NW, Kristensen SL, Dahl A, Bundgaard H, Iversen K, Eske-Bruun N, Gislason G, Torp-Pedersen C, Valeur N, Køber L, Fosbøl EL.

Am Heart J. 2019 Jun;212:144-151. doi: 10.1016/j.ahj.2019.03.010. Epub 2019 Mar 27.

PMID:
31004917
32.

Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy.

Kyhl K, Ahtarovski KA, Nepper-Christensen L, Ekström K, Ghotbi AA, Schoos M, Göransson C, Bertelsen L, Helqvist S, Holmvang L, Jørgensen E, Pedersen F, Saunamäki K, Clemmensen P, De Backer O, Høfsten DE, Køber L, Kelbæk H, Vejlstrup N, Lønborg J, Engstrøm T.

JACC Cardiovasc Interv. 2019 Apr 22;12(8):721-730. doi: 10.1016/j.jcin.2019.01.248.

PMID:
31000010
33.

Prevalence of early stages of heart failure in an elderly risk population: the Copenhagen Heart Failure Risk Study.

Gaborit FS, Kistorp C, Kümler T, Hassager C, Tønder N, Køber L, Hansen PM, Kamstrup PR, Faber J, Iversen KK, Schou M.

Open Heart. 2019 Feb 27;6(1):e000840. doi: 10.1136/openhrt-2018-000840. eCollection 2019.

34.

Availability of suPAR in emergency departments may improve risk stratification: a secondary analysis of the TRIAGE III trial.

Schultz M, Rasmussen LJH, Kallemose T, Kjøller E, Lind MN, Ravn L, Lange T, Køber L, Rasmussen LS, Eugen-Olsen J, Iversen K.

Scand J Trauma Resusc Emerg Med. 2019 Apr 11;27(1):43. doi: 10.1186/s13049-019-0621-7.

35.

Serum Lactate and A Relative Change in Lactate as Predictors of Mortality in Patients with Cardiogenic Shock - Results from The Cardshock Study.

Lindholm MG, Hongisto M, Lassus J, Spinar J, Parissis J, Banaszewski M, Silva-Cardoso J, Carubelli V, Salvatore D, Sionis A, Mebazaa A, Veli-Pekka H, Kober L.

Shock. 2019 Apr 5. doi: 10.1097/SHK.0000000000001353. [Epub ahead of print]

PMID:
30973460
36.

Time in therapeutic range and risk of thromboembolism and bleeding in patients with a mechanical heart valve prosthesis.

Havers-Borgersen E, Butt JH, Vinding NE, Torp-Pedersen C, Gislason G, Køber L, Fosbøl EL.

J Thorac Cardiovasc Surg. 2019 Feb 27. pii: S0022-5223(19)30506-9. doi: 10.1016/j.jtcvs.2019.02.061. [Epub ahead of print]

PMID:
30961980
37.

Long-Term Risk of Infective Endocarditis After Transcatheter Aortic Valve Replacement.

Butt JH, Ihlemann N, De Backer O, Søndergaard L, Havers-Borgersen E, Gislason GH, Torp-Pedersen C, Køber L, Fosbøl EL.

J Am Coll Cardiol. 2019 Apr 9;73(13):1646-1655. doi: 10.1016/j.jacc.2018.12.078.

PMID:
30947917
38.

Clinical characteristics and lipid lowering treatment of patients initiated on proprotein convertase subtilisin-kexin type 9 inhibitors: a nationwide cohort study.

Jensen JS, Weeke PE, Bang LE, Høfsten DE, Ripa MS, Schjerning AM, Theilade JE, Køber LV, Gislason GH, Pallisgaard J.

BMJ Open. 2019 Apr 1;9(4):e022702. doi: 10.1136/bmjopen-2018-022702.

39.

Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy.

Christiansen MN, Køber L, Torp-Pedersen C, Smith JG, Gustafsson F, Vejlstrup NG, Damm P, Johansen M, Andersson C, Ersbøll AS.

Heart. 2019 Jul;105(14):1057-1062. doi: 10.1136/heartjnl-2018-314552. Epub 2019 Mar 25.

PMID:
30910822
40.

Nursing Home Admission and Initiation of Domiciliary Care Following Infective Endocarditis.

Havers-Borgersen E, Fosbøl EL, Rørth R, Kragholm K, Kristensen SL, Bundgaard H, Bruun NE, Østergaard L, Aslam M, Valeur N, Gislason GH, Torp-Pedersen C, Køber L, Butt JH.

Glob Heart. 2019 Mar;14(1):41-46.e2. doi: 10.1016/j.gheart.2019.01.002. Epub 2019 Mar 21.

PMID:
30905692
41.
42.

A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF).

McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD; DAPA-HF Committees and Investigators.

Eur J Heart Fail. 2019 May;21(5):665-675. doi: 10.1002/ejhf.1432. Epub 2019 Mar 21.

43.

Long-Term Outcomes of Partial Oral Treatment of Endocarditis.

Bundgaard H, Ihlemann N, Gill SU, Bruun NE, Elming H, Madsen T, Jensen KT, Fursted K, Christensen JJ, Schultz M, Østergaard L, Rosenvinge F, Schønheyder HC, Helweg-Larsen J, Fosbøll EL, Køber L, Torp-Pedersen C, Tønder N, Moser C, Iversen K.

N Engl J Med. 2019 Apr 4;380(14):1373-1374. doi: 10.1056/NEJMc1902096. Epub 2019 Mar 17. No abstract available.

PMID:
30883059
44.

Congenital myopathies are mainly associated with a mild cardiac phenotype.

Petri H, Wahbi K, Witting N, Køber L, Bundgaard H, Kamoun E, Vellieux G, Stojkovic T, Béhin A, Laforet P, Vissing J.

J Neurol. 2019 Jun;266(6):1367-1375. doi: 10.1007/s00415-019-09267-3. Epub 2019 Mar 14.

PMID:
30874888
45.

N-Terminal Pro-B-Type Natriuretic Peptide Levels for Risk Prediction in Patients With Heart Failure and Preserved Ejection Fraction According to Atrial Fibrillation Status.

Kristensen SL, Mogensen UM, Jhund PS, Rørth R, Anand IS, Carson PE, Desai AS, Pitt B, Pfeffer MA, Solomon SD, Zile MR, Køber L, McMurray JJV.

Circ Heart Fail. 2019 Mar;12(3):e005766. doi: 10.1161/CIRCHEARTFAILURE.118.005766.

PMID:
30871349
46.

Right Ventricular Dysfunction and the Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure.

Elming MB, Hammer-Hansen S, Voges I, Nyktari E, Raja AA, Svendsen JH, Pehrson S, Signorovitch J, Køber LV, Prasad SK, Thune JJ.

Circ Arrhythm Electrophysiol. 2019 Mar;12(3):e007022. doi: 10.1161/CIRCEP.118.007022.

PMID:
30866666
47.

Reduced risk of gastrointestinal bleeding associated with proton pump inhibitor therapy in patients treated with dual antiplatelet therapy after myocardial infarction.

Sehested TSG, Carlson N, Hansen PW, Gerds TA, Charlot MG, Torp-Pedersen C, Køber L, Gislason GH, Hlatky MA, Fosbøl EL.

Eur Heart J. 2019 Jun 21;40(24):1963-1970. doi: 10.1093/eurheartj/ehz104.

PMID:
30851041
48.

Mortality associated with cardiovascular drugs in patients with chronic obstructive pulmonary disease and right-sided heart failure - A danish nationwide registry-based study.

Andersson C, Hansen PW, Steffensen IE, Andreasen C, Weeke PE, Køber L, Gislason GH, Torp-Pedersen C.

Eur J Intern Med. 2019 May;63:56-61. doi: 10.1016/j.ejim.2019.02.014. Epub 2019 Mar 1.

PMID:
30833208
49.

Left ventricular hypertrophy identified by cardiac computed tomography and ECG in hypertensive individuals: a population-based study.

Kühl JT, Nielsen JB, Stisen ZR, Fuchs A, Sigvardsen PE, Graff C, Nordestgaard BG, Køber LV, Kofoed KF.

J Hypertens. 2019 Apr;37(4):739-746. doi: 10.1097/HJH.0000000000001962.

PMID:
30817455
50.

Normal values of aortic dimensions assessed by multidetector computed tomography in the Copenhagen General Population Study.

Pham MHC, Ballegaard C, de Knegt MC, Sigvardsen PE, Sørgaard MH, Fuchs A, Kühl JT, Taudorf M, Nordestgaard BG, Køber LV, Kofoed KF.

Eur Heart J Cardiovasc Imaging. 2019 Aug 1;20(8):939-948. doi: 10.1093/ehjci/jez012.

PMID:
30809640

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