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Items: 1 to 50 of 63

1.

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents.

Morak-Młodawska B, Pluta K, Latocha M, Jeleń M, Kuśmierz D, Suwińska K, Shkurenko A, Czuba Z, Jurzak M.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1298-1306. doi: 10.1080/14756366.2019.1639695.

2.

Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.

Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):646-653. doi: 10.1016/j.bmcl.2018.12.034. Epub 2018 Dec 16.

PMID:
30626557
3.

Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.

Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH.

ChemMedChem. 2019 Jan 8;14(1):169-181. doi: 10.1002/cmdc.201800569. Epub 2018 Dec 6.

PMID:
30378281
4.

The influence of genistein on free radicals in normal dermal fibroblasts and keloid fibroblasts examined by EPR spectroscopy.

Jurzak M, Ramos P, Pilawa B.

Med Chem Res. 2017;26(6):1297-1305. doi: 10.1007/s00044-017-1848-3. Epub 2017 Mar 16.

5.

MOLECULAR EFFECTS OF AMINE DERIVATIVES OF PHENOTHIAZINE ON CANCER CELLS C-32 AND SNB-19 IN VITRO.

Latocha M, Zięba A, Polaniak R, Kuśmierz D, Nowosad A, Jurzak M, Romuk E, Kokocińska M, Sliupkas-Dyrda E.

Acta Pol Pharm. 2015 Sep-Oct;72(5):909-15.

6.

Caffeic Acid phenethyl ester and ethanol extract of propolis induce the complementary cytotoxic effect on triple-negative breast cancer cell lines.

Rzepecka-Stojko A, Kabała-Dzik A, Moździerz A, Kubina R, Wojtyczka RD, Stojko R, Dziedzic A, Jastrzębska-Stojko Ż, Jurzak M, Buszman E, Stojko J.

Molecules. 2015 May 20;20(5):9242-62. doi: 10.3390/molecules20059242.

7.

Transcripional activity of genes encoding MMPs and TIMPs in breast cancer cells treated by genistein and in normal cancer-associated fibroblasts--in vitro studies.

Latocha M, Płonka J, Kuśmierz D, Jurzak M, Polaniak R, Nowosad A.

Acta Pol Pharm. 2014 Nov-Dec;71(6):1095-102. No abstract available.

8.
9.
10.

Hepatic tissue changes in rats due to chronic invasion of Babesia microti.

Okła H, Jasik KP, Słodki J, Rozwadowska B, Słodki A, Jurzak M, Pierzchała E.

Folia Biol (Krakow). 2014;62(4):353-9.

PMID:
25916163
12.
13.

The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells.

Kapral M, Wawszczyk J, Jurzak M, Hollek A, Węglarz L.

Int J Colorectal Dis. 2012 Nov;27(11):1419-28. doi: 10.1007/s00384-012-1445-3. Epub 2012 Mar 15.

14.

Evaluation of the expression of metalloproteinases 2 and 9 and their tissue inhibitors in colon cancer cells treated with phytic acid.

Kapral M, Wawszczyk J, Jurzak M, Dymitruk D, Weglarz L.

Acta Pol Pharm. 2010 Nov-Dec;67(6):625-9.

15.

[Characteristic of the endogenous peptides--endothelins and their role in the connective tissue fibrosis].

Garncarczyk A, Jurzak M, Gojniczek K.

Wiad Lek. 2008;61(4-6):126-34. Review. Polish.

PMID:
18939363
16.

Transforming growth factor beta isoforms (TGF-beta1, TGF-beta2, TGF-beta3) messenger RNA expression in laryngeal cancer.

Kapral M, Strzalka B, Kowalczyk M, Jurzak M, Mazurek U, Gierek T, Paluch J, Markowski J, Swiatkowska L, Weglarz L.

Am J Otolaryngol. 2008 Jul-Aug;29(4):233-7. doi: 10.1016/j.amjoto.2007.08.003. Epub 2008 Mar 19.

PMID:
18598833
17.

Influence of retinoids on skin fibroblasts metabolism in vitro.

Jurzak M, Latocha M, Gojniczek K, Kapral M, Garncarczyk A, Pierzchała E.

Acta Pol Pharm. 2008 Jan-Feb;65(1):85-91.

18.

Synthesis and biodistribution of [11C]R107474, a new radiolabeled alpha2-adrenoceptor antagonist.

Van der Mey M, Windhorst AD, Klok RP, Herscheid JD, Kennis LE, Bischoff F, Bakker M, Langlois X, Heylen L, Jurzak M, Leysen JE.

Bioorg Med Chem. 2006 Jul 1;14(13):4526-34. Epub 2006 Mar 6.

PMID:
16517171
19.

Internalization of human 5-HT4a and 5-HT4b receptors is splice variant dependent.

Pindon A, Van Hecke G, Josson K, Van Gompel P, Lesage A, Leysen JE, Jurzak M.

Biosci Rep. 2004 Jun;24(3):215-23.

PMID:
16209130
20.

Synthesis and biodistribution of [(11)C]R116301, a promising PET ligand for central NK(1) receptors.

Van der Mey M, Janssen CG, Janssens FE, Jurzak M, Langlois X, Sommen FM, Verreet B, Windhorst AD, Leysen JE, Herscheid JD.

Bioorg Med Chem. 2005 Mar 1;13(5):1579-86.

PMID:
15698775
21.

Changes in TNF-alpha mRNA levels in the peripheral blood of patients with chronic hepatitis C virus (HCV) infection during alpha-interferon and ribavirin therapy.

Sypniewski D, Jurzak M, Cholewa K, Gola J, Mazurek U, Wilczok T, Rozek-Kostórkiewicz J, Mazur W, Gonciarz Z.

Viral Immunol. 2004;17(4):580-7.

PMID:
15671755
22.

Blood serum glutathione alpha s-transferase (alpha GST) activity during antiviral therapy in patients with chronic hepatitis C.

Mazur W, Gonciarz M, Kajdy M, Mazurek U, Jurzak M, Wilczok T, Gonciarz Z.

Med Sci Monit. 2003 Aug;9 Suppl 3:44-8.

PMID:
15156612
23.

Hepatitis C virus RNA level changes in sera during different regimens of treatment in patients with chronic hepatitis C.

Mazur W, Gonciarz M, Mazurek U, Jurzak M, Wilczok T, Gonciarz Z.

Med Sci Monit. 2003 Aug;9 Suppl 3:39-43.

PMID:
15156611
24.

Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas.

Woszczyk D, Gola J, Jurzak M, Mazurek U, Mykała-Cieśla J, Wilczok T.

Med Sci Monit. 2004 Jan;10(1):CR33-7.

PMID:
14704634
25.

Dynamics of HCV replication in patients with chronic hepatitis C during interferon and ribavirin combined therapy.

Mazurek U, Jurzak M, Gola J, Mazur W, Szuścik T, Krysiak R, Gonciarz Z, Wilczok T.

Med Sci Monit. 2001 May;7 Suppl 1:236-40.

PMID:
12211727
26.

Increased AST and GGT activity as marker of RT-PCR inhibition in RNA extracts from peripheral blood.

Jurzak M, Mazurek U, Mazur W, Wdowiak E, Gonciarz Z, Wilczok T.

Med Sci Monit. 2001 May;7 Suppl 1:231-5.

PMID:
12211726
27.

Interferon versus interferon and UDCA combined therapy in chronic hepatitis C.

Mazur W, Machniak M, Mazurek U, Jurzak M, Wilczok T, Gonciarz Z.

Med Sci Monit. 2001 May;7 Suppl 1:157-64.

PMID:
12211712
28.

Short-term changes of serum IL-2 and IL-6 induced by interferon alpha-2b in patients with chronic hepatitis C.

Mazur W, Mazurek U, Jurzak M, Wilczok T, Gonciarz M, Gonciarz Z.

Med Sci Monit. 2001 May;7 Suppl 1:151-6.

PMID:
12211711
29.

Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.

Taymans JM, Wintmolders C, Te Riele P, Jurzak M, Groenewegen HJ, Leysen JE, Langlois X.

Neuroscience. 2002;114(1):39-53.

PMID:
12207953
30.

Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist.

Megens AA, Ashton D, Vermeire JC, Vermote PC, Hens KA, Hillen LC, Fransen JF, Mahieu M, Heylen L, Leysen JE, Jurzak MR, Janssens F.

J Pharmacol Exp Ther. 2002 Aug;302(2):696-709.

PMID:
12130734
31.

Nuclei and subnuclei gene expression profiling in mammalian brain.

Bonaventure P, Guo H, Tian B, Liu X, Bittner A, Roland B, Salunga R, Ma XJ, Kamme F, Meurers B, Bakker M, Jurzak M, Leysen JE, Erlander MG.

Brain Res. 2002 Jul 5;943(1):38-47.

PMID:
12088837
32.

Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.

Bender E, Buist A, Jurzak M, Langlois X, Baggerman G, Verhasselt P, Ercken M, Guo HQ, Wintmolders C, Van den Wyngaert I, Van Oers I, Schoofs L, Luyten W.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8573-8.

33.

Distribution of hepatitis C virus RNA in whole blood of patients with HCV infection and HBV-HCV coinfection.

Mazurek U, Wilczok T, Mazur W, Bednarek I, Strzałka B, Jurzak M, Laskowska-Lepiarczyk E, Gonciarz Z.

Med Sci Monit. 2002 Feb;8(2):CR125-30.

PMID:
11859286
34.

Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.

Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M.

Mol Pharmacol. 2002 Jan;61(1):85-96.

PMID:
11752209
35.
36.

Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone.

Oekelen DV, Jurzak M, Van de Wiel D, Van Hecke G, Luyten WH, Leysen JE.

Eur J Pharmacol. 2001 Aug 3;425(1):21-32.

PMID:
11672571
37.

Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists.

Langlois X, te Riele P, Wintmolders C, Leysen JE, Jurzak M.

J Pharmacol Exp Ther. 2001 Nov;299(2):712-7.

PMID:
11602685
38.

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Briejer MR, Bosmans JP, Van Daele P, Jurzak M, Heylen L, Leysen JE, Prins NH, Schuurkes JA.

Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

PMID:
11438309
39.

Probing opioid receptor-ligand interactions by employment of indolizidin-9-one amino acid as a constrained Gly(2)-Gly(3) surrogate in a leucine-enkephalin mimic.

Gosselin F, Tourwé D, Ceusters M, Meert T, Heylen L, Jurzak M, Lubell WD.

J Pept Res. 2001 Apr;57(4):337-44.

PMID:
11328491
40.

Positive and negative strands of HCV-RNA in sera and peripheral blood mononuclear cells of chronically hemodialyzed patients.

Mazur W, Mazurek U, Jurzak M, Wilczok T, Bułanowski Z, Gonciarz Z.

Med Sci Monit. 2001 Jan-Feb;7(1):108-15.

PMID:
11208504
41.

Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study.

Langlois X, Wintmolders C, te Riele P, Leysen JE, Jurzak M.

Neuropharmacology. 2001;40(2):242-53.

PMID:
11114403
42.

Effects of recent and reference antipsychotic agents at human dopamine D2 and D3 receptor signaling in Chinese hamster ovary cells.

Vanhauwe JF, Ercken M, van de Wiel D, Jurzak M, Leysen JE.

Psychopharmacology (Berl). 2000 Jul;150(4):383-90.

PMID:
10958079
43.

Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations.

Brys R, Josson K, Castelli MP, Jurzak M, Lijnen P, Gommeren W, Leysen JE.

Mol Pharmacol. 2000 Jun;57(6):1132-41.

PMID:
10825383
44.

Human 5-hydroxytryptamine(5A) receptors activate coexpressed G(i) and G(o) proteins in Spodoptera frugiperda 9 cells.

Francken BJ, Josson K, Lijnen P, Jurzak M, Luyten WH, Leysen JE.

Mol Pharmacol. 2000 May;57(5):1034-44.

PMID:
10779389
45.

Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain.

Bonaventure P, Hall H, Gommeren W, Cras P, Langlois X, Jurzak M, Leysen JE.

Synapse. 2000 Apr;36(1):35-46.

PMID:
10700024
46.

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.

Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W.

J Neurochem. 2000 Feb;74(2):478-89.

47.

Vasopressin and sensory circumventricular organs.

Jurzak M, Schmid HA.

Prog Brain Res. 1998;119:221-45. Review.

PMID:
10074791
48.

Characterization of ionic currents of cells of the subfornical organ that project to the supraoptic nuclei.

Johnson RF, Beltz TG, Jurzak M, Wachtel RE, Johnson AK.

Brain Res. 1999 Jan 30;817(1-2):226-31.

PMID:
9889374
49.

The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.

Francken BJ, Jurzak M, Vanhauwe JF, Luyten WH, Leysen JE.

Eur J Pharmacol. 1998 Nov 20;361(2-3):299-309.

PMID:
9865521
50.

Angiotensin II-induced calcium signalling in neurons and astrocytes of rat circumventricular organs.

Gebke E, Müller AR, Jurzak M, Gerstberger R.

Neuroscience. 1998 Jul;85(2):509-20.

PMID:
9622248

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