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Items: 1 to 50 of 199

1.

Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018.

Genth H, Junemann J, Lämmerhirt CM, Lücke AC, Schelle I, Just I, Gerhard R, Pich A.

Front Microbiol. 2018 Dec 21;9:3078. doi: 10.3389/fmicb.2018.03078. eCollection 2018.

2.

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells.

Junemann J, Just I, Gerhard R, Pich A.

Front Microbiol. 2018 Dec 17;9:3083. doi: 10.3389/fmicb.2018.03083. eCollection 2018.

3.

Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons.

Adolf A, Rohrbeck A, Münster-Wandowski A, Johansson M, Kuhn HG, Kopp MA, Brommer B, Schwab JM, Just I, Ahnert-Hilger G, Höltje M.

Glia. 2019 Apr;67(4):703-717. doi: 10.1002/glia.23566. Epub 2018 Nov 28.

PMID:
30485542
4.

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile.

Mehner-Breitfeld D, Rathmann C, Riedel T, Just I, Gerhard R, Overmann J, Brüser T.

Front Microbiol. 2018 Oct 18;9:2446. doi: 10.3389/fmicb.2018.02446. eCollection 2018.

5.

[Examination facility at Hannover Medical School].

Just I, Fischer V.

Wien Med Wochenschr. 2019 Apr;169(5-6):119-125. doi: 10.1007/s10354-018-0663-x. Epub 2018 Sep 18. German.

PMID:
30229334
6.

The impact of the program structure at Hannover Medical School on academic success in medical studies.

Fischer V, Dudzinska A, Just I.

GMS J Med Educ. 2018 May 15;35(2):Doc22. doi: 10.3205/zma001169. eCollection 2018.

7.

MS-based quantification of RhoA/B and RhoC ADP-ribosylation.

Schröder A, Benski A, Oltmanns A, Just I, Rohrbeck A, Pich A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:268-271. doi: 10.1016/j.jchromb.2018.06.007. Epub 2018 Jun 7.

PMID:
29933219
8.

The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif.

Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I.

J Biol Chem. 2017 Oct 27;292(43):17668-17680. doi: 10.1074/jbc.M117.798231. Epub 2017 Sep 7.

9.

Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.

Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A.

Proteomics. 2017 Aug;17(15-16). doi: 10.1002/pmic.201600435. Epub 2017 Jul 18.

PMID:
28612519
10.

Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation.

von Elsner L, Hagemann S, Just I, Rohrbeck A.

J Mol Signal. 2017 Apr 3;12:1. doi: 10.5334/1750-2187-12-1.

11.

Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis.

Junemann J, Lämmerhirt CM, Polten F, Just I, Gerhard R, Genth H, Pich A.

Proteomics. 2017 May;17(9). doi: 10.1002/pmic.201700016.

PMID:
28252257
12.

Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells.

Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A.

Proteomics Clin Appl. 2017 Mar;11(3-4). doi: 10.1002/prca.201600031. Epub 2016 Nov 30.

PMID:
27860399
13.

Cell Entry of C3 Exoenzyme from Clostridium botulinum.

Rohrbeck A, Just I.

Curr Top Microbiol Immunol. 2017;406:97-118. doi: 10.1007/82_2016_44. Review.

PMID:
27832378
14.

The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme.

Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M.

J Neurochem. 2016 Oct;139(2):234-244. doi: 10.1111/jnc.13739. Epub 2016 Aug 9.

15.

C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors.

von Elsner L, Hagemann S, Just I, Rohrbeck A.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Sep;389(9):1021-31. doi: 10.1007/s00210-016-1270-2. Epub 2016 Jun 28.

16.

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.

Genth H, Schelle I, Just I.

Toxins (Basel). 2016 Apr 13;8(4):109. doi: 10.3390/toxins8040109.

17.

Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody.

Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I.

Toxins (Basel). 2016 Apr 1;8(4):100. doi: 10.3390/toxins8040100.

18.

Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.

Schröder A, Rohrbeck A, Just I, Pich A.

J Proteome Res. 2015 Nov 6;14(11):4721-33. doi: 10.1021/acs.jproteome.5b00591. Epub 2015 Oct 9.

PMID:
26393427
19.

Uptake of clostridium botulinum C3 exoenzyme into intact HT22 and J774A.1 cells.

Rohrbeck A, von Elsner L, Hagemann S, Just I.

Toxins (Basel). 2015 Feb 2;7(2):380-95. doi: 10.3390/toxins7020380.

21.

Vimentin mediates uptake of C3 exoenzyme.

Rohrbeck A, Schröder A, Hagemann S, Pich A, Höltje M, Ahnert-Hilger G, Just I.

PLoS One. 2014 Jun 26;9(6):e101071. doi: 10.1371/journal.pone.0101071. eCollection 2014.

22.

Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

Genth H, Pauillac S, Schelle I, Bouvet P, Bouchier C, Varela-Chavez C, Just I, Popoff MR.

Cell Microbiol. 2014 Nov;16(11):1706-21. doi: 10.1111/cmi.12321. Epub 2014 Aug 4.

PMID:
24905543
23.

MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease.

Chatterji B, Dickhut C, Mielke S, Krüger J, Just I, Glage S, Meier M, Wedekind D, Pich A.

Proteomics. 2014 Jul;14(13-14):1674-87. doi: 10.1002/pmic.201300558. Epub 2014 Jun 20.

PMID:
24841751
24.

Time-resolved cellular effects induced by TcdA from Clostridium difficile.

Jochim N, Gerhard R, Just I, Pich A.

Rapid Commun Mass Spectrom. 2014 May 30;28(10):1089-100. doi: 10.1002/rcm.6882.

PMID:
24711272
25.

Inhibition of PCSK9: a novel approach for the treatment of dyslipidemia.

Stawowy P, Just IA, Kaschina E.

Coron Artery Dis. 2014 Jun;25(4):353-9. doi: 10.1097/MCA.0000000000000113. Review.

PMID:
24667128
26.

Binding of Clostridium botulinum C3 exoenzyme to intact cells.

Rohrbeck A, von Elsner L, Hagemann S, Just I.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Jun;387(6):523-32. doi: 10.1007/s00210-014-0963-7. Epub 2014 Mar 2.

PMID:
24584821
27.

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

Huelsenbeck SC, Roggenkamp D, May M, Huelsenbeck J, Brakebusch C, Rottner K, Ladwein M, Just I, Fritz G, Schmidt G, Genth H.

Int J Biochem Cell Biol. 2013 Aug;45(8):1767-75. doi: 10.1016/j.biocel.2013.05.020. Epub 2013 May 31.

PMID:
23732113
28.

Substrate specificity of clostridial glucosylating toxins and their function on colonocytes analyzed by proteomics techniques.

Zeiser J, Gerhard R, Just I, Pich A.

J Proteome Res. 2013 Apr 5;12(4):1604-18. doi: 10.1021/pr300973q. Epub 2013 Mar 4.

PMID:
23387933
29.

Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons.

Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L.

Front Cell Neurosci. 2012 Oct 11;6:43. doi: 10.3389/fncel.2012.00043. eCollection 2012.

30.

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.

Huelsenbeck J, May M, Schulz F, Schelle I, Ronkina N, Hohenegger M, Fritz G, Just I, Gerhard R, Genth H.

FEBS Lett. 2012 Oct 19;586(20):3665-73. doi: 10.1016/j.febslet.2012.08.024. Epub 2012 Sep 11.

31.

Serine-71 phosphorylation of Rac1 modulates downstream signaling.

Schwarz J, Proff J, Hävemeier A, Ladwein M, Rottner K, Barlag B, Pich A, Tatge H, Just I, Gerhard R.

PLoS One. 2012;7(9):e44358. doi: 10.1371/journal.pone.0044358. Epub 2012 Sep 10.

32.

Inhibition of macrophage migration by C. botulinum exoenzyme C3.

Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Sep;385(9):883-90. doi: 10.1007/s00210-012-0764-9. Epub 2012 May 29.

PMID:
22644106
33.

Proteomic evaluation of sheep serum proteins.

Chiaradia E, Avellini L, Tartaglia M, Gaiti A, Just I, Scoppetta F, Czentnar Z, Pich A.

BMC Vet Res. 2012 May 25;8:66.

34.

Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q.

Rohrbeck A, Kolbe T, Hagemann S, Genth H, Just I.

FEBS J. 2012 Aug;279(15):2657-71. doi: 10.1111/j.1742-4658.2012.08645.x. Epub 2012 Jun 14.

35.

Molecular characterization of folate receptor 1 mutations delineates cerebral folate transport deficiency.

Grapp M, Just IA, Linnankivi T, Wolf P, Lücke T, Häusler M, Gärtner J, Steinfeld R.

Brain. 2012 Jul;135(Pt 7):2022-31. doi: 10.1093/brain/aws122. Epub 2012 May 13.

PMID:
22586289
36.

Secretome analysis of Clostridium difficile strains.

Boetzkes A, Felkel KW, Zeiser J, Jochim N, Just I, Pich A.

Arch Microbiol. 2012 Aug;194(8):675-87. doi: 10.1007/s00203-012-0802-5. Epub 2012 Mar 8.

PMID:
22398929
37.

Minimal essential length of Clostridium botulinum C3 peptides to enhance neuronal regenerative growth and connectivity in a non-enzymatic mode.

Loske P, Boato F, Hendrix S, Piepgras J, Just I, Ahnert-Hilger G, Höltje M.

J Neurochem. 2012 Mar;120(6):1084-96. doi: 10.1111/j.1471-4159.2012.07657.x. Epub 2012 Feb 6.

38.

Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivation of the tcdE gene.

Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R.

Microb Pathog. 2012 Jan;52(1):92-100. doi: 10.1016/j.micpath.2011.10.009. Epub 2011 Nov 17.

39.

Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis.

Zeiser JJ, Klodmann J, Braun HP, Gerhard R, Just I, Pich A.

J Proteomics. 2011 Dec 21;75(2):469-79. doi: 10.1016/j.jprot.2011.08.012. Epub 2011 Aug 26.

PMID:
21890007
40.

C3 peptide promotes axonal regeneration and functional motor recovery after peripheral nerve injury.

Huelsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Talini K.

Neurotherapeutics. 2012 Jan;9(1):185-98. doi: 10.1007/s13311-011-0072-y.

41.

Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI.

Jochim N, Gerhard R, Just I, Pich A.

Proteome Sci. 2011 Aug 17;9:48. doi: 10.1186/1477-5956-9-48.

42.

Clostridial C3 proteins: recent approaches to improve neuronal growth and regeneration.

Höltje M, Just I, Ahnert-Hilger G.

Ann Anat. 2011 Jul;193(4):314-20. doi: 10.1016/j.aanat.2011.01.008. Epub 2011 Mar 10. Review.

PMID:
21459564
43.

The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A.

Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R.

PLoS One. 2011 Mar 18;6(3):e17623. doi: 10.1371/journal.pone.0017623.

44.

Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.

Gerhard R, Queisser S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383(3):285-95. doi: 10.1007/s00210-010-0592-8. Epub 2011 Jan 26.

PMID:
21267712
45.

Difference in the biological effects of Clostridium difficile toxin B in proliferating and non-proliferating cells.

Lica M, Schulz F, Schelle I, May M, Just I, Genth H.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383(3):275-83. doi: 10.1007/s00210-010-0595-5. Epub 2011 Jan 7.

PMID:
21212934
46.

Therapeutic effects of Clostridium botulinum C3 exoenzyme.

Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383(3):247-52. doi: 10.1007/s00210-010-0589-3. Epub 2010 Dec 31. Review.

PMID:
21193903
47.

Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease.

Genth H, Just I.

Eur J Cell Biol. 2011 Nov;90(11):959-65. doi: 10.1016/j.ejcb.2010.10.009. Epub 2010 Dec 4. Review.

PMID:
21134703
48.

Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A.

Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383(3):253-62. doi: 10.1007/s00210-010-0574-x. Epub 2010 Nov 3.

PMID:
21046073
49.

C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts.

Boato F, Hendrix S, Huelsenbeck SC, Hofmann F, Grosse G, Djalali S, Klimaschewski L, Auer M, Just I, Ahnert-Hilger G, Höltje M.

J Cell Sci. 2010 May 15;123(Pt 10):1652-62. doi: 10.1242/jcs.066050. Epub 2010 Apr 20.

50.

Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix.

Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A.

Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):561-70. doi: 10.1002/rcm.4412.

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