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[COPD, an update of current management recommendations]. Gillissen A et al. MMW Fortschr Med. (2017)

[COPD-Management, a comprehensive review]. Gillissen A et al. MMW Fortschr Med. (2017)

Emergence of a Urogenital Pathotype of Neisseria meningitidis. Kahler CM et al. Trends Microbiol. (2017)

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Items: 1 to 50 of 135


Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates.

Furfaro LL, Chang BJ, Kahler CM, Payne MS.

PLoS One. 2019 Oct 2;14(10):e0223256. doi: 10.1371/journal.pone.0223256. eCollection 2019.


Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei.

Bzdyl NM, Scott NE, Norville IH, Scott AE, Atkins T, Pang S, Sarovich DS, Coombs G, Inglis TJJ, Kahler CM, Sarkar-Tyson M.

Infect Immun. 2019 Sep 19;87(10). pii: e00528-19. doi: 10.1128/IAI.00528-19. Print 2019 Oct.


The Detroit 562 Pharyngeal Immortalized Cell Line Model for the Assessment of Infectivity of Pathogenic Neisseria sp.

Kibble EA, Sarkar-Tyson M, Coombs GW, Kahler CM.

Methods Mol Biol. 2019;1969:123-133. doi: 10.1007/978-1-4939-9202-7_9.


Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.

Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.

Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.


Enzyme targets for drug design of new anti-virulence therapeutics.

Kahler CM, Sarkar-Tyson M, Kibble EA, Stubbs KA, Vrielink A.

Curr Opin Struct Biol. 2018 Dec;53:140-150. doi: 10.1016/ Epub 2018 Sep 14. Review.


Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting.

Kahler CM, Nawrocki KL, Anandan A, Vrielink A, Shafer WM.

Front Microbiol. 2018 Aug 21;9:1922. doi: 10.3389/fmicb.2018.01922. eCollection 2018. Review.


Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens.

Smith RP, Mohanty B, Mowlaboccus S, Paxman JJ, Williams ML, Headey SJ, Wang G, Subedi P, Doak BC, Kahler CM, Scanlon MJ, Heras B.

J Biol Chem. 2018 Oct 26;293(43):16559-16571. doi: 10.1074/jbc.RA118.004847. Epub 2018 Sep 4.


B Part of It protocol: a cluster randomised controlled trial to assess the impact of 4CMenB vaccine on pharyngeal carriage of Neisseria meningitidis in adolescents.

Marshall HS, McMillan M, Koehler A, Lawrence A, MacLennan JM, Maiden MCJ, Ramsay M, Ladhani SN, Trotter C, Borrow R, Finn A, Sullivan T, Richmond P, Kahler CM, Whelan J, Vadivelu K.

BMJ Open. 2018 Jul 10;8(7):e020988. doi: 10.1136/bmjopen-2017-020988.


Communication Ambassadors-an Australian Social Media Initiative to Develop Communication Skills in Early Career Scientists.

Wang JTH, Power CJ, Kahler CM, Lyras D, Young PR, Iredell J, Robins-Browne R.

J Microbiol Biol Educ. 2018 Mar 30;19(1). pii: 19.1.25. doi: 10.1128/jmbe.v19i1.1428. eCollection 2018.


Multidrug-resistant Neisseria gonorrhoeae: future therapeutic options.

Kahler CM.

Future Microbiol. 2018 Apr;13:499-501. doi: 10.2217/fmb-2017-0258. Epub 2018 Mar 8. No abstract available.


Genomic epidemiology and population structure of Neisseria gonorrhoeae from remote highly endemic Western Australian populations.

Al Suwayyid BA, Coombs GW, Speers DJ, Pearson J, Wise MJ, Kahler CM.

BMC Genomics. 2018 Feb 27;19(1):165. doi: 10.1186/s12864-018-4557-5.


Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.

Smith RP, Whitten AE, Paxman JJ, Kahler CM, Scanlon MJ, Heras B.

Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):31-38. doi: 10.1107/S2053230X17017800. Epub 2018 Jan 1.


[COPD-Management, a comprehensive review].

Gillissen A, Kähler CM, Koczulla AR, Sauer R, Paparoupa M.

MMW Fortschr Med. 2017 Nov;159(Suppl 3):32-43. doi: 10.1007/s15006-017-9594-5. German. No abstract available.


Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia.

Mowlaboccus S, Mullally CA, Richmond PC, Howden BP, Stevens K, Speers DJ, Keil AD, Bjørnstad ON, Perkins TT, Kahler CM.

PLoS One. 2017 Oct 24;12(10):e0186839. doi: 10.1371/journal.pone.0186839. eCollection 2017.


[COPD, an update of current management recommendations].

Gillissen A, Kähler CM, Koczulla AR, Sauer R.

MMW Fortschr Med. 2017 Jun;159(12):56-59. doi: 10.1007/s15006-017-9851-7. Review. German. No abstract available.


Clonal Expansion of New Penicillin-Resistant Clade of Neisseria meningitidis Serogroup W Clonal Complex 11, Australia.

Mowlaboccus S, Jolley KA, Bray JE, Pang S, Lee YT, Bew JD, Speers DJ, Keil AD, Coombs GW, Kahler CM.

Emerg Infect Dis. 2017 Aug;23(8):1364-1367. doi: 10.3201/eid2308.170259. Epub 2017 Aug 15.


Emergence of a Urogenital Pathotype of Neisseria meningitidis.

Kahler CM.

Trends Microbiol. 2017 Jul;25(7):510-512. doi: 10.1016/j.tim.2017.05.006. Epub 2017 May 22.


Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis.

Bartley SN, Mowlaboccus S, Mullally CA, Stubbs KA, Vrielink A, Maiden MC, Harrison OB, Perkins TT, Kahler CM.

Sci Rep. 2017 Mar 14;7:44442. doi: 10.1038/srep44442.


Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.

Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2218-2223. doi: 10.1073/pnas.1612927114. Epub 2017 Feb 13.


Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity.

Reimer A, Seufert F, Weiwad M, Ebert J, Bzdyl NM, Kahler CM, Sarkar-Tyson M, Holzgrabe U, Rudel T, Kozjak-Pavlovic V.

Int J Antimicrob Agents. 2016 Oct;48(4):401-8. doi: 10.1016/j.ijantimicag.2016.06.020. Epub 2016 Aug 1.


Temporal Changes in BEXSERO® Antigen Sequence Type Associated with Genetic Lineages of Neisseria meningitidis over a 15-Year Period in Western Australia.

Mowlaboccus S, Perkins TT, Smith H, Sloots T, Tozer S, Prempeh LJ, Tay CY, Peters F, Speers D, Keil AD, Kahler CM.

PLoS One. 2016 Jun 29;11(6):e0158315. doi: 10.1371/journal.pone.0158315. eCollection 2016.


Novel Moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity.

Ariff A, Wise MJ, Kahler CM, Tay CY, Peters F, Perkins TT, Chang BJ.

BMC Genomics. 2015 Oct 24;16:860. doi: 10.1186/s12864-015-2104-1.


Influence of in situ progressive N-terminal is still controversial truncation of glycogen branching enzyme in Escherichia coli DH5α on glycogen structure, accumulation, and bacterial viability.

Wang L, Regina A, Butardo VM Jr, Kosar-Hashemi B, Larroque O, Kahler CM, Wise MJ.

BMC Microbiol. 2015 May 7;15:96. doi: 10.1186/s12866-015-0421-9.


The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

Piek S, Wang Z, Ganguly J, Lakey AM, Bartley SN, Mowlaboccus S, Anandan A, Stubbs KA, Scanlon MJ, Vrielink A, Azadi P, Carlson RW, Kahler CM.

PLoS One. 2014 Sep 12;9(9):e106513. doi: 10.1371/journal.pone.0106513. eCollection 2014.


The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species.

Davies JK, Harrison PF, Lin YH, Bartley S, Khoo CA, Seemann T, Ryan CS, Kahler CM, Hill SA.

PLoS One. 2014 Jan 22;9(1):e86704. doi: 10.1371/journal.pone.0086704. eCollection 2014.


The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin.

Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A.

J Mol Biol. 2013 Sep 23;425(18):3389-402. doi: 10.1016/j.jmb.2013.06.029. Epub 2013 Jun 28.


Attachment and invasion of Neisseria meningitidis to host cells is related to surface hydrophobicity, bacterial cell size and capsule.

Bartley SN, Tzeng YL, Heel K, Lee CW, Mowlaboccus S, Seemann T, Lu W, Lin YH, Ryan CS, Peacock C, Stephens DS, Davies JK, Kahler CM.

PLoS One. 2013;8(2):e55798. doi: 10.1371/journal.pone.0055798. Epub 2013 Feb 6.


Diagnostic and therapeutic challenges of a large pleural inflammatory myofibroblastic tumor.

Loeffler-Ragg J, Bodner J, Freund M, Steurer M, Uprimny C, Zelger B, Kähler CM.

Case Rep Pulmonol. 2012;2012:102196. doi: 10.1155/2012/102196. Epub 2012 Dec 31.


A comparison of the endotoxin biosynthesis and protein oxidation pathways in the biogenesis of the outer membrane of Escherichia coli and Neisseria meningitidis.

Piek S, Kahler CM.

Front Cell Infect Microbiol. 2012 Dec 20;2:162. doi: 10.3389/fcimb.2012.00162. eCollection 2012. Review.


Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis.

Anandan A, Piek S, Kahler CM, Vrielink A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1494-7. doi: 10.1107/S1744309112042236. Epub 2012 Nov 14.


The German adaptation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR).

Cima K, Twiss J, Speich R, McKenna SP, Grünig E, Kähler CM, Ehlken N, Treder U, Crawford SR, Huber LC, Ulrich S.

Health Qual Life Outcomes. 2012 Sep 13;10:110. doi: 10.1186/1477-7525-10-110.


Subcutaneous implantation of a new intravenous pump system for prostacyclin treatment in patients with pulmonary arterial hypertension.

Desole S, Velik-Salchner C, Fraedrich G, Ewert R, Kähler CM.

Heart Lung. 2012 Nov-Dec;41(6):599-605. doi: 10.1016/j.hrtlng.2012.07.001. Epub 2012 Aug 21.


Treatment of pulmonary arterial hypertension (PAH): updated Recommendations of the Cologne Consensus Conference 2011.

Ghofrani HA, Distler O, Gerhardt F, Gorenflo M, Grünig E, Haefeli WE, Held M, Hoeper MM, Kähler CM, Kaemmerer H, Klose H, Köllner V, Kopp B, Mebus S, Meyer A, Miera O, Pittrow D, Riemekasten G, Rosenkranz S, Schranz D, Voswinckel R, Olschewski H.

Int J Cardiol. 2011 Dec;154 Suppl 1:S20-33. doi: 10.1016/S0167-5273(11)70490-9.


Endothelial progenitor cells: current issues on characterization and challenging clinical applications.

Resch T, Pircher A, Kähler CM, Pratschke J, Hilbe W.

Stem Cell Rev Rep. 2012 Sep;8(3):926-39. doi: 10.1007/s12015-011-9332-9. Review.


Sticky and sweet: the role of post-translational modifications on neisserial pili.

Kahler CM.

Front Microbiol. 2011 Apr 27;2:87. doi: 10.3389/fmicb.2011.00087. eCollection 2011. No abstract available.


Spontaneous haemoptysis as a late complication of plombage in a tuberculosis patient.

Bollmann T, Hegenscheid K, Busemann A, Kölble K, Hosten N, Heidecke CD, Kähler CM, Ewert R.

Wien Med Wochenschr. 2011 Apr;161(7-8):217-21. doi: 10.1007/s10354-011-0886-6.


Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan.

Kähler CM, Graziadei I, Vogelsinger H, Desole S, Cima K, Vogel W.

Wien Klin Wochenschr. 2011 Apr;123(7-8):248-52. doi: 10.1007/s00508-011-1540-4. Epub 2011 Mar 31.


Characterization of DsbD in Neisseria meningitidis.

Kumar P, Sannigrahi S, Scoullar J, Kahler CM, Tzeng YL.

Mol Microbiol. 2011 Mar;79(6):1557-73. doi: 10.1111/j.1365-2958.2011.07546.x. Epub 2011 Jan 24.


Chronic thromboembolic pulmonary hypertension as a cause of dyspnoea in an older patient with a complex history.

Kähler CM.

Eur Respir Rev. 2009 Sep;18(113):170-3. doi: 10.1183/09059180.00003409.


[Treatment of pulmonary arterial hypertension (PAH): recommendations of the Cologne Consensus Conference 2010].

Ghofrani HA, Distler O, Gerhardt F, Gorenflo M, Grünig E, Haefeli WE, Held M, Hoeper MM, Kähler CM, Kaemmerer H, Klose H, Köllner V, Kopp B, Mebus S, Meyer A, Miera O, Pittrow D, Riemekasten G, Rosenkranz S, Schranz D, Voswinckel R, Olschewski H; German Society of Cardiology (DGK), the German Society of Respiratory Medicine (DGP) and the German Society of Pediatric Cardiology (DGPK).

Dtsch Med Wochenschr. 2010 Oct;135 Suppl 3:S87-101. doi: 10.1055/s-0030-1263316. Epub 2010 Sep 22. German.


Sensory neuropeptides are potent chemoattractants for human basophils in vitro.

Cima K, Vogelsinger H, Kähler CM.

Regul Pept. 2010 Feb 25;160(1-3):42-8. doi: 10.1016/j.regpep.2009.12.013. Epub 2009 Dec 24.


Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis.

Vivian JP, Scoullar J, Rimmer K, Bushell SR, Beddoe T, Wilce MC, Byres E, Boyle TP, Doak B, Simpson JS, Graham B, Heras B, Kahler CM, Rossjohn J, Scanlon MJ.

J Mol Biol. 2009 Dec 18;394(5):931-43. doi: 10.1016/j.jmb.2009.09.065. Epub 2009 Oct 6.


[Combination therapy for the treatment of pulmonary arterial hypertension].

Kähler CM.

Dtsch Med Wochenschr. 2009 Aug;134 Suppl 5:S181-2. doi: 10.1055/s-0029-1233970. Epub 2009 Aug 28. German. No abstract available.


The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.

Paxman JJ, Borg NA, Horne J, Thompson PE, Chin Y, Sharma P, Simpson JS, Wielens J, Piek S, Kahler CM, Sakellaris H, Pearce M, Bottomley SP, Rossjohn J, Scanlon MJ.

J Biol Chem. 2009 Jun 26;284(26):17835-45. doi: 10.1074/jbc.M109.011502. Epub 2009 Apr 22.


Bench-to-bedside review: Bacterial virulence and subversion of host defences.

Webb SA, Kahler CM.

Crit Care. 2008;12(6):234. doi: 10.1186/cc7091. Epub 2008 Nov 10. Review.


[Decompensated pulmonary hypertension].

Desole S, Kähler CM.

Dtsch Med Wochenschr. 2008 Oct;133 Suppl 6:S215-8. doi: 10.1055/s-0028-1091243. Epub 2008 Sep 23. Review. German.


The structure of the L9 immunotype lipooligosaccharide from Neisseria meningitidis NMA Z2491.

Choudhury B, Kahler CM, Datta A, Stephens DS, Carlson RW.

Carbohydr Res. 2008 Nov 24;343(17):2971-9. doi: 10.1016/j.carres.2008.08.026. Epub 2008 Sep 2.


Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis.

Vivian JP, Scoullar J, Robertson AL, Bottomley SP, Horne J, Chin Y, Wielens J, Thompson PE, Velkov T, Piek S, Byres E, Beddoe T, Wilce MC, Kahler CM, Rossjohn J, Scanlon MJ.

J Biol Chem. 2008 Nov 21;283(47):32452-61. doi: 10.1074/jbc.M803990200. Epub 2008 Aug 20.


MisR/MisS two-component regulon in Neisseria meningitidis.

Tzeng YL, Kahler CM, Zhang X, Stephens DS.

Infect Immun. 2008 Feb;76(2):704-16. Epub 2007 Dec 3.

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