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Items: 1 to 50 of 97

1.

STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts.

Kinzler MN, Zielke S, Kardo S, Meyer N, Kögel D, van Wijk SJL, Fulda S.

Sci Rep. 2020 Jan 20;10(1):687. doi: 10.1038/s41598-019-56990-y.

2.

System-based approaches as prognostic tools for glioblastoma.

Salvucci M, Zakaria Z, Carberry S, Tivnan A, Seifert V, Kögel D, Murphy BM, Prehn JHM.

BMC Cancer. 2019 Nov 12;19(1):1092. doi: 10.1186/s12885-019-6280-2. Review.

3.

Autophagy in Cancer Cell Death.

Linder B, Kögel D.

Biology (Basel). 2019 Oct 29;8(4). pii: E82. doi: 10.3390/biology8040082. Review.

4.

Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells.

Meister MT, Boedicker C, Linder B, Kögel D, Klingebiel T, Fulda S.

Cancer Lett. 2019 Nov 28;465:1-11. doi: 10.1016/j.canlet.2019.08.012. Epub 2019 Aug 26.

PMID:
31465840
5.

Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D.

Cancers (Basel). 2019 Mar 12;11(3). pii: E350. doi: 10.3390/cancers11030350.

6.

Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model.

Linder B, Weirauch U, Ewe A, Uhmann A, Seifert V, Mittelbronn M, Harter PN, Aigner A, Kögel D.

Cancers (Basel). 2019 Mar 8;11(3). pii: E333. doi: 10.3390/cancers11030333.

7.

Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis.

Remy J, Linder B, Weirauch U, Konovalova J, Marschalek R, Aigner A, Kögel D.

Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):175-189. doi: 10.1016/j.bbamcr.2018.10.017. Epub 2018 Oct 30.

8.

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells.

Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, van Wijk SJL, Kögel D, Fulda S.

Cell Death Dis. 2018 Sep 24;9(10):994. doi: 10.1038/s41419-018-1003-1.

9.

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D.

Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21.

10.

Pro-survival autophagy and cancer cell resistance to therapy.

Das CK, Mandal M, Kögel D.

Cancer Metastasis Rev. 2018 Dec;37(4):749-766. doi: 10.1007/s10555-018-9727-z. Review.

PMID:
29536228
11.

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells.

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D.

Neoplasia. 2018 Mar;20(3):263-279. doi: 10.1016/j.neo.2018.01.001. Epub 2018 Feb 22.

12.

Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?

Aigner A, Kögel D.

Nanomedicine (Lond). 2018 Jan;13(1):89-103. doi: 10.2217/nnm-2017-0230. Epub 2017 Dec 4. Review.

PMID:
29199893
13.

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

Bernstock JD, Ye D, Gessler FA, Lee YJ, Peruzzotti-Jametti L, Baumgarten P, Johnson KR, Maric D, Yang W, Kögel D, Pluchino S, Hallenbeck JM.

Sci Rep. 2017 Aug 7;7(1):7425. doi: 10.1038/s41598-017-07631-9.

14.

A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction.

Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD.

Mech Ageing Dev. 2018 Mar;170:45-58. doi: 10.1016/j.mad.2017.06.004. Epub 2017 Jul 3.

PMID:
28684269
15.

A Novel Cellular Spheroid-Based Autophagy Screen Applying Live Fluorescence Microscopy Identifies Nonactin as a Strong Inducer of Autophagosomal Turnover.

Pampaloni F, Mayer B, Kabat Vel-Job K, Ansari N, Hötte K, Kögel D, Stelzer EHK.

SLAS Discov. 2017 Jun;22(5):558-570. doi: 10.1177/2472555217696798. Epub 2017 Mar 15.

PMID:
28297606
16.

Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.

Copenhaver PF, Kögel D.

Front Mol Neurosci. 2017 Jan 31;10:3. doi: 10.3389/fnmol.2017.00003. eCollection 2017. Review.

17.

Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D.

Mol Neurobiol. 2016 Nov;53(9):5985-5994. doi: 10.1007/s12035-015-9501-y. Epub 2015 Nov 2.

PMID:
26526841
18.

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.

Antonietti P, Linder B, Hehlgans S, Mildenberger IC, Burger MC, Fulda S, Steinbach JP, Gessler F, Rödel F, Mittelbronn M, Kögel D.

Mol Cancer Ther. 2017 Jan;16(1):156-168. doi: 10.1158/1535-7163.MCT-16-0262. Epub 2016 Oct 24.

19.

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M.

Oncotarget. 2016 Apr 12;7(15):20016-32. doi: 10.18632/oncotarget.7910.

20.

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.

Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn JH, Kögel D.

Biochim Biophys Acta. 2016 Apr;1863(4):499-509. doi: 10.1016/j.bbamcr.2015.12.016. Epub 2015 Dec 22.

21.

Autophagy-associated proteins BAG3 and p62 in testicular cancer.

Bartsch G, Jennewein L, Harter PN, Antonietti P, Blaheta RA, Kvasnicka HM, Kögel D, Haferkamp A, Mittelbronn M, Mani J.

Oncol Rep. 2016 Mar;35(3):1629-35. doi: 10.3892/or.2015.4505. Epub 2015 Dec 22.

PMID:
26707573
22.

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.

Zakaria Z, Tivnan A, Flanagan L, Murray DW, Salvucci M, Stringer BW, Day BW, Boyd AW, Kögel D, Rehm M, O'Brien DF, Byrne AT, Prehn JH.

Br J Cancer. 2016 Jan 19;114(2):188-98. doi: 10.1038/bjc.2015.420. Epub 2015 Dec 10.

23.

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner.

Kiprianova I, Remy J, Milosch N, Mohrenz IV, Seifert V, Aigner A, Kögel D.

Neoplasia. 2015 Jul;17(7):564-73. doi: 10.1016/j.neo.2015.07.003.

24.

Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.

Felzen V, Hiebel C, Koziollek-Drechsler I, Reißig S, Wolfrum U, Kögel D, Brandts C, Behl C, Morawe T.

Cell Death Dis. 2015 Jul 9;6:e1812. doi: 10.1038/cddis.2015.181.

25.

Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme.

Tivnan A, Zakaria Z, O'Leary C, Kögel D, Pokorny JL, Sarkaria JN, Prehn JH.

Front Neurosci. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218. eCollection 2015.

26.

Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737.

Mani J, Antonietti P, Rakel S, Blaheta R, Bartsch G, Haferkamp A, Kögel D.

World J Urol. 2016 Feb;34(2):197-205. doi: 10.1007/s00345-015-1616-2. Epub 2015 Jun 23.

PMID:
26100943
27.

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).

Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, Bartsch G, Michaelis M, Cinatl J, Haferkamp A, Kögel D.

BMC Cancer. 2015 Apr 7;15:224. doi: 10.1186/s12885-015-1239-4.

28.

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.

Fulda S, Kögel D.

Oncogene. 2015 Oct 1;34(40):5105-13. doi: 10.1038/onc.2014.458. Epub 2015 Jan 26. Review.

PMID:
25619832
29.

Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.

Afshordel S, Kern B, Clasohm J, König H, Priester M, Weissenberger J, Kögel D, Eckert GP.

Pharmacol Res. 2015 Jan;91:69-77. doi: 10.1016/j.phrs.2014.11.006. Epub 2014 Dec 8.

PMID:
25497898
30.

The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity.

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P.

J Alzheimers Dis. 2015;44(3):879-96. doi: 10.3233/JAD-140600.

PMID:
25362034
31.

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D.

Cell Death Dis. 2014 Aug 28;5:e1391. doi: 10.1038/cddis.2014.352.

32.

Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging--impact of Bcl-2 and NPD-1 like metabolites.

Afshordel S, Hagl S, Werner D, Röhner N, Kögel D, Bazan NG, Eckert GP.

Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:23-31. doi: 10.1016/j.plefa.2014.05.008. Epub 2014 Jun 9.

PMID:
24972878
33.

Quantifying the autophagy-triggering effects of drugs in cell spheroids with live fluorescence microscopy.

Ansari N, Hardung S, Hötte K, Rakel S, Antonietti P, Kögel D, Stelzer EH, Pampaloni F.

Methods Mol Biol. 2014;1165:19-29. doi: 10.1007/978-1-4939-0856-1_3.

PMID:
24839016
34.

Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid.

Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kögel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bähr O.

PLoS One. 2014 Apr 17;9(4):e94921. doi: 10.1371/journal.pone.0094921. eCollection 2014.

35.

Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.

Nensa FM, Neumann MH, Schrötter A, Przyborski A, Mastalski T, Susdalzew S, Looβe C, Helling S, El Magraoui F, Erdmann R, Meyer HE, Uszkoreit J, Eisenacher M, Suh J, Guénette SY, Röhner N, Kögel D, Theiss C, Marcus K, Müller T.

Mol Cell Proteomics. 2014 Feb;13(2):475-88. doi: 10.1074/mcp.M113.029280. Epub 2013 Nov 27.

36.

Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis.

Murphy ÁC, Weyhenmeyer B, Noonan J, Kilbride SM, Schimansky S, Loh KP, Kögel D, Letai AG, Prehn JH, Murphy BM.

Apoptosis. 2014 Apr;19(4):629-42. doi: 10.1007/s10495-013-0935-2.

37.

Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity.

Baumgarten P, Harter PN, Tönjes M, Capper D, Blank AE, Sahm F, von Deimling A, Kolluru V, Schwamb B, Rabenhorst U, Starzetz T, Kögel D, Rieker RJ, Plate KH, Ohgaki H, Radlwimmer B, Zörnig M, Mittelbronn M.

Neuropathol Appl Neurobiol. 2014 Feb;40(2):205-16. doi: 10.1111/nan.12088.

PMID:
24117486
38.

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death.

Mohrenz IV, Antonietti P, Pusch S, Capper D, Balss J, Voigt S, Weissert S, Mukrowsky A, Frank J, Senft C, Seifert V, von Deimling A, Kögel D.

Apoptosis. 2013 Nov;18(11):1416-1425. doi: 10.1007/s10495-013-0877-8.

PMID:
23801081
39.

A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.

Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Köhl U, Rieker RJ, Wachter DL, Agaimy A, Herpel E, Baumgarten P, Mittelbronn M, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M.

PLoS One. 2013 May 22;8(5):e64873. doi: 10.1371/journal.pone.0064873. Print 2013.

40.

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach.

Murphy ÁC, Weyhenmeyer B, Schmid J, Kilbride SM, Rehm M, Huber HJ, Senft C, Weissenberger J, Seifert V, Dunst M, Mittelbronn M, Kögel D, Prehn JH, Murphy BM.

Cell Death Dis. 2013 May 16;4:e629. doi: 10.1038/cddis.2013.157.

41.

STAT3 silencing inhibits glioma single cell infiltration and tumor growth.

Priester M, Copanaki E, Vafaizadeh V, Hensel S, Bernreuther C, Glatzel M, Seifert V, Groner B, Kögel D, Weissenberger J.

Neuro Oncol. 2013 Jul;15(7):840-52. doi: 10.1093/neuonc/not025. Epub 2013 Mar 13. Erratum in: Neuro Oncol. 2013 Oct;15(10):1452.

42.

Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model.

Harter PN, Dützmann S, Drott U, Zachskorn C, Hattingen E, Capper D, Gessler F, Senft C, Seifert V, Plate KH, Kögel D, Mittelbronn M.

Neuropathology. 2013 Oct;33(5):515-25. doi: 10.1111/neup.12018. Epub 2013 Feb 5.

PMID:
23384223
43.

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.

Kögel D, Deller T, Behl C.

Exp Brain Res. 2012 Apr;217(3-4):471-9. doi: 10.1007/s00221-011-2932-4. Epub 2011 Nov 16. Review.

PMID:
22086493
44.

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

Kögel D, Concannon CG, Müller T, König H, Bonner C, Poeschel S, Chang S, Egensperger R, Prehn JH.

Neurobiol Aging. 2012 Sep;33(9):2200-9. doi: 10.1016/j.neurobiolaging.2011.06.012. Epub 2011 Jul 30.

PMID:
21803450
45.

Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH.

J Biol Chem. 2011 Jul 22;286(29):25719-28. doi: 10.1074/jbc.M110.215525. Epub 2011 May 31.

46.

Knockdown of TFPI-2 promotes migration and invasion of glioma cells.

Gessler F, Voss V, Seifert V, Gerlach R, Kögel D.

Neurosci Lett. 2011 Jun 15;497(1):49-54. doi: 10.1016/j.neulet.2011.04.027. Epub 2011 Apr 20.

PMID:
21530612
47.

Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway.

Weissenberger J, Priester M, Bernreuther C, Rakel S, Glatzel M, Seifert V, Kögel D.

Clin Cancer Res. 2010 Dec 1;16(23):5781-95. doi: 10.1158/1078-0432.CCR-10-0446.

48.

Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing.

Eckert GP, Chang S, Eckmann J, Copanaki E, Hagl S, Hener U, Müller WE, Kögel D.

Biochim Biophys Acta. 2011 Jan;1808(1):236-43. doi: 10.1016/j.bbamem.2010.10.014. Epub 2010 Oct 29.

49.

Therapeutic exploitation of apoptosis and autophagy for glioblastoma.

Kögel D, Fulda S, Mittelbronn M.

Anticancer Agents Med Chem. 2010 Jul;10(6):438-49. Review.

PMID:
20879985
50.

The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.

Senft C, Polacin M, Priester M, Seifert V, Kögel D, Weissenberger J.

BMC Cancer. 2010 Sep 14;10:491. doi: 10.1186/1471-2407-10-491.

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