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Items: 1 to 50 of 70

1.

Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ.

Mol Microbiol. 2019 Mar 29. doi: 10.1111/mmi.14254. [Epub ahead of print]

PMID:
30927289
2.

Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.

Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ.

Biochem Biophys Res Commun. 2018 Nov 2;505(3):740-746. doi: 10.1016/j.bbrc.2018.09.186. Epub 2018 Oct 4.

PMID:
30292408
3.

Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.

Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ.

J Proteome Res. 2018 Feb 2;17(2):780-793. doi: 10.1021/acs.jproteome.7b00499. Epub 2017 Dec 29.

4.

The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.

Renshaw H, Vargas-Muñiz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ.

J Cell Sci. 2018 Feb 7;131(3). pii: jcs205955. doi: 10.1242/jcs.205955.

5.

Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ.

FEBS Lett. 2017 Nov;591(22):3730-3744. doi: 10.1002/1873-3468.12886. Epub 2017 Nov 9.

6.

Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization.

Moseley MA, Hughes CJ, Juvvadi PR, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Steinbach WJ, Geromanos SJ, Wildgoose J, Langridge JI, Richardson K, Vissers JPC.

J Proteome Res. 2018 Feb 2;17(2):770-779. doi: 10.1021/acs.jproteome.7b00464. Epub 2017 Dec 29.

PMID:
28901143
7.

Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization.

Moreno-Velásquez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00710-17. doi: 10.1128/AAC.00710-17. Print 2017 Oct.

8.

Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus.

Vargas-Muñiz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ.

Biochem Biophys Res Commun. 2017 Apr 1;485(2):221-226. doi: 10.1016/j.bbrc.2017.02.116. Epub 2017 Feb 24.

9.

A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ.

MBio. 2017 Feb 7;8(1). pii: e02319-16. doi: 10.1128/mBio.02319-16.

10.

Balancing iron and calcium: Flavin carrier family proteins in Aspergillus fumigatus virulence.

Juvvadi PR.

Virulence. 2017 Aug 18;8(6):621-624. doi: 10.1080/21505594.2016.1257459. Epub 2016 Nov 7. No abstract available.

11.

Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.

Vargas-Muñiz JM, Juvvadi PR, Steinbach WJ.

Microbiology. 2016 Sep;162(9):1527-1534. doi: 10.1099/mic.0.000359. Epub 2016 Aug 23. Review.

12.

Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus.

Vargas-Muñiz JM, Renshaw H, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Asfaw Y, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2016 Jun 22;7:997. doi: 10.3389/fmicb.2016.00997. eCollection 2016.

13.

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Juvvadi PR, Lee SC, Heitman J, Steinbach WJ.

Virulence. 2017 Feb 17;8(2):186-197. doi: 10.1080/21505594.2016.1201250. Epub 2016 Jun 20. Review.

14.

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA.

MBio. 2016 Apr 26;7(2):e00492-16. doi: 10.1128/mBio.00492-16.

15.

Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis.

Renshaw H, Vargas-Muñiz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ.

Infect Immun. 2016 Apr 22;84(5):1556-64. doi: 10.1128/IAI.01190-15. Print 2016 May.

16.

Editorial: Advances in Aspergillus fumigatus Pathobiology.

Lamoth F, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2016 Feb 3;7:43. doi: 10.3389/fmicb.2016.00043. eCollection 2016. No abstract available.

17.

Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.

Juvvadi PR, Pemble CW 4th, Ma Y, Steinbach WJ.

FEBS Lett. 2016 Feb;590(4):501-8. doi: 10.1002/1873-3468.12075. Epub 2016 Feb 15.

18.

Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?

Juvvadi PR, Steinbach WJ.

Pathogens. 2015 Dec 16;4(4):883-93. doi: 10.3390/pathogens4040883. Review.

19.

Potential Microbiological Effects of Higher Dosing of Echinocandins.

Steinbach WJ, Lamoth F, Juvvadi PR.

Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S669-77. doi: 10.1093/cid/civ725.

PMID:
26567286
20.

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.

Falloon K, Juvvadi PR, Richards AD, Vargas-Muñiz JM, Renshaw H, Steinbach WJ.

PLoS One. 2015 Sep 14;10(9):e0137869. doi: 10.1371/journal.pone.0137869. eCollection 2015.

21.

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.

Juvvadi PR, Muñoz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4946-55. doi: 10.1128/AAC.00263-15. Epub 2015 Jun 8.

22.

The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.

Vargas-Muñiz JM, Renshaw H, Richards AD, Lamoth F, Soderblom EJ, Moseley MA, Juvvadi PR, Steinbach WJ.

Fungal Genet Biol. 2015 Aug;81:41-51. doi: 10.1016/j.fgb.2015.05.014. Epub 2015 Jun 5.

23.

Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Steinbach WJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4727-33. doi: 10.1128/AAC.00946-15. Epub 2015 May 26.

24.

Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus.

Juvvadi PR, Ma Y, Richards AD, Soderblom EJ, Moseley MA, Lamoth F, Steinbach WJ.

Front Microbiol. 2015 Mar 13;6:175. doi: 10.3389/fmicb.2015.00175. eCollection 2015.

25.

Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis.

Lamoth F, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2015 Feb 16;6:96. doi: 10.3389/fmicb.2015.00096. eCollection 2015.

26.

Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species.

Lamoth F, Alexander BD, Juvvadi PR, Steinbach WJ.

J Antimicrob Chemother. 2015 May;70(5):1408-11. doi: 10.1093/jac/dku549. Epub 2015 Jan 3.

PMID:
25558076
28.

Aspergillus fumigatus and related species.

Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latgé JP, Steinbach WJ.

Cold Spring Harb Perspect Med. 2014 Nov 6;5(2):a019786. doi: 10.1101/cshperspect.a019786. Review.

29.

Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Steinbach WJ.

Crit Rev Microbiol. 2016;42(2):310-21. doi: 10.3109/1040841X.2014.947239. Epub 2014 Sep 22. Review.

PMID:
25243616
30.

Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.

Juvvadi PR, Lamoth F, Steinbach WJ.

Mycopathologia. 2014 Dec;178(5-6):341-8. doi: 10.1007/s11046-014-9794-9. Epub 2014 Aug 15. Review.

31.

Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ.

Antimicrob Agents Chemother. 2014;58(4):1889-96. doi: 10.1128/AAC.02286-13. Epub 2014 Jan 6.

32.

Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Gehrke C, Asfaw YG, Steinbach WJ.

J Infect Dis. 2014 Feb 1;209(3):473-81. doi: 10.1093/infdis/jit530. Epub 2013 Oct 4.

33.

Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus.

Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ.

PLoS Pathog. 2013;9(8):e1003564. doi: 10.1371/journal.ppat.1003564. Epub 2013 Aug 22.

34.

Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus.

Juvvadi PR, Belina D, Soderblom EJ, Moseley MA, Steinbach WJ.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):547-53. doi: 10.1016/j.bbrc.2013.01.020. Epub 2013 Jan 12.

35.

In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.

Lamoth F, Juvvadi PR, Gehrke C, Steinbach WJ.

Antimicrob Agents Chemother. 2013 Feb;57(2):1035-9. doi: 10.1128/AAC.01857-12. Epub 2012 Nov 19.

36.

Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Fortwendel JR, Steinbach WJ.

Eukaryot Cell. 2012 Nov;11(11):1324-32. doi: 10.1128/EC.00032-12. Epub 2012 Jul 20.

37.

Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.

Fortwendel JR, Juvvadi PR, Rogg LE, Asfaw YG, Burns KA, Randell SH, Steinbach WJ.

Eukaryot Cell. 2012 Aug;11(8):966-77. doi: 10.1128/EC.00091-12. Epub 2012 May 4.

38.

Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.

Juvvadi PR, Fortwendel JR, Rogg LE, Burns KA, Randell SH, Steinbach WJ.

Mol Microbiol. 2011 Dec;82(5):1235-59. doi: 10.1111/j.1365-2958.2011.07886.x. Epub 2011 Nov 8.

39.

The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus.

Rogg LE, Fortwendel JR, Juvvadi PR, Lilley A, Steinbach WJ.

Biochem Biophys Res Commun. 2011 Aug 5;411(3):549-54. doi: 10.1016/j.bbrc.2011.06.180. Epub 2011 Jul 5.

40.

Regulation of expression, activity and localization of fungal chitin synthases.

Rogg LE, Fortwendel JR, Juvvadi PR, Steinbach WJ.

Med Mycol. 2012 Jan;50(1):2-17. doi: 10.3109/13693786.2011.577104. Epub 2011 Apr 28. Review.

41.

Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.

Fortwendel JR, Juvvadi PR, Rogg LE, Steinbach WJ.

Eukaryot Cell. 2011 Apr;10(4):611-5. doi: 10.1128/EC.00315-10. Epub 2011 Jan 28.

42.

Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions.

Juvvadi PR, Fortwendel JR, Rogg LE, Steinbach WJ.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):238-43. doi: 10.1016/j.bbrc.2011.01.017. Epub 2011 Jan 8.

43.

Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid.

Seshime Y, Juvvadi PR, Kitamoto K, Ebizuka Y, Nonaka T, Fujii I.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4785-8. doi: 10.1016/j.bmcl.2010.06.119. Epub 2010 Jun 25.

PMID:
20630753
44.

Newer combination antifungal therapies for invasive aspergillosis.

Steinbach WJ, Juvvadi PR, Fortwendel JR, Rogg LE.

Med Mycol. 2011 Apr;49 Suppl 1:S77-81. doi: 10.3109/13693786.2010.499374. Epub 2010 Jul 7. Review.

45.

Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB.

Seshime Y, Juvvadi PR, Kitamoto K, Ebizuka Y, Fujii I.

Bioorg Med Chem. 2010 Jun 15;18(12):4542-6. doi: 10.1016/j.bmc.2010.04.058. Epub 2010 Apr 27.

PMID:
20471846
46.

Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.

Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ.

Antimicrob Agents Chemother. 2010 Apr;54(4):1555-63. doi: 10.1128/AAC.00854-09. Epub 2010 Feb 1.

47.

The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.

Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ.

Eukaryot Cell. 2010 Mar;9(3):472-6. doi: 10.1128/EC.00378-09. Epub 2010 Jan 22.

48.

Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.

Seshime Y, Juvvadi PR, Tokuoka M, Koyama Y, Kitamoto K, Ebizuka Y, Fujii I.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3288-92. doi: 10.1016/j.bmcl.2009.04.073. Epub 2009 Apr 22.

PMID:
19410456
49.

Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.

Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA Jr, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ.

Eukaryot Cell. 2009 Apr;8(4):511-9. doi: 10.1128/EC.00336-08. Epub 2009 Feb 27.

50.

Disruption of the Aopex11-1 gene involved in peroxisome proliferation leads to impaired Woronin body formation in Aspergillus oryzae.

Escaño CS, Juvvadi PR, Jin FJ, Takahashi T, Koyama Y, Yamashita S, Maruyama J, Kitamoto K.

Eukaryot Cell. 2009 Mar;8(3):296-305. doi: 10.1128/EC.00197-08. Epub 2009 Jan 9.

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