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Vitamin D and sex steroid production in men with normal or impaired Leydig cell function.

Holt R, Mortensen LJ, Harpelunde Poulsen K, Nielsen JE, Frederiksen H, Jørgensen N, Jørgensen A, Juul A, Blomberg Jensen M.

J Steroid Biochem Mol Biol. 2020 Jan 14:105589. doi: 10.1016/j.jsbmb.2020.105589. [Epub ahead of print]


A polygenic risk score suggests shared genetic architecture of voice break with early markers of pubertal onset in boys.

Lardone MC, Busch AS, Santos JL, Miranda P, Eyheramendy S, Pereira A, Juul A, Almstrup K, Mericq V.

J Clin Endocrinol Metab. 2020 Jan 9. pii: dgaa003. doi: 10.1210/clinem/dgaa003. [Epub ahead of print]


Semen quality in hypogonadal acromegalic patients.

Andreassen M, Juul A, Feldt-Rasmussen U, Jørgensen N.

Pituitary. 2019 Dec 13. doi: 10.1007/s11102-019-01018-x. [Epub ahead of print]


Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes.

Harpelunde Poulsen K, Nielsen JE, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, Perlman S, Lundvall L, Mitchell RT, Juul A, Rajpert-De Meyts E, Jørgensen A.

Hum Reprod. 2019 Nov 1;34(11):2228-2243. doi: 10.1093/humrep/dez191.


Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS.

Frederiksen H, Johannsen TH, Andersen SE, Albrethsen J, Landersoe SK, Petersen JH, Andersen AN, Vestergaard ET, Schorring ME, Linneberg A, Main KM, Andersson AM, Juul A.

J Clin Endocrinol Metab. 2019 Nov 13. pii: dgz196. doi: 10.1210/clinem/dgz196. [Epub ahead of print]


GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice.

Binder G, Reinehr T, Ibáñez L, Thiele S, Linglart A, Woelfle J, Saenger P, Bettendorf M, Zachurzok A, Gohlke B, Randell T, Hauffa BP, Claahsen van der Grinten HL, Holterhus PM, Juul A, Pfäffle R, Cianfarani S.

Horm Res Paediatr. 2019 Nov 8:1-7. doi: 10.1159/000503783. [Epub ahead of print]


Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009-2017.

Frederiksen H, Nielsen O, Koch HM, Skakkebaek NE, Juul A, Jørgensen N, Andersson AM.

Int J Hyg Environ Health. 2020 Jan;223(1):93-105. doi: 10.1016/j.ijheh.2019.10.002. Epub 2019 Oct 25.


The External Genitalia Score (EGS): A European multicenter validation study.

van der Straaten S, Springer A, Zecic A, Hebenstreit D, Tonnhofer U, Gawlik A, Baumert M, Szeliga K, Debulpaep S, Desloovere A, Tack L, Smets K, Wasniewska M, Corica D, Calafiore M, Ljubicic ML, Busch AS, Juul A, Nordenström A, Sigurdsson J, Flück CE, Haamberg T, Graf S, Hannema SE, Wolffenbuttel KP, Hiort O, Ahmed SF, Cools M.

J Clin Endocrinol Metab. 2019 Oct 29. pii: dgz142. doi: 10.1210/clinem/dgz142. [Epub ahead of print]


Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA.

Wegmann MG, Jensen RB, Thankamony A, Frystyk J, Roche E, Hoey H, Kirk J, Shaikh G, Ivarsson SA, Söder O, Dunger DB, Juul A.

J Clin Endocrinol Metab. 2019 Oct 29. pii: dgz118. doi: 10.1210/clinem/dgz118. [Epub ahead of print]


Characterisation and localisation of the endocannabinoid system components in the adult human testis.

Nielsen JE, Rolland AD, Rajpert-De Meyts E, Janfelt C, Jørgensen A, Winge SB, Kristensen DM, Juul A, Chalmel F, Jégou B, Skakkebaek NE.

Sci Rep. 2019 Sep 19;9(1):12866. doi: 10.1038/s41598-019-49177-y.


High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor.

Priskorn L, Dahl CL, Pihl AS, Skakkebaek NE, Juul A.

Eur J Obstet Gynecol Reprod Biol. 2019 Oct;241:137-138. doi: 10.1016/j.ejogrb.2019.09.005. Epub 2019 Sep 9. No abstract available.


Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.

Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J.

Horm Res Paediatr. 2019;92(1):1-14. doi: 10.1159/000502231. Epub 2019 Sep 12.


In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study.

Bräuner EV, Hickey M, Hansen ÅM, Doherty DA, Handelsman DJ, Juul A, Hart R.

Front Endocrinol (Lausanne). 2019 Aug 2;10:530. doi: 10.3389/fendo.2019.00530. eCollection 2019.


Voice break in boys-temporal relations with other pubertal milestones and likely causal effects of BMI.

Busch AS, Hollis B, Day FR, Sørensen K, Aksglaede L, Perry JRB, Ong KK, Juul A, Hagen CP.

Hum Reprod. 2019 Aug 1;34(8):1514-1522. doi: 10.1093/humrep/dez118.


Language barriers and use of interpreters in two Danish paediatric emergency units.

Dungu KHS, Kruse A, Svane SM, Dybdal DTH, Poulsen MW, Juul AW, Permin A, Poulsen A.

Dan Med J. 2019 Aug;66(8). pii: A5558.


Response to Letter to the Editor: "Clinical but Not Histological Outcomes in Males With 45,X/46,XY Mosaicism Vary Depending on Reason for Diagnosis".

Ljubicic ML, Jørgensen A, Ribeiro de Andrade JG, Balsamo A, Bertelloni S, Cools M, Cuccaro RT, Darendeliler F, Flück CE, Grinspon RP, Maciel-Guerra A, Guran T, Hannema SE, Lucas-Herald AK, Hiort O, Holterhus PM, Lichiardopol C, Looijenga LHJ, Ortolano R, Riedl S, Ahmed SF, Juul A.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):5812-5813. doi: 10.1210/jc.2019-01413. No abstract available.


The association between in-utero exposure to stressful life events during pregnancy and male reproductive function in a cohort of 20-year-old offspring: The Raine Study.

Bräuner EV, Hansen ÅM, Doherty DA, Dickinson JE, Handelsman DJ, Hickey M, Skakkebæk NE, Juul A, Hart R.

Hum Reprod. 2019 Jul 8;34(7):1345-1355. doi: 10.1093/humrep/dez070.


Clinical but Not Histological Outcomes in Males With 45,X/46,XY Mosaicism Vary Depending on Reason for Diagnosis.

Ljubicic ML, Jørgensen A, Acerini C, Andrade J, Balsamo A, Bertelloni S, Cools M, Cuccaro RT, Darendeliler F, Flück CE, Grinspon RP, Maciel-Guerra A, Guran T, Hannema SE, Lucas-Herald AK, Hiort O, Holterhus PM, Lichiardopol C, Looijenga LHJ, Ortolano R, Riedl S, Ahmed SF, Juul A.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4366-4381. doi: 10.1210/jc.2018-02752.


Populations, decreasing fertility, and reproductive health.

Skakkebaek NE, Jørgensen N, Andersson AM, Juul A, Main KM, Jensen TK, Toppari J.

Lancet. 2019 Apr 13;393(10180):1500-1501. doi: 10.1016/S0140-6736(19)30690-7. No abstract available.


PIGT-CDG, a disorder of the glycosylphosphatidylinositol anchor: description of 13 novel patients and expansion of the clinical characteristics.

Bayat A, Knaus A, Juul AW, Dukic D, Gardella E, Charzewska A, Clement E, Hjalgrim H, Hoffman-Zacharska D, Horn D, Horton R, Hurst JA, Josifova D, Larsen LHG, Lascelles K, Obersztyn E, Pagnamenta A, Pal DK, Pendziwiat M, Ryten M, Taylor J, Vogt J, Weber Y, Krawitz PM, Helbig I, Kini U, Møller RS; DDD Study Group.

Genet Med. 2019 Oct;21(10):2216-2223. doi: 10.1038/s41436-019-0512-3. Epub 2019 Apr 12.


Presence of the vitamin D inactivating enzyme CYP24A1 in human sperm and prediction of the success of intrauterine insemination: A prospective study.

Bøllehuus Hansen L, Lorenzen M, Bentin-Ley U, Nielsen JE, Krog H, Berg AH, Håkansson BS, Pedersen AM, Høst T, Juul A, Blomberg Jensen M.

J Steroid Biochem Mol Biol. 2019 Jul;191:105353. doi: 10.1016/j.jsbmb.2019.04.002. Epub 2019 Apr 6.


Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome.

Juel Mortensen L, Lorenzen M, Jørgensen N, Andersson AM, Nielsen JE, Petersen LI, Lanske B, Juul A, Hansen JB, Blomberg Jensen M.

Bone. 2019 Jun;123:103-114. doi: 10.1016/j.bone.2019.03.022. Epub 2019 Mar 23.


The Best Day of the Week: New Technology Enhancing Quality of Life in a Care Home.

Juul A, Wilding R, Baldassar L.

Int J Environ Res Public Health. 2019 Mar 19;16(6). pii: E1000. doi: 10.3390/ijerph16061000.


Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm.

Rehfeld A, Egeberg Palme DL, Almstrup K, Juul A, Skakkebaek NE.

J Vis Exp. 2019 Mar 1;(145). doi: 10.3791/59212.


Why Do Normal Children Have Acromegalic Levels of IGF-I During Puberty?

Juul A, Skakkebæk NE.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2770-2776. doi: 10.1210/jc.2018-02099.


Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort.

Jensen TK, Mustieles V, Bleses D, Frederiksen H, Trecca F, Schoeters G, Andersen HR, Grandjean P, Kyhl HB, Juul A, Bilenberg N, Andersson AM.

Environ Res. 2019 Mar;170:398-405. doi: 10.1016/j.envres.2018.12.055. Epub 2018 Dec 24.


Characterization of Human Adrenal Steroidogenesis During Fetal Development.

Melau C, Nielsen JE, Frederiksen H, Kilcoyne K, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Andersson AM, Mitchell RT, Juul A, Jørgensen A.

J Clin Endocrinol Metab. 2019 May 1;104(5):1802-1812. doi: 10.1210/jc.2018-01759.


Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy.

Assens M, Frederiksen H, Petersen JH, Larsen T, Skakkebæk NE, Juul A, Andersson AM, Main KM.

Environ Int. 2019 Feb;123:318-324. doi: 10.1016/j.envint.2018.11.047. Epub 2018 Dec 14.


Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population.

Priskorn L, Bang AK, Nordkap L, Krause M, Mendiola J, Jensen TK, Juul A, Skakkebaek NE, Swan SH, Jørgensen N.

Hum Reprod. 2019 Jan 1;34(1):12-24. doi: 10.1093/humrep/dey326.


Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis.

Jørgensen A, Macdonald J, Nielsen JE, Kilcoyne KR, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Frederiksen H, Andersson AM, Skakkebæk NE, Juul A, Sharpe RM, Rajpert-De Meyts E, Mitchell RT.

Cell Rep. 2018 Nov 13;25(7):1924-1937.e4. doi: 10.1016/j.celrep.2018.10.064.


Adult Growth Hormone Deficiency: from Transition to Senescence.

Jørgensen JO, Hermansen K, Stochholm K, Juul A.

Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):70-79. doi: 10.17458/per.vol16.2018.jhs.adultghdeficiency.


Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study.

Blomberg Jensen M, Husted H, Bjerrum PJ, Juul A, Kehlet H.

JBMR Plus. 2018 May 22;2(5):281-288. doi: 10.1002/jbm4.10053. eCollection 2018 Sep.


Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study.

Olesen IA, Joensen UN, Petersen JH, Almstrup K, Rajpert-De Meyts E, Carlsen E, McLachlan R, Juul A, Jørgensen N.

Hum Reprod. 2018 Nov 1;33(11):1963-1974. doi: 10.1093/humrep/dey283.


Quantification of the Leydig cell compartment in testicular biopsies and association with biochemical Leydig cell dysfunction in testicular cancer survivors.

Tarsitano MG, Bandak M, Jørgensen N, Skakkebaek NE, Juul A, Lenzi A, Daugaard G, Rajpert-De Meyts E.

Andrology. 2018 Sep;6(5):748-755. doi: 10.1111/andr.12508. Epub 2018 Jul 6.


Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents.

Sadov S, Virtanen HE, Main KM, Andersson AM, Juul A, Jula A, Raitakari OT, Pahkala K, Niinikoski H, Toppari J.

Acta Paediatr. 2019 Feb;108(2):321-327. doi: 10.1111/apa.14480. Epub 2018 Jul 20.


Sex Differences in Reproductive Hormones During Mini-Puberty in Infants With Normal and Disordered Sex Development.

Johannsen TH, Main KM, Ljubicic ML, Jensen TK, Andersen HR, Andersen MS, Petersen JH, Andersson AM, Juul A.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):3028-3037. doi: 10.1210/jc.2018-00482.


Transition in Pediatric and Adolescent Hypogonadal Girls: Gynecological Aspects, Estrogen Replacement Therapy, and Contraception.

Tønnes Pedersen A, Cleemann L, Main KM, Juul A.

Endocr Dev. 2018;33:113-127. doi: 10.1159/000487529. Epub 2018 Jun 12.


Ectopic Lipid Deposition Is Associated With Insulin Resistance in Postmenopausal Women.

Abildgaard J, Danielsen ER, Dorph E, Thomsen C, Juul A, Ewertsen C, Pedersen BK, Pedersen AT, Ploug T, Lindegaard B.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3394-3404. doi: 10.1210/jc.2018-00554.


Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum.

Albrethsen J, Frederiksen H, Andersson AM, Anand-Ivell R, Nordkap L, Bang AK, Jørgensen N, Juul A.

Clin Chem Lab Med. 2018 Oct 25;56(11):1913-1920. doi: 10.1515/cclm-2018-0171.


Pediatric reference intervals for general clinical chemistry components - merging of studies from Denmark and Sweden.

Ridefelt P, Hilsted L, Juul A, Hellberg D, Rustad P.

Scand J Clin Lab Invest. 2018 Sep;78(5):365-372. doi: 10.1080/00365513.2018.1474493. Epub 2018 May 28.


Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells.

Winge SB, Dalgaard MD, Belling KG, Jensen JM, Nielsen JE, Aksglaede L, Schierup MH, Brunak S, Skakkebæk NE, Juul A, Rajpert-De Meyts E, Almstrup K.

Cell Death Dis. 2018 May 22;9(6):586. doi: 10.1038/s41419-018-0671-1.


THERAPY OF ENDOCRINE DISEASE: Growth hormone replacement therapy in adults: 30 years of personal clinical experience.

Jørgensen JOL, Juul A.

Eur J Endocrinol. 2018 Jul;179(1):R47-R56. doi: 10.1530/EJE-18-0306. Epub 2018 May 1. Review.


Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years.

Priskorn L, Nordkap L, Bang AK, Krause M, Holmboe SA, Egeberg Palme DL, Winge SB, Mørup N, Carlsen E, Joensen UN, Blomberg Jensen M, Main KM, Juul A, Skakkebaek NE, Jensen TK, Jørgensen N.

Hum Reprod. 2018 Jun 1;33(6):998-1008. doi: 10.1093/humrep/dey090.


Understanding the needs of professionals who provide psychosocial care for children and adults with disorders of sex development.

Dessens A, Guaragna-Filho G, Kyriakou A, Bryce J, Sanders C, Nordenskjöld A, Rozas M, Iotova V, Ediati A, Juul A, Krawczynski M, Hiort O, Faisal Ahmed S.

BMJ Paediatr Open. 2017 Aug 31;1(1):e000132. doi: 10.1136/bmjpo-2017-000132. eCollection 2017. Erratum in: BMJ Paediatr Open. 2018 Feb 23;2(1):e000132corr1.


Serum Phthalate and Triclosan Levels Have Opposing Associations With Risk Factors for Gestational Diabetes Mellitus.

Fisher BG, Frederiksen H, Andersson AM, Juul A, Thankamony A, Ong KK, Dunger DB, Hughes IA, Acerini CL.

Front Endocrinol (Lausanne). 2018 Mar 13;9:99. doi: 10.3389/fendo.2018.00099. eCollection 2018.


Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism.

Andreassen M, Juul A, Feldt-Rasmussen U, Jørgensen N.

Endocr Connect. 2018 Apr;7(4):523-533. doi: 10.1530/EC-18-0061. Epub 2018 Mar 7.


Growth Hormone Research Society perspective on biomarkers of GH action in children and adults.

Johannsson G, Bidlingmaier M, Biller BMK, Boguszewski M, Casanueva FF, Chanson P, Clayton PE, Choong CS, Clemmons D, Dattani M, Frystyk J, Ho K, Hoffman AR, Horikawa R, Juul A, Kopchick JJ, Luo X, Neggers S, Netchine I, Olsson DS, Radovick S, Rosenfeld R, Ross RJ, Schilbach K, Solberg P, Strasburger C, Trainer P, Yuen KCJ, Wickstrom K, Jorgensen JOL; Growth Hormone Research Society.

Endocr Connect. 2018 Mar;7(3):R126-R134. doi: 10.1530/EC-18-0047. Epub 2018 Feb 26. Review.


Deletion in the uridine diphosphate glucuronyltransferase 2B17 gene is associated with delayed pubarche in healthy boys.

Mouritsen A, Busch AS, Aksglaede L, Rajpert-De Meyts E, Juul A.

Endocr Connect. 2018 Mar;7(3):460-465. doi: 10.1530/EC-18-0080. Epub 2018 Feb 21.


Postnatal Changes in Testicular Position Are Associated With IGF-I and Function of Sertoli and Leydig Cells.

Koskenniemi JJ, Virtanen HE, Wohlfahrt-Veje C, Löyttyniemi E, Skakkebaek NE, Juul A, Andersson AM, Main KM, Toppari J.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1429-1437. doi: 10.1210/jc.2017-01889.


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