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Items: 31

1.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.

2.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 Jan 3. pii: S1550-4131(18)30745-9. doi: 10.1016/j.cmet.2018.12.008. [Epub ahead of print]

3.

Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.

Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF.

Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23.

4.

A novel Sudan Black B-based analogue revives lipofuscin as a biomarker for in vivo senescence.

Tiniakos D, Jurk D.

Virchows Arch. 2018 Dec;473(6):781-783. doi: 10.1007/s00428-018-2452-8. No abstract available.

PMID:
30225657
5.

Senolytics improve physical function and increase lifespan in old age.

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL.

Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

6.

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN.

Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.

PMID:
29719225
7.

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.

Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI.

Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.

8.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

9.

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

Fielder E, von Zglinicki T, Jurk D.

J Alzheimers Dis. 2017;60(s1):S107-S131. doi: 10.3233/JAD-161221. Review.

PMID:
28436392
10.

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):780-785. doi: 10.1093/gerona/glw154.

11.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

12.

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

Roos CM, Zhang B, Palmer AK, Ogrodnik MB, Pirtskhalava T, Thalji NM, Hagler M, Jurk D, Smith LA, Casaclang-Verzosa G, Zhu Y, Schafer MJ, Tchkonia T, Kirkland JL, Miller JD.

Aging Cell. 2016 Oct;15(5):973-7. doi: 10.1111/acel.12458. Epub 2016 Aug 5.

13.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.

14.

Oxidative stress and life histories: unresolved issues and current needs.

Speakman JR, Blount JD, Bronikowski AM, Buffenstein R, Isaksson C, Kirkwood TB, Monaghan P, Ozanne SE, Beaulieu M, Briga M, Carr SK, Christensen LL, Cochemé HM, Cram DL, Dantzer B, Harper JM, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons MJ, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M, Selman C.

Ecol Evol. 2015 Nov 17;5(24):5745-57. doi: 10.1002/ece3.1790. eCollection 2015 Dec.

15.

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):3-15. Epub 2016 Jan 24.

16.

Corrigendum: NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Bagchi Chakraborty J, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA.

Nat Commun. 2015 Sep 21;6:8411. doi: 10.1038/ncomms9411. No abstract available.

17.

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. doi: 10.1152/ajplung.00293.2015. Epub 2015 Sep 18.

18.

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Chakraborty JB, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA.

Nat Commun. 2015 Apr 16;6:6818. doi: 10.1038/ncomms7818. Erratum in: Nat Commun. 2015;6:8411.

19.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.

20.

Robust multiparametric assessment of cellular senescence.

Correia-Melo C, Jurk D, Passos JF.

Methods Mol Biol. 2013;965:409-19. doi: 10.1007/978-1-62703-239-1_27.

PMID:
23296674
21.

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.

Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A, Gonos ES, Thrasivoulou C, Saffrey MJ, Cameron K, von Zglinicki T.

Aging Cell. 2012 Dec;11(6):996-1004. doi: 10.1111/j.1474-9726.2012.00870.x. Epub 2012 Sep 12.

22.

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver.

Verma S, Tachtatzis P, Penrhyn-Lowe S, Scarpini C, Jurk D, Von Zglinicki T, Coleman N, Alexander GJ.

Hepatology. 2012 Oct;56(4):1510-20. doi: 10.1002/hep.25787. Epub 2012 Aug 27.

PMID:
22504828
23.

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF.

Nat Commun. 2012 Feb 28;3:708. doi: 10.1038/ncomms1708.

24.

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF.

PLoS One. 2012;7(2):e32117. doi: 10.1371/journal.pone.0032117. Epub 2012 Feb 16.

25.

A senescent cell bystander effect: senescence-induced senescence.

Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T.

Aging Cell. 2012 Apr;11(2):345-9. doi: 10.1111/j.1474-9726.2012.00795.x. Epub 2012 Feb 9.

26.

Adult-onset, short-term dietary restriction reduces cell senescence in mice.

Wang C, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SA, Godschalk RW, Cameron K, von Zglinicki T.

Aging (Albany NY). 2010 Sep;2(9):555-66.

27.

Quantitative assessment of markers for cell senescence.

Lawless C, Wang C, Jurk D, Merz A, Zglinicki Tv, Passos JF.

Exp Gerontol. 2010 Oct;45(10):772-8. doi: 10.1016/j.exger.2010.01.018. Epub 2010 Feb 1.

PMID:
20117203
28.

DNA damage response and cellular senescence in tissues of aging mice.

Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T.

Aging Cell. 2009 Jun;8(3):311-23. doi: 10.1111/j.1474-9726.2009.00481.x. Epub 2009 Apr 9.

29.

[Physical exercise as rehabilitation method used in patients following surgery of coronary vessels (author's transl)].

Geissler W, Schulz J, Gerl H, Eichhorst E, Jurk D, Götsche A, Schilling E.

Przegl Lek. 1974;31(11):901-3. Polish. No abstract available.

PMID:
4438679
30.

[Sauna in the ambulatory treatment of patients with chronic bronchitis syndrome].

Jurk D.

Z Arztl Fortbild (Jena). 1973 Jul 15;67(14):722-5. German. No abstract available.

PMID:
4774640
31.

[Studies on the blood pressure behavior during clinical fasting treatment].

Conradi E, Jurk D.

Z Gesamte Inn Med. 1969 Jun 15;24(12):369-72. German. No abstract available.

PMID:
5404296

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