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Items: 1 to 50 of 566


Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells.

Molins EAG, Jusko WJ.

AAPS J. 2018 Jun 27;20(5):80. doi: 10.1208/s12248-018-0235-4.


Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.

Mavroudis PD, DuBois DC, Almon RR, Jusko WJ.

PLoS One. 2018 Jun 12;13(6):e0197534. doi: 10.1371/journal.pone.0197534. eCollection 2018.


Daily variation of gene expression in diverse rat tissues.

Mavroudis PD, DuBois DC, Almon RR, Jusko WJ.

PLoS One. 2018 May 10;13(5):e0197258. doi: 10.1371/journal.pone.0197258. eCollection 2018.


Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver.

Ayyar VS, Sukumaran S, DuBois DC, Almon RR, Qu J, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):557-575. doi: 10.1007/s10928-018-9585-x. Epub 2018 Apr 27.


Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells.

Zhu X, Shen X, Qu J, Straubinger RM, Jusko WJ.

Front Pharmacol. 2018 Feb 19;9:84. doi: 10.3389/fphar.2018.00084. eCollection 2018.


Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice.

Chen X, Jiang X, Doddareddy R, Geist B, McIntosh T, Jusko WJ, Zhou H, Wang W.

J Pharmacol Exp Ther. 2018 Apr;365(1):140-155. doi: 10.1124/jpet.117.244855. Epub 2018 Feb 2.


Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS.

PM R. 2018 Mar;10(3):235-243. doi: 10.1016/j.pmrj.2017.08.441. Epub 2017 Sep 1.


Mechanistic Multi-Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics.

Ayyar VS, DuBois DC, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2017 Oct;363(1):45-57. doi: 10.1124/jpet.117.242990. Epub 2017 Jul 20.


Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats.

Nie J, DuBois DC, Xue B, Jusko WJ, Almon RR.

Gene Regul Syst Bio. 2017 May 29;11:1177625017710009. doi: 10.1177/1177625017710009. eCollection 2017.


Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen.

Li X, DuBois DC, Song D, Almon RR, Jusko WJ, Chen X.

Drug Metab Dispos. 2017 Jul;45(7):834-845. doi: 10.1124/dmd.117.075614. Epub 2017 Apr 17.


Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor-α in Plasma Using Minimal Physiologically Based Pharmacokinetic Models.

Chen X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 Jul;45(7):790-797. doi: 10.1124/dmd.116.074807. Epub 2017 Apr 14.


Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models.

Chen X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 Jul;45(7):798-806. doi: 10.1124/dmd.116.074799. Epub 2017 Apr 14.


Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.

Ayyar VS, Almon RR, DuBois DC, Sukumaran S, Qu J, Jusko WJ.

J Proteomics. 2017 May 8;160:84-105. doi: 10.1016/j.jprot.2017.03.007. Epub 2017 Mar 14.


Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels.

Kamisoglu K, Acevedo A, Almon RR, Coyle S, Corbett S, Dubois DC, Nguyen TT, Jusko WJ, Androulakis IP.

Front Pharmacol. 2017 Feb 27;8:91. doi: 10.3389/fphar.2017.00091. eCollection 2017.


Modeling Sex Differences in Pharmacokinetics, Pharmacodynamics, and Disease Progression Effects of Naproxen in Rats with Collagen-Induced Arthritis.

Li X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 May;45(5):484-491. doi: 10.1124/dmd.116.074526. Epub 2017 Feb 28.


Effect of Disease-Related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats.

Li X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 May;45(5):476-483. doi: 10.1124/dmd.116.074500. Epub 2017 Feb 28.


Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest.

Vali P, Chandrasekharan P, Rawat M, Gugino S, Koenigsknecht C, Helman J, Jusko WJ, Mathew B, Berkelhamer S, Nair J, Wyckoff MH, Lakshminrusimha S.

J Am Heart Assoc. 2017 Feb 18;6(2). pii: e004402. doi: 10.1161/JAHA.116.004402.


Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases.

Koch G, Jusko WJ, Schropp J.

J Pharmacokinet Pharmacodyn. 2017 Feb;44(1):27-42. doi: 10.1007/s10928-016-9502-0. Epub 2017 Jan 10.


Target-mediated drug disposition with drug-drug interaction, Part I: single drug case in alternative formulations.

Koch G, Jusko WJ, Schropp J.

J Pharmacokinet Pharmacodyn. 2017 Feb;44(1):17-26. doi: 10.1007/s10928-016-9501-1. Epub 2017 Jan 10.


Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells.

Miao X, Koch G, Ait-Oudhia S, Straubinger RM, Jusko WJ.

Front Pharmacol. 2016 Nov 15;7:421. eCollection 2016.


Assessment of non-linear combination effect terms for drug-drug interactions.

Koch G, Schropp J, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2016 Oct;43(5):461-79. doi: 10.1007/s10928-016-9490-0. Epub 2016 Sep 16. Review.


Clarification of contraceptive drug pharmacokinetics in obesity.

Jusko WJ.

Contraception. 2017 Jan;95(1):10-16. doi: 10.1016/j.contraception.2016.08.003. Epub 2016 Aug 16. Review.


Perspectives on variability in pharmacokinetics of an oral contraceptive product.

Jusko WJ.

Contraception. 2017 Jan;95(1):5-9. doi: 10.1016/j.contraception.2016.07.019. Epub 2016 Jul 27. Review.


Mathematical modeling of the circadian dynamics of the neuroendocrine-immune network in experimentally induced arthritis.

Rao R, DuBois D, Almon R, Jusko WJ, Androulakis IP.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E310-24. doi: 10.1152/ajpendo.00006.2016. Epub 2016 May 24.


Minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody against interleukin-6 in mice with collagen-induced arthritis.

Chen X, Jiang X, Jusko WJ, Zhou H, Wang W.

J Pharmacokinet Pharmacodyn. 2016 Jun;43(3):291-304. doi: 10.1007/s10928-016-9472-2. Epub 2016 Apr 27.


Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells.

Miao X, Koch G, Straubinger RM, Jusko WJ.

Cancer Chemother Pharmacol. 2016 Jan;77(1):181-93. doi: 10.1007/s00280-015-2907-4. Epub 2015 Nov 25.


Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats.

Lon HK, DuBois DC, Earp JC, Almon RR, Jusko WJ.

Pharmacol Res Perspect. 2015 Oct;3(5):e00169. doi: 10.1002/prp2.169. Epub 2015 Aug 3.


Perspectives on the history and scientific contributions of Gerhard Levy.

Fung HL, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):429-46. doi: 10.1007/s10928-015-9442-0. Epub 2015 Sep 24. No abstract available.


Preface to the special issue to honor Gerhard Levy and 50 years of PK/PD.

Jusko WJ, Fung HL.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):427. doi: 10.1007/s10928-015-9443-z. No abstract available.


Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats.

Xue B, Nie J, Wang X, DuBois DC, Jusko WJ, Almon RR.

Gene Regul Syst Bio. 2015 Aug 10;9:15-26. doi: 10.4137/GRSB.S25172. eCollection 2015.


Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells.

Zhu X, Straubinger RM, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):477-96. doi: 10.1007/s10928-015-9429-x. Epub 2015 Aug 8.


Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.

Yoo H, Iirola T, Vilo S, Manner T, Aantaa R, Lahtinen M, Scheinin M, Olkkola KT, Jusko WJ.

Eur J Clin Pharmacol. 2015 Oct;71(10):1197-207. doi: 10.1007/s00228-015-1913-0. Epub 2015 Aug 2.


Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia.

Estepp JH, Melloni C, Thornburg CD, Wiczling P, Rogers Z, Rothman JA, Green NS, Liem R, Brandow AM, Crary SE, Howard TH, Morris MH, Lewandowski A, Garg U, Jusko WJ, Neville KA; Best Pharmaceuticals for Children Act-Pediatric Trials Network Administrative Core Committee.

J Clin Pharmacol. 2016 Mar;56(3):298-306. doi: 10.1002/jcph.598. Epub 2015 Oct 15.


Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids.

Ayyar VS, Almon RR, Jusko WJ, DuBois DC.

Physiol Rep. 2015 Jun;3(6). pii: e12382. doi: 10.14814/phy2.12382.


Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model.

Zhao J, Cao Y, Jusko WJ.

Pharm Res. 2015 Oct;32(10):3269-81. doi: 10.1007/s11095-015-1703-5. Epub 2015 May 5.


Biodistribution of etanercept to tissues and sites of inflammation in arthritic rats.

Chen X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2015 Jun;43(6):898-907. doi: 10.1124/dmd.114.062901. Epub 2015 Apr 1.


Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics.

Kamisoglu K, Sukumaran S, Nouri-Nigjeh E, Tu C, Li J, Shen X, Duan X, Qu J, Almon RR, DuBois DC, Jusko WJ, Androulakis IP.

OMICS. 2015 Feb;19(2):80-91. doi: 10.1089/omi.2014.0130. Epub 2015 Jan 22.


Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals.

Wang X, DuBois DC, Sukumaran S, Ayyar V, Jusko WJ, Almon RR.

Diabetes Metab Syndr Obes. 2014 Nov 11;7:531-41. doi: 10.2147/DMSO.S69891. eCollection 2014.


Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model.

Cao Y, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2014 Dec;41(6):571-80. doi: 10.1007/s10928-014-9374-0. Epub 2014 Aug 22.


Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment.

Wang X, DuBois DC, Cao Y, Jusko WJ, Almon RR.

Diabetes Metab Syndr Obes. 2014 Aug 1;7:381-9. doi: 10.2147/DMSO.S65818. eCollection 2014.


Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

Cao Y, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2014 Aug;41(4):375-87. doi: 10.1007/s10928-014-9372-2. Epub 2014 Jul 31.


Pharmacokinetic and pharmacodynamic analysis comparing diverse effects of detomidine, medetomidine, and dexmedetomidine in the horse: a population analysis.

Grimsrud KN, Ait-Oudhia S, Durbin-Johnson BP, Rocke DM, Mama KR, Rezende ML, Stanley SD, Jusko WJ.

J Vet Pharmacol Ther. 2015 Feb;38(1):24-34. doi: 10.1111/jvp.12139. Epub 2014 Jul 29.


Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats.

Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J.

Anal Chem. 2014 Aug 19;86(16):8149-57. doi: 10.1021/ac501380s. Epub 2014 Aug 6.


Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration.

Nguyen TT, Almon RR, Dubois DC, Sukumaran S, Jusko WJ, Androulakis IP.

Gene Regul Syst Bio. 2014 Mar 10;8:75-87. doi: 10.4137/GRSB.S13134. eCollection 2014.


Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.

He Y, Brunstrom-Hernandez JE, Thio LL, Lackey S, Gaebler-Spira D, Kuroda MM, Stashinko E, Hoon AH Jr, Vargus-Adams J, Stevenson RD, Lowenhaupt S, McLaughlin JF, Christensen A, Dosa NP, Butler M, Schwabe A, Lopez C, Roge D, Kennedy D, Tilton A, Krach LE, Lewandowski A, Dai H, Gaedigk A, Leeder JS, Jusko WJ.

J Pediatr. 2014 May;164(5):1181-1188.e8. doi: 10.1016/j.jpeds.2014.01.029. Epub 2014 Mar 5.


Meta-modeling of methylprednisolone effects on glucose regulation in rats.

Fang J, Sukumaran S, Dubois DC, Almon RR, Jusko WJ.

PLoS One. 2013 Dec 2;8(12):e81679. doi: 10.1371/journal.pone.0081679. eCollection 2013.


Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

Cao Y, Balthasar JP, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2013 Oct;40(5):597-607. doi: 10.1007/s10928-013-9332-2. Epub 2013 Aug 31.


Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells.

Hamed SS, Straubinger RM, Jusko WJ.

Cancer Chemother Pharmacol. 2013 Sep;72(3):553-63. doi: 10.1007/s00280-013-2226-6. Epub 2013 Jul 9.


Moving from basic toward systems pharmacodynamic models.

Jusko WJ.

J Pharm Sci. 2013 Sep;102(9):2930-40. doi: 10.1002/jps.23590. Epub 2013 May 16. Review.

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