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16α-Hydroxytrametenolic Acid from Poria cocos Improves Intestinal Barrier Function Through the Glucocorticoid Receptor-Mediated PI3K/Akt/NF-κB Pathway.

Xu H, Wang Y, Jurutka PW, Wu S, Chen Y, Cao C, Chen G, Tian B, Wang S, Cheng S.

J Agric Food Chem. 2019 Oct 2;67(39):10871-10879. doi: 10.1021/acs.jafc.9b04613. Epub 2019 Sep 23.


Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence.

Xu H, Wang Y, Zhao J, Jurutka PW, Huang D, Liu L, Zhang L, Wang S, Chen Y, Cheng S.

Chem Biol Drug Des. 2019 Aug 24. doi: 10.1111/cbdd.13610. [Epub ahead of print]


Methods to Generate an Array of Novel Rexinoids by SAR on a Potent Retinoid X Receptor Agonist: A Case Study with NEt-TMN.

Wagner CE, Jurutka PW.

Methods Mol Biol. 2019;2019:109-121. doi: 10.1007/978-1-4939-9585-1_8.


Methods to Assess Activity and Potency of Rexinoids Using Rapid Luciferase-Based Assays: A Case Study with NEt-TMN.

Jurutka PW, Wagner CE.

Methods Mol Biol. 2019;2019:95-108. doi: 10.1007/978-1-4939-9585-1_7.


Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention.

Zhang D, Leal AS, Carapellucci S, Shahani PH, Bhogal JS, Ibrahim S, Raban S, Jurutka PW, Marshall PA, Sporn MB, Wagner CE, Liby KT.

Cancer Prev Res (Phila). 2019 Apr;12(4):211-224. doi: 10.1158/1940-6207.CAPR-18-0317. Epub 2019 Feb 13.


Dataset on the response of Hut78 cells to novel rexinoids.

Hackney Price J, Hanish BJ, Wagner CE, Kaneko I, Jurutka PW, Marshall PA.

Data Brief. 2018 Sep 12;20:1797-1803. doi: 10.1016/j.dib.2018.09.012. eCollection 2018 Oct.


Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines.

Sabir MS, Haussler MR, Mallick S, Kaneko I, Lucas DA, Haussler CA, Whitfield GK, Jurutka PW.

Genes Nutr. 2018 Jul 11;13:19. doi: 10.1186/s12263-018-0605-7. eCollection 2018.


Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling.

Chamcheu JC, Rady I, Chamcheu RN, Siddique AB, Bloch MB, Banang Mbeumi S, Babatunde AS, Uddin MB, Noubissi FK, Jurutka PW, Liu YY, Spiegelman VS, Whitfield GK, El Sayed KA.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1791. doi: 10.3390/ijms19061791.


A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics.

Hanish BJ, Hackney Price JF, Kaneko I, Ma N, van der Vaart A, Wagner CE, Jurutka PW, Marshall PA.

Steroids. 2018 Jul;135:36-49. doi: 10.1016/j.steroids.2018.04.009. Epub 2018 Apr 26.


Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis.

Karrys A, Rady I, Chamcheu RN, Sabir MS, Mallick S, Chamcheu JC, Jurutka PW, Haussler MR, Whitfield GK.

Nutrients. 2018 Feb 4;10(2). pii: E174. doi: 10.3390/nu10020174.


Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome.

Dussik CM, Hockley M, Grozić A, Kaneko I, Zhang L, Sabir MS, Park J, Wang J, Nickerson CA, Yale SH, Rall CJ, Foxx-Orenstein AE, Borror CM, Sandrin TR, Jurutka PW.

J Neurogastroenterol Motil. 2018 Jan 30;24(1):96-106. doi: 10.5056/jnm17021.


SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation.

Sabir MS, Khan Z, Hu C, Galligan MA, Dussik CM, Mallick S, Stone AD, Batie SF, Jacobs ET, Whitfield GK, Haussler MR, Heck MC, Jurutka PW.

J Steroid Biochem Mol Biol. 2017 Sep;172:117-129. doi: 10.1016/j.jsbmb.2017.06.010. Epub 2017 Jun 19.


Total and Free Circulating Vitamin D and Vitamin D-Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans.

Andersen SW, Shu XO, Cai Q, Khankari NK, Steinwandel MD, Jurutka PW, Blot WJ, Zheng W.

Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1242-1247. doi: 10.1158/1055-9965.EPI-17-0133. Epub 2017 May 8.


Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials.

Kohler LN, Hibler EA, Harris RB, Oren E, Roe DJ, Jurutka PW, Jacobs ET.

J Nutr. 2017 Mar;147(3):421-429. doi: 10.3945/jn.116.243352. Epub 2017 Jan 25.


EDITORIAL (Thematic Issue : Rexinoids).

Wagner CE, Marshall PA, Jurutka PW.

Curr Top Med Chem. 2017;17(6):629-630. No abstract available.


Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN).

Heck MC, Wagner CE, Shahani PH, MacNeill M, Grozic A, Darwaiz T, Shimabuku M, Deans DG, Robinson NM, Salama SH, Ziller JW, Ma N, van der Vaart A, Marshall PA, Jurutka PW.

J Med Chem. 2016 Oct 13;59(19):8924-8940. Epub 2016 Sep 19.


Retinoid X Receptor Selective Agonists and their Synthetic Methods.

Wagner CE, Jurutka PW, Marshall PA, Heck MC.

Curr Top Med Chem. 2017;17(6):742-767. Review.


Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations.

Jacobs ET, Haussler MR, Alberts DS, Kohler LN, Lance P, Martínez ME, Roe DJ, Jurutka PW.

Cancer Prev Res (Phila). 2016 Jul;9(7):589-97. doi: 10.1158/1940-6207.CAPR-16-0033. Epub 2016 May 2.


Vitamin D and Colorectal, Breast, and Prostate Cancers: A Review of the Epidemiological Evidence.

Jacobs ET, Kohler LN, Kunihiro AG, Jurutka PW.

J Cancer. 2016 Jan 5;7(3):232-40. doi: 10.7150/jca.13403. eCollection 2016. Review.


1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age.

Haussler MR, Whitfield GK, Haussler CA, Sabir MS, Khan Z, Sandoval R, Jurutka PW.

Vitam Horm. 2016;100:165-230. doi: 10.1016/bs.vh.2015.11.005. Epub 2016 Jan 13.


Physical activity, sedentary behavior, and vitamin D metabolites.

Hibler EA, Sardo Molmenti CL, Dai Q, Kohler LN, Warren Anderson S, Jurutka PW, Jacobs ET.

Bone. 2016 Feb;83:248-255. doi: 10.1016/j.bone.2015.11.016. Epub 2015 Nov 24.


CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.

Hibler EA, Klimentidis YC, Jurutka PW, Kohler LN, Lance P, Roe DJ, Thompson PA, Jacobs ET.

Nutr Cancer. 2015;67(7):1131-41. doi: 10.1080/01635581.2015.1068818. Epub 2015 Aug 4.


FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes.

Kaneko I, Saini RK, Griffin KP, Whitfield GK, Haussler MR, Jurutka PW.

J Endocrinol. 2015 Sep;226(3):155-66. doi: 10.1530/JOE-15-0225. Epub 2015 Jul 6.


Distinct functional modes of SUMOylation for retinoid X receptor alpha.

Lee WP, Jena S, Rodriguez EP, O'Donovan SP, Wagner C, Jurutka PW, Thompson PD.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):195-200. doi: 10.1016/j.bbrc.2015.06.115. Epub 2015 Jun 23.


1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D.

Kaneko I, Sabir MS, Dussik CM, Whitfield GK, Karrys A, Hsieh JC, Haussler MR, Meyer MB, Pike JW, Jurutka PW.

FASEB J. 2015 Sep;29(9):4023-35. doi: 10.1096/fj.14-269811. Epub 2015 Jun 12.


Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.

Marshall PA, Jurutka PW, Wagner CE, van der Vaart A, Kaneko I, Chavez PI, Ma N, Bhogal JS, Shahani P, Swierski JC, MacNeill M.

Pharmacol Res Perspect. 2015 Mar;3(2):e00122. doi: 10.1002/prp2.122. Epub 2015 Mar 16.


Resveratrol potentiates vitamin D and nuclear receptor signaling.

Dampf Stone A, Batie SF, Sabir MS, Jacobs ET, Lee JH, Whitfield GK, Haussler MR, Jurutka PW.

J Cell Biochem. 2015 Jun;116(6):1130-43. doi: 10.1002/jcb.25070.


Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components.

Bea JW, Jurutka PW, Hibler EA, Lance P, Martínez ME, Roe DJ, Sardo Molmenti CL, Thompson PA, Jacobs ET.

Metabolism. 2015 Mar;64(3):447-59. doi: 10.1016/j.metabol.2014.11.010. Epub 2014 Nov 29.


Associations between circulating 1,25(OH)₂D concentration and odds of metachronous colorectal adenoma.

Hibler EA, Molmenti CL, Lance P, Jurutka PW, Jacobs ET.

Cancer Causes Control. 2014 Jul;25(7):809-17. doi: 10.1007/s10552-014-0382-6. Epub 2014 Apr 16.


Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling.

Lee WP, Jena S, Doherty D, Ventakesh J, Schimdt J, Furmick J, Widener T, Lemau J, Jurutka PW, Thompson PD.

PLoS One. 2014 Feb 20;9(2):e89506. doi: 10.1371/journal.pone.0089506. eCollection 2014.


Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells.

Hibler EA, Jacobs ET, Stone AD, Sardo CL, Galligan MA, Jurutka PW.

Cancer Prev Res (Phila). 2014 Apr;7(4):426-34. doi: 10.1158/1940-6207.CAPR-13-0269. Epub 2014 Jan 28.


Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin.

Austin HR, Hoss E, Batie SF, Moffet EW, Jurutka PW, Haussler MR, Whitfield GK.

Biochem Biophys Res Commun. 2014 Jan 24;443(4):1275-9. doi: 10.1016/j.bbrc.2013.12.128. Epub 2014 Jan 3.


Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes.

Hsieh JC, Estess RC, Kaneko I, Whitfield GK, Jurutka PW, Haussler MR.

J Endocrinol. 2014 Jan 8;220(2):165-78. doi: 10.1530/JOE-13-0212. Print 2014 Feb.


Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254).

Jurutka PW, Kaneko I, Yang J, Bhogal JS, Swierski JC, Tabacaru CR, Montano LA, Huynh CC, Jama RA, Mahelona RD, Sarnowski JT, Marcus LM, Quezada A, Lemming B, Tedesco MA, Fischer AJ, Mohamed SA, Ziller JW, Ma N, Gray GM, van der Vaart A, Marshall PA, Wagner CE.

J Med Chem. 2013 Nov 14;56(21):8432-54. doi: 10.1021/jm4008517. Epub 2013 Nov 1.


Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin.

Hoss E, Austin HR, Batie SF, Jurutka PW, Haussler MR, Whitfield GK.

Arch Dermatol Res. 2013 Dec;305(10):867-78. doi: 10.1007/s00403-013-1390-1. Epub 2013 Jul 10.


Association between circulating concentrations of 25(OH)D and colorectal adenoma: a pooled analysis.

Jacobs ET, Hibler EA, Lance P, Sardo CL, Jurutka PW.

Int J Cancer. 2013 Dec 15;133(12):2980-8. doi: 10.1002/ijc.28316. Epub 2013 Jul 11.


CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.

Jacobs ET, Van Pelt C, Forster RE, Zaidi W, Hibler EA, Galligan MA, Haussler MR, Jurutka PW.

Cancer Res. 2013 Apr 15;73(8):2563-73. doi: 10.1158/0008-5472.CAN-12-4134. Epub 2013 Feb 19.


Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists.

Batie S, Lee JH, Jama RA, Browder DO, Montano LA, Huynh CC, Marcus LM, Tsosie DG, Mohammed Z, Trang V, Marshall PA, Jurutka PW, Wagner CE.

Bioorg Med Chem. 2013 Feb 1;21(3):693-702. doi: 10.1016/j.bmc.2012.11.033. Epub 2012 Dec 5.


1,25-dihydroxyvitamin D(3) regulation of fibroblast growth factor-23 expression in bone cells: evidence for primary and secondary mechanisms modulated by leptin and interleukin-6.

Saini RK, Kaneko I, Jurutka PW, Forster R, Hsieh A, Hsieh JC, Haussler MR, Whitfield GK.

Calcif Tissue Int. 2013 Apr;92(4):339-53. doi: 10.1007/s00223-012-9683-5. Epub 2012 Dec 22.


Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).

Furmick JK, Kaneko I, Walsh AN, Yang J, Bhogal JS, Gray GM, Baso JC, Browder DO, Prentice JL, Montano LA, Huynh CC, Marcus LM, Tsosie DG, Kwon JS, Quezada A, Reyes NM, Lemming B, Saini P, van der Vaart A, Groy TL, Marshall PA, Jurutka PW, Wagner CE.

ChemMedChem. 2012 Sep;7(9):1551-66.


Molecular mechanisms of vitamin D action.

Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, Jurutka PW.

Calcif Tissue Int. 2013 Feb;92(2):77-98. doi: 10.1007/s00223-012-9619-0. Epub 2012 Jul 11. Review.


Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling.

Marshall PA, Hernandez Z, Kaneko I, Widener T, Tabacaru C, Aguayo I, Jurutka PW.

J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):147-59. doi: 10.1016/j.jsbmb.2012.05.001. Epub 2012 May 14.


Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.

Hibler EA, Hu C, Jurutka PW, Martinez ME, Jacobs ET.

Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):368-75. doi: 10.1158/1055-9965.EPI-11-0916. Epub 2011 Dec 5.


Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells.

Forster RE, Jurutka PW, Hsieh JC, Haussler CA, Lowmiller CL, Kaneko I, Haussler MR, Kerr Whitfield G.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):557-62. doi: 10.1016/j.bbrc.2011.09.117. Epub 2011 Oct 1.


The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis.

Haussler MR, Whitfield GK, Kaneko I, Forster R, Saini R, Hsieh JC, Haussler CA, Jurutka PW.

Rev Endocr Metab Disord. 2012 Mar;13(1):57-69. doi: 10.1007/s11154-011-9199-8. Review.


Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)₂vitamin D₃: genomic and non-genomic mechanisms.

Haussler MR, Jurutka PW, Mizwicki M, Norman AW.

Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):543-59. doi: 10.1016/j.beem.2011.05.010. Review.


Vitamin D: marker or mechanism of action?

Jacobs ET, Martínez ME, Jurutka PW.

Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):585-90. doi: 10.1158/1055-9965.EPI-10-1257.


Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites.

Hibler EA, Jurutka PW, Egan JB, Hu C, LeRoy EC, Martinez ME, Thompson PA, Jacobs ET.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):438-41. doi: 10.1016/j.jsbmb.2010.03.052. Epub 2010 Mar 20.


The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging.

Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, Bartik L, Egan JB, Wu Y, Kubicek JL, Lowmiller CL, Moffet EW, Forster RE, Jurutka PW.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):88-97. doi: 10.1016/j.jsbmb.2010.03.019. Epub 2010 Mar 20.


Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.

Bartik L, Whitfield GK, Kaczmarska M, Lowmiller CL, Moffet EW, Furmick JK, Hernandez Z, Haussler CA, Haussler MR, Jurutka PW.

J Nutr Biochem. 2010 Dec;21(12):1153-61. doi: 10.1016/j.jnutbio.2009.09.012. Epub 2010 Feb 12.

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