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Items: 1 to 50 of 344


Trends of intentional drug overdose among youth: a population-based cohort study.

Gilley M, Sivilotti MLA, Juurlink DN, Macdonald E, Yao Z, Finkelstein Y.

Clin Toxicol (Phila). 2019 Nov 24:1-5. doi: 10.1080/15563650.2019.1687900. [Epub ahead of print]


Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain: Protocol for a network meta-analysis of randomized controlled trials.

Noori A, Busse JW, Sadeghirad B, Siemieniuk RA, Wang L, Couban R, Juurlink DN, Thabane L, Guyatt GH.

Medicine (Baltimore). 2019 Oct;98(43):e17647. doi: 10.1097/MD.0000000000017647.


Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide.

Mamdani M, Gomes T, Greaves S, Manji S, Juurlink DN, Tadrous M, Kennedy SH, Antoniou T.

JAMA Netw Open. 2019 Oct 2;2(10):e1913304. doi: 10.1001/jamanetworkopen.2019.13304.


One-Year Mortality After Emergency Department Visit for Nonfatal Opioid Poisoning: A Population-Based Analysis.

Leece P, Chen C, Manson H, Orkin AM, Schwartz B, Juurlink DN, Gomes T.

Ann Emerg Med. 2019 Sep 24. pii: S0196-0644(19)30607-9. doi: 10.1016/j.annemergmed.2019.07.021. [Epub ahead of print]


Association of Mirabegron With the Risk of Arrhythmia in Adult Patients 66 Years or Older-A Population-Based Cohort Study.

Tadrous M, Matta R, Greaves S, Herschorn S, Mamdani MM, Juurlink DN, Gomes T.

JAMA Intern Med. 2019 Jul 15. doi: 10.1001/jamainternmed.2019.2011. [Epub ahead of print] No abstract available.


Prevention of Opioid Overdose.

Babu KM, Brent J, Juurlink DN.

N Engl J Med. 2019 Jun 6;380(23):2246-2255. doi: 10.1056/NEJMra1807054. Review. No abstract available.


Response to "Opioids for chronic pain".

Busse JW, Juurlink D, Buckley DN, Guyatt GH.

CMAJ. 2019 May 21;191(20):E565. doi: 10.1503/cmaj.72209. No abstract available.


In Memoriam Michael Alister McGuigan, M.D.

Juurlink DN, Thompson M, Seger DL.

Clin Toxicol (Phila). 2019 Jun;57(6):379. doi: 10.1080/15563650.2018.1560464. Epub 2019 Feb 13. No abstract available.


Impact of delisting high-strength opioid formulations from a public drug benefit formulary on opioid utilization in Ontario, Canada.

Martins D, Khuu W, Tadrous M, Juurlink DN, Mamdani MM, Paterson JM, Gomes T; Ontario Drug Policy Research Network.

Pharmacoepidemiol Drug Saf. 2019 May;28(5):726-733. doi: 10.1002/pds.4764. Epub 2019 Mar 14.


Tramadol and the risk of seizure: nested case-control study of US patients with employer-sponsored health benefits.

Morrow RL, Dormuth CR, Paterson M, Mamdani MM, Gomes T, Juurlink DN; Canadian Drug Safety Effectiveness Research Network (CDSERN).

BMJ Open. 2019 Mar 13;9(3):e026705. doi: 10.1136/bmjopen-2018-026705.


Correction to: Carfentanil: a narrative review of its pharmacology and public health concerns.

Leen JLS, Juurlink DN.

Can J Anaesth. 2019 May;66(5):625. doi: 10.1007/s12630-019-01310-1.


Evaluation of the fentanyl patch-for-patch program in Ontario, Canada.

Tadrous M, Greaves S, Martins D, Nadeem K, Singh S, Mamdani MM, Juurlink DN, Gomes T.

Int J Drug Policy. 2019 Apr;66:82-86. doi: 10.1016/j.drugpo.2019.01.025. Epub 2019 Feb 8.


Carfentanil: a narrative review of its pharmacology and public health concerns.

Leen JLS, Juurlink DN.

Can J Anaesth. 2019 Apr;66(4):414-421. doi: 10.1007/s12630-019-01294-y. Epub 2019 Jan 21. Review. Erratum in: Can J Anaesth. 2019 Feb 25;:.


Metformin Use and Kidney Cancer Survival Outcomes: A Systematic Review and Meta-Analysis.

Nayan M, Punjani N, Juurlink DN, Finelli A, Austin PC, Kulkarni GS, Uleryk E, Hamilton RJ.

Am J Clin Oncol. 2019 Mar;42(3):275-284. doi: 10.1097/COC.0000000000000512.


Association of Chronic Opioid Use With Presidential Voting Patterns in US Counties in 2016.

Goodwin JS, Kuo YF, Brown D, Juurlink D, Raji M.

JAMA Netw Open. 2018 Jun 1;1(2):e180450. doi: 10.1001/jamanetworkopen.2018.0450.


The Burden of Opioid-Related Mortality in the United States.

Gomes T, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

JAMA Netw Open. 2018 Jun 1;1(2):e180217. doi: 10.1001/jamanetworkopen.2018.0217.


Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.

Xu Y, Gomes T, Mamdani MM, Juurlink DN, Cadarette SM, Tadrous M.

Can J Diabetes. 2019 Apr;43(3):179-185.e1. doi: 10.1016/j.jcjd.2018.08.190. Epub 2018 Aug 16.


Lofexidine for Opioid Withdrawal: Small Effects at an Exorbitant Price.

Juurlink DN.

J Addict Med. 2019 May/Jun;13(3):167-168. doi: 10.1097/ADM.0000000000000473. No abstract available.


High-strength opioid formulations: the case for a ministerial recall.

Herder M, Juurlink D.

CMAJ. 2018 Dec 3;190(48):E1404-E1405. doi: 10.1503/cmaj.181289. No abstract available.


International Stakeholder Community of Pain Experts and Leaders Call for an Urgent Action on Forced Opioid Tapering.

Darnall BD, Juurlink D, Kerns RD, Mackey S, Van Dorsten B, Humphreys K, Gonzalez-Sotomayor JA, Furlan A, Gordon AJ, Gordon DB, Hoffman DE, Katz J, Kertesz SG, Satel S, Lawhern RA, Nicholson KM, Polomano RC, Williamson OD, McAnally H, Kao MC, Schug S, Twillman R, Lewis TA, Stieg RL, Lorig K, Mallick-Searle T, West RW, Gray S, Ariens SR, Sharpe Potter J, Cowan P, Kollas CD, Laird D, Ingle B, Julian Grove J, Wilson M, Lockman K, Hodson F, Palackdharry CS, Fillingim RB, Fudin J, Barnhouse J, Manhapra A, Henson SR, Singer B, Ljosenvoor M, Griffith M, Doctor JN, Hardin K, London C, Mankowski J, Anderson A, Ellsworth L, Davis Budzinski L, Brandt B, Hartley G, Nickels Heck D, Zobrosky MJ, Cheek C, Wilson M, Laux CE, Datz G, Dunaway J, Schonfeld E, Cady M, LeDantec-Boswell T, Craigie M, Sturgeon J, Flood P, Giummarra M, Whelan J, Thorn BE, Martin RL, Schatman ME, Gregory MD, Kirz J, Robinson P, Marx JG, Stewart JR, Keck PS, Hadland SE, Murphy JL, Lumley MA, Brown KS, Leong MS, Fillman M, Broatch JW, Perez A, Watford K, Kruska K, Sophia You D, Ogbeide S, Kukucka A, Lawson S, Ray JB, Wade Martin T, Lakehomer JB, Burke A, Cohen RI, Grinspoon P, Rubenstein MS, Sutherland S, Walters K, Lovejoy T.

Pain Med. 2019 Mar 1;20(3):429-433. doi: 10.1093/pm/pny228. No abstract available.


Extracorporeal treatment in salicylate poisoning.

Hoffman RS, Juurlink DN, Ghannoum M, Nolin TD, Lavergne V, Gosselin S.

Clin Toxicol (Phila). 2019 May;57(5):377-378. doi: 10.1080/15563650.2018.1517882. Epub 2018 Oct 11. No abstract available.


Studying Drug Safety in the Real World.

Zipursky J, Juurlink DN.

JAMA Intern Med. 2018 Nov 1;178(11):1533-1534. doi: 10.1001/jamainternmed.2018.5766. No abstract available.


Interprovincial Variation of Psychotropic Prescriptions Dispensed to Older Canadian Adults.

Black CD, McCarthy L, Gomes T, Mamdani M, Juurlink D, Tadrous M.

Can Geriatr J. 2018 Sep 30;21(3):269-273. doi: 10.5770/cgj.21.307. eCollection 2018 Sep.


Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada.

Gomes T, Khuu W, Martins D, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

BMJ. 2018 Aug 29;362:k3207. doi: 10.1136/bmj.k3207.


Pregabalin and the Risk for Opioid-Related Death: A Nested Case-Control Study.

Gomes T, Greaves S, van den Brink W, Antoniou T, Mamdani MM, Paterson JM, Martins D, Juurlink DN.

Ann Intern Med. 2018 Nov 20;169(10):732-734. doi: 10.7326/M18-1136. Epub 2018 Aug 21. No abstract available.


Comparing the contribution of prescribed opioids to opioid-related hospitalizations across Canada: A multi-jurisdictional cross-sectional study.

Gomes T, Khuu W, Craiovan D, Martins D, Hunt J, Lee K, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

Drug Alcohol Depend. 2018 Oct 1;191:86-90. doi: 10.1016/j.drugalcdep.2018.06.028. Epub 2018 Jul 31.


Second-generation anti-depressants and risk of new-onset seizures in the elderly.

Finkelstein Y, Macdonald EM, Li P, Mamdani MM, Gomes T, Juurlink DN.

Clin Toxicol (Phila). 2018 Dec;56(12):1179-1184. doi: 10.1080/15563650.2018.1483025. Epub 2018 Jul 10.


Depression in chronic pain: might opioids be responsible?

Mazereeuw G, Sullivan MD, Juurlink DN.

Pain. 2018 Nov;159(11):2142-2145. doi: 10.1097/j.pain.0000000000001305. Review. No abstract available.


A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride.

Antoniou T, Macdonald EM, Yao Z, Gomes T, Tadrous M, Ho JM, Mamdani MM, Juurlink DN; Canadian Drug Safety and Effectiveness Research Network.

BMC Musculoskelet Disord. 2018 May 22;19(1):160. doi: 10.1186/s12891-018-2076-9.


Clinical indications associated with opioid initiation for pain management in Ontario, Canada: a population-based cohort study.

Pasricha SV, Tadrous M, Khuu W, Juurlink DN, Mamdani MM, Paterson JM, Gomes T.

Pain. 2018 Aug;159(8):1562-1568. doi: 10.1097/j.pain.0000000000001242.


Debating the opioid guidelines: context.

Busse JW, Juurlink D, Buckley DN, Guyatt GH.

Can Fam Physician. 2018 May;64(5):330-331. No abstract available.


Debating the opioid guidelines: corrections.

Busse JW, Juurlink D, Buckley DN, Guyatt GH.

Can Fam Physician. 2018 May;64(5):328-330. No abstract available.


Measuring the Burden of Opioid-related Mortality in Ontario, Canada.

Gomes T, Greaves S, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

J Addict Med. 2018 Sep/Oct;12(5):418-419. doi: 10.1097/ADM.0000000000000412. No abstract available.


Publicly Funded Oral Chronic Hepatitis B Treatment Patterns in Ontario over 16 Years: An Ecologic Study.

Tadrous M, Brahmania M, Martins D, Knowles S, Janssen HLA, Mamdani MM, Juurlink DN, Gomes T.

J Manag Care Spec Pharm. 2018 May;24(5):464-468. doi: 10.18553/jmcp.2018.24.5.464.


Critiquing the CDC Opioid Guideline: Some Light From the Heat.

Juurlink DN.

Clin Pharmacol Ther. 2018 Jun;103(6):966-968. doi: 10.1002/cpt.1061. Epub 2018 Mar 30.


Catastrophic drug coverage: utilization insights from the Ontario Trillium Drug Program.

Tadrous M, Greaves S, Martins D, Mamdani MM, Juurlink DN, Gomes T.

CMAJ Open. 2018 Mar 14;6(1):E132-E138. doi: 10.9778/cmajo.20170132.


The authors respond to "The 2017 Canadian opioid guideline: already time for an overhaul".

Busse JW, Juurlink D, Buckley DN, Guyatt GH.

CMAJ. 2018 Mar 12;190(10):E301. doi: 10.1503/cmaj.68675. No abstract available.


Fluoroquinolones and the aorta.

Juurlink DN.

BMJ. 2018 Mar 8;360:k988. doi: 10.1136/bmj.k988. No abstract available.


Argyria caused by chronic ingestion of silver.

Bracey NA, Zipursky JS, Juurlink DN.

CMAJ. 2018 Feb 5;190(5):E139. doi: 10.1503/cmaj.171374. No abstract available.


Publicly funded overactive bladder drug treatment patterns in Ontario over 15 years: An ecological study.

Tadrous M, Elterman D, Khuu W, Mamdani MM, Juurlink DN, Gomes T.

Can Urol Assoc J. 2018 Mar;12(3):E142-E145. doi: 10.5489/cuaj.4541. Epub 2017 Dec 22.


Prior Authorization and Canadian Public Utilization of Direct-Acting Oral Anticoagulants.

Gao L, Tadrous M, Knowles S, Mamdani M, Paterson JM, Juurlink D, Gomes T.

Healthc Policy. 2017 Nov;13(2):68-78.


Challenges Interpreting Chemoprevention Studies Using Observational Data.

Nayan M, Juurlink DN, Finelli A, Kulkarni G, Hamilton RJ.

J Clin Oncol. 2018 Feb 20;36(6):628-629. doi: 10.1200/JCO.2017.76.1064. Epub 2017 Dec 20. No abstract available.


Medication use and kidney cancer survival: A population-based study.

Nayan M, Juurlink DN, Austin PC, Macdonald EM, Finelli A, Kulkarni GS, Hamilton RJ; Canadian Drug Safety and Effectiveness Research Network (CDSERN).

Int J Cancer. 2018 May 1;142(9):1776-1785. doi: 10.1002/ijc.31204. Epub 2018 Jan 3.


Impact of a Graduated Approach on Opioid Initiation and Loss of Earnings Following Workplace Injury: A Time Series Analysis.

Gomes T, Duesburry J, Theriault ME, Bain D, Singh S, Martins D, Juurlink DN.

J Occup Environ Med. 2017 Dec;59(12):1197-1201. doi: 10.1097/JOM.0000000000001187.


Availability of naloxone in Canadian pharmacies:a population-based survey.

Cressman AM, Mazereeuw G, Guan Q, Jia W, Gomes T, Juurlink DN.

CMAJ Open. 2017 Nov 8;5(4):E779-E784. doi: 10.9778/cmajo.20170123.


Impact of Injectable Furosemide Hospital Shortage on Congestive Heart Failure Outcomes: A Time Series Analysis.

Tan VS, Nash DM, McArthur E, Jain AK, Garg AX, Juurlink DN, Weir MA.

Can J Cardiol. 2017 Nov;33(11):1498-1504. doi: 10.1016/j.cjca.2017.09.003. Epub 2017 Sep 12.


Real-world health care utilization and effectiveness of omalizumab for the treatment of severe asthma.

Tadrous M, Khuu W, Lebovic G, Stanbrook MB, Martins D, Paterson JM, Mamdani MM, Juurlink DN, Gomes T.

Ann Allergy Asthma Immunol. 2018 Jan;120(1):59-65.e2. doi: 10.1016/j.anai.2017.08.016. Epub 2017 Oct 3.


Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study.

Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, van den Brink W.

PLoS Med. 2017 Oct 3;14(10):e1002396. doi: 10.1371/journal.pmed.1002396. eCollection 2017 Oct.


The authors respond to "Inconsistencies in the 2017 Canadian Guideline for Opioids for Chronic Noncancer Pain".

Busse JW, Juurlink DN, Buckley DN, Guyatt GH.

CMAJ. 2017 Oct 2;189(39):E1234-E1235. doi: 10.1503/cmaj.733313. No abstract available.


Rethinking "doing well" on chronic opioid therapy.

Juurlink DN.

CMAJ. 2017 Oct 2;189(39):E1222-E1223. doi: 10.1503/cmaj.170628. Review. No abstract available.

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