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Items: 1 to 50 of 184

1.

Biased signaling of Ca2+-sensing receptors in cardiac myocytes regulates GIRK channel activity.

Kienitz MC, Niemeyer A, König GM, Kostenis E, Pott L, Rinne A.

J Mol Cell Cardiol. 2019 May;130:107-121. doi: 10.1016/j.yjmcc.2019.03.022. Epub 2019 Mar 29.

PMID:
30935998
2.

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04.

El Maddah F, Eguereva E, Kehraus S, König GM.

Org Biomol Chem. 2019 Mar 6;17(10):2747-2752. doi: 10.1039/c9ob00198k.

PMID:
30785154
3.

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.

Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS.

Cancer Cell. 2019 Mar 18;35(3):457-472.e5. doi: 10.1016/j.ccell.2019.01.009. Epub 2019 Feb 14.

PMID:
30773340
4.

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity.

Malfacini D, Patt J, Annala S, Harpsøe K, Eryilmaz F, Reher R, Crüsemann M, Hanke W, Zhang H, Tietze D, Gloriam DE, Bräuner-Osborne H, Strømgaard K, König GM, Inoue A, Gomeza J, Kostenis E.

J Biol Chem. 2019 Apr 12;294(15):5747-5758. doi: 10.1074/jbc.RA118.007250. Epub 2019 Feb 11.

5.

Biosynthetic Basis for Structural Diversity of Aminophenylpyrrole-Derived Alkaloids.

Linares-Otoya L, Liu Y, Linares-Otoya V, Armas-Mantilla L, Crüsemann M, Ganoza-Yupanqui ML, Campos-Florian J, König GM, Schäberle TF.

ACS Chem Biol. 2019 Feb 15;14(2):176-181. doi: 10.1021/acschembio.8b00993. Epub 2019 Jan 18.

PMID:
30649848
6.

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C.

Sci Signal. 2018 Dec 4;11(559). pii: eaar5536. doi: 10.1126/scisignal.aar5536.

PMID:
30514810
7.

Soil Bacteria Isolated From Tunisian Arid Areas Show Promising Antimicrobial Activities Against Gram-Negatives.

Nasfi Z, Busch H, Kehraus S, Linares-Otoya L, König GM, Schäberle TF, Bachoual R.

Front Microbiol. 2018 Nov 13;9:2742. doi: 10.3389/fmicb.2018.02742. eCollection 2018.

8.

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.

Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J.

J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16.

PMID:
30446620
9.

Analysis of the Genome and Metabolome of Marine Myxobacteria Reveals High Potential for Biosynthesis of Novel Specialized Metabolites.

Amiri Moghaddam J, Crüsemann M, Alanjary M, Harms H, Dávila-Céspedes A, Blom J, Poehlein A, Ziemert N, König GM, Schäberle TF.

Sci Rep. 2018 Nov 9;8(1):16600. doi: 10.1038/s41598-018-34954-y.

10.

Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity.

Amiri Moghaddam J, Dávila-Céspedes A, Kehraus S, Crüsemann M, Köse M, Müller CE, König GM.

Mar Drugs. 2018 Oct 8;16(10). pii: E369. doi: 10.3390/md16100369.

11.

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway.

Lian X, Beer-Hammer S, König GM, Kostenis E, Nürnberg B, Gollasch M.

Front Physiol. 2018 Sep 4;9:1234. doi: 10.3389/fphys.2018.01234. eCollection 2018.

12.

Antimicrobial Dialkylresorcins from Marine-Derived Microorganisms: Insights into Their Mode of Action and Putative Ecological Relevance.

Harms H, Klöckner A, Schrör J, Josten M, Kehraus S, Crüsemann M, Hanke W, Schneider T, Schäberle TF, König GM.

Planta Med. 2018 Dec;84(18):1363-1371. doi: 10.1055/a-0653-7451. Epub 2018 Jul 10.

PMID:
29991081
13.

Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359.

Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai HF, Müller CE, Kostenis E, König GM, Crüsemann M.

J Nat Prod. 2018 Jul 27;81(7):1628-1635. doi: 10.1021/acs.jnatprod.8b00222. Epub 2018 Jun 26.

PMID:
29943987
14.

Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies.

Reher R, Kühl T, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, Odhiambo JP, Heimer P, Bäuml CA, Kehraus S, Crüsemann M, Kostenis E, Tietze D, König GM, Imhof D.

ChemMedChem. 2018 Aug 20;13(16):1634-1643. doi: 10.1002/cmdc.201800304. Epub 2018 Jul 3.

PMID:
29873888
15.

5-HT2A receptor-dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling.

Murat S, Bigot M, Chapron J, König GM, Kostenis E, Battaglia G, Nicoletti F, Bourinet E, Bockaert J, Marin P, Vandermoere F.

Mol Psychiatry. 2018 Jun 1. doi: 10.1038/s41380-018-0069-6. [Epub ahead of print]

PMID:
29858599
16.

The potential of three different PCR-related approaches for the authentication of mixtures of herbal substances and finished herbal medicinal products.

Doganay-Knapp K, Orland A, König GM, Knöss W.

Phytomedicine. 2018 Apr 1;43:60-67. doi: 10.1016/j.phymed.2018.03.062. Epub 2018 Mar 21.

PMID:
29747755
17.

Draft Genome Sequences of the Obligatory Marine Myxobacterial Strains Enhygromyxa salina SWB005 and SWB007.

Amiri Moghaddam J, Poehlein A, Fisch K, Alanjary M, Daniel R, König GM, Schäberle TF.

Genome Announc. 2018 Apr 26;6(17). pii: e00324-18. doi: 10.1128/genomeA.00324-18.

18.

Draft Genome Sequence of Bacillus sp. Strain M21, Isolated from the Arid Area of Matmata, Tunisia.

Nasfi Z, Poehlein A, Harms H, Goralski E, Fisch KM, Daniel R, König GM, Schäberle TF, Bachoual R.

Genome Announc. 2018 Apr 26;6(17). pii: e00323-18. doi: 10.1128/genomeA.00323-18.

19.

Lack of beta-arrestin signaling in the absence of active G proteins.

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E.

Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3.

20.

Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo.

Kock F, Hauptmann M, Osterloh A, Schäberle TF, Poppert S, Frickmann H, Menzel KD, Peschel G, Pfarr K, Schiefer A, König GM, Hoerauf A, Fleischer B, Keller C.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e01732-17. doi: 10.1128/AAC.01732-17. Print 2018 Apr.

21.

The dialkyl resorcinol stemphol disrupts calcium homeostasis to trigger programmed immunogenic necrosis in cancer.

Ji S, Lee JY, Schrör J, Mazumder A, Jang DM, Chateauvieux S, Schnekenburger M, Hong CR, Christov C, Kang HJ, Lee Y, Han BW, Kim KW, Shin HY, Dicato M, Cerella C, König GM, Orlikova B, Diederich M.

Cancer Lett. 2018 Mar 1;416:109-123. doi: 10.1016/j.canlet.2017.12.011. Epub 2017 Dec 13.

PMID:
29246646
22.

The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds.

Fisch KM, Hertzer C, Böhringer N, Wuisan ZG, Schillo D, Bara R, Kaligis F, Wägele H, König GM, Schäberle TF.

Mar Drugs. 2017 Dec 7;15(12). pii: E384. doi: 10.3390/md15120384. Review.

23.

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):836-840. doi: 10.1002/anie.201707996. Epub 2017 Dec 20.

PMID:
29194875
24.

Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia.

Nimmagadda SC, Frey S, Edelmann B, Hellmich C, Zaitseva L, König GM, Kostenis E, Bowles KM, Fischer T.

Leukemia. 2018 Mar;32(3):846-849. doi: 10.1038/leu.2017.324. Epub 2017 Nov 7. No abstract available.

25.

Diversity and Antimicrobial Potential of Predatory Bacteria from the Peruvian Coastline.

Linares-Otoya L, Linares-Otoya V, Armas-Mantilla L, Blanco-Olano C, Crüsemann M, Ganoza-Yupanqui ML, Campos-Florian J, König GM, Schäberle TF.

Mar Drugs. 2017 Oct 12;15(10). pii: E308. doi: 10.3390/md15100308.

26.

Identification and heterologous expression of the kocurin biosynthetic gene cluster.

Linares-Otoya L, Linares-Otoya V, Armas-Mantilla L, Blanco-Olano C, Crüsemann M, Ganoza-Yupanqui ML, Campos-Florian J, König GM, Schäberle TF.

Microbiology. 2017 Sep 25. doi: 10.1099/mic.0.000538. [Epub ahead of print]

PMID:
28942758
27.

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaag2288. doi: 10.1126/scitranslmed.aag2288.

PMID:
28904224
28.

Draft Genome Sequence of Zobellia sp. Strain OII3, Isolated from the Coastal Zone of the Baltic Sea.

Harms H, Poehlein A, Thürmer A, König GM, Schäberle TF.

Genome Announc. 2017 Sep 7;5(36). pii: e00737-17. doi: 10.1128/genomeA.00737-17.

29.

Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea.

Barra L, Barac P, König GM, Crüsemann M, Dickschat JS.

Org Biomol Chem. 2017 Sep 13;15(35):7411-7421. doi: 10.1039/c7ob01837a.

PMID:
28872169
30.

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.

Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D.

Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6.

31.

Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq-selective inhibitors when induced by signals generated by the platelet-activating factor receptor.

Holdfeldt A, Dahlstrand Rudin A, Gabl M, Rajabkhani Z, König GM, Kostenis E, Dahlgren C, Forsman H.

J Leukoc Biol. 2017 Sep;102(3):871-880. doi: 10.1189/jlb.2A0317-086RR. Epub 2017 Jul 31.

PMID:
28760822
32.

Antimicrobial Potential of Bacteria Associated with Marine Sea Slugs from North Sulawesi, Indonesia.

Böhringer N, Fisch KM, Schillo D, Bara R, Hertzer C, Grein F, Eisenbarth JH, Kaligis F, Schneider T, Wägele H, König GM, Schäberle TF.

Front Microbiol. 2017 Jun 14;8:1092. doi: 10.3389/fmicb.2017.01092. eCollection 2017.

33.

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6.

Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T.

Sci Rep. 2017 May 24;7(1):2380. doi: 10.1038/s41598-017-02414-8.

34.

Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia).

Bogdanov A, Hertzer C, Kehraus S, Nietzer S, Rohde S, Schupp PJ, Wägele H, König GM.

Beilstein J Org Chem. 2017 Mar 13;13:502-519. doi: 10.3762/bjoc.13.50. eCollection 2017.

35.

Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative.

Hufendiek P, Stölben SSM, Kehraus S, Merten N, Harms H, Crüsemann M, Arslan I, Gütschow M, Schneider T, König GM.

Planta Med. 2017 Aug;83(12-13):1044-1052. doi: 10.1055/s-0042-124493. Epub 2017 Jan 12.

PMID:
28081580
36.

The Rare Amino Acid Building Block 3-(3-furyl)-Alanine in the Formation of Non-ribosomal Peptides.

Maddah FE, Nazir M, König GM.

Nat Prod Commun. 2017 Jan;12(1):147-150. Review.

PMID:
30549849
37.

Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146.

Böhringer N, Gütschow M, König GM, Schäberle TF.

Nat Prod Commun. 2017 Jan;12(1):107-109.

PMID:
30549840
38.

Production of Antimicrobial Compounds by Fermentation.

Harms H, König GM, Schäberle TF.

Methods Mol Biol. 2017;1520:49-61. doi: 10.1007/978-1-4939-6634-9_3.

PMID:
27873245
39.

Insights into the Biosynthetic Origin of 3-(3-Furyl)alanine in Stachylidium sp. 293 K04 Tetrapeptides.

El Maddah F, Kehraus S, Nazir M, Almeida C, König GM.

J Nat Prod. 2016 Nov 23;79(11):2838-2845. Epub 2016 Oct 27.

PMID:
27786475
40.

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias.

Bolognini D, Moss CE, Nilsson K, Petersson AU, Donnelly I, Sergeev E, König GM, Kostenis E, Kurowska-Stolarska M, Miller A, Dekker N, Tobin AB, Milligan G.

J Biol Chem. 2016 Sep 2;291(36):18915-31. doi: 10.1074/jbc.M116.736157. Epub 2016 Jul 5.

41.

Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites.

Dávila-Céspedes A, Hufendiek P, Crüsemann M, Schäberle TF, König GM.

Beilstein J Org Chem. 2016 May 13;12:969-984. doi: 10.3762/bjoc.12.96. eCollection 2016. Review.

42.

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells.

Chang GW, Hsiao CC, Peng YM, Vieira Braga FA, Kragten NA, Remmerswaal EB, van de Garde MD, Straussberg R, König GM, Kostenis E, Knäuper V, Meyaard L, van Lier RA, van Gisbergen KP, Lin HH, Hamann J.

Cell Rep. 2016 May 24;15(8):1757-70. doi: 10.1016/j.celrep.2016.04.053. Epub 2016 May 12.

43.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.

Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, Chung KF, Amrani Y, Tobin AB.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4524-9. doi: 10.1073/pnas.1521706113. Epub 2016 Apr 8.

44.

Endolides A and B, Vasopressin and Serotonin-Receptor Interacting N-Methylated Peptides from the Sponge-Derived Fungus Stachylidium sp.

Almeida C, El Maddah F, Kehraus S, Schnakenburg G, König GM.

Org Lett. 2016 Feb 5;18(3):528-31. doi: 10.1021/acs.orglett.5b03553. Epub 2016 Jan 15.

PMID:
26771858
45.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

46.

Defensive Diterpene from the Aeolidoidean Phyllodesmium longicirrum.

Bogdanov A, Hertzer C, Kehraus S, Nietzer S, Rohde S, Schupp PJ, Wägele H, König GM.

J Nat Prod. 2016 Mar 25;79(3):611-5. doi: 10.1021/acs.jnatprod.5b00860. Epub 2015 Dec 9.

PMID:
26649919
47.

Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii.

Harms H, Kehraus S, Nesaei-Mosaferan D, Hufendieck P, Meijer L, König GM.

Steroids. 2015 Dec;104:182-8. doi: 10.1016/j.steroids.2015.09.012. Epub 2015 Oct 9.

PMID:
26440473
48.

Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives.

Schäberle TF, Schmitz A, Zocher G, Schiefer A, Kehraus S, Neu E, Roth M, Vassylyev DG, Stehle T, Bierbaum G, Hoerauf A, Pfarr K, König GM.

J Nat Prod. 2015 Oct 23;78(10):2505-9. doi: 10.1021/acs.jnatprod.5b00175. Epub 2015 Oct 2.

PMID:
26431157
49.

Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors.

Korp J, König S, Schieferdecker S, Dahse HM, König GM, Werz O, Nett M.

Chembiochem. 2015 Nov;16(17):2445-50. doi: 10.1002/cbic.201500446. Epub 2015 Oct 13.

PMID:
26416255
50.

GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum.

Nazir M, Harms H, Loef I, Kehraus S, El Maddah F, Arslan I, Rempel V, Müller CE, König GM.

Planta Med. 2015 Aug;81(12-13):1141-5. doi: 10.1055/s-0035-1545979. Epub 2015 May 8.

PMID:
26287693

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