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Items: 1 to 50 of 63

1.

Comprehensive longitudinal study of epigenetic mutations in aging.

Wang Y, Karlsson R, Jylhävä J, Hedman ÅK, Almqvist C, Karlsson IK, Pedersen NL, Almgren M, Hägg S.

Clin Epigenetics. 2019 Dec 9;11(1):187. doi: 10.1186/s13148-019-0788-9.

2.

Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins.

Karlsson IK, Ericsson M, Wang Y, Jylhävä J, Hägg S, Pedersen NL, Reynolds CA, Dahl Aslan AK.

Int J Obes (Lond). 2019 Dec 4. doi: 10.1038/s41366-019-0498-6. [Epub ahead of print]

PMID:
31801962
3.

Should we invest in biological age predictors to treat colorectal cancer in the older adults?

Hägg S, Jylhävä J.

Eur J Surg Oncol. 2019 Nov 8. pii: S0748-7983(19)30926-6. doi: 10.1016/j.ejso.2019.11.003. [Epub ahead of print]

4.

Neuroticism as a Predictor of Frailty in Old Age: A Genetically Informative Approach.

Daníelsdóttir HB, Jylhävä J, Hägg S, Lu Y, Colodro-Conde L, Martin NG, Pedersen NL, Mosing MA, Lehto K.

Psychosom Med. 2019 Nov/Dec;81(9):799-807. doi: 10.1097/PSY.0000000000000742.

PMID:
31469771
5.

Functional Aging Index Complements Frailty in Prediction of Entry Into Care and Mortality.

Finkel D, Sternäng O, Jylhävä J, Bai G, Pedersen NL.

J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(12):1980-1986. doi: 10.1093/gerona/glz155.

PMID:
31222213
6.

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study.

Li X, Ploner A, Karlsson IK, Liu X, Magnusson PKE, Pedersen NL, Hägg S, Jylhävä J.

BMC Med. 2019 May 15;17(1):94. doi: 10.1186/s12916-019-1331-8.

7.

Fcμ receptor as a Costimulatory Molecule for T Cells.

Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein B.

Cell Rep. 2019 Mar 5;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024.

8.

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.

EBioMedicine. 2019 Feb;40:710-716. doi: 10.1016/j.ebiom.2019.01.040. Epub 2019 Jan 28.

9.

Can markers of biological age predict dependency in old age?

Jylhävä J, Jiang M, Foebel AD, Pedersen NL, Hägg S.

Biogerontology. 2019 Jun;20(3):321-329. doi: 10.1007/s10522-019-09795-5. Epub 2019 Jan 21.

10.

A Frailty Index for UK Biobank Participants.

Williams DM, Jylhävä J, Pedersen NL, Hägg S.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):582-587. doi: 10.1093/gerona/gly094.

11.

Plasma cell-free DNA and qSOFA score predict 7-day mortality in 481 emergency department bacteraemia patients.

Rannikko J, Seiskari T, Huttunen R, Tarkiainen I, Jylhävä J, Hurme M, Syrjänen J, Aittoniemi J.

J Intern Med. 2018 Oct;284(4):418-426. doi: 10.1111/joim.12766. Epub 2018 Jun 3.

PMID:
29687943
12.

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins.

Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen NL, Hägg S, Debrabant B, Deary IJ, Christensen K, Christiansen L, Hjelmborg JB.

Genes (Basel). 2018 Feb 8;9(2). pii: E78. doi: 10.3390/genes9020078.

13.

Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort.

Jiang M, Foebel AD, Kuja-Halkola R, Karlsson I, Pedersen NL, Hägg S, Jylhävä J.

Aging (Albany NY). 2017 Dec 19;9(12):2629-2646. doi: 10.18632/aging.101352.

14.

Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence.

Marttila S, Nevalainen T, Jylhävä J, Kananen L, Jylhä M, Hervonen A, Hurme M.

Exp Gerontol. 2017 Oct 15;97:60-63. doi: 10.1016/j.exger.2017.07.019. Epub 2017 Aug 1.

PMID:
28774724
15.

Biological Age Predictors.

Jylhävä J, Pedersen NL, Hägg S.

EBioMedicine. 2017 Jul;21:29-36. doi: 10.1016/j.ebiom.2017.03.046. Epub 2017 Apr 1. Review.

16.

Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study.

Lisko I, Tiainen K, Raitanen J, Jylhävä J, Hurme M, Hervonen A, Jylhä M, Stenholm S.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1569-1574. doi: 10.1093/gerona/glx032.

PMID:
28329171
17.

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals.

Nevalainen T, Kananen L, Marttila S, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M.

Clin Epigenetics. 2017 Feb 14;9:20. doi: 10.1186/s13148-016-0301-7. eCollection 2017.

18.

Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals.

Nevalainen T, Kananen L, Marttila S, Jylhävä J, Jylhä M, Hervonen A, Hurme M.

PLoS One. 2016 Nov 23;11(11):e0167028. doi: 10.1371/journal.pone.0167028. eCollection 2016.

19.

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders.

Lehtonen JM, Forsström S, Bottani E, Viscomi C, Baris OR, Isoniemi H, Höckerstedt K, Österlund P, Hurme M, Jylhävä J, Leppä S, Markkula R, Heliö T, Mombelli G, Uusimaa J, Laaksonen R, Laaksovirta H, Auranen M, Zeviani M, Smeitink J, Wiesner RJ, Nakada K, Isohanni P, Suomalainen A.

Neurology. 2016 Nov 29;87(22):2290-2299. Epub 2016 Oct 28.

20.

The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies.

Kananen L, Marttila S, Nevalainen T, Kummola L, Junttila I, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M, Jylhävä J.

Age (Dordr). 2016 Jun;38(3):65. doi: 10.1007/s11357-016-9927-9. Epub 2016 Jun 14.

21.

The concentration of cell-free DNA in video-EEG patients is dependent on the epilepsy syndrome and duration of epilepsy.

Alapirtti T, Jylhävä J, Raitanen J, Mäkinen R, Peltola J, Hurme MA, Liimatainen S.

Neurol Res. 2016 Jan;38(1):45-50. doi: 10.1080/01616412.2015.1127004.

PMID:
27118450
22.

Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift.

Jylhävä J, Kananen L, Raitanen J, Marttila S, Nevalainen T, Hervonen A, Jylhä M, Hurme M.

Oncotarget. 2016 Apr 12;7(15):19228-41. doi: 10.18632/oncotarget.8278.

23.

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study.

Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Lehtimäki T, Hurme M.

BMC Genomics. 2016 Feb 9;17:103. doi: 10.1186/s12864-016-2421-z.

24.

Cytomegalovirus infection accelerates epigenetic aging.

Kananen L, Nevalainen T, Jylhävä J, Marttila S, Hervonen A, Jylhä M, Hurme M.

Exp Gerontol. 2015 Dec;72:227-9. doi: 10.1016/j.exger.2015.10.008. Epub 2015 Oct 17.

PMID:
26485162
25.

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny.

Marttila S, Kananen L, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Hurme M.

Oncotarget. 2015 Oct 13;6(31):30557-67. doi: 10.18632/oncotarget.5905.

26.

Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years.

Enroth L, Raitanen J, Hervonen A, Lehtimäki T, Jylhävä J, Hurme M, Jylhä M.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):412-9. doi: 10.1093/gerona/glv105. Epub 2015 Aug 31.

PMID:
26328604
27.

Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study.

Nevalainen T, Kananen L, Marttila S, Jylhä M, Hervonen A, Hurme M, Jylhävä J.

Age (Dordr). 2015 Aug;37(4):9814. doi: 10.1007/s11357-015-9814-9. Epub 2015 Jul 19.

28.

Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression.

Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Nykter M, Hurme M.

BMC Genomics. 2015 Mar 14;16:179. doi: 10.1186/s12864-015-1381-z.

29.

Number of sons contributes to ageing-associated inflammation.

Marttila S, Nevalainen T, Kananen L, Jylhävä J, Jylhä M, Hervonen A, Ilonen J, Hurme M.

Sci Rep. 2015 Feb 27;5:8631. doi: 10.1038/srep08631.

30.

Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy--a study with monozygotic twin pairs.

Kangas R, Pöllänen E, Rippo MR, Lanzarini C, Prattichizzo F, Niskala P, Jylhävä J, Sipilä S, Kaprio J, Procopio AD, Capri M, Franceschi C, Olivieri F, Kovanen V.

Mech Ageing Dev. 2014 Dec 15;143-144:1-8. doi: 10.1016/j.mad.2014.11.001. Epub 2014 Nov 28.

PMID:
25448133
31.

Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study.

Jylhävä J, Raitanen J, Marttila S, Hervonen A, Jylhä M, Hurme M.

BMC Med Genomics. 2014 Sep 11;7:54. doi: 10.1186/1755-8794-7-54.

32.

Plasma pentraxin-3 and coagulation and fibrinolysis variables during acute Puumala hantavirus infection and associated thrombocytopenia.

Laine OK, Koskela SM, Outinen TK, Joutsi-Korhonen L, Huhtala H, Vaheri A, Hurme MA, Jylhävä J, Mäkelä SM, Mustonen JT.

Blood Coagul Fibrinolysis. 2014 Sep;25(6):612-7. doi: 10.1097/MBC.0000000000000117.

PMID:
24751477
33.

Determinants of longevity: genetics, biomarkers and therapeutic approaches.

Jylhävä J.

Curr Pharm Des. 2014;20(38):6058-70. Review.

PMID:
24641228
34.

Circulating cell-free DNA is associated with cardiometabolic risk factors: the Health 2000 Survey.

Jylhävä J, Lehtimäki T, Jula A, Moilanen L, Kesäniemi YA, Nieminen MS, Kähönen M, Hurme M.

Atherosclerosis. 2014 Mar;233(1):268-71. doi: 10.1016/j.atherosclerosis.2013.12.022. Epub 2014 Jan 8.

PMID:
24529155
35.

High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment.

Forsblom E, Aittoniemi J, Ruotsalainen E, Helmijoki V, Huttunen R, Jylhävä J, Hurme M, Järvinen A.

PLoS One. 2014 Feb 10;9(2):e87741. doi: 10.1371/journal.pone.0087741. eCollection 2014.

36.

Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians.

Marttila S, Jylhävä J, Kananen L, Hervonen A, Jylhä M, Hurme M.

Immun Ageing. 2014 Jan 31;11(1):2. doi: 10.1186/1742-4933-11-2.

37.

The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions.

Mustonen J, Mäkelä S, Outinen T, Laine O, Jylhävä J, Arstila PT, Hurme M, Vaheri A.

Antiviral Res. 2013 Dec;100(3):589-604. doi: 10.1016/j.antiviral.2013.10.001. Epub 2013 Oct 12. Review.

PMID:
24126075
38.

Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.

Marttila S, Jylhävä J, Nevalainen T, Nykter M, Jylhä M, Hervonen A, Tserel L, Peterson P, Hurme M.

PLoS One. 2013 Jun 11;8(6):e66229. doi: 10.1371/journal.pone.0066229. Print 2013.

39.

The concentration of cell-free DNA in focal epilepsy.

Liimatainen SP, Jylhävä J, Raitanen J, Peltola JT, Hurme MA.

Epilepsy Res. 2013 Aug;105(3):292-8. doi: 10.1016/j.eplepsyres.2013.03.005. Epub 2013 Apr 11.

PMID:
23582956
40.

Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty.

Jylhävä J, Nevalainen T, Marttila S, Jylhä M, Hervonen A, Hurme M.

Aging Cell. 2013 Jun;12(3):388-97. doi: 10.1111/acel.12058. Epub 2013 Apr 1.

41.

Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis.

Kuparinen T, Marttila S, Jylhävä J, Tserel L, Peterson P, Jylhä M, Hervonen A, Hurme M.

Exp Gerontol. 2013 Mar;48(3):305-12. doi: 10.1016/j.exger.2012.12.010. Epub 2013 Jan 2.

PMID:
23291591
42.

Indoleamine 2,3-dioxygenase activity and expression in patients with chronic lymphocytic leukemia.

Lindström V, Aittoniemi J, Jylhävä J, Eklund C, Hurme M, Paavonen T, Oja SS, Itälä-Remes M, Sinisalo M.

Clin Lymphoma Myeloma Leuk. 2012 Oct;12(5):363-5. doi: 10.1016/j.clml.2012.06.001. Epub 2012 Sep 13.

PMID:
22981691
43.

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

Jylhävä J, Lyytikäinen LP, Kähönen M, Hutri-Kähönen N, Kettunen J, Viikari J, Raitakari OT, Lehtimäki T, Hurme M.

PLoS One. 2012;7(4):e35426. doi: 10.1371/journal.pone.0035426. Epub 2012 Apr 12.

44.

Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study.

Jylhävä J, Jylhä M, Lehtimäki T, Hervonen A, Hurme M.

Exp Gerontol. 2012 May;47(5):372-8. doi: 10.1016/j.exger.2012.02.011. Epub 2012 Mar 3.

PMID:
22406558
45.

Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection.

Outinen TK, Kuparinen T, Jylhävä J, Leppänen S, Mustonen J, Mäkelä S, Pörsti I, Syrjänen J, Vaheri A, Hurme M.

PLoS One. 2012;7(2):e31455. doi: 10.1371/journal.pone.0031455. Epub 2012 Feb 7.

46.

Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study.

Haarala A, Kähönen M, Lehtimäki T, Aittoniemi J, Jylhävä J, Hutri-Kähönen N, Taittonen L, Laitinen T, Juonala M, Viikari J, Raitakari OT, Hurme M.

Clin Exp Immunol. 2012 Feb;167(2):309-16. doi: 10.1111/j.1365-2249.2011.04513.x.

47.

Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response.

Kuparinen T, Seppälä I, Jylhävä J, Marttila S, Aittoniemi J, Kettunen J, Viikari J, Kähönen M, Raitakari O, Lehtimäki T, Hurme M.

Genes Immun. 2012 Feb;13(2):184-90. doi: 10.1038/gene.2011.71. Epub 2011 Oct 13.

PMID:
21993531
48.
49.

IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence.

Marttila S, Jylhävä J, Pesu M, Hämäläinen S, Jylhä M, Hervonen A, Hurme M.

Exp Gerontol. 2011 Dec;46(12):1000-2. doi: 10.1016/j.exger.2011.09.004. Epub 2011 Sep 22.

PMID:
21964236
50.

Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort study.

Huttunen R, Kuparinen T, Jylhävä J, Aittoniemi J, Vuento R, Huhtala H, Laine J, Syrjänen J, Hurme M.

PLoS One. 2011;6(7):e21700. doi: 10.1371/journal.pone.0021700. Epub 2011 Jul 1.

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