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Items: 1 to 50 of 63

1.

cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets.

Makhoul S, Trabold K, Gambaryan S, Tenzer S, Pillitteri D, Walter U, Jurk K.

Cell Commun Signal. 2019 Sep 13;17(1):122. doi: 10.1186/s12964-019-0428-1.

2.

Standardization of Light Transmission Aggregometry for Diagnosis of Platelet Disorders: An Inter-Laboratory External Quality Assessment.

Althaus K, Zieger B, Bakchoul T, Jurk K; THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) und der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH).

Thromb Haemost. 2019 Jul;119(7):1154-1161. doi: 10.1055/s-0039-1688791. Epub 2019 Jun 2.

PMID:
31154663
3.

CD133+ bone marrow stem cells (BMSC) control platelet activation - Role of ectoNTPDase-1 (CD39).

Duhme C, Lehwald N, Kehrel BE, Bauchrowitz E, Ngepi A, Schmelzle M, Kolokotronis T, Benhidjeb T, Krüger M, Jurk K, Knoefel WT, Robson SC, Schulte Am Esch J.

Blood Cells Mol Dis. 2019 Jul;77:142-148. doi: 10.1016/j.bcmd.2019.04.012. Epub 2019 Apr 27.

PMID:
31075617
4.

Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.

Hollerbach A, Müller-Calleja N, Ritter S, Häuser F, Canisius A, Orning C, Jurk K, Lackner KJ.

Thromb Haemost. 2019 Jul;119(7):1147-1153. doi: 10.1055/s-0039-1685453. Epub 2019 Apr 24.

PMID:
31018220
5.

The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIbα-Mediated Platelet Aggregation.

Trabold K, Makhoul S, Gambaryan S, van Ryn J, Walter U, Jurk K.

Thromb Haemost. 2019 Jun;119(6):916-929. doi: 10.1055/s-0039-1685139. Epub 2019 Apr 20.

PMID:
31005062
6.

High-throughput elucidation of thrombus formation reveals sources of platelet function variability.

van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM.

Haematologica. 2019 Jun;104(6):1256-1267. doi: 10.3324/haematol.2018.198853. Epub 2018 Dec 13.

7.

New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches.

Jurk K, Walter U.

Hamostaseologie. 2019 Jun;39(2):140-151. doi: 10.1055/s-0038-1675356. Epub 2018 Nov 19.

PMID:
30453341
8.

Author Correction: ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis.

Alflen A, Prüfer S, Ebner K, Reuter S, Lopez PA, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP.

Sci Rep. 2018 Sep 26;8(1):14599. doi: 10.1038/s41598-018-32187-7.

9.

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS.

Urbahn MA, Kaup SC, Reusswig F, Krüger I, Spelleken M, Jurk K, Klier M, Lang PA, Elvers M.

Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y.

10.

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis.

Klatt C, Krüger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Lückstädt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M, Elvers M.

J Clin Invest. 2018 Aug 31;128(9):3906-3925. doi: 10.1172/JCI92077. Epub 2018 Aug 13.

11.

Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets.

Makhoul S, Walter E, Pagel O, Walter U, Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K.

Nitric Oxide. 2018 Jun 1;76:71-80. doi: 10.1016/j.niox.2018.03.008. Epub 2018 Mar 14. Review.

PMID:
29550521
12.

Paraoxonase-2 regulates coagulation activation through endothelial tissue factor.

Ebert J, Wilgenbus P, Teiber JF, Jurk K, Schwierczek K, Döhrmann M, Xia N, Li H, Spiecker L, Ruf W, Horke S.

Blood. 2018 May 10;131(19):2161-2172. doi: 10.1182/blood-2017-09-807040. Epub 2018 Feb 9.

13.

Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.

Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M.

Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21.

PMID:
28943410
14.

Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels.

Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C.

PLoS One. 2017 Aug 24;12(8):e0183590. doi: 10.1371/journal.pone.0183590. eCollection 2017.

15.

Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation.

Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C.

Sci Rep. 2017 Aug 8;7(1):7621. doi: 10.1038/s41598-017-07988-x.

16.

ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis.

Alflen A, Prüfer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP.

Sci Rep. 2017 Aug 3;7(1):7184. doi: 10.1038/s41598-017-07340-3. Erratum in: Sci Rep. 2018 Sep 26;8(1):14599.

17.

Direct oral anticoagulants in patients with chronic kidney disease: patient selection and special considerations.

Lutz J, Jurk K, Schinzel H.

Int J Nephrol Renovasc Dis. 2017 Jun 12;10:135-143. doi: 10.2147/IJNRD.S105771. eCollection 2017. Review.

18.

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C.

Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.

19.

Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development.

Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W.

Blood. 2017 Apr 20;129(16):2291-2302. doi: 10.1182/blood-2016-11-749879. Epub 2017 Feb 21.

20.

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension.

Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah4923. doi: 10.1126/scitranslmed.aah4923.

PMID:
28148841
21.

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

Loroch S, Trabold K, Gambaryan S, Reiß C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K.

Thromb Haemost. 2017 Feb 28;117(3):556-569. doi: 10.1160/TH16-07-0515. Epub 2017 Jan 12.

PMID:
28078347
22.

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.

Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Pötz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A.

Blood. 2017 Jan 12;129(2):e1-e12. doi: 10.1182/blood-2016-05-714048. Epub 2016 Nov 9.

23.

Taking the stock of granule cargo: Platelet releasate proteomics.

Pagel O, Walter E, Jurk K, Zahedi RP.

Platelets. 2017 Mar;28(2):119-128. doi: 10.1080/09537104.2016.1254762. Epub 2016 Dec 8. Review.

PMID:
27928935
24.

Antiplatelet Agents and Anticoagulants in Patients with Chronic Kidney Disease - from Pathophysiology to Clinical Practice.

Lutz J, Jurk K.

Curr Pharm Des. 2017;23(9):1366-1376. doi: 10.2174/1381612822666161205112156. Review.

PMID:
27917715
25.

Platelet granules - secretory and secretive.

Jurk K.

Hamostaseologie. 2017 Aug 7;37(3):208-210. doi: 10.5482/HAMO-16-07-0023. Epub 2016 Sep 21. Review.

PMID:
27656707
26.

Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.

Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A.

Br J Pharmacol. 2017 Jun;174(12):1620-1632. doi: 10.1111/bph.13549. Epub 2016 Aug 21.

27.

Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice.

Manukyan D, Müller-Calleja N, Jäckel S, Luchmann K, Mönnikes R, Kiouptsi K, Reinhardt C, Jurk K, Walter U, Lackner KJ.

J Thromb Haemost. 2016 May;14(5):1011-20. doi: 10.1111/jth.13263. Epub 2016 Mar 16.

28.

Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice.

Larmann J, Jurk K, Janssen H, Müller M, Herzog C, Lorenz A, Schmitz M, Nofer JR, Theilmeier G.

PLoS One. 2015 Aug 27;10(8):e0131854. doi: 10.1371/journal.pone.0131854. eCollection 2015.

29.

Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice.

Bollmann F, Jäckel S, Schmidtke L, Schrick K, Reinhardt C, Jurk K, Wu Z, Xia N, Li H, Erkel G, Walter U, Kleinert H, Pautz A.

PLoS One. 2015 Jun 15;10(6):e0130401. doi: 10.1371/journal.pone.0130401. eCollection 2015.

30.

Analysis of platelet function and dysfunction.

Jurk K.

Hamostaseologie. 2015;35(1):60-72. doi: 10.5482/HAMO-14-09-0047. Epub 2014 Dec 8. Review.

PMID:
25482925
31.

Identification of platelet function defects by multi-parameter assessment of thrombus formation.

de Witt SM, Swieringa F, Cavill R, Lamers MM, van Kruchten R, Mastenbroek T, Baaten C, Coort S, Pugh N, Schulz A, Scharrer I, Jurk K, Zieger B, Clemetson KJ, Farndale RW, Heemskerk JW, Cosemans JM.

Nat Commun. 2014 Jul 16;5:4257. doi: 10.1038/ncomms5257.

32.

In vitro and in vivo characterization of a new organic nitrate hybrid drug covalently bound to pioglitazone.

Knorr M, Hausding M, Pfeffer A, Jurk K, Jansen T, Schwierczek K, Oelze M, Kröller-Schön S, Schulz E, Wenzel P, Gori T, Burgin K, Sartor D, Scherhag A, Münzel T, Daiber A.

Pharmacology. 2014;93(5-6):203-15. doi: 10.1159/000361052. Epub 2014 Jun 7.

PMID:
24923291
34.

What can proteomics tell us about platelets?

Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JW, Zahedi RP.

Circ Res. 2014 Mar 28;114(7):1204-19. doi: 10.1161/CIRCRESAHA.114.301598. Review.

PMID:
24677239
35.

Urokinase receptor mediates osteogenic differentiation of mesenchymal stem cells and vascular calcification via the complement C5a receptor.

Kalbasi Anaraki P, Patecki M, Larmann J, Tkachuk S, Jurk K, Haller H, Theilmeier G, Dumler I.

Stem Cells Dev. 2014 Feb 15;23(4):352-62. doi: 10.1089/scd.2013.0318. Epub 2013 Dec 11.

36.

CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction.

Hausding M, Jurk K, Daub S, Kröller-Schön S, Stein J, Schwenk M, Oelze M, Mikhed Y, Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB, Becker C, Münzel T, Grabbe S, Daiber A.

Basic Res Cardiol. 2013 Nov;108(6):386. doi: 10.1007/s00395-013-0386-5. Epub 2013 Sep 24.

PMID:
24061433
37.

Role for the fibrinogen-binding proteins coagulase and Efb in the Staphylococcus aureus-Candida interaction.

Fehrmann C, Jurk K, Bertling A, Seidel G, Fegeler W, Kehrel BE, Peters G, Becker K, Heilmann C.

Int J Med Microbiol. 2013 Jul;303(5):230-8. doi: 10.1016/j.ijmm.2013.02.011. Epub 2013 Mar 13.

PMID:
23684234
38.

Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases.

Bertling A, Niemann S, Hussain M, Holbrook L, Stanley RG, Brodde MF, Pohl S, Schifferdecker T, Roth J, Jurk K, Müller A, Lahav J, Peters G, Heilmann C, Gibbins JM, Kehrel BE.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1979-90. doi: 10.1161/ATVBAHA.112.246249. Epub 2012 Apr 26.

PMID:
22539594
39.

Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa.

Horn M, Bertling A, Brodde MF, Müller A, Roth J, Van Aken H, Jurk K, Heilmann C, Peters G, Kehrel BE.

J Thromb Haemost. 2012 Apr;10(4):647-61. doi: 10.1111/j.1538-7836.2012.04640.x.

40.

Modulation of basophil activity: a novel function of the neuropeptide α-melanocyte-stimulating hormone.

Böhm M, Apel M, Sugawara K, Brehler R, Jurk K, Luger TA, Haas H, Paus R, Eiz-Vesper B, Walls AF, Ponimaskin E, Gehring M, Kapp A, Raap U.

J Allergy Clin Immunol. 2012 Apr;129(4):1085-93. doi: 10.1016/j.jaci.2011.11.012. Epub 2011 Dec 17.

PMID:
22178636
41.

Extracellular protein disulfide isomerase regulates feedback activation of platelet thrombin generation via modulation of coagulation factor binding.

Jurk K, Lahav J, VAN Aken H, Brodde MF, Nofer JR, Kehrel BE.

J Thromb Haemost. 2011 Nov;9(11):2278-90. doi: 10.1111/j.1538-7836.2011.04509.x.

42.

NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet α-granules.

Gunay-Aygun M, Falik-Zaccai TC, Vilboux T, Zivony-Elboum Y, Gumruk F, Cetin M, Khayat M, Boerkoel CF, Kfir N, Huang Y, Maynard D, Dorward H, Berger K, Kleta R, Anikster Y, Arat M, Freiberg AS, Kehrel BE, Jurk K, Cruz P, Mullikin JC, White JG, Huizing M, Gahl WA.

Nat Genet. 2011 Jul 17;43(8):732-4. doi: 10.1038/ng.883.

43.

Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p.

Gunay-Aygun M, Zivony-Elboum Y, Gumruk F, Geiger D, Cetin M, Khayat M, Kleta R, Kfir N, Anikster Y, Chezar J, Arcos-Burgos M, Shalata A, Stanescu H, Manaster J, Arat M, Edwards H, Freiberg AS, Hart PS, Riney LC, Patzel K, Tanpaiboon P, Markello T, Huizing M, Maric I, Horne M, Kehrel BE, Jurk K, Hansen NF, Cherukuri PF, Jones M, Cruz P, Mullikin JC, Nurden A, White JG, Gahl WA, Falik-Zaccai T.

Blood. 2010 Dec 2;116(23):4990-5001. doi: 10.1182/blood-2010-05-286534. Epub 2010 Aug 13.

44.

[Pathophysiology and biochemistry of platelets].

Jurk K, Kehrel BE.

Internist (Berl). 2010 Sep;51(9):1086, 1088-92, 1094. doi: 10.1007/s00108-010-2595-4. Review. German.

PMID:
20700569
45.

Platelet activation and increased tissue factor expression on monocytes in reperfusion injury following orthotopic liver transplantation.

Esch JS, Jurk K, Knoefel WT, Roeder G, Voss H, Tustas RY, Schmelzle M, Krieg A, Eisenberger CF, Topp S, Rogiers X, Fischer L, Aken HV, Kehrel BE.

Platelets. 2010;21(5):348-59. doi: 10.3109/09537101003739897.

PMID:
20569187
46.

Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis.

Jurk K, Ritter MA, Schriek C, Van Aken H, Droste DW, Ringelstein EB, Kehrel BE.

Thromb Haemost. 2010 Jun;103(6):1193-202. doi: 10.1160/TH09-09-0620. Epub 2010 Mar 29.

PMID:
20352160
47.

Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3.

Jurk K, Schulz AS, Kehrel BE, Räpple D, Schulze H, Möbest D, Friedrich WW, Omran H, Deak E, Henschler R, Scheele JS, Zieger B.

Thromb Haemost. 2010 May;103(5):1053-64. doi: 10.1160/TH09-10-0689. Epub 2010 Mar 9.

PMID:
20216991
48.

Microembolic signals on transcranial Doppler ultrasound are correlated with platelet activation markers, but not with platelet-leukocyte associates: a study in patients with acute stroke and in patients with asymptomatic carotid stenosis.

Ritter MA, Jurk K, Schriek C, Nabavi DG, Droste DW, Kehrel BE, Bernd Ringelstein E.

Neurol Res. 2009 Feb;31(1):11-6. doi: 10.1179/174313208X331590. Epub 2008 Sep 3.

PMID:
18768115
49.

[The role of platelets in haemostasis, thrombosis, immune defense and inflammation].

Jurk K, Kehrel BE.

Dtsch Med Wochenschr. 2008 May;133(21):1130-5. doi: 10.1055/s-2008-1077228. Review. German.

PMID:
18478507
50.

IL-4 enhances hypoxia induced HIF-1alpha protein levels in human transformed intestinal cells.

Scharte M, Jurk K, Kehrel B, Zarbock A, Van Aken H, Singbartl K.

FEBS Lett. 2006 Nov 27;580(27):6399-404. Epub 2006 Nov 3.

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