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Items: 48

1.

Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection.

Huiting ED, Gittens K, Justement JS, Shi V, Blazkova J, Benko E, Kovacs C, Wender PA, Moir S, Sneller MC, Fauci AS, Chun TW.

J Infect Dis. 2019 Jun 19;220(2):270-274. doi: 10.1093/infdis/jiz100.

PMID:
30840763
2.

IgG3 regulates tissue-like memory B cells in HIV-infected individuals.

Kardava L, Sohn H, Youn C, Austin JW, Wang W, Buckner CM, Justement JS, Melson VA, Roth GE, Hand MA, Gittens KR, Kwan RW, Sneller MC, Li Y, Chun TW, Sun PD, Pierce SK, Moir S.

Nat Immunol. 2018 Sep;19(9):1001-1012. doi: 10.1038/s41590-018-0180-5. Epub 2018 Aug 13.

3.

Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals.

Clarridge KE, Blazkova J, Einkauf K, Petrone M, Refsland EW, Justement JS, Shi V, Huiting ED, Seamon CA, Lee GQ, Yu XG, Moir S, Sneller MC, Lichterfeld M, Chun TW.

PLoS Pathog. 2018 Jan 11;14(1):e1006792. doi: 10.1371/journal.ppat.1006792. eCollection 2018 Jan.

4.

A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection.

Sneller MC, Justement JS, Gittens KR, Petrone ME, Clarridge KE, Proschan MA, Kwan R, Shi V, Blazkova J, Refsland EW, Morris DE, Cohen KW, McElrath MJ, Xu R, Egan MA, Eldridge JH, Benko E, Kovacs C, Moir S, Chun TW, Fauci AS.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaan8848. doi: 10.1126/scitranslmed.aan8848.

PMID:
29212716
5.

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption.

Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW.

N Engl J Med. 2016 Nov 24;375(21):2037-2050. Epub 2016 Nov 9.

6.

Maintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burdens.

Buckner CM, Kardava L, Zhang X, Gittens K, Justement JS, Kovacs C, McDermott AB, Li Y, Sajadi MM, Chun TW, Fauci AS, Moir S.

J Infect Dis. 2016 Aug 1;214(3):390-8. doi: 10.1093/infdis/jiw163. Epub 2016 Apr 27.

7.

A Pilot Study of Raltegravir Plus Combination Antiretroviral Therapy in Early Human Immunodeficiency Virus Infection: Challenges and Lessons Learned.

Collier AC, Chun TW, Maenza J, Coombs RW, Tapia K, Chang M, Stevens CE, Justement JS, Murray D, Stekler JD, Mullins JI, Holte SE.

Biores Open Access. 2016 Jan 1;5(1):15-21. doi: 10.1089/biores.2015.0038. eCollection 2016.

8.

Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir.

Chun TW, Murray D, Justement JS, Blazkova J, Hallahan CW, Fankuchen O, Gittens K, Benko E, Kovacs C, Moir S, Fauci AS.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13151-6. doi: 10.1073/pnas.1414148111. Epub 2014 Aug 25.

9.

Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

Sadat MA, Moir S, Chun TW, Lusso P, Kaplan G, Wolfe L, Memoli MJ, He M, Vega H, Kim LJY, Huang Y, Hussein N, Nievas E, Mitchell R, Garofalo M, Louie A, Ireland DC, Grunes C, Cimbro R, Patel V, Holzapfel G, Salahuddin D, Bristol T, Adams D, Marciano BE, Hegde M, Li Y, Calvo KR, Stoddard J, Justement JS, Jacques J, Priel DAL, Murray D, Sun P, Kuhns DB, Boerkoel CF, Chiorini JA, Di Pasquale G, Verthelyi D, Rosenzweig SD.

N Engl J Med. 2014 Apr 24;370(17):1615-1625. doi: 10.1056/NEJMoa1302846. Epub 2014 Apr 9.

10.

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.

Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.

PLoS Pathog. 2013;9(5):e1003347. doi: 10.1371/journal.ppat.1003347. Epub 2013 May 9.

11.

Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy.

Blazkova J, Chun TW, Belay BW, Murray D, Justement JS, Funk EK, Nelson A, Hallahan CW, Moir S, Wender PA, Fauci AS.

J Infect Dis. 2012 Sep 1;206(5):765-9. doi: 10.1093/infdis/jis412. Epub 2012 Jun 25.

12.

Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy.

Blazkova J, Murray D, Justement JS, Funk EK, Nelson AK, Moir S, Chun TW, Fauci AS.

J Virol. 2012 May;86(9):5390-2. doi: 10.1128/JVI.00040-12. Epub 2012 Feb 15.

13.

Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy.

Chun TW, Murray D, Justement JS, Hallahan CW, Moir S, Kovacs C, Fauci AS.

J Infect Dis. 2011 Jul 1;204(1):135-8. doi: 10.1093/infdis/jir208.

14.

Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.

Chun TW, Justement JS, Murray D, Hallahan CW, Maenza J, Collier AC, Sheth PM, Kaul R, Ostrowski M, Moir S, Kovacs C, Fauci AS.

AIDS. 2010 Nov 27;24(18):2803-8. doi: 10.1097/QAD.0b013e328340a239.

15.

Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy.

Chun TW, Nickle DC, Justement JS, Meyers JH, Roby G, Hallahan CW, Kottilil S, Moir S, Mican JM, Mullins JI, Ward DJ, Kovacs JA, Mannon PJ, Fauci AS.

J Infect Dis. 2008 Mar 1;197(5):714-20. doi: 10.1086/527324.

PMID:
18260759
16.

Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells.

Meyers JH, Justement JS, Hallahan CW, Blair ET, Sun YA, O'Shea MA, Roby G, Kottilil S, Moir S, Kovacs CM, Chun TW, Fauci AS.

PLoS One. 2007 May 23;2(5):e458.

17.

Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus.

Chun TW, Justement JS, Moir S, Hallahan CW, Maenza J, Mullins JI, Collier AC, Corey L, Fauci AS.

J Infect Dis. 2007 Jun 15;195(12):1762-4. Epub 2007 May 2.

PMID:
17492591
18.

HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir.

Chun TW, Nickle DC, Justement JS, Large D, Semerjian A, Curlin ME, O'Shea MA, Hallahan CW, Daucher M, Ward DJ, Moir S, Mullins JI, Kovacs C, Fauci AS.

J Clin Invest. 2005 Nov;115(11):3250-5.

19.

Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily.

Moir S, Malaspina A, Pickeral OK, Donoghue ET, Vasquez J, Miller NJ, Krishnan SR, Planta MA, Turney JF, Justement JS, Kottilil S, Dybul M, Mican JM, Kovacs C, Chun TW, Birse CE, Fauci AS.

J Exp Med. 2004 Oct 4;200(7):587-99. Erratum in: J Exp Med. 2004 Oct 4;200(7): following 946.

PMID:
15508184
20.

Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily.

Moir S, Malaspina A, Pickeral OK, Donoghue ET, Vasquez J, Miller NJ, Krishnan SR, Planta MA, Turney JF, Justement JS, Kottilil S, Dybul M, Mican JM, Kovacs C, Chun TW, Birse CE, Fauci AS.

J Exp Med. 2004 Sep 6;200(5):587-99. Corrected and republished in: J Exp Med. 2004 Oct 4;200(7):587-99.

21.

Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals.

Chun TW, Justement JS, Sanford C, Hallahan CW, Planta MA, Loutfy M, Kottilil S, Moir S, Kovacs C, Fauci AS.

Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2464-9.

22.

Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals.

Chun TW, Justement JS, Lempicki RA, Yang J, Dennis G Jr, Hallahan CW, Sanford C, Pandya P, Liu S, McLaughlin M, Ehler LA, Moir S, Fauci AS.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1908-13. Epub 2003 Jan 27.

23.
24.

Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection.

Dybul M, Hidalgo B, Chun TW, Belson M, Migueles SA, Justement JS, Herpin B, Perry C, Hallahan CW, Davey RT, Metcalf JA, Connors M, Fauci AS.

J Infect Dis. 2002 Jan 1;185(1):61-8. Epub 2001 Dec 14.

PMID:
11756982
25.

Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters.

Dybul M, Chun TW, Yoder C, Hidalgo B, Belson M, Hertogs K, Larder B, Dewar RL, Fox CH, Hallahan CW, Justement JS, Migueles SA, Metcalf JA, Davey RT, Daucher M, Pandya P, Baseler M, Ward DJ, Fauci AS.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15161-6. Epub 2001 Dec 4.

26.
27.

Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes.

Chen X, Scala G, Quinto I, Liu W, Chun TW, Justement JS, Cohen OJ, vanCott TC, Iwanicki M, Lewis MG, Greenhouse J, Barry T, Venzon D, Fauci AS.

Nat Med. 2001 Nov;7(11):1225-31.

PMID:
11689887
28.

Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies.

Chun TW, Justement JS, Moir S, Hallahan CW, Ehler LA, Liu S, McLaughlin M, Dybul M, Mican JM, Fauci AS.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):253-8.

29.

CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction.

Kinter A, Catanzaro A, Monaco J, Ruiz M, Justement J, Moir S, Arthos J, Oliva A, Ehler L, Mizell S, Jackson R, Ostrowski M, Hoxie J, Offord R, Fauci AS.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11880-5.

30.

Increased in vitro tetanus-induced production of HIV type 1 following in vivo immunization of HIV type 1-infected individuals with tetanus toxoid.

Ostrowski MA, Stanley SK, Justement JS, Gantt K, Goletti D, Fauci AS.

AIDS Res Hum Retroviruses. 1997 Apr 10;13(6):473-80.

PMID:
9100988
31.

Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1.

Stanley SK, Ostrowski MA, Justement JS, Gantt K, Hedayati S, Mannix M, Roche K, Schwartzentruber DJ, Fox CH, Fauci AS.

N Engl J Med. 1996 May 9;334(19):1222-30.

32.

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.

Stanley SK, McCune JM, Kaneshima H, Justement JS, Sullivan M, Boone E, Baseler M, Adelsberger J, Bonyhadi M, Orenstein J, et al.

J Exp Med. 1993 Oct 1;178(4):1151-63.

33.

Glucocorticoids synergize with tumor necrosis factor alpha in the induction of HIV expression from a chronically infected promonocytic cell line.

Bressler P, Poli G, Justement JS, Biswas P, Fauci AS.

AIDS Res Hum Retroviruses. 1993 Jun;9(6):547-51.

PMID:
8347399
35.

CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals.

Stanley SK, Kessler SW, Justement JS, Schnittman SM, Greenhouse JJ, Brown CC, Musongela L, Musey K, Kapita B, Fauci AS.

J Immunol. 1992 Jul 15;149(2):689-97.

PMID:
1378076
36.

Retinoic acid mimics transforming growth factor beta in the regulation of human immunodeficiency virus expression in monocytic cells.

Poli G, Kinter AL, Justement JS, Bressler P, Kehrl JH, Fauci AS.

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2689-93.

37.

An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation.

Perez VL, Rowe T, Justement JS, Butera ST, June CH, Folks TM.

J Immunol. 1991 Nov 1;147(9):3145-8.

PMID:
1833465
38.
40.
41.
42.

Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

Poli G, Kinter A, Justement JS, Kehrl JH, Bressler P, Stanley S, Fauci AS.

Proc Natl Acad Sci U S A. 1990 Jan;87(2):782-5.

43.

Evidence for susceptibility of intrathymic T cell precursors to human immunodeficiency virus infection: a mechanism for T4 (CD4) lymphocyte depletion.

Schnittman SM, Denning SM, Greenhouse JJ, Justement JS, Baseler M, Haynes BF, Fauci AS.

Trans Assoc Am Physicians. 1990;103:96-101. No abstract available.

PMID:
1983432
44.

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

Folks TM, Clouse KA, Justement J, Rabson A, Duh E, Kehrl JH, Fauci AS.

Proc Natl Acad Sci U S A. 1989 Apr;86(7):2365-8.

45.

Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow.

Folks TM, Kessler SW, Orenstein JM, Justement JS, Jaffe ES, Fauci AS.

Science. 1988 Nov 11;242(4880):919-22.

PMID:
2460922
46.

Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.

Folks TM, Justement J, Kinter A, Schnittman S, Orenstein J, Poli G, Fauci AS.

J Immunol. 1988 Feb 15;140(4):1117-22.

PMID:
2449497
47.

Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

Folks TM, Justement J, Kinter A, Dinarello CA, Fauci AS.

Science. 1987 Nov 6;238(4828):800-2.

PMID:
3313729
48.

Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV.

Folks T, Kelly J, Benn S, Kinter A, Justement J, Gold J, Redfield R, Sell KW, Fauci AS.

J Immunol. 1986 Jun 1;136(11):4049-53.

PMID:
2422271

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